CS223977B2 - Method of preparation of the chinazoline derivatives - Google Patents

Method of preparation of the chinazoline derivatives Download PDF

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Publication number
CS223977B2
CS223977B2 CS80157A CS15780A CS223977B2 CS 223977 B2 CS223977 B2 CS 223977B2 CS 80157 A CS80157 A CS 80157A CS 15780 A CS15780 A CS 15780A CS 223977 B2 CS223977 B2 CS 223977B2
Authority
CS
Czechoslovakia
Prior art keywords
parts
mixture
group
alkyl
carbon atoms
Prior art date
Application number
CS80157A
Other languages
Czech (cs)
English (en)
Inventor
Jan Vandenberk
Ludo Kennis
Der Aa Marcel J M C Van
Heertum Albert H M T Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26669096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS223977(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CS223977B2 publication Critical patent/CS223977B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS80157A 1979-01-08 1980-01-07 Method of preparation of the chinazoline derivatives CS223977B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US149379A 1979-01-08 1979-01-08
US06/084,272 US4335127A (en) 1979-01-08 1979-10-12 Piperidinylalkyl quinazoline compounds, composition and method of use

Publications (1)

Publication Number Publication Date
CS223977B2 true CS223977B2 (en) 1983-11-25

Family

ID=26669096

Family Applications (1)

Application Number Title Priority Date Filing Date
CS80157A CS223977B2 (en) 1979-01-08 1980-01-07 Method of preparation of the chinazoline derivatives

Country Status (32)

Country Link
US (1) US4335127A (fr)
EP (1) EP0013612B1 (fr)
JP (1) JPS55105679A (fr)
KR (3) KR850000684B1 (fr)
AT (1) ATE5258T1 (fr)
AU (1) AU536175B2 (fr)
CA (1) CA1132557A (fr)
CS (1) CS223977B2 (fr)
CY (1) CY1252A (fr)
DE (1) DE3065489D1 (fr)
DK (1) DK170669B1 (fr)
ES (1) ES487537A0 (fr)
FI (1) FI66609C (fr)
GR (1) GR67304B (fr)
HK (1) HK76284A (fr)
HU (1) HU184222B (fr)
IE (1) IE49351B1 (fr)
IL (1) IL59084A (fr)
LU (1) LU88219I2 (fr)
MA (1) MA18694A1 (fr)
MY (1) MY8700555A (fr)
NL (1) NL930018I2 (fr)
NO (1) NO155243C (fr)
NZ (1) NZ192551A (fr)
PH (1) PH17114A (fr)
PL (1) PL125789B1 (fr)
PT (1) PT70662A (fr)
RO (1) RO79148A (fr)
SG (1) SG48684G (fr)
SU (1) SU1041034A3 (fr)
YU (1) YU42957B (fr)
ZA (1) ZA8082B (fr)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
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CN105209467B (zh) 2013-05-27 2018-06-08 诺华股份有限公司 咪唑并吡咯烷酮衍生物及其在治疗疾病中的用途
WO2014191911A1 (fr) 2013-05-28 2014-12-04 Novartis Ag Dérivés de pyrazolo-pyrrolidin-4-one et leur utilisation dans le traitement de maladie
AU2014272695B2 (en) 2013-05-28 2016-10-20 Novartis Ag Pyrazolo-pyrrolidin-4-one derivatives as BET inhibitors and their use in the treatment of disease
MX2016006667A (es) 2013-11-21 2016-07-26 Novartis Ag Derivados de pirrolo-pirrolona y su uso como inhibidores.
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CN106866625B (zh) * 2017-01-17 2019-12-13 上海鼎雅药物化学科技有限公司 酮色林的制备方法
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NO155243B (no) 1986-11-24
PL221249A1 (fr) 1980-12-01
KR850002015A (ko) 1985-04-10
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CY1252A (en) 1984-08-31
MA18694A1 (fr) 1980-10-01
NZ192551A (en) 1984-07-06
EP0013612B1 (fr) 1983-11-09
SU1041034A3 (ru) 1983-09-07
NL930018I2 (nl) 1993-09-16
DK170669B1 (da) 1995-11-27
YU4680A (en) 1983-06-30
EP0013612A2 (fr) 1980-07-23
DE3065489D1 (en) 1983-12-15
SG48684G (en) 1985-03-29
EP0013612A3 (en) 1980-10-15
FI66609B (fi) 1984-07-31
PH17114A (en) 1984-06-01
KR830001926A (ko) 1983-05-19
IL59084A0 (en) 1980-05-30
ZA8082B (en) 1981-08-26
ES8101586A1 (es) 1980-12-16
HK76284A (en) 1984-10-19
PT70662A (en) 1980-02-01
ATE5258T1 (de) 1983-11-15
HU184222B (en) 1984-07-30
NL930018I1 (nl) 1993-05-03
LU88219I2 (fr) 1994-02-03
US4335127A (en) 1982-06-15
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MY8700555A (en) 1987-12-31
GR67304B (fr) 1981-06-29
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RO79148A (fr) 1982-08-17
KR850000684B1 (ko) 1985-05-14
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CA1132557A (fr) 1982-09-28
FI800047A7 (fi) 1980-07-09
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IL59084A (en) 1984-02-29
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DK7280A (da) 1980-07-09
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JPS6346753B2 (fr) 1988-09-19
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