US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US5156840A
(en)
|
1982-03-09 |
1992-10-20 |
Cytogen Corporation |
Amine-containing porphyrin derivatives
|
US5057313A
(en)
|
1986-02-25 |
1991-10-15 |
The Center For Molecular Medicine And Immunology |
Diagnostic and therapeutic antibody conjugates
|
US4908056A
(en)
|
1986-04-25 |
1990-03-13 |
E. I. Du Pont De Nemours And Company |
Heterocyclic acyl sulfonamides
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2 Inc |
Geänderte antikörper.
|
EP0352575A3
(de)
|
1988-07-28 |
1991-08-21 |
Bayer Ag |
Substituierte anellierte Pyrrole
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
DK0590058T3
(da)
|
1991-06-14 |
2004-03-29 |
Genentech Inc |
Humaniseret heregulin-antistof
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
IT1269176B
(it)
|
1994-01-11 |
1997-03-21 |
Isagro Srl |
Eterobicicli ad attivita' fungicida
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
JP4436457B2
(ja)
|
1995-08-18 |
2010-03-24 |
モルフォシス アイピー ゲーエムベーハー |
蛋白質/(ポリ)ペプチドライブラリー
|
EP1047761A1
(en)
|
1997-10-14 |
2000-11-02 |
The Procter & Gamble Company |
Hard surface cleaning compositions comprising mid-chain branched surfactants
|
US6982265B1
(en)
|
1999-05-21 |
2006-01-03 |
Bristol Myers Squibb Company |
Pyrrolotriazine inhibitors of kinases
|
BR0014075A
(pt)
|
1999-09-17 |
2002-07-16 |
Abbott Gmbh & Co Kg |
Inibidores de quinase como agentes terapêuticos
|
US6770666B2
(en)
|
1999-12-27 |
2004-08-03 |
Japan Tobacco Inc. |
Fused-ring compounds and use thereof as drugs
|
CA2363274A1
(en)
|
1999-12-27 |
2001-07-05 |
Japan Tobacco Inc. |
Fused-ring compounds and use thereof as drugs for hepatitis c
|
BR0111747A
(pt)
|
2000-06-28 |
2003-07-08 |
Smithkline Beecham Plc |
Processo de moagem úmida
|
SI1385551T1
(sl)
|
2001-04-06 |
2008-12-31 |
Wyeth Five Giralda Farms |
Antineoplastiäśne kombinacije, ki vsebujejo cci-779 (derivat rapamicina) skupaj z gemcitabinom ali fluorouracilom
|
AR035543A1
(es)
|
2001-06-26 |
2004-06-16 |
Japan Tobacco Inc |
Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
|
AU2003272175A1
(en)
|
2002-10-21 |
2004-05-04 |
Aprea Ab |
Reactivation of wild type p53 in human tumour cells by a low molecular weight compound
|
AU2003298658A1
(en)
|
2002-11-15 |
2004-06-15 |
Idenix (Cayman) Limited |
2'-branched nucleosides and flaviviridae mutation
|
EP2368578A1
(en)
|
2003-01-09 |
2011-09-28 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
WO2004065416A2
(en)
|
2003-01-16 |
2004-08-05 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
US20050008625A1
(en)
|
2003-02-13 |
2005-01-13 |
Kalobios, Inc. |
Antibody affinity engineering by serial epitope-guided complementarity replacement
|
CA2517034A1
(en)
|
2003-03-13 |
2004-09-30 |
Synta Pharmaceuticals Corp. |
Fused pyrrole compounds
|
US7169801B2
(en)
|
2003-03-17 |
2007-01-30 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
DK1639014T3
(da)
|
2003-06-13 |
2011-01-17 |
Biogen Idec Inc |
Aglycosyl-anti-CD154 (CD40-ligand)-antistoffer og anvendelser deraf
|
FR2857966A1
(fr)
|
2003-07-24 |
2005-01-28 |
Aventis Pharma Sa |
Produits aryl-heteroaromatiques, compositions les contenant et utilisation
|
NZ545776A
(en)
|
2003-08-22 |
2009-05-31 |
Biogen Idec Inc |
