PT1140993E - Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos - Google Patents

Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos

Info

Publication number
PT1140993E
PT1140993E PT99965331T PT99965331T PT1140993E PT 1140993 E PT1140993 E PT 1140993E PT 99965331 T PT99965331 T PT 99965331T PT 99965331 T PT99965331 T PT 99965331T PT 1140993 E PT1140993 E PT 1140993E
Authority
PT
Portugal
Prior art keywords
pharmaceutical compositions
compositions containing
same
derivatives
glycopeptide derivatives
Prior art date
Application number
PT99965331T
Other languages
English (en)
Portuguese (pt)
Inventor
Paul Ross Fatheree
J Kevin Judice
Yongqi Mu
Bernice M T Lam
Michael Leadbetter
Martin Sheringham Linsell
Sean Gary Trapp
Guang Yang
Yan Zhu
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of PT1140993E publication Critical patent/PT1140993E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT99965331T 1998-12-23 1999-12-22 Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos PT1140993E (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11372898P 1998-12-23 1998-12-23
US12931399P 1999-04-14 1999-04-14
US16402499P 1999-11-04 1999-11-04
US16997899P 1999-12-10 1999-12-10

Publications (1)

Publication Number Publication Date
PT1140993E true PT1140993E (pt) 2003-10-31

Family

ID=27493926

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99965331T PT1140993E (pt) 1998-12-23 1999-12-22 Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos

Country Status (23)

