ES8304137A1 - Un procedimiento para la preparacion de compuestos b -lactamicos. - Google Patents

Un procedimiento para la preparacion de compuestos b -lactamicos.

Info

Publication number
ES8304137A1
ES8304137A1 ES513034A ES513034A ES8304137A1 ES 8304137 A1 ES8304137 A1 ES 8304137A1 ES 513034 A ES513034 A ES 513034A ES 513034 A ES513034 A ES 513034A ES 8304137 A1 ES8304137 A1 ES 8304137A1
Authority
ES
Spain
Prior art keywords
derivatives
preparation
clavulanic acid
group
nrarb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513034A
Other languages
English (en)
Other versions
ES513034A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES513034A0 publication Critical patent/ES513034A0/es
Publication of ES8304137A1 publication Critical patent/ES8304137A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS ~J-LACTAMICOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I), CON UN DERIVADO N-ACILANTE DE UN ACIDO R-CXOH; OPCIONALMENTE, A CONTINUACION, SE PUEDE ELIMINAR CUALQUIER GRUPO BLOQUEANTE DE CARBOXI; O BIEN PUEDE CONVERTIRSE EL PRODUCTO OBTENIDO (II) EN SAL O EN EL ESTER CORRESPONDIENTE. EL COMPUESTO SE PRODUCE EN FORMA DE ACIDO LIBRE O DE LA SAL O DEL ESTER HIDROLIZABLE ~AIN VIVO~B DEL MISMO FARMACEUTICAMENTE ACEPTABLE. R REPRESENTA EL GRUPO R , -OR , SR O NR<AR<B, DONDE R , R<A Y R<B REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O UN RADICAL HIDROCARBURADO; X ES OXIGENO O AZUFRE Y R ES UN GRUPO HIDROCARBONADO O HETEROCICLICO OPCIONALMENTE SUSTITUIDO.
ES513034A 1981-06-12 1982-06-11 Un procedimiento para la preparacion de compuestos b -lactamicos. Expired ES8304137A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8118108 1981-06-12
GB8128092 1981-09-17

Publications (2)

Publication Number Publication Date
ES513034A0 ES513034A0 (es) 1983-02-16
ES8304137A1 true ES8304137A1 (es) 1983-02-16

Family

ID=26279772

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513034A Expired ES8304137A1 (es) 1981-06-12 1982-06-11 Un procedimiento para la preparacion de compuestos b -lactamicos.

Country Status (3)

Country Link
EP (1) EP0068617A1 (es)
AU (1) AU8472382A (es)
ES (1) ES8304137A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518917D0 (en) * 1995-09-15 1995-11-15 Smithkline Beecham Plc Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT363181B (de) * 1976-10-25 1981-07-10 Glaxo Lab Ltd Verfahren zur herstellung von neuen clavulansaeurederivaten
NZ187013A (en) * 1977-04-27 1985-04-30 Beecham Group Ltd 9-amino-9-deoxy-clavulanic acid derivatives and pharmaceutical compositions
GB1604823A (en) * 1978-04-07 1981-12-16 Beecham Group Ltd Intermediates useful in the preparation of n-monosubstituted-9-amino-9-deoxyclavulanic acid derivatives

Also Published As

Publication number Publication date
AU8472382A (en) 1982-12-16
ES513034A0 (es) 1983-02-16
EP0068617A1 (en) 1983-01-05

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