Improved antibodies having altered effector function and methods for making the same
|
WO2005025515A2
(en)
|
2003-09-12 |
2005-03-24 |
California Institute Of Technology |
Proteasome pathway inhibitors and related methods
|
US7306631B2
(en)
|
2004-03-30 |
2007-12-11 |
The Procter & Gamble Company |
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
|
UY28931A1
(es)
|
2004-06-03 |
2005-12-30 |
Bayer Pharmaceuticals Corp |
Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
|
MY139689A
(en)
*
|
2004-07-20 |
2009-10-30 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
US20070043057A1
(en)
|
2005-02-09 |
2007-02-22 |
Threshold Pharmaceuticals, Inc. |
Lonidamine analogs
|
US20070015771A1
(en)
|
2004-07-29 |
2007-01-18 |
Threshold Pharmaceuticals, Inc. |
Lonidamine analogs
|
UY29177A1
(es)
|
2004-10-25 |
2006-05-31 |
Astex Therapeutics Ltd |
Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
|
CA2586605A1
(en)
|
2004-11-24 |
2006-06-01 |
Novartis Ag |
Combinations of jak inhibitors and at least one of bcr-abl, flt-3, fak or raf kinase inhibitors
|
WO2006124874A2
(en)
|
2005-05-12 |
2006-11-23 |
Kalypsys, Inc. |
Inhibitors of b-raf kinase
|
US8431695B2
(en)
|
2005-11-02 |
2013-04-30 |
Bayer Intellectual Property Gmbh |
Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
|
EP2385053B1
(en)
|
2005-11-17 |
2013-10-02 |
OSI Pharmaceuticals, Inc. |
Intermediates for the preparation of fused bicyclic mTOR inhibitors
|
US7514435B2
(en)
|
2005-11-18 |
2009-04-07 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
PE20070855A1
(es)
|
2005-12-02 |
2007-10-14 |
Bayer Pharmaceuticals Corp |
Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
|
CA2631741C
(en)
*
|
2005-12-02 |
2014-01-28 |
Bayer Healthcare Llc |
Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
|
CA2631732C
(en)
|
2005-12-02 |
2012-12-18 |
Bayer Healthcare Llc |
Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
|
BRPI0619817B8
(pt)
|
2005-12-13 |
2021-05-25 |
Incyte Corp |
composto 3-ciclopentil-3-[4-(7h-pirrol[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]propanonitrila e sua composição
|
EP1960372B1
(en)
|
2005-12-15 |
2015-12-09 |
Rigel Pharmaceuticals, Inc. |
Kinase inhibitors and their uses
|
CA2635231C
(en)
|
2005-12-29 |
2014-07-15 |
Abbott Laboratories |
Protein kinase inhibitors
|
JP5313875B2
(ja)
|
2006-04-12 |
2013-10-09 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
増殖性疾患の処置のためのタンパク質キナーゼplk1の阻害剤として有用な4,5−ジヒドロ−[1,2,4]トリアゾロ[4,3−f]プテリジン
|
EA018917B1
(ru)
|
2006-04-19 |
2013-11-29 |
Новартис Аг |
6-о-замещенные бензоксазолы и бензотиазолы и способы подавления передачи сигналов от csf-1r
|
WO2007125315A2
(en)
|
2006-04-25 |
2007-11-08 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
US8022088B2
(en)
|
2006-06-29 |
2011-09-20 |
Schering Corporation |
Substituted bicyclic and tricyclic thrombin receptor antagonists
|
WO2008012635A2
(en)
|
2006-07-26 |
2008-01-31 |
Pfizer Products Inc. |
Amine derivatives useful as anticancer agents
|
US8097630B2
(en)
|
2006-10-10 |
2012-01-17 |
Rigel Pharmaceuticals, Inc. |
Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors
|
MX2009005144A
(es)
*
|
2006-11-22 |
2009-05-27 |
Incyte Corp |
Imidazotriazinas e imidazopirimidinas como inhibidores de cinasa.
