CS199680B2 - Method of producing novel bis/3,5-dicarbamoyl-2,4,6-triiodanilide/dicarboxylic acids - Google Patents

Method of producing novel bis/3,5-dicarbamoyl-2,4,6-triiodanilide/dicarboxylic acids Download PDF

Info

Publication number
CS199680B2
CS199680B2 CS774059A CS405977A CS199680B2 CS 199680 B2 CS199680 B2 CS 199680B2 CS 774059 A CS774059 A CS 774059A CS 405977 A CS405977 A CS 405977A CS 199680 B2 CS199680 B2 CS 199680B2
Authority
CS
Czechoslovakia
Prior art keywords
bis
acid
formula
triiodanilide
solution
Prior art date
Application number
CS774059A
Other languages
Czech (cs)
English (en)
Inventor
Heinrich Pfeifer
Ulrich Speck
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS199680B2 publication Critical patent/CS199680B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
CS774059A 1976-06-23 1977-06-20 Method of producing novel bis/3,5-dicarbamoyl-2,4,6-triiodanilide/dicarboxylic acids CS199680B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2628517A DE2628517C2 (de) 1976-06-23 1976-06-23 Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel

Publications (1)

Publication Number Publication Date
CS199680B2 true CS199680B2 (en) 1980-07-31

Family

ID=5981407

Family Applications (1)

Application Number Title Priority Date Filing Date
CS774059A CS199680B2 (en) 1976-06-23 1977-06-20 Method of producing novel bis/3,5-dicarbamoyl-2,4,6-triiodanilide/dicarboxylic acids

Country Status (28)

Country Link
US (1) US4239747A (it)
JP (2) JPS537637A (it)
AT (1) AT361117B (it)
AU (1) AU512304B2 (it)
BE (1) BE856039A (it)
CA (2) CA1106400A (it)
CH (1) CH629751A5 (it)
CS (1) CS199680B2 (it)
DD (1) DD131014A5 (it)
DE (1) DE2628517C2 (it)
DK (2) DK150505C (it)
ES (1) ES460007A1 (it)
FI (1) FI67540C (it)
FR (1) FR2355808A1 (it)
GB (2) GB1588733A (it)
GR (1) GR71696B (it)
HU (1) HU174228B (it)
IE (2) IE45225B1 (it)
IL (2) IL52356A (it)
IT (1) IT1237314B (it)
LU (2) LU77588A1 (it)
NL (1) NL189510C (it)
NO (2) NO147447C (it)
PL (1) PL108102B1 (it)
PT (1) PT66690B (it)
SE (1) SE436871B (it)
SU (1) SU917696A3 (it)
ZA (1) ZA773782B (it)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH626873A5 (it) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
DK273280A (da) * 1979-06-28 1980-12-29 Schering Ag Trijoderede 5-aminoisophthalsyrederivater
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
US4341756A (en) * 1980-01-31 1982-07-27 The Regents Of The University Of California Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
JPS56127373A (en) * 1980-01-31 1981-10-06 Univ California Novel amino-dioxepane intermediate for synthesizing novel nonionic contrast agent
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
NO161368C (no) * 1982-11-08 1989-08-09 Nyegaard & Co As Roentgenkontrastmidler samt radiologiske preparater derav.
FR2541272A1 (fr) * 1983-02-23 1984-08-24 Guerbet Sa Composes bromes et produits opacifiants en contenant
US4650903A (en) * 1984-06-21 1987-03-17 The Bf Goodrich Company Oligomeric amides as synergists for antioxidants and UV stabilizers
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
CN1038725C (zh) * 1993-12-04 1998-06-17 吉林省鹊源国际生物工程有限公司 复方天然香菇营养液
US6149891A (en) * 1995-05-31 2000-11-21 Israel Humanitarian Foundation Ltd. X-ray contrast medium and method for protecting against harmful effects thereof
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
US7790141B2 (en) * 2003-08-11 2010-09-07 Pathak Holdings, Llc Radio-opaque compounds, compositions containing same and methods of their synthesis and use
US8920780B2 (en) 2007-07-12 2014-12-30 Ge Healthcare As Contrast agents
WO2009047315A1 (en) 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
CN101820922A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
CN101821231A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
CN101820923A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
WO2009056555A1 (en) * 2007-10-30 2009-05-07 Ge Healthcare As Contrast agents
WO2009091758A1 (en) * 2008-01-14 2009-07-23 Mallinckrodt Inc. Process for the preparation of iosimenol
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN107249570B (zh) 2014-11-21 2022-08-09 丹麦技术大学 用于局部药物释放的凝胶制剂
SG11201809729XA (en) 2016-05-20 2018-12-28 Univ Denmark Tech Dtu Palpable marker composition
EP3982922A1 (en) 2019-06-12 2022-04-20 Technical University of Denmark Dissacharide formulations for controlled drug release

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2853424A (en) * 1952-08-06 1958-09-23 Schering Ag X-ray contrast agents comprising symmetrical bifunctional analogs of nu-acyl derivatives of 2, 4, 6 triiodo-3-amino benzoic acid
US3178473A (en) * 1962-03-02 1965-04-13 Nyegaard & Co As Process for the n-alkylation of acyl anilides halogen substituted in the nucleus
US3290366A (en) * 1963-03-06 1966-12-06 Mallinckrodt Chemical Works 5-amino-nu-alkyl-2, 4, 6-triiodoisophthalamic acid derivatives
GB1033776A (en) * 1963-06-06 1966-06-22 Sterling Drug Inc Iodinated acid amides and esters and salts thereof
US3732293A (en) * 1968-03-15 1973-05-08 Sterling Drug Inc Iodinated bis(aminobenzoic acids) and esters thereof
CH502104A (de) * 1968-05-02 1971-01-31 Bracco Ind Chimica Spa Neue Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
US3701771A (en) * 1969-06-27 1972-10-31 Nyegaard & Co As N-(2,4,6-triiodobenzoyl)-sugar amines
US3660464A (en) * 1970-06-19 1972-05-02 Squibb & Sons Inc Tri-iodinated diaminobenzoic acid derivatives
BE787669A (fr) * 1971-08-17 1973-02-19 Schering Ag Anilides d'acide n-methyl-dicarboxylique triiodes, et leur procede de preparation
DD104193A5 (it) * 1972-12-22 1974-03-05
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
CH626873A5 (it) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa

