DE69735603D1 - PTHrP Analogen - Google Patents

PTHrP Analogen

Info

Publication number
DE69735603D1
DE69735603D1 DE69735603T DE69735603T DE69735603D1 DE 69735603 D1 DE69735603 D1 DE 69735603D1 DE 69735603 T DE69735603 T DE 69735603T DE 69735603 T DE69735603 T DE 69735603T DE 69735603 D1 DE69735603 D1 DE 69735603D1
Authority
DE
Germany
Prior art keywords
pthrp
pthrp analogues
parathyroid hormone
analogues
pth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69735603T
Other languages
English (en)
Other versions
DE69735603T2 (de
Inventor
Xin Dong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/779,768 external-priority patent/US5969095A/en
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of DE69735603D1 publication Critical patent/DE69735603D1/de
Application granted granted Critical
Publication of DE69735603T2 publication Critical patent/DE69735603T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69735603T 1997-01-07 1997-12-08 PTHrP Analogen Expired - Lifetime DE69735603T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/779,768 US5969095A (en) 1995-07-13 1997-01-07 Analogs of parathyroid hormone
US779768 1997-01-07
US813534 1997-03-07
US08/813,534 US5955574A (en) 1995-07-13 1997-03-07 Analogs of parathyroid hormone
PCT/US1997/022498 WO1998030590A2 (en) 1997-01-07 1997-12-08 Analogs of parathyroid hormone

Publications (2)

Publication Number Publication Date
DE69735603D1 true DE69735603D1 (de) 2006-05-18
DE69735603T2 DE69735603T2 (de) 2006-11-30

Family

ID=27119618

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69739912T Expired - Lifetime DE69739912D1 (de) 1997-01-07 1997-12-08 Parathyroidhormon Analoge
DE69735603T Expired - Lifetime DE69735603T2 (de) 1997-01-07 1997-12-08 PTHrP Analogen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69739912T Expired - Lifetime DE69739912D1 (de) 1997-01-07 1997-12-08 Parathyroidhormon Analoge

Country Status (24)