|
EP2099430A2
(en)
|
2006-12-07 |
2009-09-16 |
Schering Corporation |
Ph sensitive matrix formulation
|
CN101646671A
(zh)
|
2006-12-14 |
2010-02-10 |
弗特克斯药品有限公司 |
用作蛋白激酶抑制剂的化合物
|
CN101622248B
(zh)
|
2006-12-29 |
2013-04-17 |
里格尔制药公司 |
用作axl抑制剂的n3-杂芳基取代的三唑和n5-杂芳基取代的三唑
|
US7709482B2
(en)
|
2006-12-29 |
2010-05-04 |
Rigel Pharmaceuticals, Inc. |
Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
|
WO2008083353A1
(en)
|
2006-12-29 |
2008-07-10 |
Rigel Pharmaceuticals, Inc. |
Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors
|
EP2114980B1
(en)
|
2007-01-12 |
2012-06-27 |
BioCryst Pharmaceuticals, Inc. |
Antiviral nucleoside analogs
|
WO2008098139A2
(en)
|
2007-02-07 |
2008-08-14 |
The Regents Of The University Of Colorado |
Axl tyrosine kinase inhibitors and methods of making and using the same
|
US8124759B2
(en)
|
2007-05-09 |
2012-02-28 |
Abbott Laboratories |
Inhibitors of protein kinases
|
ES2393038T3
(es)
|
2007-05-10 |
2012-12-18 |
Biocryst Pharmaceuticals, Inc. |
Compuestos de tretrahidrofuro[3,4-D]dioxolano para su utlilización en el tratamiento de las infecciones víricas y del cáncer
|
JP2010532756A
(ja)
|
2007-07-06 |
2010-10-14 |
オーエスアイ・ファーマスーティカルズ・インコーポレーテッド |
mTORC1及びmTORC2の両方の阻害剤を含む組み合わせ抗癌療法
|
EP2173338A1
(en)
|
2007-07-06 |
2010-04-14 |
OSI Pharmaceuticals, Inc. |
Combination anti-cancer therapy
|
MX2010001677A
(es)
|
2007-08-15 |
2010-03-11 |
Vertex Pharma |
Derivados de 4-(9-(3,3-difluorociclopentil)-5,7,7-trimetil-6-oxo-6 ,7,8,9-tetrahidro-5h-pirimido[4,5-b][1,4]diazepin-2-ilamino)-3-me toxibenzamida como inhibidores de las proteinas cinasas humanas plk1 a plk4 para el tratamiento de enfermedades proli
|
AU2008304620A1
(en)
|
2007-09-25 |
2009-04-02 |
Bayer Healthcare Llc |
Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
|
GB0719803D0
(en)
|
2007-10-10 |
2007-11-21 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
MX2010004491A
(es)
|
2007-10-25 |
2010-06-21 |
Astrazeneca Ab |
Derivados de piridina y pirazina utiles en el tratamiento de trastornos proliferativos celulares.
