CN1249081C - 糖肽衍生物或含有它们的药物组合物 - Google Patents

糖肽衍生物或含有它们的药物组合物 Download PDF

Info

Publication number
CN1249081C
CN1249081C CNB99809434XA CN99809434A CN1249081C CN 1249081 C CN1249081 C CN 1249081C CN B99809434X A CNB99809434X A CN B99809434XA CN 99809434 A CN99809434 A CN 99809434A CN 1249081 C CN1249081 C CN 1249081C
Authority
CN
China
Prior art keywords
hydrogen
substituted
cooh
alkyl
glycosamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB99809434XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1315961A (zh
Inventor
J·K·朱迪斯
P·R·法瑟里
B·M·T·兰姆
M·里德伯特
M·S·林塞尔
穆永琪
S·G·特莱普
杨光
朱严
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cumberland Pharmaceuticals Inc
Original Assignee
Shiwan Pharmaceutical
Advanced Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiwan Pharmaceutical, Advanced Medicine Inc filed Critical Shiwan Pharmaceutical
Publication of CN1315961A publication Critical patent/CN1315961A/zh
Application granted granted Critical
Publication of CN1249081C publication Critical patent/CN1249081C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB99809434XA 1998-12-23 1999-12-22 糖肽衍生物或含有它们的药物组合物 Expired - Lifetime CN1249081C (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11372898P 1998-12-23 1998-12-23
US60/113,728 1998-12-23
US12931399P 1999-04-14 1999-04-14
US60/129,313 1999-04-14
US16402499P 1999-11-04 1999-11-04
US60/164,024 1999-11-04
US16997899P 1999-12-10 1999-12-10
US60/169,978 1999-12-10

Publications (2)

Publication Number Publication Date
CN1315961A CN1315961A (zh) 2001-10-03
CN1249081C true CN1249081C (zh) 2006-04-05

Family

ID=27493926

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB99809434XA Expired - Lifetime CN1249081C (zh) 1998-12-23 1999-12-22 糖肽衍生物或含有它们的药物组合物

Country Status (23)

