CO2023004594A2 - Compuestos fosfolípidos y usos de estos - Google Patents

Compuestos fosfolípidos y usos de estos

Info

Publication number
CO2023004594A2
CO2023004594A2 CONC2023/0004594A CO2023004594A CO2023004594A2 CO 2023004594 A2 CO2023004594 A2 CO 2023004594A2 CO 2023004594 A CO2023004594 A CO 2023004594A CO 2023004594 A2 CO2023004594 A2 CO 2023004594A2
Authority
CO
Colombia
Prior art keywords
compounds
phospholipid compounds
phospholipid
alone
treatment
Prior art date
Application number
CONC2023/0004594A
Other languages
English (en)
Inventor
Peiyuan Wang
Scott E Lazerwith
Philip A Morganelli
Thomas P Stratton
Jonathan William Medley
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CO2023004594A2 publication Critical patent/CO2023004594A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se describen compuestos y métodos para usar dichos compuestos, solos o en combinación con agentes adicionales, y composiciones farmacéuticas de dichos compuestos para el tratamiento de infecciones virales.
CONC2023/0004594A 2020-10-16 2023-04-13 Compuestos fosfolípidos y usos de estos CO2023004594A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063093037P 2020-10-16 2020-10-16
US202163151456P 2021-02-19 2021-02-19
PCT/US2021/055183 WO2022081973A1 (en) 2020-10-16 2021-10-15 Phospholipid compounds and uses thereof

Publications (1)

Publication Number Publication Date
CO2023004594A2 true CO2023004594A2 (es) 2023-04-17

Family

ID=78536645

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0004594A CO2023004594A2 (es) 2020-10-16 2023-04-13 Compuestos fosfolípidos y usos de estos

Country Status (16)

Country Link
US (2) US20220143052A1 (es)
EP (1) EP4228685A1 (es)
JP (1) JP2023547599A (es)
KR (1) KR20230088432A (es)
CN (1) CN116322759A (es)
AU (1) AU2021361059A1 (es)
CA (1) CA3193879A1 (es)
CL (1) CL2023001062A1 (es)
CO (1) CO2023004594A2 (es)
CR (1) CR20230164A (es)
DO (1) DOP2023000074A (es)
IL (1) IL301809A (es)
MX (1) MX2023004188A (es)
PE (1) PE20230858A1 (es)
TW (2) TWI811812B (es)
WO (1) WO2022081973A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116323630A (zh) * 2020-08-24 2023-06-23 吉利德科学公司 磷脂化合物及其用途
TWI811812B (zh) 2020-10-16 2023-08-11 美商基利科學股份有限公司 磷脂化合物及其用途
CN114903897B (zh) * 2022-04-27 2024-02-13 中国人民解放军海军军医大学 千金藤素在制备抗蜱传脑炎病毒药物中的应用