|
CA2704052C
(en)
|
2007-10-26 |
2015-04-21 |
Rigel Pharmaceuticals, Inc. |
Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors
|
DE102007051762A1
(de)
|
2007-10-30 |
2009-05-07 |
Bayer Healthcare Ag |
Substituierte Pyrrolotriazine und ihre Verwendung
|
AU2008343932B2
(en)
|
2007-12-19 |
2013-08-15 |
Amgen Inc. |
Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
|
AR070127A1
(es)
|
2008-01-11 |
2010-03-17 |
Novartis Ag |
Pirrolo - pirimidinas y pirrolo -piridinas
|
US8557814B2
(en)
|
2008-03-19 |
2013-10-15 |
OSI Pharmaceuticals, LLC |
mTOR inhibitor salt forms
|
EP2262772B8
(en)
|
2008-04-16 |
2013-03-13 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Quinoline derivatives as axl kinase inhibitors
|
HUE025528T2
(en)
|
2008-04-23 |
2016-05-30 |
Gilead Sciences Inc |
1'-substituted carba-nucleoside analogs for antiviral treatment
|
TWI539953B
(zh)
|
2008-04-28 |
2016-07-01 |
瑞波若斯治療學公司 |
用於治療乳癌之組成物和方法
|
EP2356122B1
(en)
|
2008-06-23 |
2019-03-20 |
Vertex Pharmaceuticals Incorporated |
Protein kinase inhibitors
|
KR20110018376A
(ko)
|
2008-06-23 |
2011-02-23 |
스미또모 가가꾸 가부시키가이샤 |
조성물 및 상기 조성물을 이용하여 이루어지는 발광 소자
|
EP2313102A2
(en)
|
2008-07-03 |
2011-04-27 |
Biota Scientific Management |
Bycyclic nucleosides and nucleotides as therapeutic agents
|
US8349838B2
(en)
|
2008-07-09 |
2013-01-08 |
Rigel Pharmaceuticals, Inc. |
Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
|
CA2730251C
(en)
|
2008-07-09 |
2016-08-09 |
Rigel Pharmaceuticals, Inc. |
Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
|
WO2010014755A1
(en)
|
2008-07-29 |
2010-02-04 |
The Regents Of The University Of Colorado |
Methods and compounds for enhancing anti-cancer therapy
|
WO2010025073A1
(en)
|
2008-08-28 |
2010-03-04 |
Takeda Pharmaceutical Company Limited |
Dihydroimidazo [ 1, 5-f] pteridines as polo-like kinase inhibitors
|
US8163509B2
(en)
|
2008-10-20 |
2012-04-24 |
The Regents Of The University Of Colorado, A Body Corporate |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
US8476282B2
(en)
|
2008-11-03 |
2013-07-02 |
Intellikine Llc |
Benzoxazole kinase inhibitors and methods of use
|
EP2376491B1
(en)
|
2008-12-19 |
2015-03-04 |
Cephalon, Inc. |
Pyrrolotriazines as alk and jak2 inhibitors
|
US20100204265A1
(en)
|
2009-02-09 |
2010-08-12 |
Genelabs Technologies, Inc. |
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
|
JP2012517426A
(ja)
|
2009-02-09 |
2012-08-02 |
アステックス ファーマシューティカルズ インコーポレイテッド |
ピロロピリミジニルaxlキナーゼ阻害剤
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
KR20100101055A
(ko)
|
2009-03-07 |
2010-09-16 |
주식회사 메디젠텍 |
세포핵에서 세포질로의 gsk3의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동 관련 질환의 치료 또는 예방용 약학적 조성물
|
WO2010126960A1
(en)
|
2009-04-29 |
2010-11-04 |
Locus Pharmaceuticals, Inc. |
Pyrrolotriazine compounds
|
BRPI1012159B1
(pt)
|
2009-05-22 |
2022-01-25 |
Incyte Holdings Corporation |
Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos
|
ME01838B
(me)
|
2009-06-29 |
2014-12-20 |
Lncyte Holdings Corp |
Pirimidinoni kao inhibitori pi3k
|
JP2013500991A
(ja)
|
2009-07-31 |
2013-01-10 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
mTOR阻害剤および血管新生阻害剤併用療法
|
US9249145B2
(en)
|
2009-09-01 |
2016-02-02 |
Incyte Holdings Corporation |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
US8455451B2
(en)
|
2009-09-21 |
2013-06-04 |
