MX2018005315A - Composiciones y metodos para el tratamiento del cancer. - Google Patents

Composiciones y metodos para el tratamiento del cancer.

Info

Publication number
MX2018005315A
MX2018005315A MX2018005315A MX2018005315A MX2018005315A MX 2018005315 A MX2018005315 A MX 2018005315A MX 2018005315 A MX2018005315 A MX 2018005315A MX 2018005315 A MX2018005315 A MX 2018005315A MX 2018005315 A MX2018005315 A MX 2018005315A
Authority
MX
Mexico
Prior art keywords
compositions
methods
cancer
treatment
therapeutics
Prior art date
Application number
MX2018005315A
Other languages
English (en)
Inventor
Paul Rennert
Lobb Roy
Original Assignee
Aleta Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aleta Biotherapeutics Inc filed Critical Aleta Biotherapeutics Inc
Publication of MX2018005315A publication Critical patent/MX2018005315A/es

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

Se describen composiciones, p. ej., composiciones que comprenden agentes terapéuticos celulares y/o agentes terapéuticos proteicos, y métodos de utilizar estas composiciones para tratar el cáncer.
MX2018005315A 2015-10-30 2016-10-28 Composiciones y metodos para el tratamiento del cancer. MX2018005315A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562249144P 2015-10-30 2015-10-30
US201662331010P 2016-05-03 2016-05-03
US201662396783P 2016-09-19 2016-09-19
PCT/US2016/059582 WO2017075537A1 (en) 2015-10-30 2016-10-28 Compositions and methods for treatment of cancer

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MX2018005315A true MX2018005315A (es) 2018-08-14

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MX2018005315A MX2018005315A (es) 2015-10-30 2016-10-28 Composiciones y metodos para el tratamiento del cancer.

