CN1489472A - 改良型猪肺炎支原体菌苗疫苗 - Google Patents
改良型猪肺炎支原体菌苗疫苗 Download PDFInfo
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- CN1489472A CN1489472A CNA018226345A CN01822634A CN1489472A CN 1489472 A CN1489472 A CN 1489472A CN A018226345 A CNA018226345 A CN A018226345A CN 01822634 A CN01822634 A CN 01822634A CN 1489472 A CN1489472 A CN 1489472A
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- mycoplasma hyopneumoniae
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/825—Bacterial vaccine for porcine species, e.g. swine
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- Animal Behavior & Ethology (AREA)
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- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
支原体浓缩物(>1.0×1010MHDCE/mL) | 400,000mL | 20.0 |
角鲨烷/Pluronic L121混合物 | 100,000mL | 5.0 |
Carbopol(2%w/v水溶液) | 200,000mL | 10.0 |
1%硫柳汞水溶液(w/v)和7%EDTA(四钠盐)(w/v) | 18,000mL | 0.9 |
无菌盐水 | 1,282,000mL | 64.1 |
成分 | 升 |
NaCl | 8.50克 |
NaH2PO4 | 0.22克 |
Na2HPO4 | 1.19克 |
Tween-20 | 0.50ml |
去离子水定容 | 1,000.00ml |
成分 | 每升含量 |
甘氨酸 | 0.75克 |
NaCl | 8.50克 |
去离子水定容 | 1,000.00ml |
组 | 猪的数量 | ODPV | -1DPC | 30DPC |
FDAH疫苗 | 22 | 0/22 | 0/22 | 22/22 |
BI疫苗 | 8 | 0/8 | 4/8 | 8/8 |
攻击对照 | 22 | 0/22 | 0/22 | 18/22 |
未攻击对照 | 10 | 0/10 | 0/10 | 0/10 |
组 | 猪的数量 | ODPV | -3DPC | 30DPC |
FDAH疫苗 | 23 | 0/23 | 6/23 | 23/23 |
对照 | 25 | 0/25 | 0/25 | 14/25 |
未攻击对照 | 7 | 0/7 | 0/7 | 0/7 |
组 | 猪的数量 | 平均肺病变百分率 | P-值 |
FDAH疫苗 | 22 | 15.90% | 0.19** |
BI疫苗 | 8 | 14.60% | 0.27*** |
对照 | 22 | 19.60 | |
未攻击对照 | 10 | 0% | 0.88**** |
组 | 猪的数量 | 平均肺病变百分率 | P-值 |
FDAH疫苗 | 23 | 5.50% | 0.031** |
对照 | 25 | 10.40% | |
未攻击对照 | 7 | 0.77% |
支原体浓缩物(>1.0×1010 MHDCE/ml) | 1200,000mL | 60.0 |
角鲨烷/Pluronic L121混合物 | 200,000mL | 10.0 |
Carbopol(2%w/v水溶液) | 200,000mL | 10.0 |
1%(w/v)硫柳汞水溶液和7%(w/v)EDTA(四钠盐) | 18,000mL | 0.9 |
无菌盐水 | 382,000mL | 19.1 |
Claims (18)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25663700P | 2000-12-19 | 2000-12-19 | |
US60/256,637 | 2000-12-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1489472A true CN1489472A (zh) | 2004-04-14 |
CN1296095C CN1296095C (zh) | 2007-01-24 |
Family
ID=22972978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018226345A Expired - Lifetime CN1296095C (zh) | 2000-12-19 | 2001-12-11 | 改良型猪肺炎支原体菌苗疫苗 |
Country Status (28)
Country | Link |
---|---|
US (4) | US20020131980A1 (zh) |
EP (1) | EP1343525B1 (zh) |
JP (2) | JP5074656B2 (zh) |
KR (1) | KR100874119B1 (zh) |
CN (1) | CN1296095C (zh) |
AR (1) | AR033410A1 (zh) |
AT (1) | ATE359813T1 (zh) |
AU (2) | AU2002228993B2 (zh) |
BG (1) | BG66213B1 (zh) |
BR (1) | BRPI0116249B1 (zh) |
CY (1) | CY1106669T1 (zh) |
CZ (1) | CZ307075B6 (zh) |
DE (1) | DE60127994T2 (zh) |
DK (1) | DK1343525T3 (zh) |
ES (1) | ES2283452T3 (zh) |
HK (1) | HK1056513A1 (zh) |
HR (1) | HRP20030585B1 (zh) |
HU (1) | HU227431B1 (zh) |
ME (1) | ME00570B (zh) |
MX (1) | MXPA03005357A (zh) |
MY (1) | MY129765A (zh) |
NZ (1) | NZ526904A (zh) |
PL (1) | PL211174B1 (zh) |
PT (1) | PT1343525E (zh) |
RS (1) | RS51536B (zh) |
TW (1) | TWI308872B (zh) |
WO (1) | WO2002049666A2 (zh) |
ZA (1) | ZA200305545B (zh) |
