CY1106669T1 - Βελτιωμενο i mycoplasma hy opneumoniae/ i εμβολιο βακτηρινης - Google Patents
Βελτιωμενο i mycoplasma hy opneumoniae/ i εμβολιο βακτηρινηςInfo
- Publication number
- CY1106669T1 CY1106669T1 CY20071100827T CY071100827T CY1106669T1 CY 1106669 T1 CY1106669 T1 CY 1106669T1 CY 20071100827 T CY20071100827 T CY 20071100827T CY 071100827 T CY071100827 T CY 071100827T CY 1106669 T1 CY1106669 T1 CY 1106669T1
- Authority
- CY
- Cyprus
- Prior art keywords
- immunity
- mycoplasma hyopneumoniae
- improved
- bacterin
- infection
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 241000204031 Mycoplasma Species 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 abstract 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 3
- 230000036039 immunity Effects 0.000 abstract 3
- 229920002125 Sokalan® Polymers 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 229920011250 Polypropylene Block Copolymer Polymers 0.000 abstract 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 abstract 1
- 230000007969 cellular immunity Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 229940032094 squalane Drugs 0.000 abstract 1
- 229940031439 squalene Drugs 0.000 abstract 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 abstract 1
- -1 terpene hydrocarbons Chemical class 0.000 abstract 1
- 235000007586 terpenes Nutrition 0.000 abstract 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 abstract 1
- 229940033663 thimerosal Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/825—Bacterial vaccine for porcine species, e.g. swine
Abstract
Η εφεύρεση παρέχει βελτιωμένο σκεύασμα εμβολίου βακτηρίνης Mycoplasma hyopneumoniae, το οποίο παρέχει κατά πλεονεκτικό τρόπο ανοσία από μόλυνση μετά από μια μοναδική χορήγηση. Το σκεύασμα περιέχει μια απενεργοποιημένη βακτηρίνη Mycoplasma hyopneumoniae κι ένα ανοσοενισχυτικό μίγμα, τα οποία, συνδυασμένα, παρέχουν ανοσία από μόλυνση από Mycoplasma hyopneumoniae μετά από μια μοναδική χορήγηση, και προκαλούν ανοσοαπόκριση εξειδικευμένη έναντι βακτηρίνης Mycoplasma hyopneumoniae συμπεριλαμβανομένης κυτταρικής ανοσίας και τοπικής (εκκριτικής IgA) ανοσίας. Σε μια προτιμούμενη εφαρμογή, το ανοσοενισχυτικό μίγμα περιέχει ένα πολυμερές ακρυλικού οξέος, προτιμότερα Carbopol, κι ένα μίγμα ενός μεταβολίσιμου ελαίου όπως ενός ή περισσότερων ακόρεστων τερπενικών υδρογονανθράκων, κατά προτίμηση σκουαλενίου ή σκουαλανίου, κι ενός συμπολυμερούς κατά συστάδες πολυοξυαιθυλενίου-πολυπροπυλενίου όπως Pluronic®. Το σκεύασμα εμβολίου μπορεί προαιρετικώς να περιέχει ένα συντηρητικό, κατά προτίμηση thimerosal και/ή EDTA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25663700P | 2000-12-19 | 2000-12-19 | |
PCT/US2001/047865 WO2002049666A2 (en) | 2000-12-19 | 2001-12-11 | Mycoplasma hyopneumoniae bacterin vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106669T1 true CY1106669T1 (el) | 2012-05-23 |
Family
ID=22972978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100827T CY1106669T1 (el) | 2000-12-19 | 2007-06-21 | Βελτιωμενο i mycoplasma hy opneumoniae/ i εμβολιο βακτηρινης |
Country Status (28)
Country | Link |
---|---|
US (4) | US20020131980A1 (el) |
EP (1) | EP1343525B1 (el) |
JP (2) | JP5074656B2 (el) |
KR (1) | KR100874119B1 (el) |
CN (1) | CN1296095C (el) |
AR (1) | AR033410A1 (el) |