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US (3) US10508143B1 (es)
EP (1) EP3368559A4 (es)
JP (1) JP7115982B2 (es)
KR (1) KR20180081532A (es)
CN (1) CN108602872A (es)
AU (1) AU2016343809B2 (es)
BR (1) BR112018008326A2 (es)
CA (1) CA3002674A1 (es)
CL (1) CL2018001152A1 (es)
IL (1) IL258955A (es)
MA (1) MA43135A (es)
MX (1) MX2018005315A (es)
WO (1) WO2017075537A1 (es)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016343805A1 (en) * 2015-10-30 2018-06-07 Aleta Biotherapeutics Inc. Compositions and methods for tumor transduction
US10508143B1 (en) 2015-10-30 2019-12-17 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
US11020429B2 (en) * 2015-11-05 2021-06-01 Juno Therapeutics, Inc. Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
JP2019533676A (ja) 2016-10-13 2019-11-21 ジュノー セラピューティクス インコーポレイテッド トリプトファン代謝経路調節剤を含む免疫療法の方法および組成物
CN108395482B (zh) * 2017-02-08 2021-02-05 西比曼生物科技（香港）有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
BR112019017403A2 (pt) * 2017-02-22 2020-04-14 Aleta Biotherapeutics Inc composições e métodos para o tratamento de câncer
US11344578B2 (en) 2017-04-19 2022-05-31 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
EP3621981A2 (en) 2017-05-12 2020-03-18 CRISPR Therapeutics AG Materials and methods for engineering cells and uses thereof in immuno-oncology
CN107177632B (zh) * 2017-05-27 2020-02-07 上海优卡迪生物医药科技有限公司 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用
WO2018232372A1 (en) * 2017-06-16 2018-12-20 Protelica, Inc. Fibronectin binding domain chimeric antigen receptors and methods of use thereof
WO2018233624A1 (zh) * 2017-06-20 2018-12-27 和迈生物科技有限公司 抗Her2纳米抗体及其编码序列和用途
SG11202000145XA (en) * 2017-07-12 2020-02-27 Refuge Biotechnologies Inc Methods and systems for conditionally regulating gene expression
US20210130775A1 (en) * 2017-08-02 2021-05-06 Autolus Limited Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed
US20200384022A1 (en) * 2017-11-13 2020-12-10 The Broad Institute, Inc. Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
CN111655270A (zh) * 2017-11-14 2020-09-11 纪念斯隆-凯特琳癌症中心 分泌il-36的免疫应答细胞及其用途
MA51154A (fr) * 2017-12-15 2020-10-21 Aleta Biotherapeutics Inc Variants de cd19
CN109988242A (zh) * 2018-01-02 2019-07-09 武汉波睿达生物科技有限公司 联合嵌合抗原受体、表达载体、慢病毒及t细胞
WO2019134526A1 (zh) * 2018-01-03 2019-07-11 西交利物浦大学 膜型金属蛋白酶抑制蛋白和包含其的药物和药物组合物及各自的用途
WO2020113403A1 (en) * 2018-12-04 2020-06-11 Beijing Percans Oncology Co. Ltd. Cytokine fusion proteins
CN110157675B (zh) * 2018-02-12 2022-05-27 深圳宾德生物技术有限公司 一种靶向性t淋巴细胞及其制备方法和应用
EP3561053A1 (en) * 2018-04-26 2019-10-30 Baylor College of Medicine Immune effector cells and molecular adaptors with an antigen cytokine complex for effective cancer immunotherapy
WO2019210280A1 (en) * 2018-04-27 2019-10-31 Casebia Therapeutics Limited Liability Partnership Anti-bcma car-t-cells for plasma cell depletion
EP3784256A4 (en) * 2018-04-27 2022-06-29 Baylor College of Medicine Car t cells with one or more interleukins
MX2020012028A (es) 2018-05-11 2021-03-29 Crispr Therapeutics Ag Metodos y composiciones para tratar el cancer.
CN110623977A (zh) * 2018-06-25 2019-12-31 深圳宾德生物技术有限公司 靶向bcma的嵌合抗原受体t细胞在自身免疫性疾病中的应用
CN110856751A (zh) 2018-08-24 2020-03-03 合成免疫股份有限公司 包含核酸及tcr修饰的免疫细胞的治疗剂及其应用
CN110950954B (zh) * 2018-09-26 2021-06-25 重庆精准生物技术有限公司 抗cd123人源化单链抗体及其应用
WO2020077341A1 (en) 2018-10-13 2020-04-16 Memorial Sloan-Kettering Center Center Methods and compositions for identifying and treating subjects at risk for poor car t cell therapy response
AU2019384145A1 (en) * 2018-11-20 2021-06-10 Innovative Cellular Therapeutics Holdings, Ltd. Modified cell expressing therapeutic agent and uses thereof
US20220047634A1 (en) * 2018-11-30 2022-02-17 Dana-Farber Cancer Institute, Inc. Chimeric antigen receptor factories and methods of use thereof