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
EP0262876B1 (en) 1986-09-27 1992-04-29 Toyo Jozo Kabushiki Kaisha Nucleoside-phospholipid conjugate
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
RU2258707C2 (ru) 1999-12-03 2005-08-20 Де Риджентс ов де Юниверсити ов Калифорния, Сан-Диего Фосфонатные соединения
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
MXPA02011641A (es) 2000-05-26 2004-07-30 Idenix Cayman Ltd Metodos para tatar infecciones por viurs de hepatitis delta con beta-l-2'-desoxi-nucleosidos.
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
BRPI0411900B8 (pt) 2003-06-26 2021-05-25 Biotron Ltd compostos e composições farmacêuticas compreendendo os mesmos
US8101745B2 (en) 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
US20090156545A1 (en) 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
ZA200800256B (en) 2005-06-24 2009-08-26 Biotron Ltd Antiviral compounds and methods
US20100254942A1 (en) 2007-08-03 2010-10-07 Biotron Limited Hepatitis c antiviral compositions and methods
WO2010002877A2 (en) 2008-07-03 2010-01-07 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
AU2009298802A1 (en) 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
EP2826369A3 (en) 2008-11-06 2015-03-18 Vascular Biogenics Ltd. Oxidized lipid compounds and uses thereof
WO2011100131A2 (en) 2010-01-28 2011-08-18 Alnylam Pharmacuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
TW201201815A (en) * 2010-05-28 2012-01-16 Gilead Sciences Inc 1'-substituted-carba-nucleoside prodrugs for antiviral treatment
EP2794627B1 (en) 2011-12-22 2018-09-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EA201590384A1 (ru) 2012-09-10 2015-10-30 Ф. Хоффманн-Ля Рош Аг 6-аминокислота-гетероарилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в
KR102327888B1 (ko) 2012-12-21 2021-11-17 얀센 바이오파마, 인코퍼레이트. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
WO2014143643A1 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California, A California Corporation Acyclic nucleoside phosphonate diesters
CA2913206C (en) 2013-06-26 2022-08-02 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
KR101949251B1 (ko) 2013-09-11 2019-02-18 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) B형간염바이러스 감염의 치료 방법 및 치료용 약학적 조성물
CN105829333A (zh) 2013-10-11 2016-08-03 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸及其类似物
EP3099685B1 (en) 2014-01-30 2018-04-18 F.Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
EA030115B9 (ru) 2014-03-07 2018-09-28 Ф. Хоффманн-Ля Рош Аг Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
MX2016014728A (es) 2014-05-13 2017-03-23 Hoffmann La Roche Dihidroquinolizidinonas novedosas para el tratamiento y profilaxis de la infeccion con virus de la hepatitis b.
EP3160475B1 (en) 2014-06-24 2024-01-03 Janssen Pharmaceuticals, Inc. Substituted nucleosides and nucleotides to treat filoviridae infections