AT (1) | ATE359813T1 (el) |
AU (2) | AU2002228993B2 (el) |
BG (1) | BG66213B1 (el) |
BR (1) | BRPI0116249B1 (el) |
CY (1) | CY1106669T1 (el) |
CZ (1) | CZ307075B6 (el) |
DE (1) | DE60127994T2 (el) |
DK (1) | DK1343525T3 (el) |
ES (1) | ES2283452T3 (el) |
HK (1) | HK1056513A1 (el) |
HR (1) | HRP20030585B1 (el) |
HU (1) | HU227431B1 (el) |
ME (1) | ME00570B (el) |
MX (1) | MXPA03005357A (el) |
MY (1) | MY129765A (el) |
NZ (1) | NZ526904A (el) |
PL (1) | PL211174B1 (el) |
PT (1) | PT1343525E (el) |
RS (1) | RS51536B (el) |
TW (1) | TWI308872B (el) |
WO (1) | WO2002049666A2 (el) |
ZA (1) | ZA200305545B (el) |
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MY129765A (en) * | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
US7018638B2 (en) * | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
GB0400264D0 (en) * | 2004-01-07 | 2004-02-11 | Polytherics Ltd | Complexes |
UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
US7833707B2 (en) | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
HUE054868T2 (hu) | 2005-12-29 | 2021-10-28 | Boehringer Ingelheim Animal Health Usa Inc | Multivalens PVC2 immunogén készítmények és eljárások ezek elõállítására |
DK2371383T3 (en) | 2005-12-29 | 2015-11-30 | Boehringer Ingelheim Vetmed | Use of a PCV2 immunogenic composition for reduction of clinical symptoms in pigs |
US20100129397A1 (en) | 2006-12-11 | 2010-05-27 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
RU2520087C2 (ru) | 2006-12-15 | 2014-06-20 | Бёрингер Ингельхайм Ветмедика, Инк. | Лечение свиней с помощью антигена pcv2 |
EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
US7829274B2 (en) | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
MX2010005014A (es) | 2007-11-06 | 2010-06-30 | Wyeth Llc | Vacuna viva avirulenta de mycoplasma hyopneumoniae con adyuvante. |
US20090317423A1 (en) | 2008-01-23 | 2009-12-24 | Boehringer Ingelheim Vetmedica, Inc. | Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions |
US8444989B1 (en) * | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
EP2291194B1 (en) * | 2008-06-25 | 2017-02-22 | Braasch Biotech LLC | Compositions and methods for enhanced somatostatin immunogenicity |
MX2011012362A (es) * | 2009-05-19 | 2012-04-19 | Bioproperties Pty Ltd | Cepa de vacuna de mycoplasma hyopneumoniae sensible a la temperatura y usoz de la misma. |
CN102448488B (zh) | 2009-06-04 | 2014-10-15 | 独立行政法人产业技术综合研究所 | 支原体感染症用疫苗 |
TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
KR101746880B1 (ko) * | 2009-09-10 | 2017-06-14 | 메리얼 인코포레이티드 | 사포닌-함유 면역보강제를 포함하는 신규 백신 제형 |
WO2011136738A1 (en) | 2010-04-30 | 2011-11-03 | Temasek Life Sciences Laboratory Limited | Universal vaccine against h5n1 lineages |
US20150086587A1 (en) * | 2012-03-28 | 2015-03-26 | Kansas State University Research Foundation | Vaccine adjuvant |
UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
CN103623400B (zh) * | 2012-08-24 | 2016-08-17 | 普莱柯生物工程股份有限公司 | 抗猪支原体肺炎、传染性胸膜肺炎疫苗组合物及制备方法 |
EP2938356B1 (en) * | 2012-12-28 | 2020-05-13 | Boehringer Ingelheim Vetmedica GmbH | Immunogenic composition comprising mycoplasma antigens |
CN104968365B (zh) | 2012-12-28 | 2018-04-03 | 勃林格殷格翰动物保健有限公司 | 支原体疫苗的制备方法 |
CN104338128B (zh) * | 2013-07-31 | 2017-09-05 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其制备方法和应用 |