Country Link
US (1) US5955574A (de)
EP (3) EP2206725A1 (de)
JP (1) JP3963482B2 (de)
KR (2) KR100699422B1 (de)
CN (1) CN1137898C (de)
AR (3) AR011517A1 (de)
AT (2) ATE471342T1 (de)
AU (1) AU741584B2 (de)
BR (1) BR9714200A (de)
CA (1) CA2276614C (de)
CZ (2) CZ298937B6 (de)
DE (2) DE69739912D1 (de)
DK (2) DK1645566T3 (de)
ES (2) ES2347154T3 (de)
HK (1) HK1026215A1 (de)
HU (1) HUP9904596A3 (de)
IL (1) IL130794A0 (de)
NO (1) NO993341L (de)
NZ (1) NZ336610A (de)
PL (1) PL191898B1 (de)
PT (2) PT948541E (de)
RU (1) RU2198182C2 (de)
SI (2) SI1645566T1 (de)
WO (1) WO1998030590A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410948B2 (en) * 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US6544949B1 (en) * 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
EP1005359B1 (de) * 1997-09-09 2005-06-15 F. Hoffmann-La Roche Ag HEILUNG VON BRUCHVERLETZUNGEN UNTER VERWENDUNG VON PTHrP ANALOGEN
ATE392431T1 (de) * 1998-05-05 2008-05-15 Sod Conseils Rech Applic Pth2 rezeptor selektive verbindungen
AU3826899A (en) * 1998-07-20 2000-02-14 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Peptide analogues of pacap
US6660843B1 (en) † 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
EP1257576B1 (de) 2000-02-18 2004-09-15 Dabur Research Foundation Vip-analoge
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
DE60218842T2 (de) * 2001-06-01 2007-12-20 Novartis Ag Orale verabreichung von parathyroidhormon und calcitonin
AU2002339843B2 (en) 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
JP2007501241A (ja) * 2003-08-06 2007-01-25 ローディア インコーポレイティド 骨成長を促進する方法
CA2628945A1 (en) 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
DK2957278T3 (en) * 2006-10-03 2017-07-31 Radius Health Inc STABLE COMPOSITION COMPREHENSIVE PTHRP AND APPLICATIONS THEREOF
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
JP5200027B2 (ja) * 2006-10-13 2013-05-15 イーライ リリー アンド カンパニー Ｐｔｈ受容体モジュレーターとしてのペグ化ｐｔｈおよびその使用
AU2008282805B2 (en) 2007-08-01 2014-05-01 Chugai Pharmaceutical Co., Ltd. Screening methods using G-protein coupled receptors and related compositions
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
AU2009356227A1 (en) 2009-12-07 2012-06-21 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
ME02474B (de) 2010-05-12 2017-02-20 Radius Health Inc Therapiepläne
RU2604809C2 (ru) 2010-05-13 2016-12-10 Дзе Дженерал Хоспитал Корпорейшн Аналоги паратиреоидного гормона и их применение
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
RU2737496C2 (ru) 2015-04-29 2020-12-01 Радиус Фармасьютикалз, Инк. Способы лечения рака
US20180161401A1 (en) * 2015-07-06 2018-06-14 Zheng Xin Dong Novel Formulations of PTHrP Analogue
JP7221699B2 (ja) 2016-06-22 2023-02-14 エリプセス ファーマ エルティーディー Ａｒ＋乳癌の治療方法
FI3565542T3 (fi) 2017-01-05 2024-06-24 Radius Pharmaceuticals Inc Rad1901-2hcl:n polymorfisia muotoja
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
US11643385B2 (en) 2018-07-04 2023-05-09 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (de) * 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroide Hormon-Antagonisten
EP0411096A1 (de) * 1989-02-23 1991-02-06 Gesellschaft für Biotechnologische Forschung mbH (GBF) Pth-varianten kodierende dna-sequenzen, pth-varianten, expressionsvektor, bakterieller wirt, verwendung und therapeutische zusammensetzung
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
JPH0532696A (ja) * 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
WO1993006846A1 (en) * 1991-10-10 1993-04-15 Pang Peter K T Parathyroid hormone analogues and use in osteoporosis treatment
US5434246A (en) * 1992-03-19 1995-07-18 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
CA2098639A1 (en) * 1992-06-19 1993-12-20 K. Anne Kronis Bone stimulating, non-vasoactive parathyroid hormone variants
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
HU220137B (hu) 1993-01-06 2001-11-28 Kinerton Ltd. Biológiailag lebontható poliészterek és biológiailag aktív polipeptidek ionos molekuláris konjugátumai, eljárás ezek előállítására és eljárás mikrorészecskék előállítására
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
JPH10511095A (ja) * 1994-12-19 1998-10-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド 副甲状腺ホルモン又はその作動薬の低用量継続投与
CA2178894A1 (en) * 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
JP2001508439A (ja) 2001-06-26
HK1026215A1 (en) 2000-12-08
CZ301497B6 (cs) 2010-03-24
EP1645566A3 (de) 2006-10-11
AR038552A2 (es) 2005-01-19
NO993341L (no) 1999-09-06
IL130794A0 (en) 2001-01-28
EP2206725A1 (de) 2010-07-14
DK1645566T3 (da) 2010-09-27
ES2258286T3 (es) 2006-08-16
DE69739912D1 (de) 2010-07-29
RU2198182C2 (ru) 2003-02-10
EP0948541A2 (de) 1999-10-13
KR20060030006A (ko) 2006-04-07
NZ336610A (en) 2001-07-27
WO1998030590A2 (en) 1998-07-16
CZ239899A3 (cs) 2000-01-12
ATE321784T1 (de) 2006-04-15
DK0948541T3 (da) 2006-07-17
CZ298937B6 (cs) 2008-03-19
SI0948541T1 (sl) 2006-06-30
JP3963482B2 (ja) 2007-08-22
CA2276614C (en) 2002-06-11
PT948541E (pt) 2006-07-31
CN1254347A (zh) 2000-05-24
SI1645566T1 (sl) 2010-11-30
KR100699422B1 (ko) 2007-03-28
ES2347154T3 (es) 2010-10-26
CA2276614A1 (en) 1998-07-16
KR20000069952A (ko) 2000-11-25
WO1998030590A9 (en) 1999-08-19
AU741584B2 (en) 2001-12-06
HUP9904596A3 (en) 2000-07-28
AR011517A1 (es) 2000-08-30
EP0948541B1 (de) 2006-03-29
PT1645566E (pt) 2010-08-31
DE69735603T2 (de) 2006-11-30
PL334438A1 (en) 2000-02-28
BR9714200A (pt) 2000-03-28
EP1645566A2 (de) 2006-04-12
AU5519998A (en) 1998-08-03
US5955574A (en) 1999-09-21
CN1137898C (zh) 2004-02-11
WO1998030590A3 (en) 1998-12-10
AR051906A2 (es) 2007-02-14
NO993341D0 (no) 1999-07-06
PL191898B1 (pl) 2006-07-31
EP1645566B1 (de) 2010-06-16
KR100497709B1 (ko) 2005-06-23
ATE471342T1 (de) 2010-07-15
HUP9904596A1 (hu) 2000-06-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: IPSEN PHARMA S.A.S., BOULOGNE-BILLANCOURT, FR