UA27105A1 - О-метильhі похідhі азитроміциhу а, що мають аhтибактеріальhу активhість, спосіб їх отримаhhя та проміжhі сполуки - Google Patents

О-метильhі похідhі азитроміциhу а, що мають аhтибактеріальhу активhість, спосіб їх отримаhhя та проміжhі сполуки

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Publication number
UA27105A1
UA27105A1 UA5001127A UA5001127A UA27105A1 UA 27105 A1 UA27105 A1 UA 27105A1 UA 5001127 A UA5001127 A UA 5001127A UA 5001127 A UA5001127 A UA 5001127A UA 27105 A1 UA27105 A1 UA 27105A1
Authority
UA
Ukraine
Prior art keywords
obtaining
derivatives
methyl
azithromicyne
antibacterial activity
Prior art date
Application number
UA5001127A
Other languages
English (en)
Russian (ru)
Inventor
Габріела КОБРЕХЕЛ
Слободан ДЬОКІС
Горяна ЛАЗАРЕВСКІ
Original Assignee
Пліва Фармацойтска, Кемійска, Прерамбена І Козметичка Індустрія С.П.О
Плива Фармацойтска, Кемийска, Прерамбена И Козметичка Индустрия С.П.О
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пліва Фармацойтска, Кемійска, Прерамбена І Козметичка Індустрія С.П.О, Плива Фармацойтска, Кемийска, Прерамбена И Козметичка Индустрия С.П.О filed Critical Пліва Фармацойтска, Кемійска, Прерамбена І Козметичка Індустрія С.П.О
Publication of UA27105A1 publication Critical patent/UA27105A1/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Винахід відноситься до нових напівсинтетичних макролідних антибіотиків азалідного ряду, зокрема, до О-метильних похідних азитроміцину А та їх солей. Воно стосується також способу одержання цих сполук та проміжних продуктів для цієї мети, їх використання у виробництві лікарських засобів, особливо антибактеріальних препаратів.
UA5001127A 1990-07-18 1991-07-17 О-метильhі похідhі азитроміциhу а, що мають аhтибактеріальhу активhість, спосіб їх отримаhhя та проміжhі сполуки UA27105A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU140990 1990-07-18

Publications (1)

Publication Number Publication Date
UA27105A1 true UA27105A1 (uk) 2000-02-28

Family

ID=25554060

Family Applications (1)

Application Number Title Priority Date Filing Date
UA5001127A UA27105A1 (uk) 1990-07-18 1991-07-17 О-метильhі похідhі азитроміциhу а, що мають аhтибактеріальhу активhість, спосіб їх отримаhhя та проміжhі сполуки

Country Status (20)

Country Link
US (1) US5250518A (uk)
EP (1) EP0467331B1 (uk)
JP (1) JP2657132B2 (uk)
CN (1) CN1029738C (uk)
AT (1) ATE129715T1 (uk)
BG (1) BG60593B1 (uk)
CA (1) CA2046956C (uk)
CZ (1) CZ280640B6 (uk)
DE (1) DE69114198T2 (uk)
DK (1) DK0467331T3 (uk)
ES (1) ES2081397T3 (uk)
GR (1) GR3018330T3 (uk)
HR (1) HRP920491B1 (uk)
HU (4) HU221803B1 (uk)
PL (1) PL166379B1 (uk)
RO (1) RO109338B1 (uk)
RU (1) RU2045533C1 (uk)
SI (1) SI9011409A (uk)
SK (1) SK279075B6 (uk)
UA (1) UA27105A1 (uk)

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HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
WO1999020639A2 (en) * 1997-10-16 1999-04-29 Pliva, Farmaceutska Industrija ,Dionicko, Drustvo NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
HRP980646B1 (en) * 1998-12-30 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Novel oleandomycin derivatives
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
AU2001280000A1 (en) 2000-08-23 2002-03-04 Jaweed Mukarram, Siddiqui Mohammed Process for preparation of anhydrous azithromycin
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
CA2476448A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
AU2003264910A1 (en) * 2003-05-30 2005-01-21 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
AU2003267675A1 (en) * 2003-09-02 2005-03-16 Pliva - Istrazivacki Institut D.O.O. O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
AU2006215315B2 (en) * 2005-01-13 2012-02-16 Glaxo Group Limited Macrolides with anti-inflammatory activity
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
AU2010209732B2 (en) * 2009-01-30 2012-12-20 Glaxo Group Limited Anti-inflammatory macrolide
WO2010086350A1 (en) 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases
CN101830949B (zh) * 2009-03-13 2012-05-23 上海医药工业研究院 一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) * 2011-08-28 2013-03-06 山东方明药业集团股份有限公司 聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
EP2831083A4 (en) * 2012-03-27 2016-03-09 Michael W Burnet INFLAMMATORY MAKROLIDE
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
CN110799516A (zh) 2017-04-20 2020-02-14 来兴泰德基金会 作为抗癌剂的包含鏻离子的阿奇霉素衍生物
WO2018193125A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
CA3060509A1 (en) 2017-04-21 2018-10-25 Federica Sotgia Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
CA3060510A1 (en) 2017-04-21 2018-10-25 Lunella Biotech, Inc. Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
EP3624840A4 (en) 2017-05-19 2021-03-10 Lunella Biotech, Inc. ANTIMITOSCINE: TARGETED INHIBITORS OF MITOCHONDRIAL BIOGENESIS TO DESCRIBE CANCER STEM CELLS
MX2019014806A (es) 2017-06-26 2020-02-10 Lunella Biotech Inc Mitocetoscinas: agentes terapeuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en celulas cancerosas.

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US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
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WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
EP0467331B1 (en) 1995-11-02
RU2045533C1 (ru) 1995-10-10
SI9011409A (en) 1995-10-31
HU912408D0 (en) 1991-12-30
HU211659A9 (en) 1995-12-28
CS219591A3 (en) 1992-03-18
DE69114198T2 (de) 1996-06-27
JPH05132497A (ja) 1993-05-28
HU9202619D0 (en) 1992-12-28
SK279075B6 (sk) 1998-06-03
GR3018330T3 (en) 1996-03-31
CN1059728A (zh) 1992-03-25
PL166379B1 (en) 1995-05-31
ES2081397T3 (es) 1996-03-01
DE69114198D1 (de) 1995-12-07
HU221803B1 (hu) 2003-01-28
BG60593B1 (bg) 1995-09-29
CA2046956A1 (en) 1992-01-19
HU9802439D0 (en) 1998-12-28
CN1029738C (zh) 1995-09-13
EP0467331A1 (en) 1992-01-22
HRP920491A2 (en) 1994-08-31
HUT62307A (en) 1993-04-28
JP2657132B2 (ja) 1997-09-24
US5250518A (en) 1993-10-05
DK0467331T3 (da) 1996-02-05
HRP920491B1 (en) 1998-10-31
ATE129715T1 (de) 1995-11-15
HUT59935A (en) 1992-07-28
PL291130A1 (en) 1992-11-16
RO109338B1 (ro) 1995-01-30
HU215158B (hu) 1998-12-28
CZ280640B6 (cs) 1996-03-13
CA2046956C (en) 1999-01-05

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