PT1031576E - Derivados de antibioticos de glicopeptidos - Google Patents

Derivados de antibioticos de glicopeptidos

Info

Publication number
PT1031576E
PT1031576E PT00201724T PT00201724T PT1031576E PT 1031576 E PT1031576 E PT 1031576E PT 00201724 T PT00201724 T PT 00201724T PT 00201724 T PT00201724 T PT 00201724T PT 1031576 E PT1031576 E PT 1031576E
Authority
PT
Portugal
Prior art keywords
glycopeptidos
antibiotic derivatives
antibiotic
derivatives
mixed
Prior art date
Application number
PT00201724T
Other languages
English (en)
Inventor
Michael Alexander Staszak
Richard Craig Thompson
Michael John Rodriguez
Robin David Grey Cooper
Nancy June Snyder
Mark James Zweifel
Stephen Charles Wilkie
Bret Eugene Huff
Thalia Ioanna Nicas
John Thomas Quatroche
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT1031576E publication Critical patent/PT1031576E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT00201724T 1994-01-28 1995-01-25 Derivados de antibioticos de glicopeptidos PT1031576E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18939394A 1994-01-28 1994-01-28
US35641394A 1994-12-15 1994-12-15

Publications (1)

Publication Number Publication Date
PT1031576E true PT1031576E (pt) 2004-08-31

Family

ID=26885101

Family Applications (3)

Application Number Title Priority Date Filing Date
PT95300429T PT667353E (pt) 1994-01-28 1995-01-25 Derivados de antibioticos glicopeptidicos
PT00200988T PT1016670E (pt) 1994-01-28 1995-01-25 Derivados de antibioticos glicopeptidos
PT00201724T PT1031576E (pt) 1994-01-28 1995-01-25 Derivados de antibioticos de glicopeptidos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT95300429T PT667353E (pt) 1994-01-28 1995-01-25 Derivados de antibioticos glicopeptidicos
PT00200988T PT1016670E (pt) 1994-01-28 1995-01-25 Derivados de antibioticos glicopeptidos

Country Status (30)

Country Link
US (1) US5843889A (pt)
EP (3) EP1031576B1 (pt)
JP (1) JP3756539B2 (pt)
KR (1) KR100388867B1 (pt)
CN (1) CN1071334C (pt)
AT (3) ATE253077T1 (pt)
AU (1) AU703106B2 (pt)
BR (1) BR9500365A (pt)
CA (3) CA2141106C (pt)
CO (1) CO4600679A1 (pt)
CZ (2) CZ292895B6 (pt)
DE (3) DE69532013T2 (pt)
DK (3) DK1016670T3 (pt)
EG (1) EG25884A (pt)
ES (3) ES2220335T3 (pt)
FI (3) FI117095B (pt)
HU (1) HU225164B1 (pt)
IL (1) IL112457A (pt)
MY (1) MY128335A (pt)
NO (1) NO323103B1 (pt)
NZ (1) NZ270387A (pt)
PE (1) PE40996A1 (pt)
PL (1) PL180961B1 (pt)
PT (3) PT667353E (pt)
RU (1) RU2145609C1 (pt)
SG (1) SG52719A1 (pt)
SI (2) SI1016670T1 (pt)
TW (1) TW457248B (pt)
UA (1) UA43323C2 (pt)
YU (1) YU4995A (pt)

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US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5994297A (en) * 1997-08-22 1999-11-30 Eli Lilly And Company Therapy for Staphylococcus aureus
US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
DE69936052T2 (de) 1998-05-01 2008-01-17 Eli Lilly And Co., Indianapolis N1 modifizierte glycopeptide
US6710168B1 (en) 1999-05-19 2004-03-23 The Trustees Of The University Of Princeton Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
JP2002520422A (ja) * 1998-07-14 2002-07-09 プリンストン ユニバーシティ グリコペプチド抗生物質、グリコペプチド抗生物質のコンビナトリアルライブラリーおよびその作成方法
PT1140993E (pt) 1998-12-23 2003-10-31 Theravance Inc Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
WO2001081373A2 (en) * 2000-04-25 2001-11-01 Merck & Co., Inc. Glycopeptide antibacterial compounds and methods of using same
ATE402951T1 (de) * 2000-05-02 2008-08-15 Theravance Inc Verfahren zur reduktiven alkylierung von glykopeptiden
WO2001083520A2 (en) 2000-05-02 2001-11-08 Theravance,Inc Polyacid glycopeptide derivatives
CN1223378C (zh) 2000-05-02 2005-10-19 施万制药 含有糖肽抗生素和环糊精的药物组合物
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
ATE388960T1 (de) 2000-06-22 2008-03-15 Theravance Inc Glykopeptidderivate mit carboxysacchariden
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
JP2006503015A (ja) * 2002-08-30 2006-01-26 カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント グリコペプチド抗生物質誘導体
US20050013854A1 (en) 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
JP2006528704A (ja) 2003-05-27 2006-12-21 セラヴァンス インコーポレーテッド グリコペプチド抗細菌剤と組み合わせたポリエンマクロライド抗真菌剤の使用
ATE381957T1 (de) 2003-07-22 2008-01-15 Theravance Inc Verwendung eines antimykotischen echinocandin- mittels in kombination mit einem antibakteriellen glycopeptid-mittel
CA2588285A1 (en) 2004-11-29 2006-06-01 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
KR101492525B1 (ko) 2005-04-01 2015-02-11 부케예 테크놀로지스 인코포레이티드 방음용 부직포 재료 및 제조방법
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
AU2008342149A1 (en) 2007-12-26 2009-07-02 Shionogi & Co., Ltd. Glycosylated glycopeptide antibiotic derivative
US8841440B2 (en) 2008-04-01 2014-09-23 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
EP2704688B1 (en) 2011-05-05 2019-07-10 Matinas BioPharma Nanotechnologies, Inc. Cochleate compositions and methods of making and using same
CN107759672A (zh) * 2013-08-19 2018-03-06 南京爱斯药业有限公司 万古霉素衍生物、制备方法及其应用
EP3049115A1 (en) 2013-09-23 2016-08-03 Jawaharlal Nehru Centre For Advanced Scientific Research Vancomycin-sugar conjugates and uses thereof
AU2015289602B2 (en) * 2014-07-17 2020-06-25 Abbvie Inc. High purity oritavancin and method of producing same
AU2015341763B2 (en) 2014-11-06 2019-01-17 Xellia Pharmaceuticals Aps Glycopeptide compositions
CA2972276A1 (en) * 2014-12-25 2016-06-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN107434823B (zh) * 2016-05-26 2021-11-16 江苏恒瑞医药股份有限公司 一种奥利万星中间体a82846b的纯化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
CN109053864B (zh) * 2018-07-10 2021-08-24 丽珠集团新北江制药股份有限公司 一种制备奥利万星的方法
CN109053865B (zh) * 2018-07-20 2021-04-13 丽珠集团新北江制药股份有限公司 一种羧基保护制备奥利万星的方法
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

