BG60593B1 - О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати - Google Patents

О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати Download PDF

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Publication number
BG60593B1
BG60593B1 BG94837A BG9483791A BG60593B1 BG 60593 B1 BG60593 B1 BG 60593B1 BG 94837 A BG94837 A BG 94837A BG 9483791 A BG9483791 A BG 9483791A BG 60593 B1 BG60593 B1 BG 60593B1
Authority
BG
Bulgaria
Prior art keywords
same
methyl
denote
hydrogen
benzyloxycarbonyl
Prior art date
Application number
BG94837A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG94837A (bg
Inventor
Gabrijela Kobrehel
Slobodan Djokic
Gorjana Lazarevski
Original Assignee
Pliva Farmaceutska,Kemijska,Prehrambena I Kozmetickaindustrija, Dionicko Drustvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pliva Farmaceutska,Kemijska,Prehrambena I Kozmetickaindustrija, Dionicko Drustvo filed Critical Pliva Farmaceutska,Kemijska,Prehrambena I Kozmetickaindustrija, Dionicko Drustvo
Publication of BG94837A publication Critical patent/BG94837A/bg
Publication of BG60593B1 publication Critical patent/BG60593B1/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG94837A 1990-07-18 1991-07-17 О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати BG60593B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU140990 1990-07-18

Publications (2)

Publication Number Publication Date
BG94837A BG94837A (bg) 1993-12-24
BG60593B1 true BG60593B1 (bg) 1995-09-29

Family

ID=25554060

Family Applications (1)

Application Number Title Priority Date Filing Date
BG94837A BG60593B1 (bg) 1990-07-18 1991-07-17 О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати

Country Status (20)

Country Link
US (1) US5250518A (de)
EP (1) EP0467331B1 (de)
JP (1) JP2657132B2 (de)
CN (1) CN1029738C (de)
AT (1) ATE129715T1 (de)
BG (1) BG60593B1 (de)
CA (1) CA2046956C (de)
CZ (1) CZ280640B6 (de)
DE (1) DE69114198T2 (de)
DK (1) DK0467331T3 (de)
ES (1) ES2081397T3 (de)
GR (1) GR3018330T3 (de)
HR (1) HRP920491B1 (de)
HU (4) HUT59935A (de)
PL (1) PL166379B1 (de)
RO (1) RO109338B1 (de)
RU (1) RU2045533C1 (de)
SI (1) SI9011409A (de)
SK (1) SK279075B6 (de)
UA (1) UA27105A1 (de)

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HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
US6369035B1 (en) * 1997-10-16 2002-04-09 Pliva, Farmaceutska Industrja, Dioni{Haeck Over (C)}Ko Dru{Haeck Over (S)}Tvo 3,6-hemiketals from the class of 9A-azalides
US6861411B1 (en) * 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
HRP980646B1 (en) * 1998-12-30 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Novel oleandomycin derivatives
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6787342B2 (en) * 2000-02-16 2004-09-07 Merial Limited Paste formulations
ATE306491T1 (de) 2000-08-23 2005-10-15 Wockhardt Ltd Verfahren zur herstellung von wasserfreiem azithromycin
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1482957A4 (de) 2002-02-15 2006-07-19 Merckle Gmbh Antibiotische konjugate
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
AU2003264910A1 (en) * 2003-05-30 2005-01-21 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005021567A1 (en) * 2003-09-02 2005-03-10 Pliva - Istrazivacki Institut D.O.O. O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US8080529B2 (en) * 2005-01-13 2011-12-20 Glaxo Group Limited Macrolides with anti-inflammatory activity
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
KR20110099791A (ko) 2009-01-30 2011-09-08 글락소 그룹 리미티드 항염증 마크롤리드
WO2010086350A1 (en) 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases
CN101830949B (zh) * 2009-03-13 2012-05-23 上海医药工业研究院 一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) * 2011-08-28 2013-03-06 山东方明药业集团股份有限公司 聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
CA2869461A1 (en) * 2012-03-27 2013-10-03 Michael W. BURNET Anti-inflammatory macrolides
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
CN110799516A (zh) 2017-04-20 2020-02-14 来兴泰德基金会 作为抗癌剂的包含鏻离子的阿奇霉素衍生物
WO2018193125A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
CA3060509A1 (en) 2017-04-21 2018-10-25 Federica Sotgia Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
US11197872B2 (en) 2017-04-21 2021-12-14 Lunella Biotech, Inc. Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
CR20190524A (es) 2017-05-19 2020-01-10 Lunella Biotech Inc Antimitoscinas: inhibidores específicos de la biogénesis mitocondrial para erradicar células madre cancerosas
US12006553B2 (en) 2017-05-19 2024-06-11 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
CR20200033A (es) 2017-06-26 2020-03-05 Lunella Biotech Inc Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (de) * 1984-12-08 1986-10-29 Beecham Group Plc Erythromycinderivate
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
HU215158B (hu) 1998-12-28
GR3018330T3 (en) 1996-03-31
HUT62307A (en) 1993-04-28
CN1029738C (zh) 1995-09-13
HUT59935A (en) 1992-07-28
PL166379B1 (en) 1995-05-31
SI9011409A (en) 1995-10-31
JP2657132B2 (ja) 1997-09-24
DE69114198D1 (de) 1995-12-07
CZ280640B6 (cs) 1996-03-13
HU9802439D0 (en) 1998-12-28
CA2046956A1 (en) 1992-01-19
UA27105A1 (uk) 2000-02-28
EP0467331B1 (de) 1995-11-02
BG94837A (bg) 1993-12-24
RU2045533C1 (ru) 1995-10-10
CS219591A3 (en) 1992-03-18
RO109338B1 (ro) 1995-01-30
DE69114198T2 (de) 1996-06-27
HU211659A9 (en) 1995-12-28
EP0467331A1 (de) 1992-01-22
ES2081397T3 (es) 1996-03-01
HU221803B1 (hu) 2003-01-28
PL291130A1 (en) 1992-11-16
HRP920491A2 (en) 1994-08-31
HU912408D0 (en) 1991-12-30
CA2046956C (en) 1999-01-05
HU9202619D0 (en) 1992-12-28
US5250518A (en) 1993-10-05
ATE129715T1 (de) 1995-11-15
CN1059728A (zh) 1992-03-25
DK0467331T3 (da) 1996-02-05
JPH05132497A (ja) 1993-05-28
HRP920491B1 (en) 1998-10-31
SK279075B6 (sk) 1998-06-03

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