CN1296487C - 利用微生物催化剂生产酰胺化合物的方法 - Google Patents
利用微生物催化剂生产酰胺化合物的方法 Download PDFInfo
- Publication number
- CN1296487C CN1296487C CNB018220312A CN01822031A CN1296487C CN 1296487 C CN1296487 C CN 1296487C CN B018220312 A CNB018220312 A CN B018220312A CN 01822031 A CN01822031 A CN 01822031A CN 1296487 C CN1296487 C CN 1296487C
- Authority
- CN
- China
- Prior art keywords
- reaction
- nitrile
- amide compound
- cells
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- -1 amide compound Chemical class 0.000 title claims abstract description 57
- 230000000813 microbial effect Effects 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000003054 catalyst Substances 0.000 title claims abstract description 13
- 238000006243 chemical reaction Methods 0.000 claims abstract description 52
- 108010024026 Nitrile hydratase Proteins 0.000 claims abstract description 29
- 238000004519 manufacturing process Methods 0.000 claims abstract description 21
- 239000012736 aqueous medium Substances 0.000 claims abstract description 8
- 210000004027 cell Anatomy 0.000 claims description 57
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 25
- 244000005700 microbiome Species 0.000 claims description 19
- 210000000130 stem cell Anatomy 0.000 claims description 9
- 241000590020 Achromobacter Species 0.000 claims description 5
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 5
- 241000187603 Pseudonocardia Species 0.000 claims description 5
- 241000186216 Corynebacterium Species 0.000 claims description 4
- 241000588698 Erwinia Species 0.000 claims description 4
- 241000192041 Micrococcus Species 0.000 claims description 4
- 241000187654 Nocardia Species 0.000 claims description 4
- 239000002609 medium Substances 0.000 claims description 4
- FFNVQNRYTPFDDP-UHFFFAOYSA-N 2-cyanopyridine Chemical compound N#CC1=CC=CC=N1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 claims description 3
- 241000589291 Acinetobacter Species 0.000 claims description 3
- 241000607534 Aeromonas Species 0.000 claims description 3
- 241000589158 Agrobacterium Species 0.000 claims description 3
- 241000588923 Citrobacter Species 0.000 claims description 3
- 241000588914 Enterobacter Species 0.000 claims description 3
- 241000588748 Klebsiella Species 0.000 claims description 3
- 241000589180 Rhizobium Species 0.000 claims description 3
- 241000187747 Streptomyces Species 0.000 claims description 3
- 101100412856 Mus musculus Rhod gene Proteins 0.000 claims 3
- 241000190932 Rhodopseudomonas Species 0.000 claims 3
- 101100242191 Tetraodon nigroviridis rho gene Proteins 0.000 claims 3
- 241000589565 Flavobacterium Species 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 37
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 27
- 108090000790 Enzymes Proteins 0.000 description 20
- 102000004190 Enzymes Human genes 0.000 description 20
- 210000001822 immobilized cell Anatomy 0.000 description 11
- 239000006285 cell suspension Substances 0.000 description 9
- 239000008363 phosphate buffer Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000011942 biocatalyst Substances 0.000 description 6
- 241000316848 Rhodococcus <scale insect> Species 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000011859 microparticle Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229930091371 Fructose Natural products 0.000 description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 4
- 239000005715 Fructose Substances 0.000 description 4
- 241000589516 Pseudomonas Species 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 239000003622 immobilized catalyst Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 238000009776 industrial production Methods 0.000 description 3
- 150000002825 nitriles Chemical class 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 241000187693 Rhodococcus rhodochrous Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000012364 cultivation method Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- ZBVHSUKFKJGVHO-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride Chemical compound Cl.OCC(N)(CO)CO.OCC(N)(CO)CO.OCC(N)(CO)CO ZBVHSUKFKJGVHO-UHFFFAOYSA-N 0.000 description 1
