ES2039402T3 - Empleo de peptidos n,n'-bis-l-aminoacido-l-cistina en preparados de aminoacidos para alimentacion oral y parenteral. - Google Patents

Empleo de peptidos n,n'-bis-l-aminoacido-l-cistina en preparados de aminoacidos para alimentacion oral y parenteral.

Info

Publication number
ES2039402T3
ES2039402T3 ES198787115592T ES87115592T ES2039402T3 ES 2039402 T3 ES2039402 T3 ES 2039402T3 ES 198787115592 T ES198787115592 T ES 198787115592T ES 87115592 T ES87115592 T ES 87115592T ES 2039402 T3 ES2039402 T3 ES 2039402T3
Authority
ES
Spain
Prior art keywords
amino acid
oral
bis
cystine
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787115592T
Other languages
English (en)
Inventor
Peter Dr. Stehle
Peter Prof. Dr. Furst
Werner Dr.Dr. H.C. Fekl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfrimmer Kabi GmbH and Co KG
Original Assignee
Pfrimmer Kabi GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfrimmer Kabi GmbH and Co KG filed Critical Pfrimmer Kabi GmbH and Co KG
Application granted granted Critical
Publication of ES2039402T3 publication Critical patent/ES2039402T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Confectionery (AREA)
  • Cosmetics (AREA)

Abstract

LOS PEPTIDOS DE N,N''-BIS-L-AMINOACIDO-CISTINA, SIRVEN COMO DONADORES DE CISTINA SOLUBLES EN AGUA EN SOLUCIONES ORALES O PARENTERALES DE AMINOACIDOS U OLIGOPEPTIDOS, YA QUE, A PESAR DE SU ESTABILIDAD EN LA ESTERILIZACION TERMICA, SE DESCOMPONEN RAPIDAMENTE EN EL ORGANISMO. LOS NUEVOS TRIPEPTIDOS DE CISTINA, EN LOS QUE LA CISTINA SE SUSTITUYE POR DOS AMINOACIDOS DE 3 O MAS ATOMOS DE CARBONO, PUEDEN OBTENERSE A PARTIR DE CISTEINA POR EL METODO DEL N-CARBOXIANHIDRIDO YA CONOCIDO Y LA OXIDACION A TRIPEPTIDO DE CISTEINA.
ES198787115592T 1986-10-24 1987-10-23 Empleo de peptidos n,n'-bis-l-aminoacido-l-cistina en preparados de aminoacidos para alimentacion oral y parenteral. Expired - Lifetime ES2039402T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3636334 1986-10-24

Publications (1)

Publication Number Publication Date
ES2039402T3 true ES2039402T3 (es) 1993-10-01

Family

ID=6312449

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787115592T Expired - Lifetime ES2039402T3 (es) 1986-10-24 1987-10-23 Empleo de peptidos n,n'-bis-l-aminoacido-l-cistina en preparados de aminoacidos para alimentacion oral y parenteral.

Country Status (9)

Country Link
US (1) US4968696A (es)
EP (1) EP0264953B1 (es)
JP (1) JPH01501706A (es)
AT (1) ATE63316T1 (es)
AU (1) AU605214B2 (es)
DE (1) DE3769910D1 (es)
ES (1) ES2039402T3 (es)
GR (1) GR3001922T3 (es)
WO (1) WO1988003150A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402931B (de) * 1986-11-07 1997-09-25 Pharmacia Gmbh Verfahren zur herstellung von neuen cystinverbindungen und derenverwendung
US5102871A (en) * 1989-04-24 1992-04-07 Kyowa Hakko Kogyo Co., Ltd. Nutrient composition
DK53191D0 (da) * 1991-03-25 1991-03-25 Carlbiotech Ltd As Organosvovlforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse
EP0545198B1 (de) * 1991-11-29 1999-09-15 Hoechst Aktiengesellschaft Peptide mit insulinartiger Wirkung
FR2711529B1 (fr) * 1993-10-28 1996-07-05 Clintec Nutrition Cy Composition à base d'acides aminés destinée au traitement d'une infection ou d'une agression engendrant une réaction inflammatoire, chez les animaux et chez l'homme.
FR2872042B1 (fr) * 2004-06-29 2006-09-15 Soc Extraction Principes Actif Utilisation d'un dipeptide dimerise en tant qu'agent actif dans ou pour la preparation une composition cosmetique et/ou dermatologique
JP5668271B2 (ja) * 2008-12-25 2015-02-12 ユーハ味覚糖株式会社 シスチン−アミノ酸複合体及びその製造方法
US20110262965A1 (en) 2010-04-23 2011-10-27 Life Technologies Corporation Cell culture medium comprising small peptides
US20130130317A1 (en) 2010-08-02 2013-05-23 Kyowa Hakko Kirin Co., Ltd Method for producing substance
CN115397388A (zh) * 2020-04-20 2022-11-25 赢创运营有限公司 包含cys-肽的组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL245033A (es) * 1900-01-01
CH517705A (de) * 1969-12-16 1972-01-15 Ciba Geigy Ag Verfahren zur Herstellung von Cystin-haltigen Peptiden
BE785933A (fr) * 1971-07-07 1973-01-08 Ciba Geigy Procede de preparation de peptides contenant de la cystine
US4258193A (en) * 1978-07-13 1981-03-24 Toyo Jozo Kabushiki Kaisha Disulfide derivatives having S--S exchange reactivity
US4284624A (en) * 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
DE3206784C2 (de) * 1982-02-25 1985-05-09 Pfrimmer & Co Pharmazeutische Werke Erlangen Gmbh, 8520 Erlangen Glutaminhaltige Zubereitungen für orale oder intravenöse Applikation
US4427582A (en) * 1982-06-08 1984-01-24 Smithkline Beckman Corporation Antimicrobial disulfide prodrugs

Also Published As

Publication number Publication date
EP0264953A2 (de) 1988-04-27
EP0264953A3 (en) 1988-08-31
WO1988003150A2 (en) 1988-05-05
EP0264953B1 (de) 1991-05-08
AU605214B2 (en) 1991-01-10
GR3001922T3 (en) 1992-11-23
JPH01501706A (ja) 1989-06-15
US4968696A (en) 1990-11-06
WO1988003150A3 (fr) 1988-07-14
ATE63316T1 (de) 1991-05-15
AU8230187A (en) 1988-05-25
DE3769910D1 (de) 1991-06-13

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