CN106573011A (zh) 2014-06-24 2017-04-19 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸和其类似物
WO2016012470A1 (en) 2014-07-25 2016-01-28 F. Hoffmann-La Roche Ag New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
MX2017001862A (es) 2014-08-14 2017-05-15 Hoffmann La Roche Nuevas piridazonas y triazinonas para el tratamiento y la profilaxis de infeccion por virus de hepatitis b.
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
WO2016102438A1 (en) 2014-12-23 2016-06-30 F. Hoffmann-La Roche Ag Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidine analogues
US9676793B2 (en) 2014-12-23 2017-06-13 Hoffmann-Laroche Inc. Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
JP6506845B2 (ja) 2014-12-30 2019-04-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療及び予防のための新規テトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類
JP2018504891A (ja) 2014-12-31 2018-02-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ リアルタイムＰＣＲによる細胞溶解物からのＨＢＶ ｃｃｃＤＮＡ定量化のための新規ハイスループット法
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
WO2016120186A1 (en) 2015-01-27 2016-08-04 F. Hoffmann-La Roche Ag Recombinant hbv cccdna, the method to generate thereof and the use thereof
EP3256471B1 (en) 2015-02-11 2018-12-12 F. Hoffmann-La Roche AG Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
US11963972B2 (en) 2016-03-23 2024-04-23 Emory University Antiviral agents and nucleoside analogs for treatment of Zika virus
BR112019016316A2 (pt) 2017-02-08 2020-03-31 Biotron Limited Métodos para o tratamento da influenza
TW201836615A (zh) 2017-03-14 2018-10-16 美商基利科學股份有限公司 治療貓冠狀病毒感染之方法
US11306111B2 (en) 2017-07-31 2022-04-19 January Therapeutics, Inc. Organophosphate derivatives
EP3684782A1 (en) 2017-09-18 2020-07-29 Janssen BioPharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN111971284A (zh) 2017-12-27 2020-11-20 埃默里大学 核苷和/或nadph氧化酶(nox)抑制剂作为髓样特异性抗病毒剂的联合模式
CA3092834A1 (en) 2018-03-02 2019-09-06 January Therapeutics, Inc. Nanoparticle compositions
TWI791193B (zh) 2020-02-18 2023-02-01 美商基利科學股份有限公司 抗病毒化合物
CN113292565B (zh) 2020-02-24 2023-01-31 浙江森科建设有限公司 核苷类化合物及其制备方法和应用
CN111233929B (zh) 2020-02-28 2023-02-28 成都阿奇生物医药科技有限公司 一种核苷类似物的氘代物及其制备方法和用途
CN111393243B (zh) 2020-04-22 2022-12-13 深圳市宝安区新材料研究院 一种磷手性核苷类药物的合成方法及该方法得到的药物
US20230287029A1 (en) 2020-07-24 2023-09-14 The Regents Of The University Of California Antiviral prodrugs, pharmaceutical formulations, and methods
CN116323630A (zh) 2020-08-24 2023-06-23 吉利德科学公司 磷脂化合物及其用途
CN112010916B (zh) 2020-09-09 2022-12-27 广东东阳光药业有限公司 核苷化合物的氨基磷酸酯衍生物及其用途
TWI811812B (zh) 2020-10-16 2023-08-11 美商基利科學股份有限公司 磷脂化合物及其用途
US20230113114A1 (en) 2020-10-28 2023-04-13 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors
CN112645982B (zh) 2020-12-22 2023-04-07 苏州正济药业有限公司 一种瑞德西韦关键中间体的制备和纯化方法
US11795159B2 (en) 2021-05-26 2023-10-24 Purdue Research Foundation Compounds for the treatment of SARS