Country Link
US (9) US6392012B1 (enExample)
EP (1) EP1140993B1 (enExample)
JP (1) JP4362017B2 (enExample)
KR (1) KR100665204B1 (enExample)
CN (1) CN1249081C (enExample)
AT (1) ATE242783T1 (enExample)
AU (1) AU768204B2 (enExample)
BR (1) BRPI9914221B8 (enExample)
CA (1) CA2336445C (enExample)
CZ (1) CZ301184B6 (enExample)
DE (1) DE69908819T2 (enExample)
DK (1) DK1140993T3 (enExample)
ES (1) ES2201825T3 (enExample)
HK (1) HK1040721B (enExample)
HU (1) HU230190B1 (enExample)
IL (2) IL140093A0 (enExample)
NO (1) NO326066B1 (enExample)
NZ (1) NZ508594A (enExample)
PL (1) PL198311B1 (enExample)
PT (1) PT1140993E (enExample)
SI (1) SI1140993T1 (enExample)
WO (1) WO2000039156A1 (enExample)
ZA (1) ZA200007222B (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2201825T3 (es) * 1998-12-23 2004-03-16 Theravance, Inc. Derivados del glicopeptidos y composiciones farmaceuticas que los contienen.
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
WO2000059528A1 (en) * 1999-04-02 2000-10-12 The Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same
WO2001057071A2 (en) * 2000-02-04 2001-08-09 Advanced Medicine, Inc. Glycopeptide derivatives having antibiotic activity
AU2001259298A1 (en) * 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
WO2001083521A2 (en) 2000-05-02 2001-11-08 Theravance, Inc. Reductive alkylation process on glycopeptides
DE60136926D1 (de) 2000-05-02 2009-01-22 Theravance Inc Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält
ATE388960T1 (de) * 2000-06-22 2008-03-15 Theravance Inc Glykopeptidderivate mit carboxysacchariden
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
WO2001098329A1 (en) * 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
TWI275594B (en) * 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
DE60118737T2 (de) 2001-09-19 2006-10-19 The Procter & Gamble Company, Cincinnati Farbbedruckte Mehrschichtstruktur, ein damit hergestellter absorbierender Artikel und Verfahren zu deren Herstellung
TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
CN101404986B (zh) 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
US20040033986A1 (en) 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
WO2003099858A1 (en) 2002-05-24 2003-12-04 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
WO2003106399A2 (en) 2002-06-17 2003-12-24 Theravance, Inc. PROCESS FOR PREPARING N-PROTECTED β-AMINO ALDEHYDE COMPOUNDS
CN101721412A (zh) * 2002-07-09 2010-06-09 法斯根有限责任公司 治疗人和动物中微生物感染的方法
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
AU2003298662A1 (en) * 2002-11-18 2004-06-15 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
ATE450540T1 (de) * 2003-05-23 2009-12-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika
ATE388153T1 (de) * 2003-07-11 2008-03-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika
DE102004055582A1 (de) * 2004-11-18 2006-05-24 Bayer Cropscience Ag N-Heterocyclyl-phthalsäurediamide
AU2005308160A1 (en) 2004-11-29 2006-06-01 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
US8304597B2 (en) 2004-12-15 2012-11-06 The Procter And Gamble Company Method of using an absorbent article having a functional enhancement indicator
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
WO2007035938A2 (en) 2005-09-22 2007-03-29 Medivas, Llc BIS-(α-AMINO)-DIOL-DIESTER-CONTAINING POLY(ESTER AMIDE) AND POLY(ESTER URETHANE) COMPOSITIONS AND METHODS OF USE
US20070173438A1 (en) * 2006-01-13 2007-07-26 The Scripps Research Institute [PSI[CH2NH]PG4] glycopeptide antibiotic analogs
TW200808818A (en) * 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
WO2009085562A1 (en) * 2007-12-26 2009-07-09 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
JP5517153B2 (ja) 2007-12-26 2014-06-11 塩野義製薬株式会社 グリコペプチド抗生物質配糖化誘導体
WO2009123713A1 (en) 2008-04-01 2009-10-08 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
US20140171357A1 (en) * 2011-03-24 2014-06-19 Seachaid Pharmaceuticals, Inc. Vancomycin derivatives
WO2014152332A1 (en) 2013-03-15 2014-09-25 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
EP3049115A1 (en) * 2013-09-23 2016-08-03 Jawaharlal Nehru Centre For Advanced Scientific Research Vancomycin-sugar conjugates and uses thereof
EP3240574A1 (en) * 2014-12-25 2017-11-08 Jawaharlal Nehru Centre For Advanced Scientific Research Glycopeptides and uses thereof
AU2017207875A1 (en) * 2016-01-15 2018-08-09 Universität Hamburg Methods for the production of rhamnosylated flavonoids
EP3408253A1 (en) * 2016-01-28 2018-12-05 Acatechol, Inc. Photo-cleavable primer compositions and methods of use
CN107325159A (zh) * 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
CA3062570A1 (en) * 2017-05-22 2018-11-29 Insmed Incorporated Lipo-glycopeptide cleavable derivatives and uses thereof
CN107987131B (zh) * 2017-11-16 2021-03-09 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的化合物、其制备方法和应用
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
NL2023883B1 (en) * 2019-09-24 2021-04-26 Univ Leiden Antibiotic compounds
CN111620931B (zh) * 2020-06-12 2021-12-17 苏州博源医疗科技有限公司 万古霉素衍生物及其制备方法和应用
CN114213284B (zh) * 2022-01-04 2023-08-01 丽珠集团福州福兴医药有限公司 (9h-芴-9-基)-癸基(2-氧代乙基)氨基甲酸甲酯及其合成方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497802A (en) 1983-10-21 1985-02-05 Eli Lilly And Company N-Acyl glycopeptide derivatives
GB8428619D0 (en) 1984-11-13 1984-12-19 Lepetit Spa Derivatives of antibiotic l 17046
US4914187A (en) 1984-11-13 1990-04-03 Gruppo Lepetit S.P.A Ester derivatives of antibiotic L 17046
US4698327A (en) 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
GB8704847D0 (en) 1987-03-02 1987-04-08 Lepetit Spa Substituted alkylamides of teicoplanin compounds
FR2632185B1 (fr) * 1988-06-01 1992-05-22 Rhone Poulenc Chimie Silice pour compositions dentifrices compatible notamment avec le zinc
GB8817397D0 (en) * 1988-07-21 1988-08-24 Lepetit Spa N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
US5534420A (en) 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
ATE134646T1 (de) * 1988-12-27 1996-03-15 Lepetit Spa C63-amidderivate von 34-de(acetylglucosaminyl)-34-deoxy-teicoplanine
IE64155B1 (en) * 1989-03-29 1995-07-12 Lepetit Spa New substituted alkylamide derivatives of teicoplanin
ZA909847B (en) 1989-12-13 1992-08-26 Lilly Co Eli Glycopeptide derivatives
AU647122B2 (en) 1990-05-28 1994-03-17 Gruppo Lepetit S.P.A. C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy- teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
WO1992017456A1 (fr) 1991-03-26 1992-10-15 Fujisawa Pharmaceutical Co., Ltd. Derive d'acide amine et sel dudit derive
US5750509A (en) 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
AU666862B2 (en) 1991-07-29 1996-02-29 Vicuron Pharmaceuticals Inc. Amide derivatives of antibiotic A 40926
US5840684A (en) 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
TW457248B (en) 1994-01-28 2001-10-01 Lilly Co Eli Glycopeptide antibiotic derivatives
IT1282586B1 (it) 1996-02-08 1998-03-31 Chemical And Biolog Ind Composizioni farmaceutiche per il trattamento biologico delle infezioni dovute a ceppi di enterococcus faecium resistenti agli
JP2000507246A (ja) 1996-03-21 2000-06-13 トランセル テクノロジーズ インク． 固体相のリポグリコペプチドライブラリー、組成物及び方法
AU2441697A (en) 1996-04-12 1997-11-07 Eli Lilly And Company Covalently-linked glycopeptide dimers
JP4159110B2 (ja) 1996-04-12 2008-10-01 イーライ・リリー・アンド・カンパニー グリコペプチド化合物
ATE208791T1 (de) 1996-04-23 2001-11-15 Biosearch Italia Spa Chemisches verfahren zur herstellung von amidderivaten von a 40926 antibiotikum
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5939382A (en) 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5952466A (en) 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5916873A (en) 1997-04-17 1999-06-29 Eli Lilly And Company Teicoplanin derivatives
US5977063A (en) 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5952310A (en) 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5919771A (en) 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US6518242B1 (en) * 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
WO1999042476A1 (en) 1998-02-20 1999-08-26 Advanced Medicine, Inc. Novel antibacterial agents
EP1073447B1 (en) 1998-05-01 2007-05-09 Eli Lilly And Company N1-modified glycopeptides
JP2002520422A (ja) 1998-07-14 2002-07-09 プリンストン ユニバーシティ グリコペプチド抗生物質、グリコペプチド抗生物質のコンビナトリアルライブラリーおよびその作成方法
ES2201825T3 (es) 1998-12-23 2004-03-16 Theravance, Inc. Derivados del glicopeptidos y composiciones farmaceuticas que los contienen.
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
WO2003099858A1 (en) * 2002-05-24 2003-12-04 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
ATE388153T1 (de) * 2003-07-11 2008-03-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika

Also Published As

Publication number Publication date
CN1315961A (zh) 2001-10-03
US20080103292A1 (en) 2008-05-01
ATE242783T1 (de) 2003-06-15
IL140093A (en) 2006-06-11
NZ508594A (en) 2003-05-30
US20040204346A1 (en) 2004-10-14
US6455669B1 (en) 2002-09-24
NO20006323D0 (no) 2000-12-12
NO20006323L (no) 2001-02-12
JP4362017B2 (ja) 2009-11-11
DE69908819D1 (de) 2003-07-17
US20030060598A1 (en) 2003-03-27
SI1140993T1 (en) 2003-12-31
HUP0400887A2 (hu) 2004-08-30
KR100665204B1 (ko) 2007-01-04
CA2336445A1 (en) 2000-07-06
US20060241024A1 (en) 2006-10-26
DK1140993T3 (da) 2003-10-06
US6392012B1 (en) 2002-05-21
US6962970B2 (en) 2005-11-08
JP2002533472A (ja) 2002-10-08
IL140093A0 (en) 2002-02-10
US20050239690A1 (en) 2005-10-27
BRPI9914221B8 (pt) 2021-05-25
US7723470B2 (en) 2010-05-25
CZ301184B6 (cs) 2009-12-02
US6949681B2 (en) 2005-09-27
BR9914221A (pt) 2001-06-26
HK1040721B (en) 2003-10-17
US20090215982A1 (en) 2009-08-27
HUP0400887A3 (en) 2012-09-28
PL198311B1 (pl) 2008-06-30
US7351791B2 (en) 2008-04-01
AU768204B2 (en) 2003-12-04
HU230190B1 (hu) 2015-09-28
NO326066B1 (no) 2008-09-08
ES2201825T3 (es) 2004-03-16
US6444786B1 (en) 2002-09-03
KR20010085857A (ko) 2001-09-07
US8030445B2 (en) 2011-10-04
HK1040721A1 (en) 2002-06-21
US7101964B2 (en) 2006-09-05
ZA200007222B (en) 2002-03-06
CZ200122A3 (en) 2001-06-13
PL348451A1 (en) 2002-05-20
AU3127300A (en) 2000-07-31
WO2000039156A1 (en) 2000-07-06
CA2336445C (en) 2011-07-19
EP1140993B1 (en) 2003-06-11
CN1249081C (zh) 2006-04-05
EP1140993A1 (en) 2001-10-10
DE69908819T2 (de) 2004-05-06
BR9914221B1 (pt) 2013-12-31

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