Gilead Sciences, Inc. |
2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
|
NZ599402A
(en)
|
2009-09-21 |
2014-02-28 |
Gilead Sciences Inc |
2’ -fluoro substituted carba-nucleoside analogs for antiviral treatment
|
EP2480559B1
(en)
|
2009-09-21 |
2013-07-03 |
Gilead Sciences, Inc. |
Processes and intermediates for the preparation of 1'-cyano-carbanucleoside analogs
|
JP2013512860A
(ja)
|
2009-09-25 |
2013-04-18 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼ阻害剤として有用なピリミジン誘導体の調製方法
|
IN2012DN03883A
(es)
|
2009-10-06 |
2015-09-25 |
Millennium Pharm Inc |
|
EP2311809A1
(en)
|
2009-10-16 |
2011-04-20 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Quinolinyloxyphenylsulfonamides
|
US8604217B2
(en)
|
2009-11-12 |
2013-12-10 |
Selvita S.A. |
Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent
|
WO2011075630A1
(en)
|
2009-12-18 |
2011-06-23 |
Incyte Corporation |
Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors
|
CA2787714C
(en)
|
2010-01-22 |
2019-04-09 |
Joaquin Pastor Fernandez |
Inhibitors of pi3 kinase
|
EP4036088B1
(en)
|
2010-03-10 |
2024-04-03 |
Incyte Holdings Corporation |
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
|
WO2011123493A1
(en)
*
|
2010-03-31 |
2011-10-06 |
Bristol-Myers Squibb Company |
Substituted pyrrolotriazines as protein kinase inhibitors
|
CN102471342A
(zh)
|
2010-05-05 |
2012-05-23 |
沃泰克斯药物股份有限公司 |
用作PKC-θ抑制剂的4取代的吡唑并吡啶类
|
WO2011141713A1
(en)
|
2010-05-13 |
2011-11-17 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
New bicyclic compounds as pi3-k and mtor inhibitors
|
TW201201815A
(en)
|
2010-05-28 |
2012-01-16 |
Gilead Sciences Inc |
1'-substituted-carba-nucleoside prodrugs for antiviral treatment
|
GB2480814A
(en)
|
2010-06-01 |
2011-12-07 |
Summit Corp Plc |
Compounds for the treatment of clostridium difficile-associated disease
|
KR20200052384A
(ko)
|
2010-07-19 |
2020-05-14 |
길리애드 사이언시즈, 인코포레이티드 |
부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법
|
EP2595980B1
(en)
|
2010-07-22 |
2014-09-03 |
Gilead Sciences, Inc. |
Methods and compounds for treating paramyxoviridae virus infections
|
EP2423208A1
(en)
|
2010-08-28 |
2012-02-29 |
Lead Discovery Center GmbH |
Pharmaceutically active compounds as Axl inhibitors
|
US20120077814A1
(en)
|
2010-09-10 |
2012-03-29 |
Zhong Wang |
Sulfonamide, sulfamate, and sulfamothioate derivatives
|
TW201305185A
(zh)
|
2010-09-13 |
2013-02-01 |
Gilead Sciences Inc |
用於抗病毒治療之2’-氟取代之碳-核苷類似物
|
US9643969B2
(en)
|
2010-09-29 |
2017-05-09 |
Kissei Pharmaceutical Co., Ltd. |
(aza)indolizine derivative and pharmaceutical use thereof
|
CN103249732B
(zh)
|
2010-10-08 |
2016-08-10 |
生物区欧洲有限公司 |
抑制2-乙基氨甲酰氨基-1,3-苯并噻唑-5-基的细菌拓扑异构酶ii
|
BR112013008526A2
(pt)
|
2010-10-08 |
2016-07-12 |
Elan Pharm Inc |
inibidores de quinase do tipo polo
|
ITRM20100537A1
(it)
|
2010-10-12 |
2012-04-12 |
Consiglio Nazionale Ricerche |
Aptamero inibitore del recettore tirosina chinasi axl per uso in terapia
|
JP5917545B2
(ja)
|
2010-11-19 |
2016-05-18 |
インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation |
Jak阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体
|
CA2818545C
(en)
|
2010-11-19 |
2019-04-16 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
AR084366A1
(es)
|
2010-12-20 |
2013-05-08 |
Incyte Corp |
N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
