AR051906A2 - Analogos proteicos relacionados con la hormona paratiroides - Google Patents
Analogos proteicos relacionados con la hormona paratiroidesInfo
- Publication number
- AR051906A2 AR051906A2 ARP060100191A ARP060100191A AR051906A2 AR 051906 A2 AR051906 A2 AR 051906A2 AR P060100191 A ARP060100191 A AR P060100191A AR P060100191 A ARP060100191 A AR P060100191A AR 051906 A2 AR051906 A2 AR 051906A2
- Authority
- AR
- Argentina
- Prior art keywords
- hpthrp
- aib29
- lys26
- cha23
- nle30
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 108090000445 Parathyroid hormone Proteins 0.000 abstract 1
- 102000003982 Parathyroid hormone Human genes 0.000 abstract 1
- 239000000199 parathyroid hormone Substances 0.000 abstract 1
- 229960001319 parathyroid hormone Drugs 0.000 abstract 1
- 108010067557 parathyroid hormone (1-34)amide Proteins 0.000 abstract 1
- RRBCHMCWWOHRQL-UMXFMPSGSA-N parathyroid hormone (1-34)amide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C1=CN=CN1 RRBCHMCWWOHRQL-UMXFMPSGSA-N 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Reivindicacion 1: Un análogo proteico relacionado con la hormona paratiroidea de la formula caracterizado porque comprende: [Cha22,23, Glu25, Lys26,30, Leu28, Aib29] hPTHrP(1-34)NH2; [Cha22,23, Glu25, Lys26,30, Aib29] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,31, Lys26, Aib29, Nle30] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,30,31, Lys26, Aib29] hPTHrP(1-34)NH2; [Glu22,25,29, Leu23,28,30,31, Lys26] hPTHrP(1-34)NH2; [Glu22,25,29, Leu23,28,31, Lys26, Nle30] hPTHrP(1-34)NH2; [Ser1, Ile5, Met8, Asn10, Leu11,23,28,31, His14, Cha15, Glu22,25, Lys26,30, Aib29] hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26, Leu28,31, Aib29, Nle30] hPTHrP(1-34)NH2, [Cha22,23, Glu25, Lys26,30, Leu28,31, Aib29] hPTHrP(1-34)NH2; [Cha22, Leu23,28,31, Glu25,29, Lys26, Nle30] hPTHrP(1-34)NH2; [Cha7,11,15] hPTHrP(1-34)NH2; [Cha7,8,15] hPTHrP(1-34)NH2; [Glu22, Cha23, Aib25,29, Lys26,30, Leu28,31] hPTHrP(1-34)NH2; [Glu22, Cha23, Aib25,29, Lys26, Leu28] hPTHrP(1-34)NH2; [Glu22, Leu23,28, Aib25,29, Lys26] hPTHrP(1-34)NH2; [Aib29]hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26, Leu28,31, Aib29, Nle30] hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26,30, Aib29, Leu31] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,31, Lys26, Aib29,30] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,31, Lys26, Aib29] hPTHrP(1-34)NH2; [Glu22,25, Leu23,28,31, Aib26,29, Lys30] hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26,30, Leu28,31, Aib29] hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26,30, Aib29]hPTHrP(1-34)NH2; [Glu22,25, Cha23, Lys26,30, Leu28, Aib29] hPTHrP(1-34)NH2; o [Leu27, Aib29] hPTH(1-34)NH2; o una sal farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/779,768 US5969095A (en) | 1995-07-13 | 1997-01-07 | Analogs of parathyroid hormone |
| US08/813,534 US5955574A (en) | 1995-07-13 | 1997-03-07 | Analogs of parathyroid hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051906A2 true AR051906A2 (es) | 2007-02-14 |
Family
ID=27119618
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100058A AR011517A1 (es) | 1997-01-07 | 1998-01-06 | Analogos proteicos relacionados con la hormona paratiroides |
| ARP030100515A AR038552A2 (es) | 1997-01-07 | 2003-02-17 | Analogos proteicos relacionados con la hormona paratiroides |
| ARP060100191A AR051906A2 (es) | 1997-01-07 | 2006-01-18 | Analogos proteicos relacionados con la hormona paratiroides |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100058A AR011517A1 (es) | 1997-01-07 | 1998-01-06 | Analogos proteicos relacionados con la hormona paratiroides |
| ARP030100515A AR038552A2 (es) | 1997-01-07 | 2003-02-17 | Analogos proteicos relacionados con la hormona paratiroides |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5955574A (es) |
| EP (3) | EP1645566B1 (es) |
| JP (1) | JP3963482B2 (es) |
| KR (2) | KR100699422B1 (es) |
| CN (1) | CN1137898C (es) |
| AR (3) | AR011517A1 (es) |
| AT (2) | ATE321784T1 (es) |
