CO2018000696A2 - Derivados de 3-fenoximetil-[1,2,4]triazol-2-ona, 3-fenoximetil-[1,2,3]triazol-2-ona, 3-fenoximetil-piridazin-3(2h)-ona, 3-fenoximetil-indazol, 3-fenoximetil-tetrahidroindazol y 3-fenoximetil-pirazol - Google Patents

Derivados de 3-fenoximetil-[1,2,4]triazol-2-ona, 3-fenoximetil-[1,2,3]triazol-2-ona, 3-fenoximetil-piridazin-3(2h)-ona, 3-fenoximetil-indazol, 3-fenoximetil-tetrahidroindazol y 3-fenoximetil-pirazol

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Publication number
CO2018000696A2
CO2018000696A2 CONC2018/0000696A CO2018000696A CO2018000696A2 CO 2018000696 A2 CO2018000696 A2 CO 2018000696A2 CO 2018000696 A CO2018000696 A CO 2018000696A CO 2018000696 A2 CO2018000696 A2 CO 2018000696A2
Authority
CO
Colombia
Prior art keywords
phenoxymethyl
conditions
triazol
present description
compounds
Prior art date
Application number
CONC2018/0000696A
Other languages
English (en)
Spanish (es)
Inventor
Werner Neidhart
Daniel Hunziker
Jérôme Hert
Patrizio Mattei
Markus Rudolph
Holger Kuehne
Thomas Luebbers
Rainer E Martin
Emmanuel Pinard
Hans Richter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO2018000696A2 publication Critical patent/CO2018000696A2/es

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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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CONC2018/0000696A 2015-09-04 2018-01-25 Derivados de 3-fenoximetil-[1,2,4]triazol-2-ona, 3-fenoximetil-[1,2,3]triazol-2-ona, 3-fenoximetil-piridazin-3(2h)-ona, 3-fenoximetil-indazol, 3-fenoximetil-tetrahidroindazol y 3-fenoximetil-pirazol CO2018000696A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15183953 2015-09-04
EP15197364 2015-12-01
PCT/EP2016/070561 WO2017037146A1 (en) 2015-09-04 2016-09-01 Phenoxymethyl derivatives

Publications (1)

Publication Number Publication Date
CO2018000696A2 true CO2018000696A2 (es) 2018-07-10

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CONC2018/0000696A CO2018000696A2 (es) 2015-09-04 2018-01-25 Derivados de 3-fenoximetil-[1,2,4]triazol-2-ona, 3-fenoximetil-[1,2,3]triazol-2-ona, 3-fenoximetil-piridazin-3(2h)-ona, 3-fenoximetil-indazol, 3-fenoximetil-tetrahidroindazol y 3-fenoximetil-pirazol

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US (2) US10640472B2 (enExample)
EP (1) EP3344619B1 (enExample)
JP (1) JP6886967B2 (enExample)
KR (1) KR20180043837A (enExample)
CN (1) CN108026077B (enExample)
AU (1) AU2016316717B2 (enExample)
CA (1) CA2992889A1 (enExample)
CL (1) CL2018000542A1 (enExample)
CO (1) CO2018000696A2 (enExample)
CR (1) CR20180058A (enExample)
IL (1) IL256548B (enExample)
MX (2) MX377277B (enExample)
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WO2013186159A1 (en) 2012-06-13 2013-12-19 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
HRP20191937T1 (hr) 2012-09-25 2020-01-10 F. Hoffmann - La Roche Ag Derivati heksahidropirolo [3,4-c]pirola i srodni spojevi kao inhibitori autotaksina (atx) i kao inhibitori proizvodnje lizofosfatidne kiseline (lpa) za liječenje npr. bubrežnih bolesti
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
RS56776B1 (sr) 2013-11-26 2018-04-30 Hoffmann La Roche Derivati oktahidro-ciklobuta [1,2-c;3,4-c']dipirola kao inhibitori autotaksina
WO2015117053A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
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US10640472B2 (en) 2020-05-05
US20200339522A1 (en) 2020-10-29
CR20180058A (es) 2018-02-26
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