TWI592411B
(zh)
|
2011-02-23 |
2017-07-21 |
英特爾立秦有限責任公司 |
激酶抑制劑之組合及其用途
|
KR101546693B1
(ko)
|
2011-02-28 |
2015-08-24 |
칼리토르 사이언시즈, 엘엘씨 |
치환된 퀴놀린 화합물 및 그 사용 방법
|
KR20160035613A
(ko)
|
2011-03-23 |
2016-03-31 |
암젠 인크 |
Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제
|
PL2693881T3
(pl)
|
2011-04-01 |
2020-03-31 |
University Of Utah Research Foundation |
Podstawione analogi N-fenylopirymidyno-2-aminy jako inhibitory kinazy AXL
|
CN103703174B
(zh)
|
2011-05-04 |
2017-05-10 |
因特利凯有限责任公司 |
联合药物组合物及其用途
|
WO2012154608A1
(en)
|
2011-05-06 |
2012-11-15 |
Intellikine, Llc |
Reactive mtor and pi3 kinase inhibitors and uses thereof
|
ES2604191T3
(es)
|
2011-05-17 |
2017-03-03 |
Principia Biopharma Inc. |
Inhibidores de tirosina quinasas
|
DK2710007T3
(da)
|
2011-05-17 |
2020-01-27 |
Principia Biopharma Inc |
Kinasehæmmere
|
WO2012158795A1
(en)
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
AR086913A1
(es)
|
2011-06-14 |
2014-01-29 |
Novartis Ag |
4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas
|
AU2012273164B2
(en)
|
2011-06-20 |
2015-05-28 |
Incyte Holdings Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
|
ES2598027T3
(es)
|
2011-07-01 |
2017-01-24 |
Bayer Intellectual Property Gmbh |
Pirrolotriazinas sustituidas con hidroximetilarilo como inhibidores de ALK1
|
EP2548877A1
(en)
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
EA033646B1
(ru)
|
2011-09-02 |
2019-11-13 |
Incyte Holdings Corp |
Гетероциклиламины как ингибиторы pi3k
|
JP2014526512A
(ja)
|
2011-09-18 |
2014-10-06 |
ユーロ−セルティーク エス.エイ. |
医薬組成物
|
CN102408411B
(zh)
|
2011-09-19 |
2014-10-22 |
北京康辰药业股份有限公司 |
一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用
|
MX2014004086A
(es)
|
2011-10-03 |
2014-09-22 |
Univ North Carolina |
Compuestos de pirrolopirimidina para el tratamiento del cancer.
|
CN104080786A
(zh)
|
2011-11-08 |
2014-10-01 |
因特利凯有限责任公司 |
使用多种药剂的治疗方案
|
JP6051434B2
(ja)
|
2011-11-14 |
2016-12-27 |
イグニタ、インク. |
AXLおよびc−METキナーゼ阻害剤としてのウラシル誘導体
|
CN104363914A
(zh)
|
2011-11-23 |
2015-02-18 |
因特利凯有限责任公司 |
使用mTOR抑制剂的增强的治疗方案
|
EP2788000B1
(en)
|
2011-12-06 |
2018-05-30 |
Merck Sharp & Dohme Corp. |
Pyrrolopyrimidines as janus kinase inhibitors
|
UY34484A
(es)
|
2011-12-15 |
2013-07-31 |
Bayer Ip Gmbh |
Benzotienilo-pirrolotriazinas disustituidas y sus usos
|
CN104159900B
(zh)
|
2011-12-15 |
2016-08-24 |
拜耳知识产权有限责任公司 |
取代的苯并噻吩基-吡咯并三嗪及其在癌症治疗中的用途
|
LT2810937T
(lt)
|
2012-01-31 |
2017-02-10 |
Daiichi Sankyo Company, Limited |
Piridono darinys
|
CN104080789B
(zh)
|
2012-01-31 |
2016-05-11 |
南京奥昭生物科技有限公司 |
作为布鲁顿酪氨酸激酶抑制剂的环状分子
|
US9475815B2
(en)
|
2012-02-23 |
2016-10-25 |
Bayer Intelletual Property Gmbh |
Substituted benzothienyl-pyrrolotriazines and uses thereof
|
WO2013151975A1
(en)
|
2012-04-02 |
2013-10-10 |
Northeastern University |
Compositions and methods for the inhibition of methyltransferases
|
CN103373996A
(zh)
|
2012-04-20 |
2013-10-30 |
山东亨利医药科技有限责任公司 |
作为crth2受体拮抗剂的二并环衍生物
|
WO2013162061A1
(ja)
|
2012-04-26 |
2013-10-31 |
第一三共株式会社 |
二環性ピリミジン化合物
|
US9193733B2
(en)
|
2012-05-18 |
2015-11-24 |
Incyte Holdings Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
MX368112B
(es)
|
2012-06-18 |
2019-09-18 |
Principia Biopharma Inc |
Pirrolo- o pirazolopirimidinas covalentes reversibles utiles para el tratamiento del cancer y de enfermedades autoinmunitarias.