| AU (1) | AU741584B2 (es) |
| BR (1) | BR9714200A (es) |
| CA (1) | CA2276614C (es) |
| CZ (2) | CZ298937B6 (es) |
| DE (2) | DE69735603T2 (es) |
| DK (2) | DK0948541T3 (es) |
| ES (2) | ES2258286T3 (es) |
| HU (1) | HUP9904596A3 (es) |
| IL (1) | IL130794A0 (es) |
| NO (1) | NO993341L (es) |
| NZ (1) | NZ336610A (es) |
| PL (1) | PL191898B1 (es) |
| PT (2) | PT948541E (es) |
| RU (1) | RU2198182C2 (es) |
| SI (2) | SI0948541T1 (es) |
| WO (1) | WO1998030590A2 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544949B1 (en) | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
| US7410948B2 (en) * | 1995-07-13 | 2008-08-12 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Analogs of parathyroid hormone |
| AU752925B2 (en) * | 1997-09-09 | 2002-10-03 | F. Hoffmann-La Roche Ag | Fracture healing using PTHrP analogs |
| HUP0300891A2 (hu) * | 1998-05-05 | 2003-07-28 | Beth Israel Deaconess Medical Center, Inc. | PTH2 receptor szelektív vegyületek és alkalmazásuk gyógyszerkészítmények előállÍtására |
| CA2335341A1 (en) * | 1998-07-20 | 2000-02-03 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Peptide analogues of pacap |
| US6660843B1 (en) † | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| EP1257576B1 (en) * | 2000-02-18 | 2004-09-15 | Dabur Research Foundation | Vasoactive intestinal peptide analogs |
| US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US20050124537A1 (en) * | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| CA2446929C (en) * | 2001-06-01 | 2013-04-09 | Novartis Ag | Orally administering parathyroid hormone and calcitonin |
| AU2002339843B2 (en) | 2001-07-23 | 2007-12-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| EP1651246A4 (en) * | 2003-08-06 | 2009-06-24 | Innophos Inc | METHOD FOR PROMOTING BONE GROWTH |
| CN101355959B (zh) | 2005-11-10 | 2013-02-27 | 密歇根理工大学管理委员会 | 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法 |
| US7803770B2 (en) | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| EP2073789B8 (en) * | 2006-10-03 | 2023-02-08 | Radius Health, Inc. | A stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof |
| ATE469173T1 (de) * | 2006-10-13 | 2010-06-15 | Lilly Co Eli | Pegyliertes pth als pth-rezeptormodulatoren und ihre verwendung |
| MX353986B (es) | 2007-08-01 | 2017-11-06 | Massachusetts Gen Hospital | Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas. |
| WO2010111617A2 (en) | 2009-03-27 | 2010-09-30 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| CA2782640A1 (en) | 2009-12-07 | 2011-06-16 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| SI2568806T1 (sl) | 2010-05-12 | 2016-09-30 | Radius Health, Inc. | Režimi zdravljenja |
| JP5941040B2 (ja) | 2010-05-13 | 2016-06-29 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン類似体およびその使用 |
| US9133182B2 (en) | 2010-09-28 | 2015-09-15 | Radius Health, Inc. | Selective androgen receptor modulators |
| EP4035664A3 (en) | 2014-03-28 | 2022-11-30 | Duke University | Treating cancer using selective estrogen receptor modulators |
| MX393599B (es) | 2015-04-29 | 2025-03-19 | Radius Pharmaceuticals Inc | Rad1901 para usarse en el tratamiento de cancer en sujetos con cancer positivo a receptor de estrogeno alfa resistente a farmaco |
| CN108025042A (zh) * | 2015-07-06 | 2018-05-11 | 董正欣 | PTHrP类似物的新型制剂 |
| RU2769527C2 (ru) | 2016-06-22 | 2022-04-01 | Эллипсес Фарма Лтд | Способы лечения ar+ рака молочной железы |
| DK3565542T3 (da) | 2017-01-05 | 2024-07-01 | Radius Pharmaceuticals Inc | Polymorphic forms of rad1901-2hcl |
| US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
| KR102792490B1 (ko) | 2018-07-04 | 2025-04-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| MX2021009569A (es) | 2019-02-12 | 2021-09-08 | Radius Pharmaceuticals Inc | Procesos y compuestos. |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| EP0293158A3 (en) * | 1987-05-26 | 1990-05-09 | Merck & Co. Inc. | Parathyroid hormone antagonists |
