PL125789B1 - Process for preparing novel derivatives of quinazoline - Google Patents

Process for preparing novel derivatives of quinazoline Download PDF

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Publication number
PL125789B1
PL125789B1 PL1980221249A PL22124980A PL125789B1 PL 125789 B1 PL125789 B1 PL 125789B1 PL 1980221249 A PL1980221249 A PL 1980221249A PL 22124980 A PL22124980 A PL 22124980A PL 125789 B1 PL125789 B1 PL 125789B1
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PL
Poland
Prior art keywords
alkyl
group
aryl
independently selected
substituents
Prior art date
Application number
PL1980221249A
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English (en)
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PL221249A1 (pl
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26669096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL125789(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PL221249A1 publication Critical patent/PL221249A1/xx
Publication of PL125789B1 publication Critical patent/PL125789B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

»lPc- rydynyflo/-*fletaffiOTiu, 8 czesci weglanu sodowego i 1120 czesci ^Hmetyflopentanottu-ia utrzymuje sie w 45 stanie ^wrzenia pod chlodnica zwrotna z oddziela¬ czem iwody i po upiywSe 112 godzin odsacza sie wyittworzony osad i przekrytsbaiizowujle go z 96 czesci propanolu-2. Otrzymuje sie 3 czesci 2-tf3- ¦ nyflo]^tyto}-4/3IH/-cllxiiziazoai'nonu o temperaturze tcptanenda O09U9°1C.?W analogiczny sposób wytwarza sie nastejpujace zwiafzki: sól 2WzMcMoroJ!enylo/^-{2^ 55 ^iperydynyaolH^ylo}^/3H/Hc*inazo sem /E/n2-ibuftJenoowtukarboikteyiowyffn <1:1) o tetm- peratuiae topnienia .1A9J2PC <3fl»/» wydajnosci teo- retycznejf), sól 0-ite-diBorotfenylo/*{te w -piperydymyflo]-etylo}-fc^/-^ z kwa¬ sem ^-^-buitenc^wUkarhoksylowysn peratonze topnienia aa5,«°C retycznej) i ból 9-{|2^4r^l4Hrluorolbenzoilo/-l^pdpery- dytaylo]-etyl*}^-dflenyfliomietyao/^^ « z kwasem /E/-24jutenodwufcaribofcsylo^ (1:1) o teimperaturze topnienia 22tiftC (filF/t wydajnosci teoretycznej). PL PL PL PL PL PL PL PL

Claims (1)

1.
PL1980221249A 1979-01-08 1980-01-07 Process for preparing novel derivatives of quinazoline PL125789B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US149379A 1979-01-08 1979-01-08
US06/084,272 US4335127A (en) 1979-01-08 1979-10-12 Piperidinylalkyl quinazoline compounds, composition and method of use

Publications (2)

Publication Number Publication Date
PL221249A1 PL221249A1 (pl) 1980-12-01
PL125789B1 true PL125789B1 (en) 1983-06-30

Family

ID=26669096

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1980221249A PL125789B1 (en) 1979-01-08 1980-01-07 Process for preparing novel derivatives of quinazoline

Country Status (32)

Country Link
US (1) US4335127A (pl)
EP (1) EP0013612B1 (pl)
JP (1) JPS55105679A (pl)
KR (3) KR850000684B1 (pl)
AT (1) ATE5258T1 (pl)
AU (1) AU536175B2 (pl)
CA (1) CA1132557A (pl)
CS (1) CS223977B2 (pl)
CY (1) CY1252A (pl)
DE (1) DE3065489D1 (pl)
DK (1) DK170669B1 (pl)
ES (1) ES8101586A1 (pl)
FI (1) FI66609C (pl)
GR (1) GR67304B (pl)
HK (1) HK76284A (pl)
HU (1) HU184222B (pl)
IE (1) IE49351B1 (pl)
IL (1) IL59084A (pl)
LU (1) LU88219I2 (pl)
MA (1) MA18694A1 (pl)
MY (1) MY8700555A (pl)
NL (1) NL930018I2 (pl)
NO (1) NO155243C (pl)
NZ (1) NZ192551A (pl)
PH (1) PH17114A (pl)
PL (1) PL125789B1 (pl)
PT (1) PT70662A (pl)
RO (1) RO79148A (pl)
SG (1) SG48684G (pl)
SU (1) SU1041034A3 (pl)
YU (1) YU42957B (pl)
ZA (1) ZA8082B (pl)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
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YU42957B (en) 1989-02-28
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EP0013612A2 (en) 1980-07-23
HU184222B (en) 1984-07-30
MA18694A1 (fr) 1980-10-01
IE49351B1 (en) 1985-09-18
CY1252A (en) 1984-08-31
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IL59084A (en) 1984-02-29
FI66609B (fi) 1984-07-31
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RO79148A (ro) 1982-08-17
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NO155243C (no) 1987-03-04
US4335127A (en) 1982-06-15
LU88219I2 (pl) 1994-02-03
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