CN114945586A - 一种药物组合物及其用途 - Google Patents

一种药物组合物及其用途 Download PDF

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CN114945586A
CN114945586A CN202180009111.7A CN202180009111A CN114945586A CN 114945586 A CN114945586 A CN 114945586A CN 202180009111 A CN202180009111 A CN 202180009111A CN 114945586 A CN114945586 A CN 114945586A
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polypeptide chain
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amino acid
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张晋宇
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Abstract

本发明提供一种药物组合物,其包括蛋白质和免疫检查点抑制剂,其中所述蛋白质包括融合蛋白,且所述融合蛋白中包含细胞因子IL12、IL2和GMCSF。本发明还提供包括所述药物组合物的试剂盒以及所述药物组合物或所述试剂盒在制备用于治疗肿瘤的药物中的用途。

Description

PCT国内申请,说明书已公开。

Claims (34)

  1. PCT国内申请,权利要求书已公开。
CN202180009111.7A 2020-01-21 2021-01-20 一种药物组合物及其用途 Pending CN114945586A (zh)

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Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
CN112210014B (zh) * 2019-07-12 2022-10-11 北京科诺科服生物科技有限公司 一种用于治疗动物肿瘤的融合蛋白及组合物

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1374871A (zh) * 1999-07-21 2002-10-16 利思进药品公司 增强蛋白和肽抗原免疫原性的Fc融合蛋白
CN1382158A (zh) * 1999-08-09 2002-11-27 利思进药品公司 多细胞因子-抗体复合物
EP1731531A2 (en) * 1999-08-09 2006-12-13 EMD Lexigen Research Center Corp. Multiple cytokine-antibody complexes
CN103298935A (zh) * 2007-08-15 2013-09-11 阿穆尼克斯公司 用于改善生物活性多肽性能的组合物和方法
CN108463229A (zh) * 2016-01-11 2018-08-28 斯坦福大学托管董事会 嵌合蛋白和免疫治疗方法
CN108602872A (zh) * 2015-10-30 2018-09-28 艾丽塔生物治疗剂公司 用于治疗癌症的组合物和方法
WO2018184484A1 (zh) * 2017-04-06 2018-10-11 张晋宇 细胞因子组合
WO2018199595A1 (ko) * 2017-04-24 2018-11-01 주식회사 제넥신 4-1bbl 변이체 및 이를 포함하는 융합 단백질
WO2019067770A1 (en) * 2017-09-27 2019-04-04 Epicentrx, Inc. IMMUNOMODULATORY FUSION PROTEINS
WO2019129053A1 (zh) * 2017-12-26 2019-07-04 南京金斯瑞生物科技有限公司 以抗体Fc区为骨架的融合蛋白二聚体及其应用
WO2019144309A1 (en) * 2018-01-24 2019-08-01 Beijing Percans Oncology Co. Ltd. Cytokine Fusion Proteins
WO2019147837A2 (en) * 2018-01-24 2019-08-01 Beijing Percans Oncology Co. Ltd. Cytokine fusion proteins
WO2019185792A1 (en) * 2018-03-29 2019-10-03 Philogen S.P.A Cancer treatment using immunoconjugates and immune check-point inhibitors
CN111848811A (zh) * 2019-04-27 2020-10-30 张晋宇 一种蛋白质异二聚体及其用途
CN111848810A (zh) * 2019-04-28 2020-10-30 张晋宇 一种蛋白质分子及其用途
CN112513276A (zh) * 2018-07-30 2021-03-16 张晋宇 蛋白质异二聚体及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014139468A1 (en) * 2013-03-15 2014-09-18 Admark Healthcare, Llc Fusion protein molecules and method of use

Patent Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1374871A (zh) * 1999-07-21 2002-10-16 利思进药品公司 增强蛋白和肽抗原免疫原性的Fc融合蛋白
CN1382158A (zh) * 1999-08-09 2002-11-27 利思进药品公司 多细胞因子-抗体复合物
EP1731531A2 (en) * 1999-08-09 2006-12-13 EMD Lexigen Research Center Corp. Multiple cytokine-antibody complexes
CN103298935A (zh) * 2007-08-15 2013-09-11 阿穆尼克斯公司 用于改善生物活性多肽性能的组合物和方法
CN108602872A (zh) * 2015-10-30 2018-09-28 艾丽塔生物治疗剂公司 用于治疗癌症的组合物和方法
CN108463229A (zh) * 2016-01-11 2018-08-28 斯坦福大学托管董事会 嵌合蛋白和免疫治疗方法
WO2018184484A1 (zh) * 2017-04-06 2018-10-11 张晋宇 细胞因子组合
CN108686202A (zh) * 2017-04-06 2018-10-23 张晋宇 肿瘤免疫疗法
WO2018199595A1 (ko) * 2017-04-24 2018-11-01 주식회사 제넥신 4-1bbl 변이체 및 이를 포함하는 융합 단백질
CN111511769A (zh) * 2017-09-27 2020-08-07 埃皮辛特瑞柯斯公司 免疫调节性融合蛋白
WO2019067770A1 (en) * 2017-09-27 2019-04-04 Epicentrx, Inc. IMMUNOMODULATORY FUSION PROTEINS
WO2019129053A1 (zh) * 2017-12-26 2019-07-04 南京金斯瑞生物科技有限公司 以抗体Fc区为骨架的融合蛋白二聚体及其应用
CN111527109A (zh) * 2017-12-26 2020-08-11 南京金斯瑞生物科技有限公司 以抗体Fc区为骨架的融合蛋白二聚体及其应用
WO2019147837A2 (en) * 2018-01-24 2019-08-01 Beijing Percans Oncology Co. Ltd. Cytokine fusion proteins
WO2019144309A1 (en) * 2018-01-24 2019-08-01 Beijing Percans Oncology Co. Ltd. Cytokine Fusion Proteins
CN112105632A (zh) * 2018-01-24 2020-12-18 北京智康博药肿瘤医学研究有限公司 细胞因子融合蛋白
WO2019185792A1 (en) * 2018-03-29 2019-10-03 Philogen S.P.A Cancer treatment using immunoconjugates and immune check-point inhibitors
CN112513276A (zh) * 2018-07-30 2021-03-16 张晋宇 蛋白质异二聚体及其用途
CN111848811A (zh) * 2019-04-27 2020-10-30 张晋宇 一种蛋白质异二聚体及其用途
CN111848810A (zh) * 2019-04-28 2020-10-30 张晋宇 一种蛋白质分子及其用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
QIAN WEN 等: "Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell-cell interactions", 《JOURNAL OF TRANSLATIONAL MEDICINE》, vol. 14, no. 41, 5 February 2016 (2016-02-05) *
STEPHEN D. GILLIES等: "Bi-functional cytokine fusion proteins for gene therapy and antibody-targeted treatment of cancer", 《CANCER IMMUNOL IMMUNOTHER》, vol. 51, 12 July 2002 (2002-07-12), pages 1 - 2 *
刘冬梅等: "分泌型rhGM-CSF/IL-2融合蛋白表达载体的构建", 《中国生物制品学杂志》, no. 4, 31 December 2002 (2002-12-31), pages 197 - 200 *

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