DE69114198D1 - O-Methylderivate von Azithromycin A, Verfahren und Zwischenverbindungen zu ihrer Herstellung und deren Verwendung zur Herstellung von Heilmitteln. - Google Patents

O-Methylderivate von Azithromycin A, Verfahren und Zwischenverbindungen zu ihrer Herstellung und deren Verwendung zur Herstellung von Heilmitteln.

Info

Publication number
DE69114198D1
DE69114198D1 DE69114198T DE69114198T DE69114198D1 DE 69114198 D1 DE69114198 D1 DE 69114198D1 DE 69114198 T DE69114198 T DE 69114198T DE 69114198 T DE69114198 T DE 69114198T DE 69114198 D1 DE69114198 D1 DE 69114198D1
Authority
DE
Germany
Prior art keywords
azithromycin
intermediates
manufacture
preparation
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69114198T
Other languages
English (en)
Other versions
DE69114198T2 (de
Inventor
Gabrijela Kobrehel
Slobodan Djokic
Gorjana Lazarevski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Farmaceutika dd
Original Assignee
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Application granted granted Critical
Publication of DE69114198D1 publication Critical patent/DE69114198D1/de
Publication of DE69114198T2 publication Critical patent/DE69114198T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69114198T 1990-07-18 1991-07-17 O-Methylderivate von Azithromycin A, Verfahren und Zwischenverbindungen zu ihrer Herstellung und deren Verwendung zur Herstellung von Heilmitteln. Expired - Fee Related DE69114198T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU140990 1990-07-18

Publications (2)

Publication Number Publication Date
DE69114198D1 true DE69114198D1 (de) 1995-12-07
DE69114198T2 DE69114198T2 (de) 1996-06-27

Family

ID=25554060

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69114198T Expired - Fee Related DE69114198T2 (de) 1990-07-18 1991-07-17 O-Methylderivate von Azithromycin A, Verfahren und Zwischenverbindungen zu ihrer Herstellung und deren Verwendung zur Herstellung von Heilmitteln.

Country Status (20)

Country Link
US (1) US5250518A (de)
EP (1) EP0467331B1 (de)
JP (1) JP2657132B2 (de)
CN (1) CN1029738C (de)
AT (1) ATE129715T1 (de)
BG (1) BG60593B1 (de)
CA (1) CA2046956C (de)
CZ (1) CZ280640B6 (de)
DE (1) DE69114198T2 (de)
DK (1) DK0467331T3 (de)
ES (1) ES2081397T3 (de)
GR (1) GR3018330T3 (de)
HR (1) HRP920491B1 (de)
HU (4) HUT59935A (de)
PL (1) PL166379B1 (de)
RO (1) RO109338B1 (de)
RU (1) RU2045533C1 (de)
SI (1) SI9011409A (de)
SK (1) SK279075B6 (de)
UA (1) UA27105A1 (de)

Families Citing this family (39)

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HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
PT1437359E (pt) * 1997-10-16 2007-04-30 Glaxosmithkline Zagreb Novos 3,6-hemicetais da classe dos 9a-azalidos
US6861411B1 (en) * 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
HRP980646B1 (en) * 1998-12-30 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Novel oleandomycin derivatives
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6787342B2 (en) * 2000-02-16 2004-09-07 Merial Limited Paste formulations
DE60114028T2 (de) 2000-08-23 2006-07-13 Wockhardt Ltd. Verfahren zur herstellung von wasserfreiem azithromycin
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
EP1482957A4 (de) 2002-02-15 2006-07-19 Merckle Gmbh Antibiotische konjugate
US20040005641A1 (en) 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
CA2476423A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
WO2004106353A1 (en) * 2003-05-30 2004-12-09 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005021567A1 (en) * 2003-09-02 2005-03-10 Pliva - Istrazivacki Institut D.O.O. O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
KR20070105993A (ko) * 2005-01-13 2007-10-31 글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오. 소염 활성을 갖는 마크로라이드
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
WO2010086350A1 (en) 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases
TW201038277A (en) * 2009-01-30 2010-11-01 Glaxosmithkline Zagreb Anti-inflammatory macrolide
CN101830949B (zh) * 2009-03-13 2012-05-23 上海医药工业研究院 一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) * 2011-08-28 2013-03-06 山东方明药业集团股份有限公司 聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
AU2013239679A1 (en) 2012-03-27 2014-10-30 Michael W. BURNET Anti-inflammatory macrolides
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
US11427606B2 (en) 2017-04-20 2022-08-30 Rising Tide Foundation Azithromycin derivatives containing a phosphonium ion as anticancer agents
JP2020517748A (ja) * 2017-04-20 2020-06-18 ライジング タイド ファウンデーション 抗がん剤としてホスホニウムイオンを含むアジスロマイシン誘導体
CA3060510A1 (en) 2017-04-21 2018-10-25 Lunella Biotech, Inc. Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
WO2018195446A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
PE20200605A1 (es) 2017-05-19 2020-03-10 Lunella Biotech Inc Antimitoscinas: inhibidores especificos de la biogenesis mitocondrial para erradicar celulas madre cancerosas
US12006553B2 (en) 2017-05-19 2024-06-11 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
CU20190106A7 (es) 2017-06-26 2020-11-30 Lunella Biotech Inc Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (de) * 1984-12-08 1986-10-29 Beecham Group Plc Erythromycinderivate
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
ATE129715T1 (de) 1995-11-15
BG94837A (bg) 1993-12-24
EP0467331B1 (de) 1995-11-02
CS219591A3 (en) 1992-03-18
PL166379B1 (en) 1995-05-31
DK0467331T3 (da) 1996-02-05
HU9802439D0 (en) 1998-12-28
BG60593B1 (bg) 1995-09-29
HU221803B1 (hu) 2003-01-28
US5250518A (en) 1993-10-05
DE69114198T2 (de) 1996-06-27
CZ280640B6 (cs) 1996-03-13
UA27105A1 (uk) 2000-02-28
CA2046956C (en) 1999-01-05
SK279075B6 (sk) 1998-06-03
HU912408D0 (en) 1991-12-30
HU211659A9 (en) 1995-12-28
GR3018330T3 (en) 1996-03-31
HUT62307A (en) 1993-04-28
HUT59935A (en) 1992-07-28
HU9202619D0 (en) 1992-12-28
PL291130A1 (en) 1992-11-16
CN1059728A (zh) 1992-03-25
CN1029738C (zh) 1995-09-13
JPH05132497A (ja) 1993-05-28
SI9011409A (en) 1995-10-31
HU215158B (hu) 1998-12-28
EP0467331A1 (de) 1992-01-22
HRP920491B1 (en) 1998-10-31
ES2081397T3 (es) 1996-03-01
HRP920491A2 (en) 1994-08-31
RU2045533C1 (ru) 1995-10-10
RO109338B1 (ro) 1995-01-30
CA2046956A1 (en) 1992-01-19
JP2657132B2 (ja) 1997-09-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee