PT89961A - Processo para a preparacao de n-carboxianidridos de aminoacidos protegidos por uretano - Google Patents

Processo para a preparacao de n-carboxianidridos de aminoacidos protegidos por uretano

Info

Publication number
PT89961A
PT89961A PT89961A PT8996189A PT89961A PT 89961 A PT89961 A PT 89961A PT 89961 A PT89961 A PT 89961A PT 8996189 A PT8996189 A PT 8996189A PT 89961 A PT89961 A PT 89961A
Authority
PT
Portugal
Prior art keywords
urethane
preparation
carboxyanidrides
protein aminoacid
protein
Prior art date
Application number
PT89961A
Other languages
English (en)
Other versions
PT89961B (pt
Inventor
William D Fuller
Michael Phillip Cohen
Fred R Naider
Murray Goodman
Original Assignee
Bioresearch Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Inc filed Critical Bioresearch Inc
Publication of PT89961A publication Critical patent/PT89961A/pt
Publication of PT89961B publication Critical patent/PT89961B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
PT89961A 1988-03-11 1989-03-09 Processo para a preparacao de n-carboxianidridos de aminoacidos protegidos por uretano PT89961B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/168,087 US4946942A (en) 1988-03-11 1988-03-11 Urethane-protected amino acid-N-carboxyanhydrides

Publications (2)

Publication Number Publication Date
PT89961A true PT89961A (pt) 1989-11-10
PT89961B PT89961B (pt) 1994-04-29

Family

ID=22610066

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89961A PT89961B (pt) 1988-03-11 1989-03-09 Processo para a preparacao de n-carboxianidridos de aminoacidos protegidos por uretano

Country Status (21)

Country Link
US (1) US4946942A (pt)
EP (1) EP0357750B1 (pt)
JP (1) JP2875834B2 (pt)
KR (1) KR970002229B1 (pt)
CN (1) CN1022412C (pt)
AT (1) ATE108438T1 (pt)
AU (1) AU616054B2 (pt)
CA (1) CA1321280C (pt)
CZ (1) CZ148989A3 (pt)
DD (1) DD280322A5 (pt)
DE (1) DE68916722T2 (pt)
FI (1) FI102379B1 (pt)
HK (1) HK1007744A1 (pt)
HU (1) HU205091B (pt)
IE (1) IE65149B1 (pt)
IL (1) IL89541A0 (pt)
NO (1) NO306304B1 (pt)
NZ (1) NZ228282A (pt)
PT (1) PT89961B (pt)
RU (1) RU2007396C1 (pt)
WO (1) WO1989008643A1 (pt)

