CN1432022A - 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3－丝氨酸蛋白酶抑制剂 - Google Patents

含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3－丝氨酸蛋白酶抑制剂 Download PDF

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Publication number
CN1432022A
CN1432022A CN01810566A CN01810566A CN1432022A CN 1432022 A CN1432022 A CN 1432022A CN 01810566 A CN01810566 A CN 01810566A CN 01810566 A CN01810566 A CN 01810566A CN 1432022 A CN1432022 A CN 1432022A
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China
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alkyl
mmol
aryl
compound
conhch
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Pending
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CN01810566A
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English (en)
Chinese (zh)
Inventor
S·文卡特拉曼
K·X·陈
A·阿拉萨潘
F·G·恩约罗格
V·M·基里亚瓦拉布汉
覃天佑
B·A·麦克基特里克
A·J·普伦盖
V·S·马迪森
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN01810566A 2000-04-19 2001-04-17 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3－丝氨酸蛋白酶抑制剂 Pending CN1432022A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19820400P 2000-04-19 2000-04-19
US60/198,204 2000-04-19

Related Child Applications (2)

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CNA2006101537103A Division CN1935833A (zh) 2000-04-19 2001-04-17 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3－丝氨酸蛋白酶抑制剂
CNA2009100067369A Division CN101580536A (zh) 2000-04-19 2001-04-17 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂

Publications (1)

Publication Number Publication Date
CN1432022A true CN1432022A (zh) 2003-07-23

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CN01810566A Pending CN1432022A (zh) 2000-04-19 2001-04-17 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3－丝氨酸蛋白酶抑制剂
CNA2009100067369A Pending CN101580536A (zh) 2000-04-19 2001-04-17 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂
CNA2006101537103A Pending CN1935833A (zh) 2000-04-19 2001-04-17 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3－丝氨酸蛋白酶抑制剂

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CNA2009100067369A Pending CN101580536A (zh) 2000-04-19 2001-04-17 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂
CNA2006101537103A Pending CN1935833A (zh) 2000-04-19 2001-04-17 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3－丝氨酸蛋白酶抑制剂

Country Status (22)

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US (1) US6914122B2 (cg-RX-API-DMAC7.html)
EP (1) EP1274724A2 (cg-RX-API-DMAC7.html)
JP (1) JP4748912B2 (cg-RX-API-DMAC7.html)
KR (1) KR20020097220A (cg-RX-API-DMAC7.html)
CN (3) CN1432022A (cg-RX-API-DMAC7.html)
AR (1) AR030558A1 (cg-RX-API-DMAC7.html)
AU (1) AU2001253621A1 (cg-RX-API-DMAC7.html)
BR (1) BR0110104A (cg-RX-API-DMAC7.html)
CA (1) CA2406532A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ20023473A3 (cg-RX-API-DMAC7.html)
HK (1) HK1048479A1 (cg-RX-API-DMAC7.html)
HU (1) HUP0302957A2 (cg-RX-API-DMAC7.html)
IL (1) IL151935A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA02010375A (cg-RX-API-DMAC7.html)
NO (1) NO20025030L (cg-RX-API-DMAC7.html)
NZ (1) NZ521456A (cg-RX-API-DMAC7.html)
PE (1) PE20011288A1 (cg-RX-API-DMAC7.html)
PL (1) PL358591A1 (cg-RX-API-DMAC7.html)
RU (1) RU2002131163A (cg-RX-API-DMAC7.html)
SK (1) SK14952002A3 (cg-RX-API-DMAC7.html)
WO (1) WO2001081325A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200208014B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101273052B (zh) * 2005-07-29 2016-01-13 爱尔兰詹森科学公司 丙型肝炎病毒的大环抑制剂

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