UA43323C2 - Антибіотичні похідні глікопептидів, спосіб отримання та фармацевтична композиція - Google Patents

Антибіотичні похідні глікопептидів, спосіб отримання та фармацевтична композиція

Info

Publication number
UA43323C2
UA43323C2 UA95018070A UA95018070A UA43323C2 UA 43323 C2 UA43323 C2 UA 43323C2 UA 95018070 A UA95018070 A UA 95018070A UA 95018070 A UA95018070 A UA 95018070A UA 43323 C2 UA43323 C2 UA 43323C2
Authority
UA
Ukraine
Prior art keywords
glycopeptide antibiotic
preparation
pharmaceutical composition
antibiotic derivatives
derivative compounds
Prior art date
Application number
UA95018070A
Other languages
English (en)
Russian (ru)
Inventor
Робін Девід Грей Купер
Робин Девид Грей Купер
Брет Юджин Хафф
Талія Іоанна Нікас
Талия Иоанна Никас
Джон Томас Куотроуш
Майкл Джон Родрігес
Майкл Джон Родригес
Ненсі Джун Снайдер
Ненси Джун Снайдер
Майкл Александер Стащак
Річард Крейг Томпсон
Ричард Крейг Томпсон
Стівен Чарльз Уілкі
Стивен Чарльз Уилки
Марк Джеймс Звейфель
Original Assignee
Елі Ліллі Енд Компані
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Елі Ліллі Енд Компані, Эли Лилли Энд Компани filed Critical Елі Ліллі Енд Компані
Publication of UA43323C2 publication Critical patent/UA43323C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Даний винахід стосується антибіотичних похідних глікопептидів, що мають антибактеріальну активність, включаючи активність стосовно ізолятів, стійких до ванкоміцину. Запропоновано також способи виготовлення й використання цих сполук.
UA95018070A 1994-01-28 1995-01-24 Антибіотичні похідні глікопептидів, спосіб отримання та фармацевтична композиція UA43323C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18939394A 1994-01-28 1994-01-28
US35641394A 1994-12-15 1994-12-15

Publications (1)

Publication Number Publication Date
UA43323C2 true UA43323C2 (uk) 2001-12-17

Family

ID=26885101

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95018070A UA43323C2 (uk) 1994-01-28 1995-01-24 Антибіотичні похідні глікопептидів, спосіб отримання та фармацевтична композиція

Country Status (30)

Country Link
US (1) US5843889A (uk)
EP (3) EP0667353B1 (uk)
JP (1) JP3756539B2 (uk)
KR (1) KR100388867B1 (uk)
CN (1) CN1071334C (uk)
AT (3) ATE253077T1 (uk)
AU (1) AU703106B2 (uk)
BR (1) BR9500365A (uk)
CA (3) CA2546910C (uk)
CO (1) CO4600679A1 (uk)
CZ (2) CZ292895B6 (uk)
DE (3) DE69532013T2 (uk)
DK (3) DK1016670T3 (uk)
EG (1) EG25884A (uk)
ES (3) ES2220335T3 (uk)
FI (3) FI117095B (uk)
HU (1) HU225164B1 (uk)
IL (1) IL112457A (uk)
MY (1) MY128335A (uk)
NO (1) NO323103B1 (uk)
NZ (1) NZ270387A (uk)
PE (1) PE40996A1 (uk)
PL (1) PL180961B1 (uk)
PT (3) PT667353E (uk)
RU (1) RU2145609C1 (uk)
SG (1) SG52719A1 (uk)
SI (2) SI0667353T1 (uk)
TW (1) TW457248B (uk)
UA (1) UA43323C2 (uk)
YU (1) YU4995A (uk)