- GZPHSAQLYPIAIN-UHFFFAOYSA-N 3-pyridinecarbonitrile Chemical compound N#CC1=CC=CN=C1 GZPHSAQLYPIAIN-UHFFFAOYSA-N 0.000 description 1
- ZDAGSAVGPNEZKR-UHFFFAOYSA-N 5-(dimethylamino)-2-methylhex-2-enamide Chemical compound CN(C)C(C)CC=C(C)C(N)=O ZDAGSAVGPNEZKR-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 1
- GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 description 1
- 241001467578 Microbacterium Species 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 241000589506 Xanthobacter Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- BTGRAWJCKBQKAO-UHFFFAOYSA-N adiponitrile Chemical compound N#CCCCCC#N BTGRAWJCKBQKAO-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 238000007444 cell Immobilization Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229920006391 phthalonitrile polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229940047670 sodium acrylate Drugs 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- IAHFWCOBPZCAEA-UHFFFAOYSA-N succinonitrile Chemical compound N#CCCC#N IAHFWCOBPZCAEA-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000387537 | 2000-12-20 | ||
| JP387537/2000 | 2000-12-20 | ||
| JP387537/00 | 2000-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1486370A CN1486370A (zh) | 2004-03-31 |
| CN1296487C true CN1296487C (zh) | 2007-01-24 |
Family
ID=18854447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB018220312A Ceased CN1296487C (zh) | 2000-12-20 | 2001-12-19 | 利用微生物催化剂生产酰胺化合物的方法 |
Country Status (9)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1352865B1 (en) * | 2002-04-12 | 2011-09-28 | Kabushiki Kaisha Toshiba | Sheet collection apparatus |
| US20070027294A1 (en) * | 2003-04-10 | 2007-02-01 | Dia-Nitrix Co., Ltd. | Process for producing high-quality acrylamide polymer with enzyme |
| GB0327901D0 (en) | 2003-12-02 | 2004-01-07 | Ciba Spec Chem Water Treat Ltd | Process for producing polymers |
| ATE449860T1 (de) * | 2003-12-02 | 2009-12-15 | Ciba Spec Chem Water Treat Ltd | Herstellung von amiden |
| RU2403280C2 (ru) | 2003-12-02 | 2010-11-10 | Циба Спешиалти Кемикэлз Уотер Тритментс Лимитед | Штамм rhodococcus rhodochrous ncimb 41164 и его применение в качестве продуцента нитрилгидратазы |
| GB0416101D0 (en) * | 2004-07-19 | 2004-08-18 | Ciba Spec Chem Water Treat Ltd | Process for preparing monomers and polymers thereof |
| JP2006187257A (ja) * | 2005-01-07 | 2006-07-20 | Daiyanitorikkusu Kk | アミド化合物の製造方法およびアクリルアミド系ポリマー |
| KR20110038183A (ko) * | 2005-10-07 | 2011-04-13 | 미쓰이 가가쿠 가부시키가이샤 | 아미드 화합물의 제조방법 |
| AU2011239258B2 (en) * | 2005-10-07 | 2012-09-27 | Mitsui Chemicals, Inc. | Method for producing amide compound |
| WO2009113654A1 (ja) | 2008-03-14 | 2009-09-17 | ダイヤニトリックス株式会社 | アミド化合物の製造方法 |
| JP5831231B2 (ja) * | 2009-12-25 | 2015-12-09 | 三菱レイヨン株式会社 | 微生物触媒を用いたアクリルアミドの製造方法 |
| JPWO2011138966A1 (ja) * | 2010-05-06 | 2013-07-22 | ダイヤニトリックス株式会社 | 微生物触媒を用いたアクリルアミドの製造方法 |
| CN103687844B (zh) * | 2011-05-19 | 2015-06-10 | 三菱丽阳株式会社 | 丙烯酰胺水溶液的制造方法 |
| AU2012256707B2 (en) | 2011-05-19 | 2015-07-16 | Mitsubishi Chemical Corporation | Method for producing aqueous acrylamide solution |
| US10160982B2 (en) | 2012-12-10 | 2018-12-25 | Mitsubishi Chemical Corporation | Method for producing acrylamide |
| CN107075494B (zh) * | 2014-09-30 | 2021-11-23 | 巴斯夫欧洲公司 | 制备具有较少丙烯酸的酰胺化合物的手段和方法 |
| CN105316263A (zh) * | 2015-11-25 | 2016-02-10 | 沈阳化工研究院有限公司 | 一种氰类化合物降解菌及其应用 |
| CN110157751A (zh) * | 2019-06-05 | 2019-08-23 | 英德市云超聚合材料有限公司 | 一种低电导率酰胺化合物水溶液的合成方法 |
| CN112626141B (zh) * | 2020-11-16 | 2022-12-06 | 广东宝莫生物化工有限公司 | 一种丙烯酰胺溶液的生产方法 |
| CN115216465A (zh) * | 2022-08-15 | 2022-10-21 | 武汉宏择一碳环保科技有限公司 | 一种基于膜分离工艺的丙烯酰胺制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054614A (zh) * | 1990-02-28 | 1991-09-18 | 日东化学工业株式会社 | 编码具有腈水化酶活性的多肽的基因、含该基因的转化株和用该转化株生产酰胺的方法 |