Country Link
US (9) US6392012B1 (enExample)
EP (1) EP1140993B1 (enExample)
JP (1) JP4362017B2 (enExample)
KR (1) KR100665204B1 (enExample)
CN (1) CN1249081C (enExample)
AT (1) ATE242783T1 (enExample)
AU (1) AU768204B2 (enExample)
BR (1) BRPI9914221B8 (enExample)
CA (1) CA2336445C (enExample)
CZ (1) CZ301184B6 (enExample)
DE (1) DE69908819T2 (enExample)
DK (1) DK1140993T3 (enExample)
ES (1) ES2201825T3 (enExample)
HK (1) HK1040721B (enExample)
HU (1) HU230190B1 (enExample)
IL (2) IL140093A0 (enExample)
NO (1) NO326066B1 (enExample)
NZ (1) NZ508594A (enExample)
PL (1) PL198311B1 (enExample)
PT (1) PT1140993E (enExample)
SI (1) SI1140993T1 (enExample)
WO (1) WO2000039156A1 (enExample)
ZA (1) ZA200007222B (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL140093A0 (en) * 1998-12-23 2002-02-10 Advanced Medicine Inc Glycopeptide derivatives and pharmaceutical compositions containing the same
EP1173193A4 (en) * 1999-04-02 2003-01-29 Univ Princeton DES-LEUCYL GLYCOPEPTIDANTIBIOTICS AND METHODS FOR THE PRODUCTION THEREOF
US6699836B2 (en) * 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
WO2001057071A2 (en) * 2000-02-04 2001-08-09 Advanced Medicine, Inc. Glycopeptide derivatives having antibiotic activity
JP4870314B2 (ja) * 2000-05-02 2012-02-08 セラヴァンス， インコーポレーテッド シクロデキストリンを含むグリコペプチド抗生物質組成物
AU2001259298A1 (en) * 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
EP1276759B1 (en) 2000-05-02 2008-07-30 Theravance, Inc. Reductive alkylation process on glycopeptides
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
AU2001259303A1 (en) 2000-06-22 2002-01-02 Advanced Medicine, Inc. Glycopeptide carboxy-saccharide derivatives
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
AU2001259816A1 (en) * 2000-06-22 2002-01-02 Advanced Medecine, Inc. Polyhydroxy glycopeptide derivatives
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
TWI275594B (en) * 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
DE60118737T2 (de) 2001-09-19 2006-10-19 The Procter & Gamble Company, Cincinnati Farbbedruckte Mehrschichtstruktur, ein damit hergestellter absorbierender Artikel und Verfahren zu deren Herstellung
TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
US20040033986A1 (en) 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
CN101404986B (zh) 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
AU2003231833A1 (en) 2002-05-24 2003-12-12 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
AU2003243574A1 (en) 2002-06-17 2003-12-31 Theravance, Inc. PROCESS FOR PREPARING N-PROTECTED Beta-AMINO ALDEHYDE COMPOUNDS
US20060135568A1 (en) * 2002-07-09 2006-06-22 Townsend Craig A Methods of treating microbial infections in humans and animals
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
DK1565201T3 (en) * 2002-11-18 2019-02-25 Vicuron Pharmaceuticals Llc METHODS OF ADMINISTRATING DALBAVANCIN TO TREAT Bacterial Infections
EP1633759B1 (en) 2003-05-23 2009-12-02 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
WO2005005436A2 (en) * 2003-07-11 2005-01-20 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
DE102004055582A1 (de) 2004-11-18 2006-05-24 Bayer Cropscience Ag N-Heterocyclyl-phthalsäurediamide
JP4330169B2 (ja) 2004-11-29 2009-09-16 国立大学法人名古屋大学 グリコペプチド抗生物質モノマー誘導体
US8304597B2 (en) 2004-12-15 2012-11-06 The Procter And Gamble Company Method of using an absorbent article having a functional enhancement indicator
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
WO2007084507A2 (en) * 2006-01-13 2007-07-26 The Scripps Research Institute [ψ[CH2NH]PG4] GLYCOPEPTIDE ANTIBIOTIC ANALOGS
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
CA2710417A1 (en) 2007-12-26 2009-07-02 Shionogi & Co., Ltd. Glycosylated glycopeptide antibiotic derivatives
CA2710602A1 (en) * 2007-12-26 2009-07-09 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
CN102083862A (zh) 2008-04-01 2011-06-01 康奈尔大学 有机-可溶性壳聚糖盐和由其制备的壳聚糖衍生生物材料
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
WO2012129493A1 (en) * 2011-03-24 2012-09-27 Seachaid Pharmaceuticals, Inc. Vancomycin derivatives
CA2904387C (en) 2013-03-15 2021-12-07 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
AU2014322817A1 (en) * 2013-09-23 2016-04-21 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
EP3240574A1 (en) * 2014-12-25 2017-11-08 Jawaharlal Nehru Centre For Advanced Scientific Research Glycopeptides and uses thereof