Also Published As

Publication number Publication date
CH629751A5 (de) 1982-05-14
PL199019A1 (pl) 1978-03-28
NO148811B (no) 1983-09-12
IL52356A (en) 1981-03-31
ATA443777A (de) 1980-07-15
PT66690A (de) 1977-07-01
AU512304B2 (en) 1980-10-02
IL60344A0 (en) 1980-09-16
IE45225L (en) 1977-12-03
DK165973C (da) 1993-07-26
IE45226B1 (en) 1982-07-14
DK595284A (da) 1984-12-12
DK595284D0 (da) 1984-12-12
NO772202L (no) 1977-12-27
FI771900A (it) 1977-12-24
ES460007A1 (es) 1978-05-01
NO822674L (no) 1977-12-27
JPS61126059A (ja) 1986-06-13
FI67540C (fi) 1985-04-10
SE436871B (sv) 1985-01-28
JPS6111220B2 (it) 1986-04-01
CA1106401A (en) 1981-08-04
GR71696B (it) 1983-06-21
PL108102B1 (pl) 1980-03-31
JPS6232185B2 (it) 1987-07-13
DD131014A5 (de) 1978-05-24
GB1588733A (en) 1981-04-29
FI67540B (fi) 1984-12-31
BE856039A (fr) 1977-12-23
IE45226L (en) 1982-07-14
NO147447B (no) 1983-01-03
NO147447C (no) 1983-04-13
DE2628517C2 (de) 1985-02-21
FR2355808B1 (it) 1979-03-09
NL7705509A (nl) 1977-12-28
DK165973B (da) 1993-02-22
HU174228B (hu) 1979-11-28
DK150505C (da) 1988-01-11
DK266177A (da) 1977-12-24
SE7707230L (sv) 1977-12-24
IT1237314B (it) 1993-05-29
DE2628517A1 (de) 1978-01-05
NL189510B (nl) 1992-12-01
FR2355808A1 (fr) 1978-01-20
US4239747A (en) 1980-12-16
PT66690B (de) 1978-11-17
SU917696A3 (ru) 1982-03-30
GB1588734A (en) 1981-04-29
AT361117B (de) 1981-02-25
DK150505B (da) 1987-03-16
CA1106400A (en) 1981-08-04
IL52356A0 (en) 1977-08-31
NO148811C (no) 1983-12-21
LU88292I2 (de) 1994-05-04
AU2632577A (en) 1979-01-04
ZA773782B (en) 1978-05-30
LU77588A1 (it) 1977-09-29
NL189510C (nl) 1993-05-03
JPS537637A (en) 1978-01-24
IE45225B1 (en) 1982-07-14

Similar Documents

Publication Publication Date Title
CS199680B2 (en) Method of producing novel bis/3,5-dicarbamoyl-2,4,6-triiodanilide/dicarboxylic acids
JP3949714B2 (ja) 肝臓胆管不磁気共鳴コントラスト剤
EP0230893B1 (en) Paramagnetic chelates
US5885548A (en) Multiply substituted DTPA derivatives and their metal complexes, and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents
JP2569144B2 (ja) 新規ジカルボン酸ービス（３，５ージカルバモイルー２，４，６ートリヨードーアニリド）、その製法及びこれを含有するレントゲン造影剤
JPS63119446A (ja) ポリ−（酸−アルキレン−アミノ）−アルカンの常磁性多価金属塩
JPH0222066B2 (it)
US5409689A (en) MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
IT9022088A1 (it) 1, 3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2, 4, 6-triiodo-benzoil-amino)-idrossi- o idrossi-alchilpropani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
JPS6313428B2 (it)
EP0805815A1 (en) Bismuth compounds
US5019371A (en) Novel x-ray contrast agents, compositions and methods
JP3249112B2 (ja) 非イオン性化合物及び該化合物を含有する放射線造影剤組成物
IE64759B1 (en) New substituted dicarboxylic acid-bis (3,5-dicarbamoyl-2,4,6-triiodoanilides) process for their production as well as x-ray contrast media containing them
CA1339666C (en) Non-ionic polyol contrast media from ionic contrast media
US5616312A (en) Thiol ligands and complexes for X-ray imaging
EP0716091B1 (en) Tris(substituted phenyl)bismuth derivative
US5035877A (en) Non-ionic contrast media from ionic contrast media
JPH0374211B2 (it)
US3781338A (en) Nitrilotriacyltriimino-tris-(2,4,6-triiodobenzoic acid)compounds
JPH09505833A (ja) Ｘ線放射線医学における造影剤としてのヨウ素化誘導体、それらの製造および用途
JP2807852B2 (ja) 新規キレート化剤、該キレート化剤と金属原子との錯化合物及びそれを含む診断剤
DE69709700T2 (de) Kontrastmittel
US20080267884A1 (en) Contrast Agents and Diagnostic Compositions Based on Iodine-Containing Cyanuric Acid Derivatives
FI58589B (fi) Roentgenkontrastmedel innehaollande 3,6,9-trioxiundekan-1,11-dioyl-bis-(3-karboxi-2,4,6-trijod-anilid) eller salt daerav och foerfarande foer framstaellning av detta