BR112018008326A2 - composições e métodos para o tratamento de câncer - Google Patents

composições e métodos para o tratamento de câncer

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Publication number
BR112018008326A2
BR112018008326A2 BR112018008326-7A BR112018008326A BR112018008326A2 BR 112018008326 A2 BR112018008326 A2 BR 112018008326A2 BR 112018008326 A BR112018008326 A BR 112018008326A BR 112018008326 A2 BR112018008326 A2 BR 112018008326A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
cancer treatment
therapeutic agents
treating cancer
Prior art date
Application number
BR112018008326-7A
Other languages
English (en)
Inventor
Lobb Roy
Rennert Paul
Original Assignee
Aleta Biotherapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aleta Biotherapeutics Inc. filed Critical Aleta Biotherapeutics Inc.
Publication of BR112018008326A2 publication Critical patent/BR112018008326A2/pt

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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K14/70596Molecules with a "CD"-designation not provided for elsewhere
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract

são descritos composições, por exemplo, composições compreendendo agentes terapêuticos celulares e/ou agentes terapêuticos proteicos, e métodos de uso de tais composições para o tratamento de câncer.
BR112018008326-7A 2015-10-30 2016-10-28 composições e métodos para o tratamento de câncer BR112018008326A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562249144P 2015-10-30 2015-10-30
US62/249,144 2015-10-30
US201662331010P 2016-05-03 2016-05-03
US62/331,010 2016-05-03
US201662396783P 2016-09-19 2016-09-19
US62/396,783 2016-09-19
PCT/US2016/059582 WO2017075537A1 (en) 2015-10-30 2016-10-28 Compositions and methods for treatment of cancer

Publications (1)

Publication Number Publication Date
BR112018008326A2 true BR112018008326A2 (pt) 2018-10-30

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BR112018008326-7A BR112018008326A2 (pt) 2015-10-30 2016-10-28 composições e métodos para o tratamento de câncer

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US (3) US10508143B1 (pt)
EP (1) EP3368559A4 (pt)
JP (1) JP7115982B2 (pt)
KR (1) KR20180081532A (pt)
CN (1) CN108602872A (pt)
AU (1) AU2016343809B2 (pt)
BR (1) BR112018008326A2 (pt)
CA (1) CA3002674A1 (pt)
CL (1) CL2018001152A1 (pt)
IL (1) IL258955A (pt)
MA (1) MA43135A (pt)
MX (1) MX2018005315A (pt)
WO (1) WO2017075537A1 (pt)

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KR20180083868A (ko) 2015-10-30 2018-07-23 알레타 바이오쎄라퓨틱스, 인크. 종양 형질도입용 조성물 및 방법
CA3002674A1 (en) 2015-10-30 2017-05-04 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
US11020429B2 (en) * 2015-11-05 2021-06-01 Juno Therapeutics, Inc. Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
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