KR20210094657A (ko) * 2016-01-15 2021-07-29 함부르크대학교 람노실화된 플라보노이드의 제조 방법
JP2019511561A (ja) * 2016-01-28 2019-04-25 アカテコール・インコーポレイテッドＡＣａｔｅｃｈｏｌ， Ｉｎｃ． 光開裂性プライマー組成物および使用方法
CN107325159A (zh) * 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
GB2577420B (en) 2017-05-22 2022-07-06 Insmed Inc Glycopeptide derivative compounds and uses thereof
CN107987131B (zh) * 2017-11-16 2021-03-09 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的化合物、其制备方法和应用
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
NL2023883B1 (en) * 2019-09-24 2021-04-26 Univ Leiden Antibiotic compounds
CN111620931B (zh) * 2020-06-12 2021-12-17 苏州博源医疗科技有限公司 万古霉素衍生物及其制备方法和应用
CN114213284B (zh) * 2022-01-04 2023-08-01 丽珠集团福州福兴医药有限公司 (9h-芴-9-基)-癸基(2-氧代乙基)氨基甲酸甲酯及其合成方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497802A (en) 1983-10-21 1985-02-05 Eli Lilly And Company N-Acyl glycopeptide derivatives
GB8428619D0 (en) 1984-11-13 1984-12-19 Lepetit Spa Derivatives of antibiotic l 17046
US4914187A (en) 1984-11-13 1990-04-03 Gruppo Lepetit S.P.A Ester derivatives of antibiotic L 17046
US4698327A (en) 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
GB8704847D0 (en) 1987-03-02 1987-04-08 Lepetit Spa Substituted alkylamides of teicoplanin compounds
FR2632185B1 (fr) * 1988-06-01 1992-05-22 Rhone Poulenc Chimie Silice pour compositions dentifrices compatible notamment avec le zinc
GB8817397D0 (en) 1988-07-21 1988-08-24 Lepetit Spa N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
US5534420A (en) 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
EP0376041B1 (en) 1988-12-27 1996-02-28 GRUPPO LEPETIT S.p.A. C63-Amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanins
IE64155B1 (en) * 1989-03-29 1995-07-12 Lepetit Spa New substituted alkylamide derivatives of teicoplanin
IL96603A (en) 1989-12-13 1998-02-08 Lilly Co Eli Antibacterial glycopeptide derivatives, process for their preparation and pharmaceutical compositions containing them
AU647122B2 (en) 1990-05-28 1994-03-17 Gruppo Lepetit S.P.A. C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy- teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
WO1992017456A1 (fr) 1991-03-26 1992-10-15 Fujisawa Pharmaceutical Co., Ltd. Derive d'acide amine et sel dudit derive
JP3418762B2 (ja) 1991-07-29 2003-06-23 バイオサーチ・イタリア・ソチエタ・ペル・アチオニ 抗生物質ａ４０９２６のアミド誘導体類
US5750509A (en) 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
RU2145609C1 (ru) 1994-01-28 2000-02-20 Эли Лилли Энд Компани Производные гликопептида или их соли, способ получения, фармацевтическая композиция
US5840684A (en) 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
IT1282586B1 (it) 1996-02-08 1998-03-31 Chemical And Biolog Ind Composizioni farmaceutiche per il trattamento biologico delle infezioni dovute a ceppi di enterococcus faecium resistenti agli
CA2249323A1 (en) 1996-03-21 1997-09-25 Transcell Technologies, Inc. Solid phase lipoglycopeptide library, compositions and methods
AU2609297A (en) 1996-04-12 1997-11-07 Eli Lilly And Company Glycopeptide compounds
WO1997038702A1 (en) 1996-04-12 1997-10-23 Eli Lilly And Company Covalently-linked glycopeptide dimers
KR20000010589A (ko) 1996-04-23 2000-02-15 클라우디오 쿼르타 항생제a40926의아미드유도체의개선된화학적제조방법
US5919756A (en) 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5916873A (en) 1997-04-17 1999-06-29 Eli Lilly And Company Teicoplanin derivatives
US5919771A (en) 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5952310A (en) 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5977063A (en) 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
CA2318394A1 (en) 1998-02-20 1999-08-26 Advanced Medicine, Inc. Novel antibacterial agents
US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
EP1073447B1 (en) 1998-05-01 2007-05-09 Eli Lilly And Company N1-modified glycopeptides
EP1095058A4 (en) 1998-07-14 2003-07-16 Univ Princeton GLYCOPEPTIDANTIBIOTICS, COMBINATIONAL LIBRARIES OF GLYCOPEPTIDANTIBIOTICS AND METHOD FOR THEIR PRODUCTION
IL140093A0 (en) 1998-12-23 2002-02-10 Advanced Medicine Inc Glycopeptide derivatives and pharmaceutical compositions containing the same
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
AU2003231833A1 (en) 2002-05-24 2003-12-12 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
WO2005005436A2 (en) 2003-07-11 2005-01-20 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics

