KR100876509B1 - 산화 방호 효과가 높은 용매를 사용한 환원형 보효소ｑ１０의 제조 방법 - Google Patents

산화 방호 효과가 높은 용매를 사용한 환원형 보효소ｑ１０의 제조 방법 Download PDF

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KR100876509B1
KR100876509B1 KR1020047000449A KR20047000449A KR100876509B1 KR 100876509 B1 KR100876509 B1 KR 100876509B1 KR 1020047000449 A KR1020047000449 A KR 1020047000449A KR 20047000449 A KR20047000449 A KR 20047000449A KR 100876509 B1 KR100876509 B1 KR 100876509B1
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Prior art keywords
coenzyme
crystallization
reduced coenzyme
solvent
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Korean (ko)
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KR20040017293A (ko
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타카히로 우에다
시로 키타무라
야스요시 우에다
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가부시키가이샤 가네카
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
KR1020047000449A 2001-07-13 2002-07-15 산화 방호 효과가 높은 용매를 사용한 환원형 보효소ｑ１０의 제조 방법 Expired - Lifetime KR100876509B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2001214471 2001-07-13
JPJP-P-2001-00214471 2001-07-13
JP2002114854 2002-04-17
JPJP-P-2002-00114854 2002-04-17
PCT/JP2002/007143 WO2003006408A1 (fr) 2001-07-13 2002-07-15 Procede de production de coenzyme q10 reduite a l'aide d'un solvant ayant un effet anti-oxydation puissant

Publications (2)

Publication Number Publication Date
KR20040017293A KR20040017293A (ko) 2004-02-26
KR100876509B1 true KR100876509B1 (ko) 2008-12-31

Family

ID=26618740

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047000449A Expired - Lifetime KR100876509B1 (ko) 2001-07-13 2002-07-15 산화 방호 효과가 높은 용매를 사용한 환원형 보효소ｑ１０의 제조 방법

Country Status (9)

Country Link
US (1) US7145044B2 (enExample)
EP (4) EP2402303A3 (enExample)
JP (1) JP4057523B2 (enExample)
KR (1) KR100876509B1 (enExample)
CN (3) CN101774996B (enExample)
AU (1) AU2002318843B2 (enExample)
CA (1) CA2453158C (enExample)
TW (1) TWI310029B (enExample)
WO (1) WO2003006408A1 (enExample)