|
WO2013192273A1
(en)
|
2012-06-19 |
2013-12-27 |
Sunovion Pharmaceuticals Inc. |
Heteroaryl compounds and methods of use thereof
|
US9260436B2
(en)
|
2012-06-22 |
2016-02-16 |
Sumitomo Chemical Company, Limited |
Fused heterocyclic compound
|
WO2014022569A1
(en)
|
2012-08-03 |
2014-02-06 |
Principia Biopharma Inc. |
Treatment of dry eye
|
WO2014035140A2
(en)
|
2012-08-30 |
2014-03-06 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating histone methyltransferase activity
|
EP2892534B8
(en)
|
2012-09-06 |
2021-09-15 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
WO2014042433A2
(en)
|
2012-09-14 |
2014-03-20 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating adenosine a3 receptor activity
|
AU2013323426A1
(en)
*
|
2012-09-26 |
2015-04-23 |
The Regents Of The University Of California |
Modulation of ire1
|
US9457039B2
(en)
|
2012-10-17 |
2016-10-04 |
Merck Sharp & Dohme Corp. |
2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
|
WO2014062774A1
(en)
|
2012-10-17 |
2014-04-24 |
The University Of North Carolina At Chapel Hill |
Pyrazolopyrimidine compounds for the treatment of cancer
|
WO2014059901A1
(en)
|
2012-10-17 |
2014-04-24 |
Merck Sharp & Dohme Corp. |
2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases
|
KR20150074193A
(ko)
|
2012-11-01 |
2015-07-01 |
인사이트 코포레이션 |
Jak 억제제로서 트리사이클릭 융합된 티오펜 유도체
|
EP2919785A4
(en)
|
2012-11-16 |
2016-10-05 |
Biocryst Pharm Inc |
ANTIVIRAL NUCLEOSIDES CONTAINING AZASUCRE
|
JP6218848B2
(ja)
|
2012-11-20 |
2017-10-25 |
プロキナーゼ ゲゼルシャフト ミット ベシュレンクテル ハフツング |
プロテインキナーゼ阻害剤としてのチオエーテル誘導体
|
WO2014109858A1
(en)
|
2013-01-14 |
2014-07-17 |
Amgen Inc. |
Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
|
EA034395B1
(ru)
|
2013-01-18 |
2020-02-04 |
Бристол-Майерс Сквибб Компани |
Фталазиноны и изохинолиноны в качестве ингибиторов rock
|
WO2014113942A1
(en)
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2014130856A2
(en)
|
2013-02-21 |
2014-08-28 |
Wayne Rothbaum |
Treatment of skeletal-related disorders
|
US9050345B2
(en)
|
2013-03-11 |
2015-06-09 |
Bristol-Myers Squibb Company |
Pyrrolotriazines as potassium ion channel inhibitors
|
TW201522337A
(zh)
|
2013-03-12 |
2015-06-16 |
Arqule Inc |
經取代之三環吡唑並-嘧啶化合物類
|
TWI649308B
(zh)
|
2013-07-24 |
2019-02-01 |
小野藥品工業股份有限公司 |
喹啉衍生物
|
EP3057970A1
(en)
|
2013-10-18 |
2016-08-24 |
Medivation Technologies, Inc. |
Heterocyclic compounds and methods of use
