EA200001071A1 - Способ получения полимер-связанных циклических пептидов - Google Patents

Способ получения полимер-связанных циклических пептидов

Info

Publication number
EA200001071A1
EA200001071A1 EA200001071A EA200001071A EA200001071A1 EA 200001071 A1 EA200001071 A1 EA 200001071A1 EA 200001071 A EA200001071 A EA 200001071A EA 200001071 A EA200001071 A EA 200001071A EA 200001071 A1 EA200001071 A1 EA 200001071A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyclic peptides
obtaining polymer
connected cyclic
synthesis
parathyroid hormones
Prior art date
Application number
EA200001071A
Other languages
English (en)
Inventor
Адам В. Следески
Джеймс Дж. Менсел
Original Assignee
Авентис Фармасьютикалз Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фармасьютикалз Продактс Инк. filed Critical Авентис Фармасьютикалз Продактс Инк.
Publication of EA200001071A1 publication Critical patent/EA200001071A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к способу твердофазного на основе ферментов синтеза полимер-связанных циклических пептидных аналогов паратироидных гормонов и аналогов белков, родственных паратироидным гормонам, которые содержат, по крайней мере, один мостик между боковыми цепями двух несмежных аминокислотных остатков, и к полезным для синтеза пептидным фрагментам.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001071A 1998-04-15 1999-04-15 Способ получения полимер-связанных циклических пептидов EA200001071A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8189798P 1998-04-15 1998-04-15
PCT/US1999/008435 WO1999052933A1 (en) 1998-04-15 1999-04-15 Process for the preparation of resin-bound cyclic peptides

Publications (1)

Publication Number Publication Date
EA200001071A1 true EA200001071A1 (ru) 2001-08-27

Family

ID=22167111

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001071A EA200001071A1 (ru) 1998-04-15 1999-04-15 Способ получения полимер-связанных циклических пептидов

Country Status (20)

Country Link
US (1) US6569993B1 (ru)
EP (1) EP1093458A4 (ru)
JP (1) JP2002511483A (ru)
KR (1) KR20010085236A (ru)
CN (2) CN1163504C (ru)
AP (1) AP1117A (ru)
AU (1) AU744812B2 (ru)
BG (1) BG104903A (ru)
BR (1) BR9909634A (ru)
CA (1) CA2325572A1 (ru)
CZ (1) CZ20003798A3 (ru)
EA (1) EA200001071A1 (ru)
HU (1) HUP0101629A2 (ru)
IL (1) IL138338A0 (ru)
NO (1) NO20005165L (ru)
OA (1) OA11501A (ru)
PL (1) PL347103A1 (ru)
SK (1) SK15352000A3 (ru)
UA (1) UA72460C2 (ru)
WO (1) WO1999052933A1 (ru)

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US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20040082783A1 (en) * 2002-08-06 2004-04-29 Schafmeister Christian E. Bis (amino acid) molecular scaffolds
EP1680443B9 (en) 2003-11-05 2014-09-03 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds
TW200626611A (en) * 2004-09-20 2006-08-01 Lonza Ag Peptide cyclisation
GB0505199D0 (en) * 2005-03-14 2005-04-20 Southampton Polypeptides Process
DK2084183T3 (da) 2006-10-13 2010-08-16 Lilly Co Eli Pegyleret PTH som PTH-receptormodulatorer og anvendelser deraf
CN101235080B (zh) * 2007-01-31 2010-09-08 中国科学院上海有机化学研究所 一种达托霉素的合成方法
JP5649825B2 (ja) 2007-01-31 2015-01-07 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 安定化させたｐ５３ペプチドおよびその使用法
ES2430067T3 (es) 2007-03-28 2013-11-18 President And Fellows Of Harvard College Polipéptidos cosidos
US20090275519A1 (en) 2008-02-08 2009-11-05 Aileron Therapeutics, Inc. Therapeutic peptidomimetic macrocycles
US20110144303A1 (en) * 2008-04-08 2011-06-16 Aileron Therapeutics, Inc. Biologically Active Peptidomimetic Macrocycles
CN104961795A (zh) * 2008-09-22 2015-10-07 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
JP2013505300A (ja) 2009-09-22 2013-02-14 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
KR20170058446A (ko) 2010-08-13 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CA2862038C (en) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6526563B2 (ja) 2012-11-01 2019-06-05 エイルロン セラピューティクス，インコーポレイテッド 二置換アミノ酸ならびにその調製および使用の方法
MX2017003797A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
CA2961029A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
CN107614003A (zh) 2015-03-20 2018-01-19 艾瑞朗医疗公司 拟肽大环化合物及其用途
CN106146648B (zh) * 2015-03-26 2020-06-12 深圳翰宇药业股份有限公司 一种甲状旁腺激素类似物的合成方法
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
CN110551178B (zh) * 2018-06-01 2020-07-21 深圳翰宇药业股份有限公司 一种含脯氨酸的首尾环肽合成方法
CN112538103B (zh) * 2020-12-28 2022-10-25 合肥科生景肽生物科技有限公司 制备生长激素释放抑制素的方法

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HUP0101629A2 (en) 1998-04-15 2003-03-28 Aventis Pharma Inc Process for the preparation of resin-bound cyclic peptides

Also Published As

Publication number Publication date
HUP0101629A2 (en) 2003-03-28
US6569993B1 (en) 2003-05-27
EP1093458A1 (en) 2001-04-25
CN1323313A (zh) 2001-11-21
UA72460C2 (en) 2005-03-15
CN1163504C (zh) 2004-08-25
CZ20003798A3 (cs) 2001-08-15
NO20005165L (no) 2000-12-15
JP2002511483A (ja) 2002-04-16
AU3567999A (en) 1999-11-01
AU744812B2 (en) 2002-03-07
BG104903A (bg) 2001-07-31
BR9909634A (pt) 2001-10-16
EP1093458A4 (en) 2001-07-18
CN1552737A (zh) 2004-12-08
AP1117A (en) 2002-11-02
WO1999052933A1 (en) 1999-10-21
AP2000001972A0 (en) 2000-12-31
NO20005165D0 (no) 2000-10-13
CA2325572A1 (en) 1999-10-21
SK15352000A3 (sk) 2001-04-09
OA11501A (en) 2004-05-14
KR20010085236A (ko) 2001-09-07
IL138338A0 (en) 2001-10-31
PL347103A1 (en) 2002-03-25

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