| CN1070686A (zh) * | 1991-08-05 | 1993-04-07 | 三菱化成株式会社 | 制备酰胺的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2294999A1 (fr) * | 1974-12-18 | 1976-07-16 | Anvar | Procede de preparation d'amides par hydrolyse biologique |
| GB2018240B (en) * | 1978-03-29 | 1982-12-22 | Nitto Chemical Industry Co Ltd | Process for producing acrylamide or methacrylamide utilizing microoganisms |
| JPS5937951B2 (ja) * | 1981-11-18 | 1984-09-12 | 秀明 山田 | アミドの生物学的製造法 |
| JPS61162193A (ja) | 1985-01-08 | 1986-07-22 | Nitto Chem Ind Co Ltd | 微生物によるアミド類の製造法 |
| JPS61162194A (ja) * | 1985-01-11 | 1986-07-22 | Nitto Chem Ind Co Ltd | 微生物によるアミド類の製造法 |
| JPH0740948B2 (ja) * | 1985-06-04 | 1995-05-10 | 旭化成工業株式会社 | アミドの微生物学的製造法 |
| MX169933B (es) * | 1987-09-18 | 1993-08-02 | Hideaki Yamada | Procedimiento para la produccion biologica de amidas |
| JPH0822221B2 (ja) * | 1988-12-28 | 1996-03-06 | 日東化学工業株式会社 | シュードモナス属細菌の培養法 |
| AU627648B2 (en) * | 1990-02-28 | 1992-08-27 | Teruhiko Beppu | Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant |
| EP0502476B1 (en) * | 1991-03-04 | 2001-07-18 | Mitsubishi Rayon Co., Ltd. | Hybrid plasmid vectors containing genes encoding nitrile degrading enzymes and methods of producing amides and acids |
| JPH06225780A (ja) * | 1993-02-05 | 1994-08-16 | Mitsui Toatsu Chem Inc | 微生物によるアミド類の製造法 |
| RU2053300C1 (ru) * | 1993-12-17 | 1996-01-27 | Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Штамм бактерий rhodococcus rhodochrous - продуцент нитрилгидратазы |
| JP3531997B2 (ja) * | 1995-03-29 | 2004-05-31 | 三井化学株式会社 | 形質転換体を用いたアミド化合物の製造法 |
| GB9506389D0 (en) * | 1995-03-29 | 1995-05-17 | King S College London | Catalyst and process for preparing amides |
| RU2077588C1 (ru) * | 1996-01-16 | 1997-04-20 | Государственное унитарное предприятие Саратовский научно-исследовательский институт биокатализа | Способ получения акриламида |
| DE69739026D1 (de) * | 1996-02-14 | 2008-11-20 | Mitsui Chemicals Inc | Nitril-Hydratase, ihre Derivate und Verfahren zur Herstellung von Verbindungen |
| US5866379A (en) * | 1997-01-28 | 1999-02-02 | Novus International | Enzymatic conversion of α-hydroxynitriles to the corresponding .alpha. |
-
2001
- 2001-12-19 EP EP01271129A patent/EP1352965B1/en not_active Expired - Lifetime
- 2001-12-19 JP JP2002551176A patent/JP4708677B2/ja not_active Expired - Lifetime
- 2001-12-19 IN IN1050CH2003 patent/IN209344B/en unknown
- 2001-12-19 KR KR20037008207A patent/KR100547080B1/ko not_active Expired - Lifetime
- 2001-12-19 US US10/450,532 patent/US7749739B2/en not_active Expired - Lifetime
- 2001-12-19 RU RU2003122208/13A patent/RU2288270C2/ru active
- 2001-12-19 CN CNB018220312A patent/CN1296487C/zh not_active Ceased
- 2001-12-19 WO PCT/JP2001/011149 patent/WO2002050297A1/ja active IP Right Grant
- 2001-12-19 DE DE60133130T patent/DE60133130T2/de not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054614A (zh) * | 1990-02-28 | 1991-09-18 | 日东化学工业株式会社 | 编码具有腈水化酶活性的多肽的基因、含该基因的转化株和用该转化株生产酰胺的方法 |
| CN1070686A (zh) * | 1991-08-05 | 1993-04-07 | 三菱化成株式会社 | 制备酰胺的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002050297A1 (fr) | 2002-06-27 |
| IN209344B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2007-09-21 |
| RU2288270C2 (ru) | 2006-11-27 |
| EP1352965A1 (en) | 2003-10-15 |
| EP1352965A4 (en) | 2004-03-31 |
| EP1352965B1 (en) | 2008-03-05 |
| US7749739B2 (en) | 2010-07-06 |
| KR100547080B1 (ko) | 2006-01-31 |
| JPWO2002050297A1 (ja) | 2004-04-22 |
| CN1486370A (zh) | 2004-03-31 |
| DE60133130T2 (de) | 2009-02-26 |
| JP4708677B2 (ja) | 2011-06-22 |
| KR20030066720A (ko) | 2003-08-09 |
| DE60133130D1 (de) | 2008-04-17 |
| US20040048348A1 (en) | 2004-03-11 |
| IN2003CH01050A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2005-04-22 |
| RU2003122208A (ru) | 2005-01-20 |
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