CN1656100A - 带有修饰的内酯环的喜树碱 - Google Patents

带有修饰的内酯环的喜树碱 Download PDF

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Publication number
CN1656100A
CN1656100A CNA038125439A CN03812543A CN1656100A CN 1656100 A CN1656100 A CN 1656100A CN A038125439 A CNA038125439 A CN A038125439A CN 03812543 A CN03812543 A CN 03812543A CN 1656100 A CN1656100 A CN 1656100A
Authority
CN
China
Prior art keywords
camptothecine
alkyl
iminomethyl
branched
high camptothecine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038125439A
Other languages
English (en)
Chinese (zh)
Inventor
M·马尔齐
E·马拉斯托尼
S·彭科
C·皮萨诺
M·O·廷蒂
L·韦希
F·祖尼诺
D·韦尔加尼
W·卡布里
M·阿尔佩贾尼
M·G·帕特里西奥
T·达内利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of CN1656100A publication Critical patent/CN1656100A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
CNA038125439A 2002-05-31 2003-05-28 带有修饰的内酯环的喜树碱 Pending CN1656100A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2002A000305 2002-05-31
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.

Publications (1)

Publication Number Publication Date
CN1656100A true CN1656100A (zh) 2005-08-17

Family

ID=11456338

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038125439A Pending CN1656100A (zh) 2002-05-31 2003-05-28 带有修饰的内酯环的喜树碱

Country Status (22)

Country Link
US (1) US7273873B2 (https=)
EP (2) EP1719775B1 (https=)
JP (1) JP4693410B2 (https=)
KR (1) KR101042042B1 (https=)
CN (1) CN1656100A (https=)
AR (1) AR040139A1 (https=)
AT (2) ATE403659T1 (https=)
AU (2) AU2003241160B2 (https=)
BR (2) BR0311333A (https=)
CA (2) CA2485201C (https=)
CY (2) CY1107311T1 (https=)
DE (2) DE60322754D1 (https=)
DK (2) DK1719775T3 (https=)
ES (2) ES2273002T7 (https=)
IT (1) ITRM20020305A1 (https=)
MX (1) MXPA04011682A (https=)
PE (1) PE20050120A1 (https=)
PL (1) PL374346A1 (https=)
PT (2) PT1719775E (https=)
SI (2) SI1511752T1 (https=)
TW (1) TWI325866B (https=)
WO (1) WO2003101995A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746314A (zh) * 2011-04-18 2012-10-24 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
PT2170900E (pt) 2007-08-01 2013-01-24 Sigma Tau Ind Farmaceuti Forma cristalina ii de 7-(dimetoximetil)-camptotecina, sua utilização como intermediário e produtos obtidos a partir dela
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
CA3099155A1 (en) 2018-05-14 2019-11-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CA3138197A1 (en) 2019-05-14 2020-11-19 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
EP4058464A1 (en) 2019-11-13 2022-09-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
MX2023011241A (es) 2021-03-23 2023-10-03 Nuvation Bio Inc Compuestos dirigidos a receptores de hormonas nucleares contra el cancer.
JP2024516024A (ja) 2021-05-03 2024-04-11 ニューベイション・バイオ・インコーポレイテッド 抗がん核内ホルモン受容体標的化化合物
WO2024073626A2 (en) * 2022-09-28 2024-04-04 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
DE69623961T2 (de) * 1995-06-21 2003-05-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.), Paris Camptothecinanaloge, verfahren zur ihrer herstellung, ihre verwendungals arzneimittel und diese enthaltende pharmazeutische zusammenfassungen
EP1044977B1 (en) 1999-03-09 2002-05-02 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Camptothecin derivatives having antitumor activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746314A (zh) * 2011-04-18 2012-10-24 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途

Also Published As

Publication number Publication date
ES2312090T3 (es) 2009-02-16
WO2003101995A3 (en) 2004-02-19
EP1719775A1 (en) 2006-11-08
KR20050036909A (ko) 2005-04-20
PL374346A1 (en) 2005-10-17
WO2003101995A8 (en) 2004-12-23
DE60322754D1 (de) 2008-09-18
DE60308368T3 (de) 2010-09-16
EP1511752B1 (en) 2006-09-13
EP1511752B3 (en) 2010-03-10
DE60308368D1 (de) 2006-10-26
BR0311329A (pt) 2005-02-22
CY1108793T1 (el) 2014-04-09
DK1511752T5 (da) 2010-06-14
AU2003241160A1 (en) 2003-12-19
JP4693410B2 (ja) 2011-06-01
AU2009236044A1 (en) 2009-12-03
EP1511752A2 (en) 2005-03-09
AU2009236044A8 (en) 2011-07-21
EP1511752B8 (en) 2007-04-18
US20050154003A1 (en) 2005-07-14
AU2003241160B2 (en) 2009-08-20
EP1719775B1 (en) 2008-08-06
AU2009236044B8 (en) 2011-07-21
CA2485201A1 (en) 2003-12-11
WO2003101995A2 (en) 2003-12-11
JP2005531602A (ja) 2005-10-20
BR0311333A (pt) 2005-03-15
AU2009236044B2 (en) 2011-03-24
TWI325866B (en) 2010-06-11
US7273873B2 (en) 2007-09-25
ITRM20020305A1 (it) 2003-12-01
PE20050120A1 (es) 2005-03-04
AR040139A1 (es) 2005-03-16
CY1107311T1 (el) 2012-11-21
ES2273002T3 (es) 2007-05-01
MXPA04011682A (es) 2005-03-31
ES2273002T7 (es) 2011-08-01
ITRM20020305A0 (it) 2002-05-31
TW200404806A (en) 2004-04-01
ATE339422T1 (de) 2006-10-15
ATE403659T1 (de) 2008-08-15
PT1719775E (pt) 2008-09-30
DK1511752T3 (da) 2007-01-29
PT1511752E (pt) 2007-01-31
CA2706635A1 (en) 2003-12-11
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
KR101042042B1 (ko) 2011-06-16
CA2485201C (en) 2010-11-02
SI1719775T1 (sl) 2009-04-30
SI1511752T1 (sl) 2007-02-28

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