ES8306756A1 - Un procedimiento para la preparacion de un enantiomero de beta-lactama. - Google Patents

Un procedimiento para la preparacion de un enantiomero de beta-lactama.

Info

Publication number
ES8306756A1
ES8306756A1 ES512172A ES512172A ES8306756A1 ES 8306756 A1 ES8306756 A1 ES 8306756A1 ES 512172 A ES512172 A ES 512172A ES 512172 A ES512172 A ES 512172A ES 8306756 A1 ES8306756 A1 ES 8306756A1
Authority
ES
Spain
Prior art keywords
enantiomer
preparation
joined
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512172A
Other languages
English (en)
Other versions
ES512172A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES512172A0 publication Critical patent/ES512172A0/es
Publication of ES8306756A1 publication Critical patent/ES8306756A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN ENANTIOMERO DE ~J-LACTAMA. DE UNA MEZCLA DE DIASTEROISOMEROS DE UN COMPUESTO DE FORMULA (I), DONDE R ES ACETILO, ~C-HIDROXIETILO O UN DERIVADO PROTEGIDO DEL MISMO. R Y R SON GRUPOS HIDROCARBONADOS SUSTITUIDOS O NO, O R Y R ESTAN UNIDOS FORMANDO UN ANILLO CARBOCICLICO O HETEROCICLICO, CONTENIENDO COMO MINIMO UNO DE ELLOS UN CENTRO QUIRAL, Y R Y R SON INDEPENDIENTEMENTE HIDROGENO O UN GRUPO ORGANICO UNIDO POR UN ATOMO DE CARBONO AL ANILLO DE TETRAHIDRO-OXAZINA O R Y R ESTAN UNIDOS FORMANDO UN ANILLO DE CICLOALQUILO C -C O DE HETEROCICLICO, OPCIONALMENTE SUSTITUIDOS, JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS, SE SEPARA EL ENANTIOMERO POR CRISTALIZACION Y/O POR CROMATOGRAFIA. DE APLICACION EN LA PREPARACION DE ANTIBIOTICOS DE CARBAPENEM OPTICAMENTE ACTIVOS.
ES512172A 1981-05-14 1982-05-13 Un procedimiento para la preparacion de un enantiomero de beta-lactama. Expired ES8306756A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8114848 1981-05-14

Publications (2)

Publication Number Publication Date
ES512172A0 ES512172A0 (es) 1983-06-01
ES8306756A1 true ES8306756A1 (es) 1983-06-01

Family

ID=10521812

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512172A Expired ES8306756A1 (es) 1981-05-14 1982-05-13 Un procedimiento para la preparacion de un enantiomero de beta-lactama.

Country Status (7)

Country Link
US (1) US4443599A (es)
EP (1) EP0067517B1 (es)
JP (1) JPS57193483A (es)
AU (1) AU8361682A (es)
DE (1) DE3269313D1 (es)
ES (1) ES8306756A1 (es)
ZA (1) ZA823278B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093485A3 (en) * 1982-03-16 1985-04-10 Beecham Group Plc Process for the preparation of substituted 3-oxa-1-aza-bicyclo(4.2.0)octan-8-ones, and intermediates obtained thereby
US4595750A (en) * 1985-02-19 1986-06-17 Merck & Co., Inc. Process for chiral synthesis of 1-β-methylcarbapenem intermediates
US4617152A (en) * 1985-02-19 1986-10-14 Merck & Co., Inc. β-lactams containing an α-exocyclic double bond
US5075436A (en) * 1986-01-08 1991-12-24 Merck & Co., Inc. Chiral 1-β-methyl-carbapenem intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1085392A (en) * 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
US4348320A (en) * 1976-11-19 1982-09-07 Merck & Co., Inc. Substituted azetidiones
GB2013667B (en) * 1978-02-02 1982-06-30 Beecham Group Ltd Chemical intemediates
US4245089A (en) * 1978-02-02 1981-01-13 Beecham Group Limited Novel intermediates for β-lactams
EP0018594B1 (en) * 1979-04-27 1985-08-21 Merck & Co. Inc. Process for the preparation of 3-(1-hydroxyethyl)-azetidinones

Also Published As

Publication number Publication date
EP0067517B1 (en) 1986-02-26
ES512172A0 (es) 1983-06-01
AU8361682A (en) 1982-11-18
US4443599A (en) 1984-04-17
EP0067517A1 (en) 1982-12-22
DE3269313D1 (en) 1986-04-03
ZA823278B (en) 1983-03-30
JPS57193483A (en) 1982-11-27

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