CN1527807A - 利用防氧化效果高的溶剂生产还原型辅酶q10的方法 - Google Patents

利用防氧化效果高的溶剂生产还原型辅酶q10的方法 Download PDF

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Publication number
CN1527807A
CN1527807A CNA028141369A CN02814136A CN1527807A CN 1527807 A CN1527807 A CN 1527807A CN A028141369 A CNA028141369 A CN A028141369A CN 02814136 A CN02814136 A CN 02814136A CN 1527807 A CN1527807 A CN 1527807A
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CN
China
Prior art keywords
reduced coenzyme
coenzyme
solvent
crystallization
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028141369A
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English (en)
Chinese (zh)
Inventor
ֲ���к�
植田尚宏
北村志郎
上田恭义
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26618740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1527807(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of CN1527807A publication Critical patent/CN1527807A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
CNA028141369A 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法 Pending CN1527807A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001214471 2001-07-13
JP214471/2001 2001-07-13
JP114854/2002 2002-04-17
JP2002114854 2002-04-17

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN200910266328.7A Division CN101774996B (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法
CN2010101807452A Division CN101906026A (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法

Publications (1)

Publication Number Publication Date
CN1527807A true CN1527807A (zh) 2004-09-08

Family

ID=26618740

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA028141369A Pending CN1527807A (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法
CN2010101807452A Pending CN101906026A (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法
CN200910266328.7A Expired - Lifetime CN101774996B (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2010101807452A Pending CN101906026A (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法
CN200910266328.7A Expired - Lifetime CN101774996B (zh) 2001-07-13 2002-07-15 利用防氧化效果高的溶剂生产还原型辅酶q10的方法

Country Status (9)

Country Link
US (1) US7145044B2 (enExample)
EP (4) EP1415969A4 (enExample)
JP (1) JP4057523B2 (enExample)
KR (1) KR100876509B1 (enExample)
CN (3) CN1527807A (enExample)
AU (1) AU2002318843B2 (enExample)
CA (1) CA2453158C (enExample)
TW (1) TWI310029B (enExample)
WO (1) WO2003006408A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103635452A (zh) * 2011-06-24 2014-03-12 株式会社钟化 稳定性优良的还原型辅酶q10晶体
CN104109880A (zh) * 2014-04-22 2014-10-22 北京泰克美高新技术有限公司 一种还原型辅酶q10的制备方法及其装置
CN101514148B (zh) * 2009-03-27 2015-05-13 玉溪健坤生物药业有限公司 一种还原型辅酶q10的制备方法

Families Citing this family (32)

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TWI329510B (en) 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
JP3822479B2 (ja) 2001-10-10 2006-09-20 株式会社カネカ 還元型補酵素ｑ水溶液の安定化組成
TWI349039B (en) 2001-12-27 2011-09-21 Kaneka Corp Processes for producing coenzyme q10
KR20060130016A (ko) * 2003-09-10 2006-12-18 가부시키가이샤 가네카 안정성이 우수한 환원형 보효소 ｑ10 결정 및 환원형보효소 ｑ10 결정을 함유하는 조성물
US7358402B2 (en) * 2003-09-10 2008-04-15 Kaneka Corporation Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
US20060147542A1 (en) * 2004-12-24 2006-07-06 Tadao Ono Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
US20080254016A1 (en) * 2005-03-29 2008-10-16 Kaneka Corporation Composition For Increasing Anti-Oxidation Activity In Blood
JP4469772B2 (ja) * 2005-09-15 2010-05-26 株式会社資生堂 コエンザイムｑ１０高負荷細胞の作製方法、コエンザイムｑ１０高負荷細胞増殖添加剤及びコエンザイムｑ１０高負荷培地
US8506956B2 (en) 2005-10-31 2013-08-13 Kaneka Corporation Method for stabilizing reduced coenzyme Q10
TW200808344A (en) 2006-04-28 2008-02-16 Kaneka Corp Stabilization method of reduced coenzyme Q10
US20070258967A1 (en) * 2006-04-28 2007-11-08 Kaneka Corporation Purification method of reduced coenzyme q10
EP2062574B1 (en) 2006-09-08 2015-03-25 Kaneka Corporation Composition comprising reduced coenzyme q10 and lysolecithin
WO2009044852A1 (ja) * 2007-10-05 2009-04-09 Kaneka Corporation 還元型補酵素ｑ１０の製造方法
CN101842340B (zh) * 2007-10-30 2014-08-13 株式会社钟化 使用含水有机溶剂制备还原型辅酶q10的方法
AU2009226019C1 (en) 2008-03-20 2014-02-20 Virun, Inc. Emulsions including a PEG-derivative of tocopherol
US8337931B2 (en) * 2008-06-23 2012-12-25 Virun, Inc. Compositions containing non-polar compounds
EP2415467A4 (en) * 2009-03-31 2012-12-19 Mitsubishi Gas Chemical Co METHOD FOR PRODUCING A UBICHINONE POWDER FOR USE IN PREPARATIONS AND PRODUCTS THEREOF
JP2010275253A (ja) * 2009-05-29 2010-12-09 Mitsubishi Gas Chemical Co Inc コエンザイムｑ１０含有経口投与組成物
CN102656133B (zh) 2009-10-16 2015-04-15 株式会社钟化 还原型辅酶q10的制造方法、稳定化方法以及含有还原型辅酶q10的组合物
WO2011045934A1 (ja) 2009-10-16 2011-04-21 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
CN103037708B (zh) 2010-03-23 2015-05-20 维尔恩公司 含有蔗糖脂肪酸酯的纳米乳液
JP5546935B2 (ja) * 2010-04-20 2014-07-09 株式会社カネカ 還元型補酵素ｑ１０含有組成物及びその製法方法
WO2011162802A1 (en) 2010-06-21 2011-12-29 Virun, Inc. Compositions containing non-polar compounds
WO2013120025A1 (en) 2012-02-10 2013-08-15 Virun, Inc. Beverage compositions containing non-polar compounds
JP2013224272A (ja) * 2012-04-20 2013-10-31 Idemitsu Kosan Co Ltd １−アダマンタノールの製造方法
JP2015131766A (ja) 2012-04-27 2015-07-23 株式会社カネカ 還元型補酵素ｑ１０の製造方法
CN104119209B (zh) * 2013-04-25 2018-03-02 浙江医药股份有限公司新昌制药厂 一种还原型辅酶q10干粉及其组合物以及制备方法
CN107428645A (zh) * 2015-03-20 2017-12-01 诺西斯有限公司 固体形式的还原甲萘醌
JP7330987B2 (ja) * 2018-08-30 2023-08-22 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof
CN115087631B (zh) * 2020-02-12 2024-05-14 株式会社钟化 FormII型的还原型辅酶Q10结晶的制造方法

