ES2052674T3 - Adyuvante de vacunas. - Google Patents

Adyuvante de vacunas.

Info

Publication number
ES2052674T3
ES2052674T3 ES88118263T ES88118263T ES2052674T3 ES 2052674 T3 ES2052674 T3 ES 2052674T3 ES 88118263 T ES88118263 T ES 88118263T ES 88118263 T ES88118263 T ES 88118263T ES 2052674 T3 ES2052674 T3 ES 2052674T3
Authority
ES
Spain
Prior art keywords
emulsion
amount
adjuvant
optionally
toxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88118263T
Other languages
English (en)
Inventor
Anthony Clifford Allison
Noelene Elva Byars
Cherng-Chyi Fu
Deborah Marilyn Lidgate
Philip Lewis Felgner
Linda Cheryl Foster
William Alfred Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2052674T3 publication Critical patent/ES2052674T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Abstract

UN ADYUVANTE PARA LA POTENCIACION DE LA INMUNOGENICIDAD DE UN ANTIGENO ADECUADO PARA LA FABRICACION A UNA ESCALA COMERCIAL, ES UNA EMULSION QUE TIENE PARTICULAS OLEOSAS DISPERSAS EN UNA FASE CONTINUA ACUOSA, LA EMULSION COMPRENDE: UNA CANTIDAD DE FORMADOR DE LA EMULSION DE UN TETRAPOLIOL NO TOXICO O UN POLIMERO EN BLOQUE DE POILIOXIETILENO - POLIOXIPROPILENO (POP - POE); OPCIONALMENTE UNA CANTIDAD DE UN FORMADOR DE LA EMULSION, UN ACETITE METABOLIZABLE NO TOXICO, OPCIONALMENTE UNA CANTIDAD DE ESTABILIZADOR DE LA EMULSION UNSURADYUVANTE GLICOLETER BASICO Y UNA CANTIDAD DE UN INMUNOPOTENCIADOR UN GLICOPEPTIDO; EN DONDE SUSTANCIALMENTE CADA UNA DE LAS DICHAS PARTICULAS OLEOSAS TIENEN UN DIAMETRO MENOR DE 800 NM SI ESTA PRESENTE EL POLIMERO EN BLOQUE POP - POE.
ES88118263T 1987-11-03 1988-11-02 Adyuvante de vacunas. Expired - Lifetime ES2052674T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11642587A 1987-11-03 1987-11-03

Publications (1)

Publication Number Publication Date
ES2052674T3 true ES2052674T3 (es) 1994-07-16

Family

ID=22367122

Family Applications (2)

Application Number Title Priority Date Filing Date
ES92113037T Expired - Lifetime ES2097840T3 (es) 1987-11-03 1988-11-02 Adyuvante de vacuna que comprende un tetrapoliol.
ES88118263T Expired - Lifetime ES2052674T3 (es) 1987-11-03 1988-11-02 Adyuvante de vacunas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES92113037T Expired - Lifetime ES2097840T3 (es) 1987-11-03 1988-11-02 Adyuvante de vacuna que comprende un tetrapoliol.

Country Status (11)

Country Link
EP (2) EP0315153B1 (es)
JP (2) JP2746272B2 (es)
AT (1) ATE149091T1 (es)
AU (1) AU626271B2 (es)
CA (1) CA1338618C (es)
DE (2) DE3889521T2 (es)
ES (2) ES2097840T3 (es)
HU (1) HU210825A9 (es)
IE (1) IE63692B1 (es)
NZ (1) NZ226811A (es)
ZA (1) ZA888209B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0832638B2 (ja) 1989-05-25 1996-03-29 カイロン コーポレイション サブミクロン油滴乳剤を含んで成るアジュバント製剤
US5709860A (en) * 1991-07-25 1998-01-20 Idec Pharmaceuticals Corporation Induction of cytotoxic T-lymphocyte responses
ES2053402B1 (es) * 1993-01-15 1995-02-01 Hipra Lab Sa Metodo de preparacion de vacunas inactivadas y vacunas vivas adyuvantadas asi como las vacunas obtenidas por dicho metodo.
DE4333376C2 (de) * 1993-09-30 1995-09-07 Gerbu Biotechnik Gmbh Mittel zur Steigerung der Ausbeute von Antikörpern in der Immunologie
GB9326253D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
ES2242604T3 (es) 1999-02-26 2005-11-16 Chiron Corporation Microemulsiones con macroparticulas y microparticulas adsorbidas.
US7854934B2 (en) 1999-08-20 2010-12-21 Sloan-Kettering Institute For Cancer Research Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
AU6921300A (en) 1999-08-20 2001-03-19 Sloan-Kettering Institute For Cancer Research Novel glycoconjugates, glycoamino, acids, intermediates thereto, and uses thereof
US7824687B2 (en) 1999-08-20 2010-11-02 Sloan-Kettering Institute For Cancer Research Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
AU770475B2 (en) * 1999-12-23 2004-02-19 Aphton Corporation A stable immunogenic composition for frozen storage
FR2804026B1 (fr) * 2000-01-21 2004-06-11 Merial Sas Vaccination contre l'herpesvirose canine et vaccins
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
MY129765A (en) * 2000-12-19 2007-04-30 Wyeth Corp Improved mycoplasma hyopneumoniae bacterin vaccine
RU2541809C2 (ru) 2003-04-04 2015-02-20 Зоетис Пи ЛЛК Микрофлюидизированные эмульсии "масло в воде" и композиции вакцины
AU2011265184B2 (en) 2010-06-11 2016-08-04 Sloan-Kettering Institute For Cancer Research Multivalent glycopeptide constructs and uses thereof
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
DE3750176T2 (de) * 1986-09-22 1994-10-13 Univ Emory Impfstoff und verfahren zur herstellung.

Also Published As

Publication number Publication date
EP0315153B1 (en) 1994-05-11
AU626271B2 (en) 1992-07-30
EP0513861A1 (en) 1992-11-19
AU2458888A (en) 1989-05-04
IE63692B1 (en) 1995-05-31
CA1338618C (en) 1996-10-01
IE883305L (en) 1989-05-03
EP0513861B1 (en) 1997-02-26
NZ226811A (en) 1991-06-25
ATE149091T1 (de) 1997-03-15
JPH1053535A (ja) 1998-02-24
DE3855807D1 (de) 1997-04-03
DE3889521T2 (de) 1994-12-08
ZA888209B (en) 1990-07-25
JP2746272B2 (ja) 1998-05-06
JP2816337B2 (ja) 1998-10-27
EP0315153A2 (en) 1989-05-10
DE3855807T2 (de) 1997-06-12
DE3889521D1 (de) 1994-06-16
JPH01157918A (ja) 1989-06-21
EP0315153A3 (en) 1989-08-09
ES2097840T3 (es) 1997-04-16
HU210825A9 (en) 1995-08-28

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