Also Published As

Publication number Publication date
WO2000039156A1 (en) 2000-07-06
NO20006323D0 (no) 2000-12-12
EP1140993A1 (en) 2001-10-10
DE69908819T2 (de) 2004-05-06
SI1140993T1 (en) 2003-12-31
CZ200122A3 (en) 2001-06-13
BR9914221A (pt) 2001-06-26
KR100665204B1 (ko) 2007-01-04
US20040204346A1 (en) 2004-10-14
PT1140993E (pt) 2003-10-31
ATE242783T1 (de) 2003-06-15
PL348451A1 (en) 2002-05-20
US20030060598A1 (en) 2003-03-27
IL140093A0 (en) 2002-02-10
IL140093A (en) 2006-06-11
JP2002533472A (ja) 2002-10-08
NZ508594A (en) 2003-05-30
AU768204B2 (en) 2003-12-04
PL198311B1 (pl) 2008-06-30
US7101964B2 (en) 2006-09-05
ZA200007222B (en) 2002-03-06
US6949681B2 (en) 2005-09-27
DE69908819D1 (de) 2003-07-17
CA2336445A1 (en) 2000-07-06
NO326066B1 (no) 2008-09-08
CZ301184B6 (cs) 2009-12-02
CN1315961A (zh) 2001-10-03
ES2201825T3 (es) 2004-03-16
US6392012B1 (en) 2002-05-21
US7723470B2 (en) 2010-05-25
KR20010085857A (ko) 2001-09-07
DK1140993T3 (da) 2003-10-06
EP1140993B1 (en) 2003-06-11
US8030445B2 (en) 2011-10-04
US6962970B2 (en) 2005-11-08
US20050239690A1 (en) 2005-10-27
BR9914221B1 (pt) 2013-12-31
US20080103292A1 (en) 2008-05-01
JP4362017B2 (ja) 2009-11-11
HUP0400887A3 (en) 2012-09-28
HK1040721A1 (en) 2002-06-21
US7351791B2 (en) 2008-04-01
CA2336445C (en) 2011-07-19
NO20006323L (no) 2001-02-12
US6455669B1 (en) 2002-09-24
US20090215982A1 (en) 2009-08-27
BRPI9914221B8 (pt) 2021-05-25
US6444786B1 (en) 2002-09-03
HU230190B1 (hu) 2015-09-28
US20060241024A1 (en) 2006-10-26
HUP0400887A2 (hu) 2004-08-30
HK1040721B (en) 2003-10-17
AU3127300A (en) 2000-07-31

Similar Documents

Publication Publication Date Title
CN1249081C (zh) 糖肽衍生物或含有它们的药物组合物
CN1223378C (zh) 含有糖肽抗生素和环糊精的药物组合物
CN1034506C (zh) 含糖肽衍生物的药物组合物的制备方法
CN1437611A (zh) 糖肽膦酸盐衍生物
CN1671732A (zh) 纯化糖肽膦酸酯衍生物的方法
CN1425025A (zh) 作为抗菌剂的新颖的脂肽
CN1423656A (zh) 作为抗菌剂的脂肽
CN87106483A (zh) 糖肽抗生素的制备方法
CN1423655A (zh) 作为抗菌剂的新颖的脂肽
CN1129596C (zh) 头孢烯化合物的合成中间体
CN1551887A (zh) 新颖的缩肽和制备它们的方法
CN101065365A (zh) 二苯并二氮杂䓬酮类似物，它们的生产方法和它们作为药物的用途
CN1373770A (zh) 假单胞菌素前药
CN1432023A (zh) 还原性烷基化方法
US20030008812A1 (en) Glycopeptide derivatives
CN1030790A (zh) 有抗生作用的ksb-1939化合物、其制法及含有这类化合物的杀虫剂
CN1279906C (zh) 硫藤黄菌素二氧化物及其衍生物在制备用于治疗cns疾病的药物中的用途及其制备方法
CN1157482C (zh) 具有抗真菌活性的化合物及其制备方法
CN1311794A (zh) 气丝菌素类似物、它们的制备和用途
CN1923196A (zh) 含有左奥硝唑的药物组合物及其应用
CN1325408A (zh) 具有生长激素释放特性的化合物
CN1914221A (zh) 6－11双环酮大环内酯衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: SCHWAN BIOPHARMA ANTIBIOTICS IP CO., LTD.

Free format text: FORMER OWNER: SCHWAN PHARMACY

Effective date: 20140806

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20140806

Address after: American California

Patentee after: THERAVANCE BIOPHARMA ANTIBIOTICS IP LLC

Address before: American California

Patentee before: Shiwan Pharmaceuticals Inc.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20190417

Address after: Tennessee

Patentee after: Cumberland Pharmaceuticals Inc.

Address before: American California

Patentee before: THERAVANCE BIOPHARMA ANTIBIOTICS IP LLC

CX01 Expiry of patent term

Granted publication date: 20060405

CX01 Expiry of patent term