MX2020000294A - Metodos y sistemas para regular condicionalmente la expresion genica. - Google Patents
Metodos y sistemas para regular condicionalmente la expresion genica.Info
- Publication number
- MX2020000294A MX2020000294A MX2020000294A MX2020000294A MX2020000294A MX 2020000294 A MX2020000294 A MX 2020000294A MX 2020000294 A MX2020000294 A MX 2020000294A MX 2020000294 A MX2020000294 A MX 2020000294A MX 2020000294 A MX2020000294 A MX 2020000294A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- systems
- gene expression
- regulating gene
- gene
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000001105 regulatory effect Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 230000031146 intracellular signal transduction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
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- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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- C—CHEMISTRY; METALLURGY
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- A61K2121/00—Preparations for use in therapy
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente divulgación proporciona sistemas, métodos, y composiciones para regular condicionalmente la expresión de un gen objetivo. Los aspectos de la presente divulgación utilizan vías de transducción de señal intracelular para regular la expresión de un gen (p.ej., transgén, gen exógeno, gen endógeno).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762531752P | 2017-07-12 | 2017-07-12 | |
US201762587668P | 2017-11-17 | 2017-11-17 | |
PCT/US2018/041704 WO2019014390A1 (en) | 2017-07-12 | 2018-07-11 | METHODS AND SYSTEMS FOR CONDITIONAL REGULATION OF GENE EXPRESSION |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020000294A true MX2020000294A (es) | 2020-07-22 |
Family
ID=65001804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020000294A MX2020000294A (es) | 2017-07-12 | 2018-07-11 | Metodos y sistemas para regular condicionalmente la expresion genica. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20200157534A1 (es) |
EP (1) | EP3651781A4 (es) |
JP (2) | JP2020530309A (es) |
KR (1) | KR20200056980A (es) |
CN (1) | CN111093679A (es) |
AU (1) | AU2018301667A1 (es) |
BR (1) | BR112020000731A2 (es) |
CA (1) | CA3069522A1 (es) |
IL (1) | IL271883B2 (es) |
MX (1) | MX2020000294A (es) |
SG (1) | SG11202000145XA (es) |
WO (1) | WO2019014390A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019183572A1 (en) * | 2018-03-23 | 2019-09-26 | Refuge Biotechnologies, Inc. | Gene regulation via conditional nuclear localization of gene modulating polypeptides |
WO2020227307A1 (en) * | 2019-05-07 | 2020-11-12 | Refuge Biotechnologies, Inc. | Systems and methods for nuclear localization of gene modulating polypeptides |
WO2021126930A1 (en) * | 2019-12-17 | 2021-06-24 | University Of Miami | Methods for identifying modulators of g protein-coupled receptors |
JP2023507816A (ja) * | 2019-12-20 | 2023-02-27 | エンジン バイオサイエンシズ プライベート リミテッド | がんを治療するための方法及び組成物 |
EP4110401A4 (en) * | 2020-02-25 | 2024-03-27 | Symvivo Corporation | GENE DELIVERY SYSTEM |
EP4114955A4 (en) * | 2020-03-05 | 2024-06-05 | Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud Foundation | CHIMERIC ADAPTER PROTEINS AND METHODS FOR REGULATION OF GENE EXPRESSION |
CN111500719B (zh) * | 2020-03-24 | 2022-06-07 | 中国辐射防护研究院 | Ighmbp2基因用作预测辐射敏感性的分子标志物的用途 |
US20240016838A1 (en) * | 2020-10-26 | 2024-01-18 | City Of Hope | Engineered nk cells |
WO2022174829A1 (en) * | 2021-02-19 | 2022-08-25 | Wuhan University | Editing of double-stranded dna with relaxed pam requirement field of the disclosure |
AU2022294896A1 (en) * | 2021-06-16 | 2024-01-25 | Senti Biosciences, Inc. | Armed chimeric receptors and methods of use thereof |
CN116004697B (zh) * | 2022-06-30 | 2024-02-13 | 深圳技术大学 | 一种异源产虫草素的米曲霉工程菌及其构建方法与应用 |
CN116240173B (zh) * | 2023-02-02 | 2024-09-27 | 西安电子科技大学 | 一种冷热肿瘤调控型car-单核/巨噬细胞及其制备方法和应用 |
WO2024166035A1 (en) * | 2023-02-09 | 2024-08-15 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud Foundation | Regulating gene expression in gamma delta t cell receptors expressing cells |
CN116790615A (zh) * | 2023-07-11 | 2023-09-22 | 康霖生物科技(杭州)有限公司 | 一种用于过敏性疾病的基因治疗载体核酸构建体及其使用方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA119135C2 (uk) * | 2012-09-07 | 2019-05-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб отримання трансгенної рослини |
EP3004375A4 (en) * | 2013-06-06 | 2017-05-10 | Agency For Science, Technology And Research | Protease-responsive peptide biosensors and methods for analyte detection |
EP3011029B1 (en) * | 2013-06-17 | 2019-12-11 | The Broad Institute, Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
US9809862B2 (en) * | 2014-08-11 | 2017-11-07 | Georgia Tech Research Corporation | G-protein coupled receptor (GPCR)-based biosensors and uses thereof |
WO2016095934A2 (en) * | 2014-12-14 | 2016-06-23 | El Abd Hisham Mohamed Magdy | A novel genetic device to engineer cell behavior |
CN108064283B (zh) * | 2015-02-24 | 2024-01-09 | 加利福尼亚大学董事会 | 结合触发的转录开关及其使用方法 |
EP3294764B1 (en) * | 2015-05-15 | 2020-12-30 | City of Hope | Chimeric antigen receptor compositions |
AU2016343809B2 (en) * | 2015-10-30 | 2022-08-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
US11052111B2 (en) * | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
KR20180096800A (ko) * | 2016-01-11 | 2018-08-29 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 키메라 단백질 및 유전자 발현을 조절하는 방법 |
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2018
- 2018-07-11 BR BR112020000731-5A patent/BR112020000731A2/pt unknown
- 2018-07-11 EP EP18831219.3A patent/EP3651781A4/en active Pending
- 2018-07-11 KR KR1020207004111A patent/KR20200056980A/ko not_active Application Discontinuation
- 2018-07-11 CA CA3069522A patent/CA3069522A1/en active Pending
- 2018-07-11 CN CN201880059217.6A patent/CN111093679A/zh active Pending
- 2018-07-11 MX MX2020000294A patent/MX2020000294A/es unknown
- 2018-07-11 WO PCT/US2018/041704 patent/WO2019014390A1/en unknown
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2020
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EP3651781A1 (en) | 2020-05-20 |
AU2018301667A1 (en) | 2020-02-06 |
IL271883A (en) | 2020-02-27 |
KR20200056980A (ko) | 2020-05-25 |
IL271883B2 (en) | 2024-08-01 |
SG11202000145XA (en) | 2020-02-27 |
BR112020000731A2 (pt) | 2020-07-14 |
WO2019014390A1 (en) | 2019-01-17 |
US20200157534A1 (en) | 2020-05-21 |
CN111093679A (zh) | 2020-05-01 |
JP2020530309A (ja) | 2020-10-22 |
JP2023182720A (ja) | 2023-12-26 |
CA3069522A1 (en) | 2019-01-17 |
EP3651781A4 (en) | 2021-04-21 |
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