US11834408B2 (en) 2021-05-28 2023-12-05 Purdue Research Foundation Compounds for the treatment of SARS
WO2022265964A1 (en) 2021-06-14 2022-12-22 VenatoRx Pharmaceuticals, Inc. Orally-bioavailable nucleoside analogs
CN115475171A (zh) 2021-06-16 2022-12-16 中国医学科学院医药生物技术研究所 一种具有抗冠状病毒活性的化合物及其应用
JPWO2022270478A1 (es) 2021-06-21 2022-12-29
CN115504940A (zh) 2021-06-23 2022-12-23 中国科学院上海药物研究所 一种酰胺类化合物、其制备方法和制药用途
WO2022268111A1 (zh) 2021-06-25 2022-12-29 前沿生物药业(南京)股份有限公司 抗病毒药物组合物及其制备方法和应用
KR20230001595A (ko) 2021-06-28 2023-01-05 재단법인 대구경북첨단의료산업진흥재단 트리아지노인돌 유도체를 유효성분으로 하는 항바이러스제
WO2023279031A1 (en) 2021-06-29 2023-01-05 The Regents Of The University Of California Methods and compositions for treatment of covid-19
WO2023272571A1 (zh) 2021-06-30 2023-01-05 中国人民解放军军事科学院军事医学研究院 2,3-环氧丁二酰衍生物的医药用途
EP4366717A1 (en) 2021-07-08 2024-05-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Broad-spectrum antiviral drugs
EP4366831A1 (en) 2021-07-09 2024-05-15 Aligos Therapeutics, Inc. Anti-viral compounds
WO2023283831A1 (zh) 2021-07-14 2023-01-19 上海药明康德新药开发有限公司 病毒主蛋白酶抑制剂及其制备方法和用途
JPWO2023286844A1 (es) 2021-07-15 2023-01-19
EP4119145A1 (en) 2021-07-15 2023-01-18 Dompe' Farmaceutici S.P.A. Compounds for the treatment of covid-19
TW202321210A (zh) 2021-07-22 2023-06-01 瑞士商諾華公司 用於治療冠狀病毒相關疾病之化合物及組成物
WO2023003610A1 (en) 2021-07-23 2023-01-26 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
KR20230018351A (ko) 2021-07-29 2023-02-07 가톨릭대학교 산학협력단 렘데시비르와 면역조절제 병용투여법을 통한 자가면역류마티스 질환 치료용 조성물
WO2023009187A1 (en) 2021-07-29 2023-02-02 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
JPWO2023008530A1 (es) 2021-07-30 2023-02-02
CN117836272A (zh) 2021-08-02 2024-04-05 北京华益健康药物研究中心 用于治疗或预防冠状病毒感染的3cl蛋白酶小分子抑制剂及其用途
EP4130001A1 (en) 2021-08-03 2023-02-08 Studiengesellschaft Kohle mbH Process for the direct catalytic glycosylation of arenes
AU2022322889A1 (en) 2021-08-03 2024-02-22 Cocrystal Pharma, Inc. Inhibitors for coronaviruses
WO2023012329A1 (en) 2021-08-06 2023-02-09 Intervet International B.V. Method of treating veterinary viral diseases
CN115703796A (zh) 2021-08-09 2023-02-17 苏州恩泰新材料科技有限公司 一种瑞德西韦重要中间体制备方法
JP2023026155A (ja) 2021-08-13 2023-02-24 国立研究開発法人理化学研究所 感染症治療薬
US11865111B2 (en) 2021-08-17 2024-01-09 Southwest Research Institute Antiviral drugs targeting the N-terminal domain (NTD) of the coronavirus spike receptor binding domain (RBD)
WO2023023469A1 (en) 2021-08-17 2023-02-23 Southwest Research Institute Inhibitors for coronavirus
WO2023021092A1 (en) 2021-08-17 2023-02-23 Farahani Ensieh Compounds for treatment of viral infections by neurotropic virus
WO2023021132A1 (en) 2021-08-18 2023-02-23 Katholieke Universiteit Leuven 6-substituted- and 6,7-disubstituted-7-deazapurine ribonucleoside analogues
WO2023023631A1 (en) 2021-08-18 2023-02-23 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
CN113648293B (zh) 2021-08-19 2022-07-05 山东达因海洋生物制药股份有限公司 对苯醌和/或对苯醌衍生物在制备抗新型冠状病毒药物中的应用