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US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
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US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
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US6710168B1 (en) 1999-05-19 2004-03-23 The Trustees Of The University Of Princeton Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
WO2000004044A1 (en) * 1998-07-14 2000-01-27 Princeton University Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
IL140093A0 (en) 1998-12-23 2002-02-10 Advanced Medicine Inc Glycopeptide derivatives and pharmaceutical compositions containing the same
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WO2001081373A2 (en) * 2000-04-25 2001-11-01 Merck & Co., Inc. Glycopeptide antibacterial compounds and methods of using same
US6831150B2 (en) * 2000-05-02 2004-12-14 Theravance, Inc. Reductive alkylation process
WO2001083520A2 (en) 2000-05-02 2001-11-08 Theravance,Inc Polyacid glycopeptide derivatives
EP1292611B1 (en) 2000-06-22 2008-03-12 Theravance, Inc. Glycopeptide carboxy-saccharide derivatives
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
US20050250677A1 (en) * 2002-08-30 2005-11-10 Jan Balzarini Glycopeptide antibiotic derivatives
US20050013854A1 (en) 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
US7521418B2 (en) 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
WO2005018743A1 (en) * 2003-07-22 2005-03-03 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
BRPI0516657A (pt) * 2004-11-29 2008-09-16 Univ Nagoya Nat Univ Corp derivados de monÈmero antibiótico de glicopeptìdeo
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
CN101189380B (zh) 2005-04-01 2012-12-19 博凯技术公司 用于隔音的非织造材料和制造工艺
US8445007B2 (en) 2005-09-22 2013-05-21 Medivas, Llc Bis-(α-amino)-diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use
EP1933881B1 (en) 2005-09-22 2019-03-13 Medivas, LLC Solid polymer delivery compositions and methods for use thereof
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
RU2481354C2 (ru) * 2007-12-26 2013-05-10 Шионоги Энд Ко., Лтд. Гликозилированные гликопептидные антибиотические производные
EP2260060A4 (en) 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
AU2012250568B2 (en) 2011-05-05 2017-06-29 Matinas Biopharma Nanotechnologies, Inc. Cochleate compositions and methods of making and using same
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CN104418941B (zh) * 2013-08-19 2017-11-07 爱斯医药科技(南京)有限公司 万古霉素衍生物、制备方法及其应用
EP3049115A1 (en) 2013-09-23 2016-08-03 Jawaharlal Nehru Centre For Advanced Scientific Research Vancomycin-sugar conjugates and uses thereof
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JP6797795B2 (ja) 2014-11-06 2020-12-09 クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ グリコペプチド組成物
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CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN107434823B (zh) * 2016-05-26 2021-11-16 江苏恒瑞医药股份有限公司 一种奥利万星中间体a82846b的纯化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
CN109053864B (zh) * 2018-07-10 2021-08-24 丽珠集团新北江制药股份有限公司 一种制备奥利万星的方法
CN109053865B (zh) * 2018-07-20 2021-04-13 丽珠集团新北江制药股份有限公司 一种羧基保护制备奥利万星的方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

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Also Published As

Publication number Publication date
RU2145609C1 (ru) 2000-02-20
NO323103B1 (no) 2007-01-02
PE40996A1 (es) 1996-10-14
US5843889A (en) 1998-12-01
KR100388867B1 (ko) 2003-10-08
MY128335A (en) 2007-01-31
DE69532013T2 (de) 2004-07-08
NO950298L (no) 1995-07-31
ATE248856T1 (de) 2003-09-15
FI117097B (fi) 2006-06-15
CZ18495A3 (en) 1995-08-16
JP3756539B2 (ja) 2006-03-15
CA2141106A1 (en) 1995-07-29
ATE253077T1 (de) 2003-11-15
CZ292921B6 (cs) 2004-01-14
AU1138995A (en) 1995-08-10
FI117096B (fi) 2006-06-15
EP1016670A1 (en) 2000-07-05
RU95101039A (ru) 1996-10-27
DE69531709D1 (de) 2003-10-09
DK1031576T3 (da) 2004-08-16
FI117095B (fi) 2006-06-15
HUT68715A (en) 1995-07-28
SI1016670T1 (en) 2004-02-29
CA2546625C (en) 2008-09-09
AU703106B2 (en) 1999-03-18
EP1031576A3 (en) 2000-12-27
BR9500365A (pt) 1995-10-17
ES2210274T3 (es) 2004-07-01
CN1071334C (zh) 2001-09-19
CN1119649A (zh) 1996-04-03
SG52719A1 (en) 1998-09-28
ES2204444T3 (es) 2004-05-01
DE69532013D1 (de) 2003-12-04
CA2546910C (en) 2010-09-14
NZ270387A (en) 1996-11-26
KR950032274A (ko) 1995-12-20
JPH07258289A (ja) 1995-10-09
FI20050512A (fi) 2005-05-13
FI20050513A (fi) 2005-05-13
YU4995A (sh) 1998-07-10
PL306976A1 (en) 1995-08-07
CZ292895B6 (cs) 2003-12-17
IL112457A0 (en) 1995-03-30
PT1031576E (pt) 2004-08-31
HU9500230D0 (en) 1995-03-28
PL180961B1 (pl) 2001-05-31
PT1016670E (pt) 2003-12-31
SI0667353T1 (en) 2004-04-30
NO950298D0 (no) 1995-01-26
EP1016670B1 (en) 2003-09-03
CO4600679A1 (es) 1998-05-08
CA2546625A1 (en) 1995-07-29
DE69533004T2 (de) 2005-04-07
EP0667353B1 (en) 2003-10-29
PT667353E (pt) 2004-03-31
CA2546910A1 (en) 1995-07-29
EP1031576B1 (en) 2004-05-06
DE69531709T2 (de) 2004-07-15
DE69533004D1 (de) 2004-06-09
EP1031576A2 (en) 2000-08-30
IL112457A (en) 2004-06-20
CA2141106C (en) 2007-01-23
FI950374A0 (fi) 1995-01-27
EG25884A (en) 2012-09-24
DK0667353T3 (da) 2004-03-22
FI950374A (fi) 1995-07-29
HU225164B1 (en) 2006-07-28
ES2220335T3 (es) 2004-12-16
DK1016670T3 (da) 2004-01-05
ATE266042T1 (de) 2004-05-15
TW457248B (en) 2001-10-01
EP0667353A1 (en) 1995-08-16

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