| US5457047A (en) * | 1989-02-23 | 1995-10-10 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | DNA Sequences coding for PTH variants, PTH variants, expression vector, bacterial host, use and therapeutic composition |
| CA2040264A1 (en) * | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| JPH0532696A (ja) * | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| AU2807892A (en) * | 1991-10-10 | 1993-05-03 | Peter K.T. Pang | Parathyroid hormone analogues and use in osteoporosis treatment |
| US5434246A (en) * | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
| CA2098639A1 (en) * | 1992-06-19 | 1993-12-20 | K. Anne Kronis | Bone stimulating, non-vasoactive parathyroid hormone variants |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5821225A (en) * | 1992-07-14 | 1998-10-13 | Syntex (U.S.A.) Inc. | Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| EP0678018B1 (en) | 1993-01-06 | 2003-04-09 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| CN1070500C (zh) * | 1993-07-13 | 2001-09-05 | 森德克斯(美国)股份有限公司 | 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途 |
| WO1996019246A1 (en) * | 1994-12-19 | 1996-06-27 | Beth Israel Hospital Association | Continuous low-dose administration of parathyroid hormone or its agonist |
| CA2178894A1 (en) * | 1995-06-15 | 1996-12-16 | Tsunehiko Fukuda | Parathyroid hormone derivatives and their use |
| US5723577A (en) * | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
-
1997
- 1997-03-07 US US08/813,534 patent/US5955574A/en not_active Expired - Lifetime
- 1997-12-08 ES ES97951595T patent/ES2258286T3/es not_active Expired - Lifetime
- 1997-12-08 CA CA002276614A patent/CA2276614C/en not_active Expired - Fee Related
- 1997-12-08 CZ CZ0239899A patent/CZ298937B6/cs not_active IP Right Cessation
- 1997-12-08 EP EP05026436A patent/EP1645566B1/en not_active Expired - Lifetime
- 1997-12-08 PT PT97951595T patent/PT948541E/pt unknown
- 1997-12-08 NZ NZ336610A patent/NZ336610A/en not_active IP Right Cessation
- 1997-12-08 EP EP97951595A patent/EP0948541B1/en not_active Expired - Lifetime
- 1997-12-08 PL PL334438A patent/PL191898B1/pl not_active IP Right Cessation
- 1997-12-08 IL IL13079497A patent/IL130794A0/xx not_active IP Right Cessation
- 1997-12-08 KR KR1020057003295A patent/KR100699422B1/ko not_active Expired - Fee Related
- 1997-12-08 SI SI9730730T patent/SI0948541T1/sl unknown
- 1997-12-08 EP EP10156965A patent/EP2206725A1/en not_active Withdrawn
- 1997-12-08 PT PT05026436T patent/PT1645566E/pt unknown
- 1997-12-08 WO PCT/US1997/022498 patent/WO1998030590A2/en not_active Ceased
- 1997-12-08 DK DK97951595T patent/DK0948541T3/da active
- 1997-12-08 RU RU99117145/04A patent/RU2198182C2/ru not_active IP Right Cessation
- 1997-12-08 CZ CZ20050594A patent/CZ301497B6/cs not_active IP Right Cessation
- 1997-12-08 BR BR9714200-0A patent/BR9714200A/pt not_active IP Right Cessation
- 1997-12-08 CN CNB971819157A patent/CN1137898C/zh not_active Expired - Fee Related
- 1997-12-08 AT AT97951595T patent/ATE321784T1/de active
- 1997-12-08 HU HU9904596A patent/HUP9904596A3/hu unknown
- 1997-12-08 KR KR10-1999-7006165A patent/KR100497709B1/ko not_active Expired - Fee Related
- 1997-12-08 AT AT05026436T patent/ATE471342T1/de active
- 1997-12-08 AU AU55199/98A patent/AU741584B2/en not_active Ceased
- 1997-12-08 DE DE69735603T patent/DE69735603T2/de not_active Expired - Lifetime
- 1997-12-08 JP JP53086598A patent/JP3963482B2/ja not_active Expired - Fee Related
- 1997-12-08 DK DK05026436.5T patent/DK1645566T3/da active
- 1997-12-08 SI SI9730795T patent/SI1645566T1/sl unknown
- 1997-12-08 ES ES05026436T patent/ES2347154T3/es not_active Expired - Lifetime
- 1997-12-08 DE DE69739912T patent/DE69739912D1/de not_active Expired - Lifetime
-
1998
- 1998-01-06 AR ARP980100058A patent/AR011517A1/es active IP Right Grant
-
1999
- 1999-07-06 NO NO993341A patent/NO993341L/no not_active Application Discontinuation
-
2003
- 2003-02-17 AR ARP030100515A patent/AR038552A2/es active IP Right Grant
-
2006
- 2006-01-18 AR ARP060100191A patent/AR051906A2/es unknown
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