PT3436461T - Compostos de pirrolotriazina como inibidores de tam - Google Patents

Compostos de pirrolotriazina como inibidores de tam

Info

Publication number
PT3436461T
PT3436461T PT177156205T PT17715620T PT3436461T PT 3436461 T PT3436461 T PT 3436461T PT 177156205 T PT177156205 T PT 177156205T PT 17715620 T PT17715620 T PT 17715620T PT 3436461 T PT3436461 T PT 3436461T
Authority
PT
Portugal
Prior art keywords
pyrrolotriazine compounds
tam inhibitors
tam
inhibitors
pyrrolotriazine
Prior art date
Application number
PT177156205T
Other languages
English (en)
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PT3436461T publication Critical patent/PT3436461T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
PT177156205T 2016-03-28 2017-03-27 Compostos de pirrolotriazina como inibidores de tam PT3436461T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662314066P 2016-03-28 2016-03-28
US201662362934P 2016-07-15 2016-07-15
US201662438750P 2016-12-23 2016-12-23

Publications (1)

Publication Number Publication Date
PT3436461T true PT3436461T (pt) 2024-01-23

Family

ID=58489114

Family Applications (1)

Application Number Title Priority Date Filing Date
PT177156205T PT3436461T (pt) 2016-03-28 2017-03-27 Compostos de pirrolotriazina como inibidores de tam

Country Status (28)

Country Link
US (4) US9981975B2 (pt)
EP (2) EP3436461B1 (pt)
JP (3) JP7034084B2 (pt)
KR (3) KR20230111268A (pt)
CN (3) CN114456176A (pt)
AU (3) AU2017241524B2 (pt)
BR (1) BR112018069612A2 (pt)
CA (1) CA3019145A1 (pt)
CL (1) CL2018002759A1 (pt)
CO (1) CO2018011550A2 (pt)
CR (1) CR20180516A (pt)
DK (1) DK3436461T3 (pt)
EC (2) ECSP18081153A (pt)
FI (1) FI3436461T3 (pt)
HR (1) HRP20231614T1 (pt)
IL (2) IL261957B (pt)
LT (1) LT3436461T (pt)
MX (1) MX2018011792A (pt)
PE (1) PE20190175A1 (pt)
PH (1) PH12018502102A1 (pt)
PL (1) PL3436461T3 (pt)
PT (1) PT3436461T (pt)
RS (1) RS65129B1 (pt)
SG (2) SG11201808582RA (pt)
SI (1) SI3436461T1 (pt)
TW (2) TWI753892B (pt)
UA (1) UA123785C2 (pt)
WO (1) WO2017172596A1 (pt)

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US20200197385A1 (en) 2017-08-23 2020-06-25 Ono Pharmaceutical Co., Ltd. Therapeutic agent for cancer containing axl inhibitor as active ingredient
PE20210002A1 (es) * 2017-09-27 2021-01-05 Incyte Corp Sales de derivados de pirrolotriazina utiles como inhibidores tam
WO2019074116A1 (ja) 2017-10-13 2019-04-18 小野薬品工業株式会社 Ａｘｌ阻害剤を有効成分として含む固形がん治療剤
EP3741752A4 (en) * 2018-01-17 2021-05-26 Nanjing Transthera Biosciences Co., Ltd. TAM / ET CSF1R FAMILY KINASE INHIBITOR AND ITS USE
EA202091777A1 (ru) 2018-01-26 2020-10-14 Бристол-Маерс Сквибб Компани Аминопирролотриазины в качестве ингибиторов киназы
CN110627796B (zh) * 2018-06-21 2022-07-12 北京越之康泰生物医药科技有限公司 含氮杂环类衍生物及其在医药上的应用
SG11202013163TA (en) 2018-06-29 2021-01-28 Incyte Corp Formulations of an axl/mer inhibitor
UY38349A (es) * 2018-08-30 2020-03-31 Array Biopharma Inc Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
CN111689991B (zh) * 2019-03-13 2023-06-09 习峰 取代的杂芳基化合物及其组合物和用途
CN110156836A (zh) * 2019-06-10 2019-08-23 成家钢 一种环丙基羰基亚甲基三苯基磷的制备方法
EP4005637A4 (en) * 2019-07-29 2023-07-19 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
CN112409361B (zh) * 2019-08-23 2022-08-16 山东轩竹医药科技有限公司 Tam抑制剂及其用途
CN116283916A (zh) * 2019-09-06 2023-06-23 中国科学院上海药物研究所 具有Axl与c-Met激酶抑制活性的化合物及其制备和应用
CN113336758B (zh) * 2020-03-03 2022-08-19 北京桦冠医药科技有限公司 化合物7-碘吡咯并[2，1-f][1，2，4]三嗪-4-胺的一种新合成方法
KR20230017165A (ko) 2020-03-06 2023-02-03 인사이트 코포레이션 Axl/mer 및 pd-1/pd-l1 억제제를 포함하는 병행 요법
CN111233870A (zh) * 2020-03-11 2020-06-05 中国科学技术大学 用于快速制备瑞德西韦药物中间体的方法
WO2021233236A1 (zh) * 2020-05-18 2021-11-25 北京范恩柯尔生物科技有限公司 取代的杂芳基化合物及其组合物和用途
JP2023533771A (ja) * 2020-07-10 2023-08-04 ベイジン ファインドキュア バイオサイエンシーズ リミテッド トリアジン系化合物およびその組成物と用途
WO2022166610A1 (zh) * 2021-02-05 2022-08-11 四川科伦博泰生物医药股份有限公司 一类哒嗪酮杂环化合物及其制备方法和用途
CN117561260A (zh) * 2021-08-12 2024-02-13 四川科伦博泰生物医药股份有限公司 一类杂环化合物及其制备方法和用途
TW202330519A (zh) * 2021-09-29 2023-08-01 香港商德琪研發有限公司 作為ｔａｍ抑制劑的吡唑并吡啶化合物
WO2023155886A1 (en) * 2022-02-17 2023-08-24 Shanghai Antengene Corporation Limited Pyrazolopyridine compounds as tam inhibitors
WO2024054793A1 (en) 2022-09-09 2024-03-14 University Of Rochester Inhibition of efferocytosis as a treatment to prevent bone loss and increase bone density and strength

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