CN1243766C - 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物 - Google Patents

4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物 Download PDF

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Publication number
CN1243766C
CN1243766C CNB2004100491122A CN200410049112A CN1243766C CN 1243766 C CN1243766 C CN 1243766C CN B2004100491122 A CNB2004100491122 A CN B2004100491122A CN 200410049112 A CN200410049112 A CN 200410049112A CN 1243766 C CN1243766 C CN 1243766C
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China
Prior art keywords
compound
solution
general formula
added
compounds
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Expired - Lifetime
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CNB2004100491122A
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English (en)
Chinese (zh)
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CN1566129A (zh
Inventor
B·S·布罗克
M·A·勒塔威克
金子卓史
秉薇·V·杨
E·A·格拉瑟
程恒淼
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Zoetis LLC
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Pfizer Products Inc
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Publication of CN1566129A publication Critical patent/CN1566129A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB2004100491122A 1997-06-11 1998-05-29 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物 Expired - Lifetime CN1243766C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
US60/049,348 1997-06-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB988059223A Division CN1172947C (zh) 1997-06-11 1998-05-29 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2006100513455A Division CN1793155B (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Publications (2)

Publication Number Publication Date
CN1566129A CN1566129A (zh) 2005-01-19
CN1243766C true CN1243766C (zh) 2006-03-01

Family

ID=21959336

Family Applications (4)

Application Number Title Priority Date Filing Date
CNB2004100491122A Expired - Lifetime CN1243766C (zh) 1997-06-11 1998-05-29 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物
CN2006100513455A Expired - Lifetime CN1793155B (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CNB988059223A Expired - Lifetime CN1172947C (zh) 1997-06-11 1998-05-29 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN200910145318A Pending CN101691390A (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN2006100513455A Expired - Lifetime CN1793155B (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CNB988059223A Expired - Lifetime CN1172947C (zh) 1997-06-11 1998-05-29 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN200910145318A Pending CN101691390A (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Country Status (49)

Country Link
US (4) US6420536B1 (OSRAM)
EP (1) EP0988310B9 (OSRAM)
JP (2) JP3315704B2 (OSRAM)
KR (1) KR100396168B1 (OSRAM)
CN (4) CN1243766C (OSRAM)
AP (1) AP1231A (OSRAM)
AR (1) AR013086A1 (OSRAM)
AT (1) ATE251173T1 (OSRAM)
AU (1) AU749816B2 (OSRAM)
BG (1) BG64391B1 (OSRAM)
BR (1) BRPI9810519B8 (OSRAM)
CA (1) CA2293823C (OSRAM)
CO (1) CO4950611A1 (OSRAM)
CZ (1) CZ298556B6 (OSRAM)
DE (2) DE69818665T2 (OSRAM)
DK (1) DK0988310T3 (OSRAM)
DZ (1) DZ2514A1 (OSRAM)
EA (1) EA002441B1 (OSRAM)
EG (1) EG24081A (OSRAM)
ES (1) ES2205487T3 (OSRAM)
FR (1) FR04C0013I2 (OSRAM)
GT (1) GT199800077A (OSRAM)
HN (1) HN1998000086A (OSRAM)
HR (1) HRP980314B1 (OSRAM)
HU (2) HU228005B1 (OSRAM)
ID (1) ID22992A (OSRAM)
IL (1) IL132809A0 (OSRAM)
IS (1) IS1998B (OSRAM)
LU (1) LU91076I9 (OSRAM)
MA (1) MA24564A1 (OSRAM)
ME (1) ME00876B (OSRAM)
MY (1) MY123354A (OSRAM)
NL (1) NL300150I2 (OSRAM)
NO (1) NO316911B1 (OSRAM)
NZ (2) NZ514871A (OSRAM)
OA (1) OA11224A (OSRAM)
PA (1) PA8452201A1 (OSRAM)
PE (1) PE79699A1 (OSRAM)
PL (1) PL191601B1 (OSRAM)
PT (1) PT988310E (OSRAM)
RS (1) RS49675B (OSRAM)
SI (1) SI0988310T1 (OSRAM)
SK (1) SK284171B6 (OSRAM)
TN (1) TNSN98082A1 (OSRAM)
TW (1) TW472060B (OSRAM)
UA (1) UA67744C2 (OSRAM)
UY (1) UY25040A1 (OSRAM)
WO (1) WO1998056802A1 (OSRAM)
ZA (1) ZA985017B (OSRAM)