|
WO2015066371A1
(en)
|
2013-10-31 |
2015-05-07 |
Forum Pharmaceuticals, Inc. |
SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS
|
ES2685661T3
(es)
|
2013-11-08 |
2018-10-10 |
Ono Pharmaceutical Co., Ltd. |
Derivado de pirrolopirimidina
|
CN105916859A
(zh)
*
|
2014-02-03 |
2016-08-31 |
卡迪拉保健有限公司 |
杂环化合物
|
EP3104712B1
(en)
|
2014-02-12 |
2020-05-06 |
Firmenich Incorporated |
Improved process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
|
JP6621477B2
(ja)
|
2014-12-18 |
2019-12-18 |
ファイザー・インク |
ピリミジンおよびトリアジン誘導体ならびにaxl阻害薬としてのそれらの使用
|
US9840503B2
(en)
|
2015-05-11 |
2017-12-12 |
Incyte Corporation |
Heterocyclic compounds and uses thereof
|
WO2017027717A1
(en)
*
|
2015-08-12 |
2017-02-16 |
Incyte Corporation |
Bicyclic fused pyrimidine compounds as tam inhibitors
|
WO2017035366A1
(en)
|
2015-08-26 |
2017-03-02 |
Incyte Corporation |
Pyrrolopyrimidine derivatives as tam inhibitors
|
WO2017062797A1
(en)
|
2015-10-07 |
2017-04-13 |
The University Of North Carolina At Chapel Hill |
The methods for treatment of tumors
|
CO2018003968A2
(es)
|
2015-10-13 |
2018-09-20 |
Nihon Nohyaku Co Ltd |
Compuesto heterocíclico condensado con contenido de grupo oxima o su sal, insecticida agrícola y hortícola que comprende el compuesto y método para controlar plagas.
|
JP6905662B2
(ja)
|
2015-11-14 |
2021-07-21 |
サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. |
置換キノリン化合物の結晶形およびその医薬組成物
|
US9920033B2
(en)
|
2015-11-14 |
2018-03-20 |
Calitor Sciences, Llc |
Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
|
CA3019145A1
(en)
|
2016-03-28 |
2017-10-05 |
Incyte Corporation |
Pyrrolotriazine compounds as tam inhibitors
|
ES2963148T3
(es)
|
2016-04-22 |
2024-03-25 |
Incyte Corp |
Formulaciones de un inhibidor de LSD1
|
TW201803871A
(zh)
|
2016-06-24 |
2018-02-01 |
英塞特公司 |
作為PI3K-γ抑制劑之雜環化合物
|
BR112019000356A2
(pt)
|
2016-07-15 |
2019-04-16 |
Ionis Pharmaceuticals, Inc. |
compostos e métodos para modulação de smn2
|
JOP20170153A1
(ar)
|
2016-07-15 |
2019-01-30 |
Lilly Co Eli |
نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
|
GEP20227429B
(en)
|
2017-09-27 |
2022-10-25 |
Incyte Corp |
Salts of pyrrolotriazine derivatives useful as tam inhibitors
|
AR117600A1
(es)
|
2018-06-29 |
2021-08-18 |
Incyte Corp |
Formulaciones de un inhibidor de axl / mer
|
KR20230017165A
(ko)
|
2020-03-06 |
2023-02-03 |
인사이트 코포레이션 |
Axl/mer 및 pd-1/pd-l1 억제제를 포함하는 병행 요법
|