KR100547080B1 - 미생물 촉매를 이용한 아미드 화합물의 제조 방법 - Google Patents
미생물 촉매를 이용한 아미드 화합물의 제조 방법 Download PDFInfo
- Publication number
- KR100547080B1 KR100547080B1 KR20037008207A KR20037008207A KR100547080B1 KR 100547080 B1 KR100547080 B1 KR 100547080B1 KR 20037008207 A KR20037008207 A KR 20037008207A KR 20037008207 A KR20037008207 A KR 20037008207A KR 100547080 B1 KR100547080 B1 KR 100547080B1
- Authority
- KR
- South Korea
- Prior art keywords
- genus
- nitrile
- compound
- amide compound
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 amide compound Chemical class 0.000 title claims abstract description 60
- 230000000813 microbial effect Effects 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 20
- 239000003054 catalyst Substances 0.000 title claims abstract description 19
- 238000006243 chemical reaction Methods 0.000 claims abstract description 57
- 230000000694 effects Effects 0.000 claims abstract description 35
- 108010024026 Nitrile hydratase Proteins 0.000 claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- 239000012736 aqueous medium Substances 0.000 claims abstract description 8
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 24
- 244000005700 microbiome Species 0.000 claims description 18
- 241000316848 Rhodococcus <scale insect> Species 0.000 claims description 10
- 241000589516 Pseudomonas Species 0.000 claims description 9
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 7
- 239000002609 medium Substances 0.000 claims description 7
- 241000186216 Corynebacterium Species 0.000 claims description 6
- 150000002825 nitriles Chemical class 0.000 claims description 6
- 241000590020 Achromobacter Species 0.000 claims description 4
- 241000589291 Acinetobacter Species 0.000 claims description 4
- 241000589158 Agrobacterium Species 0.000 claims description 4
- 241000192041 Micrococcus Species 0.000 claims description 4
- 241000187654 Nocardia Species 0.000 claims description 4
- 241000187603 Pseudonocardia Species 0.000 claims description 4
- FFNVQNRYTPFDDP-UHFFFAOYSA-N 2-cyanopyridine Chemical compound N#CC1=CC=CC=N1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 claims description 3
- 241000607534 Aeromonas Species 0.000 claims description 3
- 241000588923 Citrobacter Species 0.000 claims description 3
- 241000588914 Enterobacter Species 0.000 claims description 3
- 241000588698 Erwinia Species 0.000 claims description 3
- 241000588748 Klebsiella Species 0.000 claims description 3
- 241000589180 Rhizobium Species 0.000 claims description 3
- 241000187747 Streptomyces Species 0.000 claims description 3
- 241000589506 Xanthobacter Species 0.000 claims description 3
- 241001646398 Pseudomonas chlororaphis Species 0.000 claims description 2
- 241000187693 Rhodococcus rhodochrous Species 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 abstract description 6
- 230000003100 immobilizing effect Effects 0.000 abstract description 4
- 150000001408 amides Chemical class 0.000 abstract description 2
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 51
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 29
- 108090000790 Enzymes Proteins 0.000 description 17
- 102000004190 Enzymes Human genes 0.000 description 17
- 239000006285 cell suspension Substances 0.000 description 9
- 210000001822 immobilized cell Anatomy 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000011942 biocatalyst Substances 0.000 description 6
- 239000008363 phosphate buffer Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 229930091371 Fructose Natural products 0.000 description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 4
- 239000005715 Fructose Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 238000012364 cultivation method Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 1
- ZBVHSUKFKJGVHO-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride Chemical compound Cl.OCC(N)(CO)CO.OCC(N)(CO)CO.OCC(N)(CO)CO ZBVHSUKFKJGVHO-UHFFFAOYSA-N 0.000 description 1
