ES460007A1 - Procedimiento para la preparacion de nuevas bis (3,5-dicar- bamoil-2,4,6-triyodoanilidas) de acidos dicarboxilicos. - Google Patents

Procedimiento para la preparacion de nuevas bis (3,5-dicar- bamoil-2,4,6-triyodoanilidas) de acidos dicarboxilicos.

Info

Publication number
ES460007A1
ES460007A1 ES460007A ES460007A ES460007A1 ES 460007 A1 ES460007 A1 ES 460007A1 ES 460007 A ES460007 A ES 460007A ES 460007 A ES460007 A ES 460007A ES 460007 A1 ES460007 A1 ES 460007A1
Authority
ES
Spain
Prior art keywords
triiodoanilides
dicarbamoyl
useful
dicarboxylic acid
acid bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES460007A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES460007A1 publication Critical patent/ES460007A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

Procedimiento para la preparación de nuevas bis(3,5-dicarbamoil-2, 4, 6-triyodoanilidas) de ácido dicarboxílico de la fórmula general I en donde R1 significa un radical monohidroxialcohilo o polihidroxialcohilo de cadena recta o ramificada; *** Ver imagen 01 *** Ver imagen 02
ES460007A 1976-06-23 1977-06-22 Procedimiento para la preparacion de nuevas bis (3,5-dicar- bamoil-2,4,6-triyodoanilidas) de acidos dicarboxilicos. Expired ES460007A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2628517A DE2628517C2 (de) 1976-06-23 1976-06-23 Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel

Publications (1)

Publication Number Publication Date
ES460007A1 true ES460007A1 (es) 1978-05-01

Family

ID=5981407

Family Applications (1)

Application Number Title Priority Date Filing Date
ES460007A Expired ES460007A1 (es) 1976-06-23 1977-06-22 Procedimiento para la preparacion de nuevas bis (3,5-dicar- bamoil-2,4,6-triyodoanilidas) de acidos dicarboxilicos.

Country Status (28)

Country Link
US (1) US4239747A (es)
JP (2) JPS537637A (es)
AT (1) AT361117B (es)
AU (1) AU512304B2 (es)
BE (1) BE856039A (es)
CA (2) CA1106400A (es)
CH (1) CH629751A5 (es)
CS (1) CS199680B2 (es)
DD (1) DD131014A5 (es)
DE (1) DE2628517C2 (es)
DK (2) DK150505C (es)
ES (1) ES460007A1 (es)
FI (1) FI67540C (es)
FR (1) FR2355808A1 (es)
GB (2) GB1588733A (es)
GR (1) GR71696B (es)
HU (1) HU174228B (es)
IE (2) IE45225B1 (es)
IL (2) IL52356A (es)
IT (1) IT1237314B (es)
LU (2) LU77588A1 (es)
NL (1) NL189510C (es)
NO (2) NO147447C (es)
PL (1) PL108102B1 (es)
PT (1) PT66690B (es)
SE (1) SE436871B (es)
SU (1) SU917696A3 (es)
ZA (1) ZA773782B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH626873A5 (es) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
DK273280A (da) * 1979-06-28 1980-12-29 Schering Ag Trijoderede 5-aminoisophthalsyrederivater
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
JPS56127373A (en) * 1980-01-31 1981-10-06 Univ California Novel amino-dioxepane intermediate for synthesizing novel nonionic contrast agent
US4341756A (en) * 1980-01-31 1982-07-27 The Regents Of The University Of California Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
EP0108638B1 (en) * 1982-11-08 1986-07-16 NYEGAARD & CO. A/S X-ray contrast agents
FR2541272A1 (fr) * 1983-02-23 1984-08-24 Guerbet Sa Composes bromes et produits opacifiants en contenant
US4650903A (en) * 1984-06-21 1987-03-17 The Bf Goodrich Company Oligomeric amides as synergists for antioxidants and UV stabilizers
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
CN1038725C (zh) * 1993-12-04 1998-06-17 吉林省鹊源国际生物工程有限公司 复方天然香菇营养液
US6149891A (en) * 1995-05-31 2000-11-21 Israel Humanitarian Foundation Ltd. X-ray contrast medium and method for protecting against harmful effects thereof
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
US7790141B2 (en) * 2003-08-11 2010-09-07 Pathak Holdings, Llc Radio-opaque compounds, compositions containing same and methods of their synthesis and use
ES2486296T3 (es) 2007-07-12 2014-08-18 Ge Healthcare As Agentes de contraste
CN101820923A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
ES2413160T3 (es) 2007-10-12 2013-07-15 Ge Healthcare As Agentes de contraste
CN101820922A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
ES2389974T3 (es) 2007-10-12 2012-11-05 Ge Healthcare As Agentes de contraste
CN101842120A (zh) * 2007-10-30 2010-09-22 通用电气医疗集团股份有限公司 造影剂
US8445725B2 (en) * 2008-01-14 2013-05-21 Mallinckrodt Llc Process for the preparation of iosimenol
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
US11065201B2 (en) 2014-11-21 2021-07-20 Technical University Of Denmark Gel formulations for local drug release
AU2017266410B2 (en) 2016-05-20 2022-07-14 Nanovi Radiotherapy Aps Palpable marker composition
WO2020249801A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2853424A (en) * 1952-08-06 1958-09-23 Schering Ag X-ray contrast agents comprising symmetrical bifunctional analogs of nu-acyl derivatives of 2, 4, 6 triiodo-3-amino benzoic acid
US3178473A (en) * 1962-03-02 1965-04-13 Nyegaard & Co As Process for the n-alkylation of acyl anilides halogen substituted in the nucleus
US3290366A (en) * 1963-03-06 1966-12-06 Mallinckrodt Chemical Works 5-amino-nu-alkyl-2, 4, 6-triiodoisophthalamic acid derivatives
GB1033777A (en) * 1963-06-06 1966-06-22 Sterling Drug Inc Bis-anilide derivatives
US3732293A (en) * 1968-03-15 1973-05-08 Sterling Drug Inc Iodinated bis(aminobenzoic acids) and esters thereof
CH502104A (de) * 1968-05-02 1971-01-31 Bracco Ind Chimica Spa Neue Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
NL153083B (nl) * 1969-06-27 1977-05-16 Nijegaard & Co A S Werkwijze ter bereiding van trijoodbenzoezuuramiden.
US3660464A (en) * 1970-06-19 1972-05-02 Squibb & Sons Inc Tri-iodinated diaminobenzoic acid derivatives
BE787669A (fr) * 1971-08-17 1973-02-19 Schering Ag Anilides d'acide n-methyl-dicarboxylique triiodes, et leur procede de preparation
DD104193A5 (es) * 1972-12-22 1974-03-05
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
CH626873A5 (es) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa

Also Published As

Publication number Publication date
ATA443777A (de) 1980-07-15
CH629751A5 (de) 1982-05-14
GB1588733A (en) 1981-04-29
FI67540B (fi) 1984-12-31
GR71696B (es) 1983-06-21
NL189510B (nl) 1992-12-01
PL108102B1 (pl) 1980-03-31
NO148811B (no) 1983-09-12
HU174228B (hu) 1979-11-28
IT1237314B (it) 1993-05-29
DK165973B (da) 1993-02-22
LU77588A1 (es) 1977-09-29
JPS537637A (en) 1978-01-24
US4239747A (en) 1980-12-16
PL199019A1 (pl) 1978-03-28
DE2628517A1 (de) 1978-01-05
SU917696A3 (ru) 1982-03-30
DK595284D0 (da) 1984-12-12
DK266177A (da) 1977-12-24
NL189510C (nl) 1993-05-03
NO147447B (no) 1983-01-03
DK150505B (da) 1987-03-16
NO822674L (no) 1977-12-27
FR2355808B1 (es) 1979-03-09
IL52356A (en) 1981-03-31
JPS6111220B2 (es) 1986-04-01
IE45226L (en) 1982-07-14
DE2628517C2 (de) 1985-02-21
NO772202L (no) 1977-12-27
FR2355808A1 (fr) 1978-01-20
IL60344A0 (en) 1980-09-16
DK595284A (da) 1984-12-12
CA1106401A (en) 1981-08-04
FI771900A (es) 1977-12-24
IE45225B1 (en) 1982-07-14
FI67540C (fi) 1985-04-10
AU512304B2 (en) 1980-10-02
IL52356A0 (en) 1977-08-31
LU88292I2 (de) 1994-05-04
PT66690A (de) 1977-07-01
DK165973C (da) 1993-07-26
GB1588734A (en) 1981-04-29
ZA773782B (en) 1978-05-30
NO148811C (no) 1983-12-21
SE436871B (sv) 1985-01-28
CA1106400A (en) 1981-08-04
BE856039A (fr) 1977-12-23
JPS61126059A (ja) 1986-06-13
AT361117B (de) 1981-02-25
DK150505C (da) 1988-01-11
CS199680B2 (en) 1980-07-31
NO147447C (no) 1983-04-13
SE7707230L (sv) 1977-12-24
IE45225L (en) 1977-12-03
PT66690B (de) 1978-11-17
JPS6232185B2 (es) 1987-07-13
AU2632577A (en) 1979-01-04
DD131014A5 (de) 1978-05-24
NL7705509A (nl) 1977-12-28
IE45226B1 (en) 1982-07-14

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