WO2023023651A1 (en) 2021-08-19 2023-02-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Quinacrine and derivatives thereof for treatment of viral infections
JPWO2023022231A1 (es) 2021-08-20 2023-02-23
IL310854A (en) 2021-08-20 2024-04-01 Shionogi & Co Nucleoside compounds and their drug derivatives possessing viral growth inhibitory activity
CN115716833A (zh) 2021-08-26 2023-02-28 苏州旺山旺水生物医药有限公司 一种抗病毒核苷类似物的制备方法
US20230102656A1 (en) 2021-08-27 2023-03-30 Ut-Battelle, Llc Covalent inhibitors of coronavirus papain-like protease
CN117886870A (zh) 2021-08-27 2024-04-16 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
WO2023034854A1 (en) 2021-08-31 2023-03-09 Pardes Biosciences, Inc. Crystalline inhibitors of cysteine proteases and methods of use thereof
CN115721661A (zh) 2021-09-01 2023-03-03 常晓宇 嘌呤核苷类药物预防或治疗冠状病毒感染性疾病的用途
CN115745960A (zh) 2021-09-02 2023-03-07 中国科学院上海药物研究所 一类含喹啉酮酰胺的化合物及其制备方法、药物组合物和用途
CN115737665A (zh) 2021-09-02 2023-03-07 广州谷森制药有限公司 胞苷衍生物和与其相关的抗病毒用途
WO2023033098A1 (ja) 2021-09-03 2023-03-09 塩野義製薬株式会社 ウイルス増殖阻害活性を有する二環性含窒素複素環誘導体およびそれらを含有する医薬組成物
TW202328095A (zh) 2021-09-07 2023-07-16 大陸商上海齊魯製藥研究中心有限公司 3CLpro 蛋白酶抑制劑
CN117500801A (zh) 2021-09-09 2024-02-02 广东众生睿创生物科技有限公司 酮酰胺衍生物及其应用
EP4148042A1 (en) 2021-09-10 2023-03-15 Centre National de la Recherche Scientifique Phenoxy-acetyl-thioureido-benzenesulfonamide derivatives, and their uses
WO2023043830A1 (en) 2021-09-15 2023-03-23 Clear Creek Bio, Inc. Combination therapies to treat viral infections
WO2023042879A1 (ja) 2021-09-17 2023-03-23 塩野義製薬株式会社 ウイルス増殖阻害活性を有する二環性複素環誘導体およびそれらを含有する医薬組成物
CN115819391A (zh) 2021-09-17 2023-03-21 中国科学院上海药物研究所 一类黄芩素衍生物、其制备方法和用途
US20230140238A1 (en) 2021-09-17 2023-05-04 Aligos Therapeutics, Inc. Anti-viral compounds
WO2023044462A1 (en) 2021-09-17 2023-03-23 Pardes Biosciences, Inc. Cysteine protease inhibitor formulations and method of use thereof
CN115554303A (zh) 2021-09-18 2023-01-03 上海科技大学 一种三环类化合物、其制备方法及其应用
WO2023044171A1 (en) 2021-09-20 2023-03-23 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
WO2023048151A1 (ja) 2021-09-22 2023-03-30 塩野義製薬株式会社 ウイルス増殖阻害活性を有する環状ペプチド
WO2023049643A1 (en) 2021-09-23 2023-03-30 City Of Hope Inhibitors of sars-cov-2
WO2023046900A1 (en) 2021-09-23 2023-03-30 Katholieke Universiteit Leuven Ribonucleoside analogues against -sars-cov-2
US20230108588A1 (en) 2021-09-27 2023-04-06 The Governors Of The University Of Alberta Rna virus inhibitor compounds and uses thereof
TW202320793A (zh) 2021-09-28 2023-06-01 日商塩野義製藥股份有限公司 含有三嗪衍生物之醫藥組合物
TW202330513A (zh) 2021-09-28 2023-08-01 加拿大商愛彼特生物製藥公司 )抑制劑及其使用方法
WO2023054759A1 (ko) 2021-09-30 2023-04-06 한국화학연구원 2-아미노퀴나졸린 유도체 및 이를 포함하는 항바이러스용 조성물
GB202114032D0 (en) 2021-09-30 2021-11-17 Univ Strathclyde Antivirals
CN116113631B (zh) 2021-09-30 2023-09-26 中国科学院上海药物研究所 一类氰基化合物、其制备方法及用途
EP4159721A1 (en) 2021-09-30 2023-04-05 Qubit Pharmaceuticals Condensed 3,3-difluoro-piperidine derivatives as inhibitors of coronaviruses 3-chymotrypsin-like protease