EA035265B1 (ru) | 2013-10-02 | 2020-05-21 | Бёрингер Ингельхайм Энимал Хелс Ю-Эс-Эй Инк. | Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы |
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CN117100851A (zh) * | 2023-10-23 | 2023-11-24 | 成都依思康生物科技有限公司 | 一种佐剂、疫苗组合物及其制备方法和应用 |
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US7018638B2 (en) * | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
MY129765A (en) * | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
ATE412426T2 (de) * | 2001-07-02 | 2008-11-15 | Pfizer Prod Inc | Vakzination in einer dosis mit i mycoplasma hyopneumoniae /i |
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2001
- 2001-11-27 MY MYPI20015418A patent/MY129765A/en unknown
- 2001-12-11 RS YUP-493/03A patent/RS51536B/sr unknown
- 2001-12-11 DK DK01990123T patent/DK1343525T3/da active
- 2001-12-11 BR BRPI0116249A patent/BRPI0116249B1/pt active IP Right Grant
- 2001-12-11 ES ES01990123T patent/ES2283452T3/es not_active Expired - Lifetime
- 2001-12-11 HU HU0400687A patent/HU227431B1/hu unknown
- 2001-12-11 KR KR1020037008293A patent/KR100874119B1/ko active IP Right Grant
- 2001-12-11 DE DE60127994T patent/DE60127994T2/de not_active Expired - Lifetime
- 2001-12-11 MX MXPA03005357A patent/MXPA03005357A/es active IP Right Grant
- 2001-12-11 ME MEP-2008-859A patent/ME00570B/me unknown
- 2001-12-11 EP EP01990123A patent/EP1343525B1/en not_active Expired - Lifetime
- 2001-12-11 CZ CZ2003-1721A patent/CZ307075B6/cs not_active IP Right Cessation
- 2001-12-11 JP JP2002551004A patent/JP5074656B2/ja not_active Expired - Lifetime
- 2001-12-11 WO PCT/US2001/047865 patent/WO2002049666A2/en active IP Right Grant
- 2001-12-11 AT AT01990123T patent/ATE359813T1/de active
- 2001-12-11 CN CNB018226345A patent/CN1296095C/zh not_active Expired - Lifetime
- 2001-12-11 AU AU2002228993A patent/AU2002228993B2/en not_active Expired
- 2001-12-11 AU AU2899302A patent/AU2899302A/xx active Pending
- 2001-12-11 PT PT01990123T patent/PT1343525E/pt unknown
- 2001-12-11 NZ NZ526904A patent/NZ526904A/en not_active IP Right Cessation
- 2001-12-11 PL PL363220A patent/PL211174B1/pl unknown
- 2001-12-14 TW TW090131039A patent/TWI308872B/zh not_active IP Right Cessation
- 2001-12-18 AR ARP010105861A patent/AR033410A1/es not_active Application Discontinuation
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2002
- 2002-01-08 US US10/039,383 patent/US20020131980A1/en not_active Abandoned
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2003
- 2003-06-11 BG BG107898A patent/BG66213B1/bg unknown
- 2003-07-17 ZA ZA200305545A patent/ZA200305545B/en unknown
- 2003-07-18 HR HR20030585A patent/HRP20030585B1/xx not_active IP Right Cessation
- 2003-12-09 HK HK03108934A patent/HK1056513A1/xx not_active IP Right Cessation
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2006
- 2006-08-21 US US11/507,231 patent/US7666439B2/en not_active Expired - Lifetime
-
2007
- 2007-06-21 CY CY20071100827T patent/CY1106669T1/el unknown
-
2008
- 2008-11-13 JP JP2008291001A patent/JP2009073855A/ja active Pending
-
2010
- 2010-01-22 US US12/692,275 patent/US8187588B2/en not_active Expired - Lifetime
-
2012
- 2012-04-27 US US13/458,541 patent/US9238065B2/en not_active Expired - Fee Related
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