CU20160138A7 - Nuevos inhibidores de las vías de señalización de wnt y composiciones farmacéuticas que los contienen - Google Patents

Nuevos inhibidores de las vías de señalización de wnt y composiciones farmacéuticas que los contienen

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Publication number
CU20160138A7
CU20160138A7 CUP2016000138A CU20160138A CU20160138A7 CU 20160138 A7 CU20160138 A7 CU 20160138A7 CU P2016000138 A CUP2016000138 A CU P2016000138A CU 20160138 A CU20160138 A CU 20160138A CU 20160138 A7 CU20160138 A7 CU 20160138A7
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CU
Cuba
Prior art keywords
wnt signaling
pharmaceutical compositions
compositions containing
new inhibitors
signaling routes
Prior art date
Application number
CUP2016000138A
Other languages
English (en)
Inventor
Kai Thede
Eckhard Bender
William Scott
Anja Giese
Ludwig Zorn
Ningshu Liu
Ursula Mönning
Franziska Siegel
Stefan Golz
Andrea Hägebarth
Philip Lienau
Florian Puehler
Daniel Basting
Dirk Schneider
Manfred Möwes
Jens Geisler
Original Assignee
Bayer Pharma AG
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Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CU20160138A7 publication Critical patent/CU20160138A7/es

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Abstract

La presente invención se refiere a inhibidores de las vías de señalización de Wnt de Ia formula general (I) ESPACIO PARA FÓRMULA y a las composiciones farmacéuticas que las contienen. Estos compuestos y estas composiciones se pueden usar para tratar una variedad de trastornos y enfermedades en los que está implicada la señalización Wnt, tales como cáncer y otras enfermedades asociadas con angiogénesis anormal proliferación celular y ciclado celular. Conforme a ello, los compuestos y composiciones proporcionados en la presente se pueden usar para tratar cáncer, para reducir o inhibir la angiogénesis, para reducir o inhibir la proliferación celular y corregir un trastorno genético debido a mutaciones en los componentes de señalizacion de Wnt.
CUP2016000138A 2014-03-20 2016-09-20 Nuevos inhibidores de las vías de señalización de wnt y composiciones farmacéuticas que los contienen CU20160138A7 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461968172P 2014-03-20 2014-03-20
EP14185274 2014-09-18
PCT/EP2015/055629 WO2015140195A1 (en) 2014-03-20 2015-03-18 Novel compounds

Publications (1)

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CU20160138A7 true CU20160138A7 (es) 2017-02-02

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US (1) US20170107212A1 (es)
EP (1) EP3119759A1 (es)
JP (1) JP2017509650A (es)
KR (1) KR20160127138A (es)
CN (1) CN106458983A (es)
AP (1) AP2016009432A0 (es)
AU (1) AU2015233558A1 (es)
BR (1) BR112016021648A2 (es)
CA (1) CA2943002A1 (es)
CR (1) CR20160433A (es)
CU (1) CU20160138A7 (es)
DO (1) DOP2016000253A (es)
EA (1) EA201691881A1 (es)
MX (1) MX2016012175A (es)
PE (1) PE20170186A1 (es)
PH (1) PH12016501807A1 (es)
SG (1) SG11201606693SA (es)
WO (1) WO2015140195A1 (es)

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US10130633B2 (en) 2013-03-20 2018-11-20 Bayer Pharma Aktiengesellschaft Compounds
MA39761A (fr) * 2014-03-20 2017-01-25 Bayer Pharma AG Inhibiteurs des voies de signalisation wnt
PE20170127A1 (es) 2014-03-20 2017-03-30 Samumed Llc Indazol-3-carboxamidas 5-sustituidas y preparacion y uso de las mismas
CA2988147C (en) 2015-06-03 2023-06-13 Bristol-Myers Squibb Company 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders
WO2017097215A1 (zh) * 2015-12-07 2017-06-15 杭州雷索药业有限公司 内嵌脲类结构的wnt通路抑制剂
US11542254B2 (en) 2016-03-25 2023-01-03 Universisity Of Utah Research Foundation Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors
WO2017167150A1 (zh) * 2016-03-31 2017-10-05 苏州云轩医药科技有限公司 一种3-氟吡啶杂环化合物及其应用
CN115583938A (zh) * 2021-07-05 2023-01-10 南通聚太生物科技有限公司 靶向BCL9/β-连环蛋白互相作用的小分子化合物
KR20230066213A (ko) 2021-11-06 2023-05-15 윤보라 무선 이어폰 보안 시스템
TW202334157A (zh) * 2022-01-29 2023-09-01 大陸商杭州阿諾生物醫藥科技有限公司 一種Ｗｎｔ通路抑制劑化合物
WO2024022521A1 (zh) * 2022-07-28 2024-02-01 南通环聚泰生物科技有限公司 靶向BCL9/β-连环蛋白互相作用的小分子化合物
CN117396482B (zh) * 2022-07-28 2026-02-27 杭州阿诺生物医药科技有限公司 一种Wnt通路抑制剂化合物
CN115850202B (zh) * 2022-12-26 2024-06-25 上海科技大学 一种卷曲受体7的小分子抑制剂及其制备方法和应用

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WO2013093508A2 (en) * 2011-12-22 2013-06-27 Oslo University Hospital Hf Wnt pathway inhibitors
US10130633B2 (en) * 2013-03-20 2018-11-20 Bayer Pharma Aktiengesellschaft Compounds
JP2016521259A (ja) * 2013-03-20 2016-07-21 バイエル・ファルマ・アクティエンゲゼルシャフト 置換Ｎ−ビフェニル−３−アセチルアミノ−ベンズアミドおよびＮ−［３−（アセチルアミノ）フェニル］−ビフェニル−カルボキサミドならびにＷｎｔシグナル伝達経路の阻害剤としてのそれらの使用

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AU2015233558A1 (en) 2016-09-01
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EP3119759A1 (en) 2017-01-25
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