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CN102458462A (zh) * | 2009-05-19 | 2012-05-16 | 澳大利亚生物资源公司 | 一种温度敏感的猪肺炎支原体疫苗株及其应用 |
CN103623400A (zh) * | 2012-08-24 | 2014-03-12 | 普莱柯生物工程股份有限公司 | 抗猪支原体肺炎、传染性胸膜肺炎疫苗组合物及制备方法 |
CN104338128A (zh) * | 2013-07-31 | 2015-02-11 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其制备方法和应用 |
CN110227151A (zh) * | 2012-12-28 | 2019-09-13 | 勃林格殷格翰动物保健有限公司 | 包含支原体抗原的免疫原性组合物 |
CN117100851A (zh) * | 2023-10-23 | 2023-11-24 | 成都依思康生物科技有限公司 | 一种佐剂、疫苗组合物及其制备方法和应用 |
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-
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- 2001-11-27 MY MYPI20015418A patent/MY129765A/en unknown
- 2001-12-11 DE DE60127994T patent/DE60127994T2/de not_active Expired - Lifetime
- 2001-12-11 PT PT01990123T patent/PT1343525E/pt unknown
- 2001-12-11 AT AT01990123T patent/ATE359813T1/de active
- 2001-12-11 WO PCT/US2001/047865 patent/WO2002049666A2/en active IP Right Grant
- 2001-12-11 ME MEP-2008-859A patent/ME00570B/me unknown
- 2001-12-11 NZ NZ526904A patent/NZ526904A/en not_active IP Right Cessation
- 2001-12-11 MX MXPA03005357A patent/MXPA03005357A/es active IP Right Grant
- 2001-12-11 JP JP2002551004A patent/JP5074656B2/ja not_active Expired - Lifetime
- 2001-12-11 AU AU2002228993A patent/AU2002228993B2/en not_active Expired
- 2001-12-11 EP EP01990123A patent/EP1343525B1/en not_active Expired - Lifetime
- 2001-12-11 AU AU2899302A patent/AU2899302A/xx active Pending
- 2001-12-11 KR KR1020037008293A patent/KR100874119B1/ko active IP Right Grant
- 2001-12-11 ES ES01990123T patent/ES2283452T3/es not_active Expired - Lifetime
- 2001-12-11 HU HU0400687A patent/HU227431B1/hu unknown
- 2001-12-11 PL PL363220A patent/PL211174B1/pl unknown
- 2001-12-11 DK DK01990123T patent/DK1343525T3/da active
- 2001-12-11 CZ CZ2003-1721A patent/CZ307075B6/cs not_active IP Right Cessation
- 2001-12-11 CN CNB018226345A patent/CN1296095C/zh not_active Expired - Lifetime
- 2001-12-11 BR BRPI0116249A patent/BRPI0116249B1/pt active IP Right Grant
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- 2001-12-18 AR ARP010105861A patent/AR033410A1/es not_active Application Discontinuation
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- 2002-01-08 US US10/039,383 patent/US20020131980A1/en not_active Abandoned
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- 2003-06-11 BG BG107898A patent/BG66213B1/bg unknown
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102458462A (zh) * | 2009-05-19 | 2012-05-16 | 澳大利亚生物资源公司 | 一种温度敏感的猪肺炎支原体疫苗株及其应用 |
CN102458462B (zh) * | 2009-05-19 | 2014-03-19 | 澳大利亚生物资源公司 | 一种温度敏感的猪肺炎支原体疫苗株及其应用 |
CN103623400A (zh) * | 2012-08-24 | 2014-03-12 | 普莱柯生物工程股份有限公司 | 抗猪支原体肺炎、传染性胸膜肺炎疫苗组合物及制备方法 |
CN103623400B (zh) * | 2012-08-24 | 2016-08-17 | 普莱柯生物工程股份有限公司 | 抗猪支原体肺炎、传染性胸膜肺炎疫苗组合物及制备方法 |
CN110227151A (zh) * | 2012-12-28 | 2019-09-13 | 勃林格殷格翰动物保健有限公司 | 包含支原体抗原的免疫原性组合物 |
CN104338128A (zh) * | 2013-07-31 | 2015-02-11 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其制备方法和应用 |
CN117100851A (zh) * | 2023-10-23 | 2023-11-24 | 成都依思康生物科技有限公司 | 一种佐剂、疫苗组合物及其制备方法和应用 |
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