HRP920491B1 - O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals - Google Patents

O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Info

Publication number
HRP920491B1
HRP920491B1 HRP-1409/90A HRP920491A HRP920491B1 HR P920491 B1 HRP920491 B1 HR P920491B1 HR P920491 A HRP920491 A HR P920491A HR P920491 B1 HRP920491 B1 HR P920491B1
Authority
HR
Croatia
Prior art keywords
preparation
azithromycin
pharmaceuticals
intermediates
methyl derivatives
Prior art date
Application number
HRP-1409/90A
Other languages
English (en)
Inventor
Slobodan Dokic
Original Assignee
Slobodan Dokic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slobodan Dokic filed Critical Slobodan Dokic
Priority to HRP-1409/90A priority Critical patent/HRP920491B1/xx
Publication of HRP920491A2 publication Critical patent/HRP920491A2/hr
Publication of HRP920491B1 publication Critical patent/HRP920491B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HRP-1409/90A 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals HRP920491B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HRP-1409/90A HRP920491B1 (en) 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YU140990 1990-07-18
HRP-1409/90A HRP920491B1 (en) 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Publications (2)

Publication Number Publication Date
HRP920491A2 HRP920491A2 (en) 1994-08-31
HRP920491B1 true HRP920491B1 (en) 1998-10-31

Family

ID=25554060

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-1409/90A HRP920491B1 (en) 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Country Status (20)

Country Link
US (1) US5250518A (xx)
EP (1) EP0467331B1 (xx)
JP (1) JP2657132B2 (xx)
CN (1) CN1029738C (xx)
AT (1) ATE129715T1 (xx)
BG (1) BG60593B1 (xx)
CA (1) CA2046956C (xx)
CZ (1) CZ280640B6 (xx)
DE (1) DE69114198T2 (xx)
DK (1) DK0467331T3 (xx)
ES (1) ES2081397T3 (xx)
GR (1) GR3018330T3 (xx)
HR (1) HRP920491B1 (xx)
HU (4) HU215158B (xx)
PL (1) PL166379B1 (xx)
RO (1) RO109338B1 (xx)
RU (1) RU2045533C1 (xx)
SI (1) SI9011409A (xx)
SK (1) SK279075B6 (xx)
UA (1) UA27105A1 (xx)

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HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
HUP0004085A3 (en) * 1997-10-16 2003-05-28 Pliva Pharm & Chem Works Novel 3,6-hemiketals from the class of 9a-azalides
US6861411B1 (en) * 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
HRP980646B1 (en) * 1998-12-30 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Novel oleandomycin derivatives
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6787342B2 (en) * 2000-02-16 2004-09-07 Merial Limited Paste formulations
WO2002015842A2 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
EP1483579A4 (en) 2002-02-15 2006-07-12 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THE PREPARATION AND USE OF CONJUGATES, FORMULATION AND PHARMACEUTICAL APPLICATIONS OBTAINED FROM SUCH CONJUGATES
US20050171342A1 (en) 2002-02-15 2005-08-04 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070254A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
AU2003264910A1 (en) * 2003-05-30 2005-01-21 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
AU2003267675A1 (en) * 2003-09-02 2005-03-16 Pliva - Istrazivacki Institut D.O.O. O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
DE602006015919D1 (de) * 2005-01-13 2010-09-16 Glaxosmithkline Zagreb Makrolide mit entzündungshemmender wirkung
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
AR075340A1 (es) 2009-01-30 2011-03-23 Glaxosmithkline Zagreb 3'-n-desmetil-4''-o-(2-dietilaminoetanoil)-6-o-metil-9a-aza-9a-homoeritromicina a,formas cristalinas 1, 2 y 3, proceso para su preparacion, composicion farmaceutica que lo comprende y su uso para la preparacion de un medicamento util para el tratamiento de enfermedades inflamatorias
WO2010086350A1 (en) 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases
CN101830949B (zh) * 2009-03-13 2012-05-23 上海医药工业研究院 一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) * 2011-08-28 2013-03-06 山东方明药业集团股份有限公司 聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
WO2013148874A1 (en) * 2012-03-27 2013-10-03 Burnet Michael W Anti-inflammatory macrolides
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
JP2020517749A (ja) * 2017-04-20 2020-06-18 ライジング タイド ファウンデーション 抗がん剤としてホスホニウムイオンを含むアジスロマイシン誘導体
US11560395B2 (en) 2017-04-20 2023-01-24 Rising Tide Foundation Azithromycin derivatives containing a phosphonium ion as anticancer agents
WO2018195434A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
US11229657B2 (en) 2017-04-21 2022-01-25 Lunella Biotech, Inc. Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy
US12006553B2 (en) 2017-05-19 2024-06-11 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
RU2019142102A (ru) 2017-05-19 2021-06-21 Лунелла Байотек, Инк. Антимитосцины: направленные ингибиторы митохондриального биогенеза для эрадикации злокачественных стволовых клеток
CU20190106A7 (es) 2017-06-26 2020-11-30 Lunella Biotech Inc Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (en) * 1984-12-08 1986-10-29 Beecham Group Plc Erythromycin derivatives
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
HU215158B (hu) 1998-12-28
SI9011409A (en) 1995-10-31
JP2657132B2 (ja) 1997-09-24
CA2046956A1 (en) 1992-01-19
BG94837A (bg) 1993-12-24
HUT59935A (en) 1992-07-28
CZ280640B6 (cs) 1996-03-13
EP0467331B1 (en) 1995-11-02
DE69114198T2 (de) 1996-06-27
HU9802439D0 (en) 1998-12-28
JPH05132497A (ja) 1993-05-28
ES2081397T3 (es) 1996-03-01
HU9202619D0 (en) 1992-12-28
CA2046956C (en) 1999-01-05
PL291130A1 (en) 1992-11-16
RO109338B1 (ro) 1995-01-30
EP0467331A1 (en) 1992-01-22
CN1059728A (zh) 1992-03-25
US5250518A (en) 1993-10-05
BG60593B1 (bg) 1995-09-29
HU221803B1 (hu) 2003-01-28
ATE129715T1 (de) 1995-11-15
PL166379B1 (en) 1995-05-31
DE69114198D1 (de) 1995-12-07
SK279075B6 (sk) 1998-06-03
CN1029738C (zh) 1995-09-13
DK0467331T3 (da) 1996-02-05
HUT62307A (en) 1993-04-28
UA27105A1 (uk) 2000-02-28
HRP920491A2 (en) 1994-08-31
HU912408D0 (en) 1991-12-30
HU211659A9 (en) 1995-12-28
RU2045533C1 (ru) 1995-10-10
CS219591A3 (en) 1992-03-18
GR3018330T3 (en) 1996-03-31

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B1PR Patent granted
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Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,

PPPP Transfer of rights

Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR

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Payment date: 20070713

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Effective date: 20080719