CN115894587A (zh) 2021-09-30 2023-04-04 知和(山东)大药厂有限公司 一种核苷衍生物的制备及其在抗病毒药物领域中的用途
WO2023059792A1 (en) 2021-10-06 2023-04-13 C4 Thrapeutics, Inc. Coronavirus non-structural protein 3 degrading compounds
KR20230049329A (ko) 2021-10-06 2023-04-13 (주)스파크바이오파마 피리미도디아제핀계 화합물 및 코로나바이러스 감염의 치료 또는 예방을 위한 이의 용도
CN115947758A (zh) 2021-10-07 2023-04-11 南京知和医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
WO2023063884A2 (en) 2021-10-12 2023-04-20 Nanyang Technological University Generation of chiral sulfinate esters
CA3235441A1 (en) 2021-10-13 2023-04-20 Clear Creek Bio, Inc. Compounds and methods for treating coronaviruses
CN115710297A (zh) 2021-10-20 2023-02-24 知和(山东)大药厂有限公司 一种新型核苷酸衍生物类及其药物组合物和用途
CN115583954B (zh) 2021-11-04 2023-08-11 深圳安泰维生物医药有限公司 一种异丁酸酯核苷化合物的晶型及制备方法
CN115806570B (zh) 2021-11-15 2023-09-12 南京知和医药科技有限公司 一种拟肽衍生物及其药物组合物和用途
KR20230119022A (ko) 2021-11-24 2023-08-14 시오노기 앤드 컴파니, 리미티드 트라이아진 유도체를 함유하는 경구 투여하는 제제
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
CN115518058A (zh) 2021-12-29 2022-12-27 河北医科大学 N-环烷基取代的芳甲胺类化合物在制备抗病毒药物中的用途及结构和制备方法
US11760722B2 (en) 2022-01-18 2023-09-19 Ascletis Bioscience Co., Ltd. Inhibitors of cysteine proteases and methods of use thereof
JP7273455B1 (ja) 2022-01-19 2023-05-15 塩野義製薬株式会社 新型コロナウイルス感染症治療用医薬
CN116925040A (zh) 2022-03-31 2023-10-24 陕西盘龙药业集团股份有限公司 一种靶向冠状病毒3CL蛋白酶的PROTACs及其制备方法与应用
CN115504964A (zh) 2022-04-12 2022-12-23 海创药业股份有限公司 氘代杂环酮类化合物及其用途
CN115650959B (zh) 2022-05-20 2023-10-20 南京济群医药科技股份有限公司 化合物的制备方法或纯化方法
CN115636817B (zh) 2022-06-20 2023-11-24 山东大学 含三唑环的靛红类衍生物及其制备方法与应用
CN116496266A (zh) 2022-07-08 2023-07-28 歌礼生物科技（杭州）有限公司 三嗪衍生物
CN115572298A (zh) 2022-07-22 2023-01-06 苏州旺山旺水生物医药有限公司 一种核苷类似物及其盐的晶型、制备方法和应用
CN115466225A (zh) 2022-08-16 2022-12-13 中国科学院上海药物研究所 一种酰胺类化合物及其制备方法、药物组合物和用途
CN115521208B (zh) 2022-09-21 2023-09-01 天津科技大学 新型冠状病毒3cl蛋白酶抑制剂和应用
CN115521316A (zh) 2022-09-23 2022-12-27 深圳安泰维生物医药有限公司 一种核苷类化合物或其中间体的制备方法和核苷类化合物的中间体
CN115521337A (zh) 2022-09-26 2022-12-27 南京康立瑞生物科技有限公司 一种瑞德西韦中间体的合成方法
CN115894498A (zh) 2022-10-01 2023-04-04 海化生命(厦门)科技有限公司 一种潜在抗病毒药物中间体bl及其合成方法
US11655255B2 (en) 2022-10-17 2023-05-23 Sph No.1 Biochemical & Pharmaceutical Co., Ltd. Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
CN115894504A (zh) 2022-10-21 2023-04-04 深圳信立泰药业股份有限公司 一种冠状病毒3cl蛋白酶抑制剂及其用途
CN115651022A (zh) 2022-10-27 2023-01-31 南京康立瑞生物科技有限公司 一种高纯度瑞德西韦中间体的合成方法
CN115887471B (zh) 2022-11-01 2024-02-13 南开大学 瑞德西韦在制备治疗皮肤纤维化疾病药物中的应用
CN115894443B (zh) 2022-11-17 2024-03-29 上海市重大传染病和生物安全研究院 一种化合物艾奎斯韦及其应用
CN115504968B (zh) 2022-11-21 2023-04-18 歌礼生物科技（杭州）有限公司 三嗪衍生物
CN115819423A (zh) 2022-11-29 2023-03-21 武汉大学 一种瑞德西韦或其中间体的protac化合物及其制备方法与抗ev71的应用
CN115850338A (zh) 2022-12-12 2023-03-28 西安交通大学 一种含有双吖丙啶核苷类化合物及制备方法和应用
CN115947759A (zh) 2022-12-13 2023-04-11 安徽大学 一种治疗新冠药物瑞德西韦的制备方法
CN115785080A (zh) 2022-12-16 2023-03-14 陕西盘龙药业集团股份有限公司 一种尿嘧啶母核类化合物及其制备方法和应用