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TWI329510B (en) * 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
JP3822479B2 (ja) * 2001-10-10 2006-09-20 株式会社カネカ 還元型補酵素ｑ水溶液の安定化組成
TWI305547B (en) 2001-12-27 2009-01-21 Kaneka Corp Processes for producing coenzyme q10
US7358402B2 (en) * 2003-09-10 2008-04-15 Kaneka Corporation Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
JPWO2005033054A1 (ja) * 2003-09-10 2007-11-15 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶及び還元型補酵素ｑ１０結晶を含有する組成物
US20060147542A1 (en) * 2004-12-24 2006-07-06 Tadao Ono Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
US20080254016A1 (en) * 2005-03-29 2008-10-16 Kaneka Corporation Composition For Increasing Anti-Oxidation Activity In Blood
JP4469772B2 (ja) * 2005-09-15 2010-05-26 株式会社資生堂 コエンザイムｑ１０高負荷細胞の作製方法、コエンザイムｑ１０高負荷細胞増殖添加剤及びコエンザイムｑ１０高負荷培地
US8506956B2 (en) 2005-10-31 2013-08-13 Kaneka Corporation Method for stabilizing reduced coenzyme Q10
WO2007126083A1 (ja) 2006-04-28 2007-11-08 Kaneka Corporation 還元型補酵素ｑ10の安定化方法
WO2007126086A1 (ja) 2006-04-28 2007-11-08 Kaneka Corporation 還元型補酵素ｑ10の精製方法
US20080152636A1 (en) * 2006-09-08 2008-06-26 Kaneka Corporation Composition containing reduced coenzyme Q10 and lysolecithin
JP5558823B2 (ja) * 2007-10-05 2014-07-23 株式会社カネカ 還元型補酵素ｑ１０の製造方法
CN101842340B (zh) * 2007-10-30 2014-08-13 株式会社钟化 使用含水有机溶剂制备还原型辅酶q10的方法
MX2010010050A (es) 2008-03-20 2011-03-15 Virun Inc Star Emulsiones que incluyen un derivado de polietilen glicol de tocoferol.
CN102131407B (zh) * 2008-06-23 2015-01-07 维尔恩公司 含有非极性化合物的组合物
CN101514148B (zh) * 2009-03-27 2015-05-13 玉溪健坤生物药业有限公司 一种还原型辅酶q10的制备方法
NZ595512A (en) * 2009-03-31 2013-11-29 Mitsubishi Gas Chemical Co Production method for ubiquinone powder for use in preparations and product thereof
JP2010275253A (ja) * 2009-05-29 2010-12-09 Mitsubishi Gas Chemical Co Inc コエンザイムｑ１０含有経口投与組成物
JP4786000B2 (ja) 2009-10-16 2011-10-05 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
CN102656134A (zh) 2009-10-16 2012-09-05 株式会社钟化 还原型辅酶q10的制造方法、稳定化方法以及含有还原型辅酶q10的组合物
US9320295B2 (en) 2010-03-23 2016-04-26 Virun, Inc. Compositions containing non-polar compounds
JP5546935B2 (ja) * 2010-04-20 2014-07-09 株式会社カネカ 還元型補酵素ｑ１０含有組成物及びその製法方法
US8741373B2 (en) 2010-06-21 2014-06-03 Virun, Inc. Compositions containing non-polar compounds
DK2725004T3 (en) * 2011-06-24 2018-04-16 Kaneka Corp REDUCED COENZYM Q10 CRYSTAL WITH EXCELLENT STABILITY
EP2811847B1 (en) 2012-02-10 2017-12-13 Virun, Inc. Beverage compositions containing non-polar compounds
JP2013224272A (ja) * 2012-04-20 2013-10-31 Idemitsu Kosan Co Ltd １−アダマンタノールの製造方法
JP2015131766A (ja) * 2012-04-27 2015-07-23 株式会社カネカ 還元型補酵素ｑ１０の製造方法
CN104119209B (zh) * 2013-04-25 2018-03-02 浙江医药股份有限公司新昌制药厂 一种还原型辅酶q10干粉及其组合物以及制备方法
CN104109880B (zh) * 2014-04-22 2016-05-18 北京泰克美高新技术有限公司 一种还原型辅酶q10的制备方法及其装置
JP2018514507A (ja) * 2015-03-20 2018-06-07 グノーシス ソシエタ ペル アチオニ メナキノールの固体形態
CN112839921B (zh) * 2018-08-30 2024-02-20 株式会社钟化 稳定性优异的还原型辅酶q10结晶的制造方法
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof
US20230339836A1 (en) * 2020-02-12 2023-10-26 Kaneka Corporation Method for producing reduced coenzyme q10 form ii crystals

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JPS609796B2 (ja) * 1977-04-21 1985-03-13 日清製粉株式会社 補酵素ｑの製造法
JPS54140793A (en) * 1978-04-21 1979-11-01 Fujisawa Pharmaceut Co Ltd Preparation of dihydro-coenzyme q10
JPS5770834A (en) * 1980-10-17 1982-05-01 Takara Shuzo Co Ltd Preparation of coenzyme q
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AU4510596A (en) * 1994-12-06 1996-06-26 National Research Council Of Canada Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
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US8753675B1 (en) * 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications

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Also Published As

Publication number Publication date
CN101906026A (zh) 2010-12-08
CA2453158C (en) 2011-05-24
TWI310029B (enExample) 2009-05-21
KR20040017293A (ko) 2004-02-26
CN1527807A (zh) 2004-09-08
US20040215040A1 (en) 2004-10-28
JPWO2003006408A1 (ja) 2004-10-28
CN101774996B (zh) 2015-02-11
EP2402303A2 (en) 2012-01-04
EP3321248A2 (en) 2018-05-16
US7145044B2 (en) 2006-12-05
AU2002318843B2 (en) 2008-10-30
EP3321248A3 (en) 2018-06-06
CN101774996A (zh) 2010-07-14
EP2402303A3 (en) 2012-04-25
JP4057523B2 (ja) 2008-03-05
EP1415969A1 (en) 2004-05-06
AU2002318843A2 (en) 2003-01-29
EP2228360A1 (en) 2010-09-15
WO2003006408A1 (fr) 2003-01-23
CA2453158A1 (en) 2003-01-23
EP1415969A4 (en) 2005-04-27

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