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Also Published As

Publication number Publication date
ES2204444T3 (es) 2004-05-01
CN1071334C (zh) 2001-09-19
DE69531709D1 (de) 2003-10-09
FI117095B (fi) 2006-06-15
SG52719A1 (en) 1998-09-28
IL112457A0 (en) 1995-03-30
EP0667353B1 (en) 2003-10-29
HU225164B1 (en) 2006-07-28
DE69533004D1 (de) 2004-06-09
DE69533004T2 (de) 2005-04-07
NO323103B1 (no) 2007-01-02
PE40996A1 (es) 1996-10-14
UA43323C2 (uk) 2001-12-17
AU703106B2 (en) 1999-03-18
PL306976A1 (en) 1995-08-07
EP1016670A1 (en) 2000-07-05
EP0667353A1 (en) 1995-08-16
EP1031576B1 (en) 2004-05-06
SI1016670T1 (en) 2004-02-29
HUT68715A (en) 1995-07-28
ATE248856T1 (de) 2003-09-15
RU2145609C1 (ru) 2000-02-20
SI0667353T1 (en) 2004-04-30
DK1031576T3 (da) 2004-08-16
PL180961B1 (pl) 2001-05-31
CZ292921B6 (cs) 2004-01-14
CA2141106C (en) 2007-01-23
BR9500365A (pt) 1995-10-17
IL112457A (en) 2004-06-20
FI950374A (fi) 1995-07-29
NZ270387A (en) 1996-11-26
CA2546910C (en) 2010-09-14
EP1031576A3 (en) 2000-12-27
FI117096B (fi) 2006-06-15
FI20050513A (fi) 2005-05-13
PT1016670E (pt) 2003-12-31
US5843889A (en) 1998-12-01
PT667353E (pt) 2004-03-31
NO950298D0 (no) 1995-01-26
ATE266042T1 (de) 2004-05-15
DK0667353T3 (da) 2004-03-22
JP3756539B2 (ja) 2006-03-15
ES2210274T3 (es) 2004-07-01
CA2546910A1 (en) 1995-07-29
CZ18495A3 (en) 1995-08-16
CZ292895B6 (cs) 2003-12-17
CO4600679A1 (es) 1998-05-08
CA2141106A1 (en) 1995-07-29
FI20050512A (fi) 2005-05-13
CA2546625C (en) 2008-09-09
AU1138995A (en) 1995-08-10
ES2220335T3 (es) 2004-12-16
EP1016670B1 (en) 2003-09-03
TW457248B (en) 2001-10-01
EG25884A (en) 2012-09-24
HU9500230D0 (en) 1995-03-28
ATE253077T1 (de) 2003-11-15
CA2546625A1 (en) 1995-07-29
EP1031576A2 (en) 2000-08-30
DK1016670T3 (da) 2004-01-05
JPH07258289A (ja) 1995-10-09
RU95101039A (ru) 1996-10-27
DE69531709T2 (de) 2004-07-15
KR950032274A (ko) 1995-12-20
FI950374A0 (fi) 1995-01-27
DE69532013D1 (de) 2003-12-04
KR100388867B1 (ko) 2003-10-08
MY128335A (en) 2007-01-31
YU4995A (sh) 1998-07-10
CN1119649A (zh) 1996-04-03
FI117097B (fi) 2006-06-15
DE69532013T2 (de) 2004-07-08
NO950298L (no) 1995-07-31

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