CR20180516A - Compuestos de iprrolotriazina como inhibidores de tam - Google Patents

Compuestos de iprrolotriazina como inhibidores de tam

Info

Publication number
CR20180516A
CR20180516A CR20180516A CR20180516A CR20180516A CR 20180516 A CR20180516 A CR 20180516A CR 20180516 A CR20180516 A CR 20180516A CR 20180516 A CR20180516 A CR 20180516A CR 20180516 A CR20180516 A CR 20180516A
Authority
CR
Costa Rica
Prior art keywords
compounds
iprrolotriazine
tam inhibitors
tam
inhibitors
Prior art date
Application number
CR20180516A
Other languages
English (en)
Inventor
Jincong Zhuo
Taisheng; Huang
Yun-Long; Li
David M ; Burns
xiaozhao Wang
Joseph; Barbosa
Hao; Feng
Chunhong; He
Joseph; Glenn
Song; Mei
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CR20180516A publication Critical patent/CR20180516A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente solicitud hace referencia a compuestos de Fórmula I o sales farmacéuticamente aceptable de estos, que son inhibidores de cinasas TAM que resultan útiles para el tratamiento de trastornos tales como cáncer
CR20180516A 2016-03-28 2017-03-27 Compuestos de iprrolotriazina como inhibidores de tam CR20180516A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662314066P 2016-03-28 2016-03-28
US201662362934P 2016-07-15 2016-07-15
US201662438750P 2016-12-23 2016-12-23
PCT/US2017/024270 WO2017172596A1 (en) 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors

Publications (1)

Publication Number Publication Date
CR20180516A true CR20180516A (es) 2019-03-05

Family

ID=58489114

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20180516A CR20180516A (es) 2016-03-28 2017-03-27 Compuestos de iprrolotriazina como inhibidores de tam

Country Status (32)

Country Link
US (5) US9981975B2 (es)
EP (2) EP3436461B1 (es)
JP (2) JP7034084B2 (es)
KR (3) KR102483020B1 (es)
CN (3) CN109348715B (es)
AU (3) AU2017241524B2 (es)
BR (1) BR112018069612A2 (es)
CA (1) CA3019145A1 (es)
CL (1) CL2018002759A1 (es)
CO (1) CO2018011550A2 (es)
CR (1) CR20180516A (es)
DK (1) DK3436461T3 (es)
EC (2) ECSP18081153A (es)
ES (1) ES2967866T3 (es)
FI (1) FI3436461T3 (es)
HR (1) HRP20231614T1 (es)
HU (1) HUE064656T2 (es)
IL (2) IL261957B (es)
LT (1) LT3436461T (es)
MD (1) MD3436461T2 (es)
MX (1) MX2018011792A (es)
MY (1) MY202022A (es)
PE (1) PE20190175A1 (es)
PH (1) PH12018502102A1 (es)
PL (1) PL3436461T3 (es)
PT (1) PT3436461T (es)
RS (1) RS65129B1 (es)
SG (2) SG10202009423QA (es)
SI (1) SI3436461T1 (es)
TW (2) TWI753892B (es)
UA (1) UA123785C2 (es)
WO (1) WO2017172596A1 (es)

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CN110156836A (zh) * 2019-06-10 2019-08-23 成家钢 一种环丙基羰基亚甲基三苯基磷的制备方法
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CN113336758B (zh) * 2020-03-03 2022-08-19 北京桦冠医药科技有限公司 化合物7-碘吡咯并[2,1-f][1,2,4]三嗪-4-胺的一种新合成方法
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CN111233870A (zh) * 2020-03-11 2020-06-05 中国科学技术大学 用于快速制备瑞德西韦药物中间体的方法
CN113683629B (zh) * 2020-05-18 2023-07-04 北京范恩柯尔生物科技有限公司 取代的杂芳基化合物及其组合物和用途
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WO2022166610A1 (zh) * 2021-02-05 2022-08-11 四川科伦博泰生物医药股份有限公司 一类哒嗪酮杂环化合物及其制备方法和用途
CN117561260A (zh) * 2021-08-12 2024-02-13 四川科伦博泰生物医药股份有限公司 一类杂环化合物及其制备方法和用途
TW202330519A (zh) * 2021-09-29 2023-08-01 香港商德琪研發有限公司 作為tam抑制劑的吡唑并吡啶化合物
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