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JPS609796B2 (ja) * 1977-04-21 1985-03-13 日清製粉株式会社 補酵素ｑの製造法
JPS54140793A (en) * 1978-04-21 1979-11-01 Fujisawa Pharmaceut Co Ltd Preparation of dihydro-coenzyme q10
JPS5692238A (en) * 1979-12-26 1981-07-25 Ajinomoto Co Inc Separation and recovery of hydroquinone derivative
JPS5770834A (en) 1980-10-17 1982-05-01 Takara Shuzo Co Ltd Preparation of coenzyme q
JPS6075294A (ja) 1984-03-16 1985-04-27 Nisshin Flour Milling Co Ltd 補酵素ｑの製造法
JPS6419933A (en) 1987-07-13 1989-01-24 Shibaura Eng Works Ltd Motor
EP0796108A2 (en) * 1994-12-06 1997-09-24 Ryan Pharmaceuticals, Inc. Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
IT1284873B1 (it) 1996-07-26 1998-05-22 Idi Farmaceutici Spa Derivati stabili di ubichinolo procedimenti per la loro produzione e loro impiego farmaceutico
JP3889481B2 (ja) * 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
JP3926888B2 (ja) * 1997-05-27 2007-06-06 株式会社カネカ コレステロール低下剤
US8753675B1 (en) * 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101514148B (zh) * 2009-03-27 2015-05-13 玉溪健坤生物药业有限公司 一种还原型辅酶q10的制备方法
CN103635452A (zh) * 2011-06-24 2014-03-12 株式会社钟化 稳定性优良的还原型辅酶q10晶体
US9388109B2 (en) 2011-06-24 2016-07-12 Kaneka Corporation Reduced coenzyme Q10 crystal having excellent stability
US9556098B2 (en) 2011-06-24 2017-01-31 Kaneka Corporation Reduced coenzyme Q10 crystal having excellent stability
TWI568718B (zh) * 2011-06-24 2017-02-01 Kaneka Corp Stability of the reduction of coenzyme Q10 crystallization
CN103635452B (zh) * 2011-06-24 2017-03-15 株式会社钟化 稳定性优良的还原型辅酶q10晶体
CN104109880A (zh) * 2014-04-22 2014-10-22 北京泰克美高新技术有限公司 一种还原型辅酶q10的制备方法及其装置
CN104109880B (zh) * 2014-04-22 2016-05-18 北京泰克美高新技术有限公司 一种还原型辅酶q10的制备方法及其装置

Also Published As

Publication number Publication date
EP2228360A1 (en) 2010-09-15
EP3321248A2 (en) 2018-05-16
EP2402303A3 (en) 2012-04-25
WO2003006408A1 (fr) 2003-01-23
CN101906026A (zh) 2010-12-08
CN101774996B (zh) 2015-02-11
US7145044B2 (en) 2006-12-05
TWI310029B (enExample) 2009-05-21
CA2453158C (en) 2011-05-24
CN101774996A (zh) 2010-07-14
AU2002318843B2 (en) 2008-10-30
AU2002318843A2 (en) 2003-01-29
CA2453158A1 (en) 2003-01-23
KR20040017293A (ko) 2004-02-26
EP2402303A2 (en) 2012-01-04
JP4057523B2 (ja) 2008-03-05
JPWO2003006408A1 (ja) 2004-10-28
KR100876509B1 (ko) 2008-12-31
EP1415969A1 (en) 2004-05-06
US20040215040A1 (en) 2004-10-28
EP1415969A4 (en) 2005-04-27
EP3321248A3 (en) 2018-06-06

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