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US5006661A (en) * 1987-06-16 1991-04-09 University Of Cincinnati Selective stereospecific biologically active beta-lactams
DE3839379A1 (de) * 1988-11-22 1990-05-23 Hoechst Ag Verfahren zur herstellung von tripeptiden
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
DK0834576T3 (da) 1990-12-06 2002-04-22 Affymetrix Inc A Delaware Corp Påvisning af nukleinsyresekvenser
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
TW306932B (pt) * 1993-08-27 1997-06-01 Holland Sweetener Co
US7625697B2 (en) * 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
IN184759B (pt) * 1997-07-22 2000-09-23 Kaneka Corp
CZ293008B6 (cs) 1998-07-21 2004-01-14 Kaneka Corporation Způsob krystalizace soli kyseliny maleinové s N-(1(S)-ethoxykarbonyl-3-fenylpropyl)-L-alanyl-L-prolinem
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
SE0000382D0 (sv) 2000-02-07 2000-02-07 Astrazeneca Ab New process
CN1388804A (zh) * 2000-07-04 2003-01-01 三井化学株式会社 在氮原子上具有取代基的氨基酸－n－羧基酸酐
DE10333368B4 (de) * 2003-07-23 2008-08-28 Universität Leipzig Oberflächenfunktionalisiertes Trägermaterial, Verfahren zu dessen Herstellung und dessen Verwendungen
FR2858976B1 (fr) * 2003-08-22 2006-02-10 Isochem Sa Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane
EP1809616B1 (en) * 2004-10-26 2010-12-22 Sigma-Aldrich Co. Synthesis of amino acid, n-carboxyanhydrides
WO2007070801A2 (en) 2005-12-12 2007-06-21 Allaccem, Inc. Methods and systems for preparing antimicrobial films and coatings
DK2125026T3 (en) 2007-02-21 2014-12-08 Allaccem Inc FORMATIONS BASED ON bridged POLYCYCLIC COMPOUNDS FOR INHIBITION AND RELIEF OF DISEASES
WO2009017775A2 (en) * 2007-08-02 2009-02-05 Scinopharm Taiwan Ltd. Process for the preparation of a polypeptide
US8153617B2 (en) * 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in humans
US8188068B2 (en) * 2007-08-10 2012-05-29 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in pets
US8153618B2 (en) * 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for topical applications for pets
US20090074833A1 (en) * 2007-08-17 2009-03-19 Whiteford Jeffery A Bridged polycyclic compound based compositions for controlling bone resorption
FR2928372B1 (fr) * 2008-03-10 2010-12-31 Solvay Procede de synthese peptidique
US20100004218A1 (en) * 2008-06-20 2010-01-07 Whiteford Jeffery A Bridged polycyclic compound based compositions for renal therapy
US20100016270A1 (en) * 2008-06-20 2010-01-21 Whiteford Jeffery A Bridged polycyclic compound based compositions for controlling cholesterol levels
BR112013021241B1 (pt) * 2011-03-25 2019-10-29 Nippon Soda Co., Ltd. Método para cristalizar um anidrido n-carboxílico de benzil éster de ácido glutâmico
WO2016149464A1 (en) * 2015-03-17 2016-09-22 Regeneron Pharmaceuticals, Inc. Amino acid acylation reagents and methods of using the same
JP6766432B2 (ja) * 2016-04-28 2020-10-14 Jsr株式会社 ポリアミノ酸の製造方法
AU2018228182B2 (en) * 2017-03-02 2024-04-11 Glytech, Inc. Production method for amino-acid polymer
CN112778236A (zh) * 2019-11-08 2021-05-11 华东理工大学 β、γ-氨基酸N-羧基硫代羰基环内酸酐单体的合成、聚合反应、聚合物制备及其应用

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GB1173562A (en) * 1966-04-25 1969-12-10 Pierrel Spa Chloramphenicol Ester Salts, the Preparation therof and Compositions Containing them
US4267344A (en) * 1972-09-22 1981-05-12 Proteinkemisk Institut. Tilknyttet Akademiet For De Tekniske Videnskaber N-Substituted N-carboxyanhydrides of α-amino acids and their application in the preparation of peptides
US4038411A (en) * 1973-09-25 1977-07-26 Merck & Co., Inc. Antihypertensive amino acid esters
US4038282A (en) * 1975-11-26 1977-07-26 Merck & Co., Inc. Pyridyl-4-methyl-succinimidocarbonate and process for its preparation
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones

Also Published As

Publication number Publication date
IL89541A0 (en) 1989-09-10
CN1040793A (zh) 1990-03-28
FI102379B (fi) 1998-11-30
CZ148989A3 (en) 1997-11-12
NO306304B1 (no) 1999-10-18
HU891841D0 (en) 1990-04-28
HU205091B (en) 1992-03-30
FI895382A0 (fi) 1989-11-10
JPH02503923A (ja) 1990-11-15
IE65149B1 (en) 1995-10-04
RU2007396C1 (ru) 1994-02-15
WO1989008643A1 (en) 1989-09-21
KR900700469A (ko) 1990-08-13
KR970002229B1 (ko) 1997-02-26
DE68916722D1 (de) 1994-08-18
DD280322A5 (de) 1990-07-04
EP0357750A1 (en) 1990-03-14
HK1007744A1 (en) 1999-04-23
DE68916722T2 (de) 1994-11-03
ATE108438T1 (de) 1994-07-15
NO894503D0 (no) 1989-11-10
HUT52488A (en) 1990-07-28
EP0357750B1 (en) 1994-07-13
CA1321280C (en) 1993-08-10
AU4188789A (en) 1989-10-05
EP0357750A4 (en) 1991-01-30
FI102379B1 (fi) 1998-11-30
JP2875834B2 (ja) 1999-03-31
IE890778L (en) 1989-09-11
CN1022412C (zh) 1993-10-13
PT89961B (pt) 1994-04-29
AU616054B2 (en) 1991-10-17
US4946942A (en) 1990-08-07
NZ228282A (en) 1990-10-26
NO894503L (no) 1989-11-10

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Legal Events

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FG3A Patent granted, date of granting

Effective date: 19931018

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090309