ES8707244A1 - Un procedimiento para la preparacion de nuevos derivados penem. - Google Patents

Un procedimiento para la preparacion de nuevos derivados penem.

Info

Publication number
ES8707244A1
ES8707244A1 ES539853A ES539853A ES8707244A1 ES 8707244 A1 ES8707244 A1 ES 8707244A1 ES 539853 A ES539853 A ES 539853A ES 539853 A ES539853 A ES 539853A ES 8707244 A1 ES8707244 A1 ES 8707244A1
Authority
ES
Spain
Prior art keywords
intermediates
preparation
denotes
hetero
denotes hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539853A
Other languages
English (en)
Other versions
ES539853A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848402085A external-priority patent/GB8402085D0/en
Priority claimed from GB848417659A external-priority patent/GB8417659D0/en
Priority claimed from GB848425889A external-priority patent/GB8425889D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8707244A1 publication Critical patent/ES8707244A1/es
Publication of ES539853A0 publication Critical patent/ES539853A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE PENEM. CONSISTE EN DESHIDRATAR A UN COMPUESTO DE FORMULA (II), CON HIDROXIDO ALCALINO, ENTRE C20 Y 100JC Y EN TETRAHIDROFURANO O ACETATO DE ETILO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: R1 Y R2, H O UN ANILLO HETEROAROMATICO DE 5 MIEMBROS NO SUSTITUIDO O SUSTITUIDO A TRAVES DE 1C Y SELECCIONADO ENTRE N, O Y S; R3, H O -R4; R4, HIDROCARBILO DE C 1 A 10 Y OTROS Y R13 Y R14 UNA SUBFORMULA (III); R16, H O R3 Y RX O UN GRUPO BLOQUEADOR DE CARBOXILO. SE UTILIZA PARA TRATAR LAS INFECCIONES DEL TRACTO URINARIO.
ES539853A 1984-01-26 1985-01-25 Un procedimiento para la preparacion de nuevos derivados penem. Expired ES8707244A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB848402085A GB8402085D0 (en) 1984-01-26 1984-01-26 Compounds
GB848417659A GB8417659D0 (en) 1984-07-11 1984-07-11 Compounds
GB848425889A GB8425889D0 (en) 1984-10-12 1984-10-12 Compounds

Publications (2)

Publication Number Publication Date
ES8707244A1 true ES8707244A1 (es) 1987-07-16
ES539853A0 ES539853A0 (es) 1987-07-16

Family

ID=27262267

Family Applications (3)

Application Number Title Priority Date Filing Date
ES539853A Expired ES8707244A1 (es) 1984-01-26 1985-01-25 Un procedimiento para la preparacion de nuevos derivados penem.
ES548033A Expired ES8609338A1 (es) 1984-01-26 1985-10-18 Un procedimiento para la preparacion de nuevos derivados pe-nem
ES553604A Expired ES8800683A1 (es) 1984-01-26 1986-04-01 Un procedimiento para la preparacion de nuevos derivados penem

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES548033A Expired ES8609338A1 (es) 1984-01-26 1985-10-18 Un procedimiento para la preparacion de nuevos derivados pe-nem
ES553604A Expired ES8800683A1 (es) 1984-01-26 1986-04-01 Un procedimiento para la preparacion de nuevos derivados penem

Country Status (19)

Country Link
US (1) US4798828A (es)
EP (1) EP0154132B1 (es)
JP (1) JPH0696579B2 (es)
KR (1) KR850005444A (es)
AU (1) AU569366B2 (es)
CA (1) CA1272479A (es)
DE (1) DE3585095D1 (es)
DK (1) DK32485A (es)
ES (3) ES8707244A1 (es)
FI (1) FI82471C (es)
GR (1) GR850208B (es)
HU (1) HU197013B (es)
IL (1) IL74153A (es)
NO (1) NO850314L (es)
NZ (1) NZ210929A (es)
PH (1) PH23447A (es)
PL (1) PL149297B1 (es)
PT (1) PT79873B (es)
YU (1) YU45695B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518422D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8711391D0 (en) * 1987-05-14 1987-06-17 Beecham Group Plc Process
GB8729614D0 (en) * 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
GB8729613D0 (en) * 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
DE69016719T2 (de) * 1989-09-04 1995-06-01 Beecham Group Plc Cephalosporinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate und Zwischenverbindungen.
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
GB9305837D0 (en) * 1993-03-20 1993-05-05 Smithkline Beecham Plc Novel compounds
GB9326248D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Plc Pharmaceutical formulations
US5464616A (en) * 1994-08-04 1995-11-07 Synphar Laboratories, Ind. 6β-substituted penicillanic acids as beta-lactamase inhibitors
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
AU2012233003B2 (en) * 2005-12-07 2014-12-18 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
PT2308874E (pt) * 2005-12-07 2013-04-26 Basilea Pharmaceutica Ag Monobactamas ligadas por pontes, úteis como inibidores de beta-lactamase
US10399041B2 (en) * 2014-11-17 2019-09-03 Qatar Foundation For Education, Science And Community Development Two-dimensional metal carbide antimicrobial membrane and antimicrobial agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041768B1 (en) * 1980-04-24 1987-11-11 Beecham Group Plc Beta-lactam compounds, their preparation and use
DE3167198D1 (en) * 1980-08-16 1984-12-20 Beecham Group Plc Process for the preparation of 2-thio penem derivatives and intermediates therefor
EP0120613A1 (en) * 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors

Also Published As

Publication number Publication date
CA1272479A (en) 1990-08-07
YU45695B (sh) 1992-07-20
FI82471B (fi) 1990-11-30
PL149297B1 (en) 1990-01-31
KR850005444A (ko) 1985-08-26
JPH0696579B2 (ja) 1994-11-30
IL74153A (en) 1990-04-29
FI82471C (fi) 1991-03-11
FI850174L (fi) 1985-07-27
NZ210929A (en) 1987-08-31
HUT38352A (en) 1986-05-28
PT79873A (en) 1985-02-01
DK32485D0 (da) 1985-01-24
PH23447A (en) 1989-08-07
EP0154132A1 (en) 1985-09-11
HU197013B (en) 1989-02-28
JPS60185786A (ja) 1985-09-21
ES553604A0 (es) 1987-11-16
GR850208B (es) 1985-05-24
YU11685A (en) 1988-02-29
ES539853A0 (es) 1987-07-16
PT79873B (pt) 1986-06-02
ES8609338A1 (es) 1986-09-01
US4798828A (en) 1989-01-17
DE3585095D1 (de) 1992-02-20
AU3805885A (en) 1985-08-01
AU569366B2 (en) 1988-01-28
DK32485A (da) 1985-07-27
ES548033A0 (es) 1986-09-01
ES8800683A1 (es) 1987-11-16
PL251703A1 (en) 1985-12-03
FI850174A0 (fi) 1985-01-15
EP0154132B1 (en) 1992-01-08
NO850314L (no) 1985-07-29

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506