CN109468283A (zh) * 2018-11-30 2019-03-15 北京美康基免生物科技有限公司 一种基于cd19和bcma的双重嵌合抗原受体基因修饰的免疫细胞及其应用
CN109536444B (zh) * 2018-12-11 2022-06-28 吉林省拓华生物科技有限公司 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法
CN113677703A (zh) * 2018-12-17 2021-11-19 鳄鱼生物科学公司 多肽
CN111378046B (zh) * 2018-12-27 2024-03-15 上海细胞治疗集团有限公司 一种免疫效应细胞转换受体
CN111378623B (zh) * 2018-12-29 2023-10-20 深圳市第三人民医院 一种靶向性抗肿瘤t细胞及其制备方法和应用
AU2020224160A1 (en) * 2019-02-21 2021-08-26 John M. LUK Artificial immunosurveillance chimeric antigen receptor (AI-CAR) and cells expressing the same
WO2020172641A1 (en) * 2019-02-21 2020-08-27 Arbele Limited Artificial immunosurveillance chimeric antigen receptor and cells expressing the same
EP3931212A1 (en) 2019-03-01 2022-01-05 Universität für Bodenkultur Wien Stabilized extracellular domain of cd19
CA3137962A1 (en) * 2019-04-26 2020-10-29 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
CA3138633A1 (en) 2019-04-30 2020-11-05 Crispr Therapeutics Ag Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
AU2020296197A1 (en) * 2019-06-21 2022-01-20 Shattuck Labs, Inc. Chimeric protein expressing T-cells
KR20220036941A (ko) * 2019-06-21 2022-03-23 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 암 및 기타 질환의 치료를 위한 알파3베타1 인테그린 표적화
BR112022003735A2 (pt) * 2019-08-29 2022-06-21 Nat Institute For Biotechnology In The Negev Ltd Anticorpo de domínio único para alvejar antígeno de membrana específico da próstata (psma)
CN114502723A (zh) * 2019-09-26 2022-05-13 原启生物科技(上海)有限责任公司 一种经修饰的免疫细胞及其用途
WO2021096275A1 (ko) * 2019-11-15 2021-05-20 주식회사 제넥신 변형된 인터루킨-7 및 tgf 베타 수용체 ii를 포함하는 융합단백질 및 이의 용도
CN114945586A (zh) * 2020-01-21 2022-08-26 张晋宇 一种药物组合物及其用途
CN115701999A (zh) * 2020-07-09 2023-02-14 南京传奇生物科技有限公司 用白介素-36工程化γδT细胞用于免疫疗法
US20230272341A1 (en) * 2020-08-10 2023-08-31 Crage Medical Co., Limited Multifunctional immune effector cell and use thereof
CN111944063A (zh) * 2020-08-20 2020-11-17 深圳市因诺转化医学研究院 特异性识别人cd19嵌合抗原受体的融合蛋白、核酸分子及其应用
WO2022049217A1 (en) 2020-09-04 2022-03-10 Miltenyi Biotec B.V. & Co. KG System for inducible expression of an adapter in immune cells
JP2023541455A (ja) 2020-09-14 2023-10-02 ブイオーアール バイオファーマ インコーポレーテッド Ｃｄ３３に対する単一ドメイン抗体
CA3196402A1 (en) * 2020-10-22 2022-04-28 Dale L. Ludwig Combination radioimmunotherapy and cd47 blockade in the treatment of cancer
CN112225822B (zh) * 2020-12-14 2021-03-23 北京基因启明生物科技有限公司 高扩增、存续能力和杀瘤作用的CAR-iNKT及应用
CN114163512A (zh) * 2021-03-24 2022-03-11 深圳市新靶向生物科技有限公司 一种与肝癌驱动基因突变相关的抗原肽组合及其应用
WO2022246041A2 (en) * 2021-05-20 2022-11-24 Achelois Biopharma, Inc. Compositions and methods for multivalent surface display on enveloped particles
CN113238061B (zh) * 2021-07-09 2021-10-01 中南大学湘雅医院 以cd180阴性b细胞指示重症肌无力病情的试剂盒及应用
CN116338196A (zh) * 2021-12-15 2023-06-27 上海佳文英莉生物技术有限公司 老年痴呆症诊断及治疗的新靶点及其应用
KR20230101284A (ko) * 2021-12-29 2023-07-06 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 대장암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR20230101285A (ko) * 2021-12-29 2023-07-06 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 유방암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR20230101287A (ko) * 2021-12-29 2023-07-06 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 흑색종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR20230101283A (ko) * 2021-12-29 2023-07-06 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 폐 유두상 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR20230101286A (ko) * 2021-12-29 2023-07-06 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 폐 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
WO2023201238A1 (en) 2022-04-11 2023-10-19 Vor Biopharma Inc. Binding agents and methods of use thereof