- GZPHSAQLYPIAIN-UHFFFAOYSA-N 3-pyridinecarbonitrile Chemical compound N#CC1=CC=CN=C1 GZPHSAQLYPIAIN-UHFFFAOYSA-N 0.000 description 1
- ZDAGSAVGPNEZKR-UHFFFAOYSA-N 5-(dimethylamino)-2-methylhex-2-enamide Chemical compound CN(C)C(C)CC=C(C)C(N)=O ZDAGSAVGPNEZKR-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- BMFMQGXDDJALKQ-BYPYZUCNSA-N Argininic acid Chemical compound NC(N)=NCCC[C@H](O)C(O)=O BMFMQGXDDJALKQ-BYPYZUCNSA-N 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 description 1
- 241001467578 Microbacterium Species 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- BTGRAWJCKBQKAO-UHFFFAOYSA-N adiponitrile Chemical compound N#CCCCCC#N BTGRAWJCKBQKAO-UHFFFAOYSA-N 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 230000006229 amino acid addition Effects 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- XQZYPMVTSDWCCE-UHFFFAOYSA-N phthalonitrile Chemical compound N#CC1=CC=CC=C1C#N XQZYPMVTSDWCCE-UHFFFAOYSA-N 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229940047670 sodium acrylate Drugs 0.000 description 1
- YFGAFXCSLUUJRG-WCCKRBBISA-M sodium;(2s)-2-amino-5-(diaminomethylideneamino)pentanoate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCCN=C(N)N YFGAFXCSLUUJRG-WCCKRBBISA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- IAHFWCOBPZCAEA-UHFFFAOYSA-N succinonitrile Chemical compound N#CCCC#N IAHFWCOBPZCAEA-UHFFFAOYSA-N 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPJP-P-2000-00387537 | 2000-12-20 | ||
| JP2000387537 | 2000-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20030066720A KR20030066720A (ko) | 2003-08-09 |
| KR100547080B1 true KR100547080B1 (ko) | 2006-01-31 |
Family
ID=18854447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20037008207A Expired - Lifetime KR100547080B1 (ko) | 2000-12-20 | 2001-12-19 | 미생물 촉매를 이용한 아미드 화합물의 제조 방법 |
Country Status (9)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1352865B1 (en) * | 2002-04-12 | 2011-09-28 | Kabushiki Kaisha Toshiba | Sheet collection apparatus |
| KR101116976B1 (ko) * | 2003-04-10 | 2012-03-14 | 다이야니트릭스 가부시키가이샤 | 효소를 이용한 고품질 아크릴아미드계 중합체의 제조 방법 |
| GB0327901D0 (en) * | 2003-12-02 | 2004-01-07 | Ciba Spec Chem Water Treat Ltd | Process for producing polymers |
| KR101106943B1 (ko) * | 2003-12-02 | 2012-01-19 | 시바 스페셜티 케미칼스 워터 트리트먼츠 리미티드 | 로도코커스 로도크로스 ncimb 41164의 균주 및 니트릴하이드라타제의 생산자로서의 이의 용도 |
| US7816106B2 (en) * | 2003-12-02 | 2010-10-19 | Ciba Specialty Chemicals Water Treatments Ltd. | Manufacture of amides |
| GB0416101D0 (en) * | 2004-07-19 | 2004-08-18 | Ciba Spec Chem Water Treat Ltd | Process for preparing monomers and polymers thereof |
| JP2006187257A (ja) * | 2005-01-07 | 2006-07-20 | Daiyanitorikkusu Kk | アミド化合物の製造方法およびアクリルアミド系ポリマー |
| WO2007043466A1 (ja) * | 2005-10-07 | 2007-04-19 | Mitsui Chemicals, Inc. | アミド化合物の製造方法 |
| AU2011239258B2 (en) * | 2005-10-07 | 2012-09-27 | Mitsui Chemicals, Inc. | Method for producing amide compound |
| US8889907B2 (en) | 2008-03-14 | 2014-11-18 | Mitsubishi Rayon Co., Ltd. | Process for production of amide compounds |
| JP5831231B2 (ja) * | 2009-12-25 | 2015-12-09 | 三菱レイヨン株式会社 | 微生物触媒を用いたアクリルアミドの製造方法 |
| US20130059349A1 (en) * | 2010-05-06 | 2013-03-07 | Dia-Nitrix Co., Ltd. | Method for producing acrylamide using microbial catalyst |
| AU2012256707B2 (en) | 2011-05-19 | 2015-07-16 | Mitsubishi Chemical Corporation | Method for producing aqueous acrylamide solution |
| WO2012157777A1 (ja) * | 2011-05-19 | 2012-11-22 | ダイヤニトリックス株式会社 | アクリルアミド水溶液の製造方法 |
| CN105247063B (zh) * | 2012-12-10 | 2020-10-23 | 三菱化学株式会社 | 丙烯酰胺的制造方法 |
| JP7055633B2 (ja) * | 2014-09-30 | 2022-04-18 | ビーエーエスエフ ソシエタス・ヨーロピア | アクリル酸含有量がより少ないアミド化合物を産生する手段および方法 |
| CN105316263A (zh) * | 2015-11-25 | 2016-02-10 | 沈阳化工研究院有限公司 | 一种氰类化合物降解菌及其应用 |
| CN110157751A (zh) * | 2019-06-05 | 2019-08-23 | 英德市云超聚合材料有限公司 | 一种低电导率酰胺化合物水溶液的合成方法 |
| CN112626141B (zh) * | 2020-11-16 | 2022-12-06 | 广东宝莫生物化工有限公司 | 一种丙烯酰胺溶液的生产方法 |
