MX2020000294A - Metodos y sistemas para regular condicionalmente la expresion genica. - Google Patents

Metodos y sistemas para regular condicionalmente la expresion genica.

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Publication number
MX2020000294A
MX2020000294A MX2020000294A MX2020000294A MX2020000294A MX 2020000294 A MX2020000294 A MX 2020000294A MX 2020000294 A MX2020000294 A MX 2020000294A MX 2020000294 A MX2020000294 A MX 2020000294A MX 2020000294 A MX2020000294 A MX 2020000294A
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Mexico
Prior art keywords
methods
systems
gene expression
regulating gene
gene
Prior art date
Application number
MX2020000294A
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English (en)
Inventor
Bing Wang
Jianbin Wang
Pei-Qi Liu
Original Assignee
Refuge Biotechnologies Inc
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Publication date
Application filed by Refuge Biotechnologies Inc filed Critical Refuge Biotechnologies Inc
Publication of MX2020000294A publication Critical patent/MX2020000294A/es

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Abstract

La presente divulgación proporciona sistemas, métodos, y composiciones para regular condicionalmente la expresión de un gen objetivo. Los aspectos de la presente divulgación utilizan vías de transducción de señal intracelular para regular la expresión de un gen (p.ej., transgén, gen exógeno, gen endógeno).
MX2020000294A 2017-07-12 2018-07-11 Metodos y sistemas para regular condicionalmente la expresion genica. MX2020000294A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762531752P 2017-07-12 2017-07-12
US201762587668P 2017-11-17 2017-11-17
PCT/US2018/041704 WO2019014390A1 (en) 2017-07-12 2018-07-11 METHODS AND SYSTEMS FOR CONDITIONAL REGULATION OF GENE EXPRESSION

Publications (1)

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MX2020000294A true MX2020000294A (es) 2020-07-22

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US (1) US20200157534A1 (es)
EP (1) EP3651781A4 (es)
JP (2) JP2020530309A (es)
KR (1) KR20200056980A (es)
CN (1) CN111093679A (es)
AU (1) AU2018301667A1 (es)
BR (1) BR112020000731A2 (es)
CA (1) CA3069522A1 (es)
IL (1) IL271883B2 (es)
MX (1) MX2020000294A (es)
SG (1) SG11202000145XA (es)
WO (1) WO2019014390A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019183572A1 (en) * 2018-03-23 2019-09-26 Refuge Biotechnologies, Inc. Gene regulation via conditional nuclear localization of gene modulating polypeptides
WO2020227307A1 (en) * 2019-05-07 2020-11-12 Refuge Biotechnologies, Inc. Systems and methods for nuclear localization of gene modulating polypeptides
WO2021126930A1 (en) * 2019-12-17 2021-06-24 University Of Miami Methods for identifying modulators of g protein-coupled receptors
JP2023507816A (ja) * 2019-12-20 2023-02-27 エンジン バイオサイエンシズ プライベート リミテッド がんを治療するための方法及び組成物
EP4110401A4 (en) * 2020-02-25 2024-03-27 Symvivo Corporation GENE DELIVERY SYSTEM
EP4114955A4 (en) * 2020-03-05 2024-06-05 Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud Foundation CHIMERIC ADAPTER PROTEINS AND METHODS FOR REGULATION OF GENE EXPRESSION
CN111500719B (zh) * 2020-03-24 2022-06-07 中国辐射防护研究院 Ighmbp2基因用作预测辐射敏感性的分子标志物的用途
US20240016838A1 (en) * 2020-10-26 2024-01-18 City Of Hope Engineered nk cells
WO2022174829A1 (en) * 2021-02-19 2022-08-25 Wuhan University Editing of double-stranded dna with relaxed pam requirement field of the disclosure
AU2022294896A1 (en) * 2021-06-16 2024-01-25 Senti Biosciences, Inc. Armed chimeric receptors and methods of use thereof
CN116004697B (zh) * 2022-06-30 2024-02-13 深圳技术大学 一种异源产虫草素的米曲霉工程菌及其构建方法与应用
CN116240173B (zh) * 2023-02-02 2024-09-27 西安电子科技大学 一种冷热肿瘤调控型car-单核/巨噬细胞及其制备方法和应用
WO2024166035A1 (en) * 2023-02-09 2024-08-15 Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud Foundation Regulating gene expression in gamma delta t cell receptors expressing cells
CN116790615A (zh) * 2023-07-11 2023-09-22 康霖生物科技(杭州)有限公司 一种用于过敏性疾病的基因治疗载体核酸构建体及其使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA119135C2 (uk) * 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб отримання трансгенної рослини
EP3004375A4 (en) * 2013-06-06 2017-05-10 Agency For Science, Technology And Research Protease-responsive peptide biosensors and methods for analyte detection
EP3011029B1 (en) * 2013-06-17 2019-12-11 The Broad Institute, Inc. Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
US9809862B2 (en) * 2014-08-11 2017-11-07 Georgia Tech Research Corporation G-protein coupled receptor (GPCR)-based biosensors and uses thereof
WO2016095934A2 (en) * 2014-12-14 2016-06-23 El Abd Hisham Mohamed Magdy A novel genetic device to engineer cell behavior
CN108064283B (zh) * 2015-02-24 2024-01-09 加利福尼亚大学董事会 结合触发的转录开关及其使用方法
EP3294764B1 (en) * 2015-05-15 2020-12-30 City of Hope Chimeric antigen receptor compositions
AU2016343809B2 (en) * 2015-10-30 2022-08-04 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
US11052111B2 (en) * 2015-12-08 2021-07-06 Chimera Bioengineering, Inc. Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses
KR20180096800A (ko) * 2016-01-11 2018-08-29 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 키메라 단백질 및 유전자 발현을 조절하는 방법

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US20200157534A1 (en) 2020-05-21
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