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
US5614191A (en) 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
WO1998002548A2 (en) 1996-07-17 1998-01-22 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Infectious papillomavirus pseudoviral particles
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
WO1998055607A2 (en) 1997-06-04 1998-12-10 Oxford Biomedica (Uk) Limited Tumor targeted vector
WO1999013056A1 (en) 1997-09-05 1999-03-18 Medimmune, Inc. IN VITRO METHOD FOR DISASSEMBLY/REASSEMBLY OF PAPILLOMAVIRUS VIRUS-LIKE PARTICLES (VLPs)
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
AU1086501A (en) 1999-10-15 2001-04-30 Carnegie Institution Of Washington Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
AU6541801A (en) 2000-06-22 2002-01-02 Idec Pharma Corp Bispecific fusion protein and method of use for enhancing effector cell killing of target cells
EP1334188B1 (en) 2000-11-07 2006-08-30 City of Hope Cd19-specific redirected immune cells
CN1114690C (zh) 2001-05-15 2003-07-16 乔良 乳头瘤假病毒及其制备方法
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
AU2006218489B2 (en) 2005-03-02 2011-02-24 Biogen Ma Inc. KIM-1 antibodies for treatment of Th2-mediated conditions
EP1909832A4 (en) 2005-06-29 2010-01-13 Univ Miami ANTIBODY IMMUNOCELL LIGAND FUSION PROTEIN FOR CANCER THERAPY
DK2009990T3 (en) 2006-04-07 2017-01-09 Univ Texas METHODS AND COMPOSITIONS RELATED TO adenoassociated VIRUSFAGPARTIKLER
CA2686990C (en) 2007-05-08 2018-04-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Papillomavirus pseudoviruses for detection and therapy of tumors
CA2695385A1 (en) * 2007-07-31 2009-02-05 Atul Bedi Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders
JP6035009B2 (ja) 2007-08-22 2016-11-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用
WO2009117117A1 (en) * 2008-03-19 2009-09-24 Altor Bioscience Corporation T cell receptor fusions and conjugates and methods of use there of
AU2009288289B2 (en) 2008-08-25 2012-11-08 Amplimmune, Inc. PD-1 antagonists and methods of use thereof
CA2742777A1 (en) * 2008-11-06 2010-05-14 University Of Guelph Methods of improving the therapeutic efficacy and utility of antibody fragments
JP5851842B2 (ja) 2009-01-12 2016-02-03 サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. 改変した抗体組成物、それを作製および使用する方法
WO2010096838A2 (en) 2009-02-23 2010-08-26 Cytomx Therapeutics, Llc Proproteins and methods of use thereof
US20130209514A1 (en) * 2009-06-09 2013-08-15 Eli Gilboa Aptamer-targeted costimulatory ligand aptamer
CA3083324A1 (en) * 2010-03-05 2011-09-09 The Johns Hopkins University Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
EP2632482A4 (en) * 2010-10-27 2015-05-27 Baylor College Medicine CHIMERIC CD27 RECEPTORS FOR REALIGNMENT OF T CELLS TO CD70 POSITIVE MALIGNOMES
AU2012314860B2 (en) 2011-09-26 2017-02-23 Philogen S.P.A. Immunocytokine combination therapy
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
IN2014MN02164A (es) 2012-04-27 2015-08-28 Cytomx Therapeutics Inc
KR20150037857A (ko) 2012-06-22 2015-04-08 싸이톰스 테라퓨틱스, 인크. 항-jagged 1/jagged 2 교차-반응성 항체, 활성화가능한 항-jagged 항체 및 이의 제조 방법
US9487590B2 (en) 2012-09-25 2016-11-08 Cytomx Therapeutics, Inc. Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
CN109897100A (zh) * 2013-05-13 2019-06-18 瑟勒提斯公司 Cd19特异性嵌合抗原受体及其用途
SG11201600167SA (en) 2013-07-19 2016-02-26 Vib Vzw Targeted modified il-1 family members
JP6734774B2 (ja) * 2013-10-15 2020-08-05 ザ スクリプス リサーチ インスティテュート ペプチドキメラ抗原受容体ｔ細胞スイッチおよびその使用
KR20230007559A (ko) * 2013-12-20 2023-01-12 프레드 허친슨 캔서 센터 태그된 키메라 이펙터 분자 및 그의 리셉터
EP3811970A1 (en) 2014-03-15 2021-04-28 Novartis AG Regulatable chimeric antigen receptor
ES2939760T3 (es) 2014-03-15 2023-04-26 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico para antígenos
ES2842212T3 (es) * 2015-01-26 2021-07-13 Cellectis Receptores de antígenos quiméricos monocatenarios específicos anti-CLL1 (scCAR) para inmunoterapia contra el cáncer
EP3283113A4 (en) * 2015-04-15 2018-12-05 The California Institute for Biomedical Research Optimized pne-based chimeric receptor t cell switches and uses thereof
RU2018107754A (ru) * 2015-08-11 2019-09-12 Селлектис Клетки для иммунотерапии, созданные для таргетинга антигена cd38 и для инактивации гена cd38
AU2016343805A1 (en) 2015-10-30 2018-06-07 Aleta Biotherapeutics Inc. Compositions and methods for tumor transduction
US10508143B1 (en) 2015-10-30 2019-12-17 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
US10259876B2 (en) * 2016-01-21 2019-04-16 Pfizer Inc. Chimeric antigen receptors targeting epidermal growth factor receptor variant III
CA3016555A1 (en) * 2016-03-08 2017-09-14 Ventana Medical Systems, Inc. Multiplexed immunohistochemistry using recombinant antibodies with epitope tags
CN109562126A (zh) * 2016-06-24 2019-04-02 美商生物细胞基因治疗有限公司 嵌合抗原受体(car)、组合物及其使用方法

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