ES8700859A1 - Un procedimiento para la preparacion de nuevos derivados pe-nem - Google Patents
Un procedimiento para la preparacion de nuevos derivados pe-nemInfo
- Publication number
- ES8700859A1 ES8700859A1 ES548147A ES548147A ES8700859A1 ES 8700859 A1 ES8700859 A1 ES 8700859A1 ES 548147 A ES548147 A ES 548147A ES 548147 A ES548147 A ES 548147A ES 8700859 A1 ES8700859 A1 ES 8700859A1
- Authority
- ES
- Spain
- Prior art keywords
- pemens
- alkylidene
- intermediates
- preparation
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000543 intermediate Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS PENEM DE FORMULA GENERAL (II), SUS SALES FARMACEUTICAMENTE ACEPTABLES O UN ESTER HIDROLIZABLE <IN VIVO>. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (XIII), CON UN TIOL DE FORMULA GENERAL R4-SH, O UN DERIVADO DEL MISMO Y DESPUES SEPARAR CUALQUIER GRUPO BLOQUEANTE DEL CARBOXILO O CONVERTIR EL PRODUCTO EN EL ACIDO LIBRE O EN LA SAL O EL ESTER HIDROLIZABLE. ESTOS COMPUESTOS B-LACTAMICOS Y EN ESPECIAL LOS PERTENECIENTES A LA CLASE 6-ALQUILIDEN-PENEM, POSEEN PROPIEDADES ANTIBACTERIANAS E INHINBIDORAS DE B-LACTAMASAS Y PUEDEN EMPLEARSE EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS EN EL HOMBRE Y ANIMALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848402086A GB8402086D0 (en) | 1984-01-26 | 1984-01-26 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8700859A1 true ES8700859A1 (es) | 1986-11-16 |
ES548147A0 ES548147A0 (es) | 1986-11-16 |
Family
ID=10555586
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES539854A Expired ES8704951A1 (es) | 1984-01-26 | 1985-01-25 | Un procedimiento para la preparacion de nuevos derivados penem. |
ES548147A Expired ES8700859A1 (es) | 1984-01-26 | 1985-10-23 | Un procedimiento para la preparacion de nuevos derivados pe-nem |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES539854A Expired ES8704951A1 (es) | 1984-01-26 | 1985-01-25 | Un procedimiento para la preparacion de nuevos derivados penem. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0150781A1 (es) |
JP (1) | JPS60197691A (es) |
AU (1) | AU3806185A (es) |
ES (2) | ES8704951A1 (es) |
GB (1) | GB8402086D0 (es) |
GR (1) | GR850207B (es) |
IE (1) | IE850161L (es) |
ZA (1) | ZA85564B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8518416D0 (en) * | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
DE3752124T2 (de) * | 1986-01-17 | 1998-03-26 | Beecham Group Plc | Verfahren zur Herstellung von Penem Derivaten und Zwischenprodukte zu dieser Herstellung |
GB8711391D0 (en) * | 1987-05-14 | 1987-06-17 | Beecham Group Plc | Process |
AR039774A1 (es) | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
AR039475A1 (es) | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3176517D1 (en) * | 1980-04-24 | 1987-12-17 | Beecham Group Plc | Beta-lactam compounds, their preparation and use |
-
1984
- 1984-01-26 GB GB848402086A patent/GB8402086D0/en active Pending
-
1985
- 1985-01-18 EP EP85100520A patent/EP0150781A1/en not_active Withdrawn
- 1985-01-24 ZA ZA85564A patent/ZA85564B/xx unknown
- 1985-01-24 AU AU38061/85A patent/AU3806185A/en not_active Abandoned
- 1985-01-24 GR GR850207A patent/GR850207B/el unknown
- 1985-01-24 IE IE850161A patent/IE850161L/xx unknown
- 1985-01-25 ES ES539854A patent/ES8704951A1/es not_active Expired
- 1985-01-25 JP JP60013394A patent/JPS60197691A/ja active Pending
- 1985-10-23 ES ES548147A patent/ES8700859A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES548147A0 (es) | 1986-11-16 |
JPS60197691A (ja) | 1985-10-07 |
ES539854A0 (es) | 1987-04-16 |
EP0150781A1 (en) | 1985-08-07 |
GB8402086D0 (en) | 1984-02-29 |
IE850161L (en) | 1985-07-26 |
AU3806185A (en) | 1985-08-01 |
GR850207B (es) | 1985-05-23 |
ES8704951A1 (es) | 1987-04-16 |
ZA85564B (en) | 1986-08-27 |
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