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CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
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CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
GT199800077A (es) 1999-12-02
NO996106L (no) 2000-02-10
DE122004000018I1 (de) 2004-09-30
SK168399A3 (en) 2000-11-07
ME00876B (me) 2012-06-20
LU91076I2 (fr) 2004-07-05
EP0988310A1 (en) 2000-03-29
BG103945A (en) 2000-07-31
AP1231A (en) 2003-12-11
NL300150I2 (nl) 2004-09-01
YU58699A (OSRAM) 2002-08-12
DE122004000018I2 (de) 2011-01-13
NL300150I1 (nl) 2004-08-02
CZ442199A3 (cs) 2000-07-12
HRP980314B1 (en) 2004-04-30
HK1028048A1 (en) 2001-02-02
HK1088014A1 (zh) 2006-10-27
ES2205487T3 (es) 2004-05-01
CN1172947C (zh) 2004-10-27
NZ500660A (en) 2002-03-01
PA8452201A1 (es) 2000-05-24
EA199901015A1 (ru) 2000-06-26
PE79699A1 (es) 1999-08-25
OA11224A (en) 2003-07-16
TW472060B (en) 2002-01-11
JP3315704B2 (ja) 2002-08-19
CN1566129A (zh) 2005-01-19
US6420536B1 (en) 2002-07-16
AU749816B2 (en) 2002-07-04
BRPI9810519B1 (pt) 2012-02-22
BRPI9810519A (pt) 2000-09-19
DE69818665T2 (de) 2004-04-29
HUP0002209A2 (hu) 2000-12-28
HK1068893A1 (en) 2005-07-29
EP0988310B1 (en) 2003-10-01
CO4950611A1 (es) 2000-09-01
LU91076I9 (en) 2018-07-02
UA67744C2 (uk) 2004-07-15
EA002441B1 (ru) 2002-04-25
CA2293823A1 (en) 1998-12-17
PL191601B1 (pl) 2006-06-30
ATE251173T1 (de) 2003-10-15
FR04C0013I2 (OSRAM) 2005-10-21
WO1998056802A1 (en) 1998-12-17
CN1793155A (zh) 2006-06-28
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
US6936592B2 (en) 2005-08-30
SI0988310T1 (en) 2004-02-29
US20040023896A1 (en) 2004-02-05
JP2000514098A (ja) 2000-10-24
ID22992A (id) 1999-12-23
IS5252A (is) 1999-11-16
ZA985017B (en) 1999-12-17
RS49675B (sr) 2007-11-15
HU228005B1 (en) 2012-08-28
JP2002316933A (ja) 2002-10-31
CN101691390A (zh) 2010-04-07
PL337505A1 (en) 2000-08-28
US20040180842A1 (en) 2004-09-16
CN1259136A (zh) 2000-07-05
BRPI9810519B8 (pt) 2022-11-16
AU7347598A (en) 1998-12-30
US20020061858A1 (en) 2002-05-23
DE69818665D1 (de) 2003-11-06
NO996106D0 (no) 1999-12-10
SK284171B6 (sk) 2004-10-05
HRP980314A2 (en) 1999-04-30
CA2293823C (en) 2004-02-17
DK0988310T3 (da) 2003-12-15
IL132809A0 (en) 2001-03-19
KR20010013632A (ko) 2001-02-26
PT988310E (pt) 2003-12-31
MY123354A (en) 2006-05-31
HUS1200028I1 (hu) 2016-08-29
NZ514871A (en) 2003-08-29
NO316911B1 (no) 2004-06-21
MA24564A1 (fr) 1998-12-31
TNSN98082A1 (fr) 2005-03-15
DZ2514A1 (fr) 2003-02-01
KR100396168B1 (ko) 2003-08-27
HUP0002209A3 (en) 2003-05-28
UY25040A1 (es) 2000-09-29
AP9801255A0 (en) 1998-06-30
HN1998000086A (es) 1999-03-08
EG24081A (en) 2008-05-11
FR04C0013I1 (OSRAM) 2004-06-11
CN1793155B (zh) 2010-05-12
CZ298556B6 (cs) 2007-11-07
BG64391B1 (bg) 2004-12-30
IS1998B (is) 2005-03-15
US6777393B2 (en) 2004-08-17

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