Also Published As

Publication number Publication date
CL2023001062A1 (es) 2023-11-10
CN116322759A (zh) 2023-06-23
TW202344257A (zh) 2023-11-16
CR20230164A (es) 2023-06-23
KR20230088432A (ko) 2023-06-19
WO2022081973A1 (en) 2022-04-21
IL301809A (en) 2023-05-01
AU2021361059A1 (en) 2023-06-08
CA3193879A1 (en) 2022-04-21
EP4228685A1 (en) 2023-08-23
US20230248753A1 (en) 2023-08-10
JP2023547599A (ja) 2023-11-13
PE20230858A1 (es) 2023-05-29
US11963967B2 (en) 2024-04-23
DOP2023000074A (es) 2023-05-31
US20220143052A1 (en) 2022-05-12
TWI811812B (zh) 2023-08-11
TW202233203A (zh) 2022-09-01
MX2023004188A (es) 2023-05-03

Similar Documents

Publication Publication Date Title
CL2023000555A1 (es) Compuestos y métodos para el tratamiento de infecciones virales
CO2023001953A2 (es) Compuestos fosfolípidos y usos de los mismos
DOP2022000293A (es) Análogos de nucleósido de 1’-ciano y usos de los mismos
CO2023004594A2 (es) Compuestos fosfolípidos y usos de estos
CL2023001949A1 (es) Anticuerpos que se dirigen al gp120 de vih y métodos de uso (divisional de solicitud de patente no. 3422-2020)
CO2022008697A2 (es) Compuestos moduladores de la diacilglicerol quinasa
AR112271A1 (es) Composiciones que comprenden un inhibidor de arn polimerasa y ciclodextrina para el tratamiento de infecciones virales
CL2017003436A1 (es) Compuestos de benzoxacepina oxazolidinona y métodos de uso
CL2019002368A1 (es) Composiciones y métodos para el tratamiento de cáncer.
BR112018008326A2 (pt) composições e métodos para o tratamento de câncer
ECSP21038390A (es) Compuestos, composiciones farmacéuticas y métodos de preparación de compuestos y de su uso como inhibidores de la cinasa atr
CL2017002482A1 (es) Compuestos heterocíclicos y su uso en la prevención o tratamiento de las infecciones bacterianas
BR112022000503A2 (pt) Compostos úteis para tratar infecções por vírus influenza
CO2022001210A2 (es) Conjugados de il-2 y métodos de uso para tratar enfermedades autoinmunes
CL2021001753A1 (es) Compuestos derivados de 2,4-diaminoquinazolina; composición farmacéutica; y su uso para el tratamiento de una infección vírica, cáncer, entre otras (divisional de solicitud 202002253).
CL2022000531A1 (es) Composiciones y métodos para el tratamiento de infecciones virales.
CO2022007814A2 (es) Ligandos de la pseudoquinasa tyk2
CO2022000266A2 (es) Inhibidores de enzimas
CO2022000270A2 (es) Inhibidores de enzimas
CO2022014499A2 (es) Moduladores de nlrp3
CU20210008A7 (es) Aspirasas solubilizadas
CO2021007006A2 (es) Moduladores de la expresión de irf5
CO2023013321A2 (es) Compuestos de oxoisoindolina sustituidos con piridinilo
PE20181450A1 (es) Compuestos de 1,3,4-tiadiazol y su uso en el tratamiento del cancer
CO2018011420A2 (es) Formulaciones líquidas de fosfaplatino