| CN115216465A (zh) * | 2022-08-15 | 2022-10-21 | 武汉宏择一碳环保科技有限公司 | 一种基于膜分离工艺的丙烯酰胺制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08266277A (ja) * | 1995-03-29 | 1996-10-15 | Mitsui Toatsu Chem Inc | 形質転換体を用いたアミド化合物の製造法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2294999A1 (fr) * | 1974-12-18 | 1976-07-16 | Anvar | Procede de preparation d'amides par hydrolyse biologique |
| IT1162484B (it) * | 1978-03-29 | 1987-04-01 | Nitto Chemical Industry Co Ltd | Procedimento pe produrre acrilammide o metacrilammide impiegando microorganismi |
| JPS5937951B2 (ja) | 1981-11-18 | 1984-09-12 | 秀明 山田 | アミドの生物学的製造法 |
| JPS61162193A (ja) * | 1985-01-08 | 1986-07-22 | Nitto Chem Ind Co Ltd | 微生物によるアミド類の製造法 |
| JPS61162194A (ja) * | 1985-01-11 | 1986-07-22 | Nitto Chem Ind Co Ltd | 微生物によるアミド類の製造法 |
| JPH0740948B2 (ja) | 1985-06-04 | 1995-05-10 | 旭化成工業株式会社 | アミドの微生物学的製造法 |
| DD274631A5 (de) * | 1987-09-18 | 1989-12-27 | Kk | Verfahren zur biologischen herstellung von amiden |
| JPH0822221B2 (ja) * | 1988-12-28 | 1996-03-06 | 日東化学工業株式会社 | シュードモナス属細菌の培養法 |
| JP2907479B2 (ja) | 1990-02-28 | 1999-06-21 | 輝彦 別府 | ニトリルヒドラターゼ活性を有するポリペプチドをコードする遺伝子dna、これを含有する形質転換体及びアミド類の製造法 |
| AU627648B2 (en) * | 1990-02-28 | 1992-08-27 | Teruhiko Beppu | Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant |
| DE69231939T2 (de) * | 1991-03-04 | 2002-04-04 | Teruhiko Beppu | Hybrid-Plasmid-Vektoren, die für Nitril-abbauende Enzyme kodierende Gene enthalten und Verfahren zur Herstellung von Amiden und Säuren |
| AU2077392A (en) | 1991-08-05 | 1993-04-29 | Mitsubishi Kasei Corporation | Process for preparing amides |
| JPH06225780A (ja) | 1993-02-05 | 1994-08-16 | Mitsui Toatsu Chem Inc | 微生物によるアミド類の製造法 |
| RU2053300C1 (ru) * | 1993-12-17 | 1996-01-27 | Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Штамм бактерий rhodococcus rhodochrous - продуцент нитрилгидратазы |
| GB9506389D0 (en) * | 1995-03-29 | 1995-05-17 | King S College London | Catalyst and process for preparing amides |
| RU2077588C1 (ru) * | 1996-01-16 | 1997-04-20 | Государственное унитарное предприятие Саратовский научно-исследовательский институт биокатализа | Способ получения акриламида |
| CN1240833C (zh) | 1996-02-14 | 2006-02-08 | 三井化学株式会社 | 新型腈水合酶 |
| US5866379A (en) * | 1997-01-28 | 1999-02-02 | Novus International | Enzymatic conversion of α-hydroxynitriles to the corresponding .alpha. |
-
2001
- 2001-12-19 US US10/450,532 patent/US7749739B2/en not_active Expired - Lifetime
- 2001-12-19 DE DE60133130T patent/DE60133130T2/de not_active Expired - Lifetime
- 2001-12-19 RU RU2003122208/13A patent/RU2288270C2/ru active
- 2001-12-19 CN CNB018220312A patent/CN1296487C/zh not_active Ceased
- 2001-12-19 WO PCT/JP2001/011149 patent/WO2002050297A1/ja active IP Right Grant
- 2001-12-19 IN IN1050CH2003 patent/IN209344B/en unknown
- 2001-12-19 EP EP01271129A patent/EP1352965B1/en not_active Expired - Lifetime
- 2001-12-19 JP JP2002551176A patent/JP4708677B2/ja not_active Expired - Lifetime
- 2001-12-19 KR KR20037008207A patent/KR100547080B1/ko not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08266277A (ja) * | 1995-03-29 | 1996-10-15 | Mitsui Toatsu Chem Inc | 形質転換体を用いたアミド化合物の製造法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1296487C (zh) | 2007-01-24 |
| WO2002050297A1 (fr) | 2002-06-27 |
| DE60133130D1 (de) | 2008-04-17 |
| KR20030066720A (ko) | 2003-08-09 |
| RU2003122208A (ru) | 2005-01-20 |
| JP4708677B2 (ja) | 2011-06-22 |
| RU2288270C2 (ru) | 2006-11-27 |
| JPWO2002050297A1 (ja) | 2004-04-22 |
| EP1352965B1 (en) | 2008-03-05 |
| IN209344B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2007-09-21 |
| US20040048348A1 (en) | 2004-03-11 |
| DE60133130T2 (de) | 2009-02-26 |
| US7749739B2 (en) | 2010-07-06 |
| CN1486370A (zh) | 2004-03-31 |
| IN2003CH01050A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2005-04-22 |
| EP1352965A1 (en) | 2003-10-15 |
| EP1352965A4 (en) | 2004-03-31 |
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