CN1222528C - 提纯克拉布兰酸盐的方法 - Google Patents

提纯克拉布兰酸盐的方法 Download PDF

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Publication number
CN1222528C
CN1222528C CNB018094236A CN01809423A CN1222528C CN 1222528 C CN1222528 C CN 1222528C CN B018094236 A CNB018094236 A CN B018094236A CN 01809423 A CN01809423 A CN 01809423A CN 1222528 C CN1222528 C CN 1222528C
Authority
CN
China
Prior art keywords
acid
salt
clablanic
medium
impurities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018094236A
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English (en)
Chinese (zh)
Other versions
CN1429227A (zh
Inventor
张国
约翰·麦克奈特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26244256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1222528(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0011519A external-priority patent/GB0011519D0/en
Priority claimed from GB0011521A external-priority patent/GB0011521D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1429227A publication Critical patent/CN1429227A/zh
Application granted granted Critical
Publication of CN1222528C publication Critical patent/CN1222528C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
CNB018094236A 2000-05-13 2001-05-09 提纯克拉布兰酸盐的方法 Expired - Lifetime CN1222528C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0011519A GB0011519D0 (en) 2000-05-13 2000-05-13 Process
GB0011519.6 2000-05-13
GB0011521.2 2000-05-13
GB0011521A GB0011521D0 (en) 2000-05-13 2000-05-13 Process

Publications (2)

Publication Number Publication Date
CN1429227A CN1429227A (zh) 2003-07-09
CN1222528C true CN1222528C (zh) 2005-10-12

Family

ID=26244256

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018094236A Expired - Lifetime CN1222528C (zh) 2000-05-13 2001-05-09 提纯克拉布兰酸盐的方法

Country Status (23)

Country Link
US (1) US7767823B2 (enExample)
EP (1) EP1284978B2 (enExample)
JP (1) JP4954421B2 (enExample)
KR (1) KR100827898B1 (enExample)
CN (1) CN1222528C (enExample)
AT (1) ATE273982T1 (enExample)
AU (1) AU776184B2 (enExample)
BR (1) BRPI0110774B8 (enExample)
CA (1) CA2408853C (enExample)
CZ (1) CZ304775B6 (enExample)
DE (1) DE60105016T3 (enExample)
DK (1) DK1284978T4 (enExample)
ES (1) ES2225524T5 (enExample)
HU (1) HU228593B1 (enExample)
IL (2) IL152643A0 (enExample)
MX (1) MXPA02011192A (enExample)
NO (1) NO328528B1 (enExample)
NZ (1) NZ522414A (enExample)
PL (1) PL206316B1 (enExample)
PT (1) PT1284978E (enExample)
SI (1) SI1284978T2 (enExample)
WO (1) WO2001087891A1 (enExample)
ZA (1) ZA200209141B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108558909A (zh) * 2018-05-17 2018-09-21 国药集团威奇达药业有限公司 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1284978E (pt) 2000-05-13 2004-12-31 Smithkline Beecham Plc Processo para a purificacao de um sal de acido clavulanico
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
JP2019527214A (ja) 2016-07-14 2019-09-26 アカオジェン インコーポレイテッド 細菌感染症の処置における使用のためのセフチブテンとクラブラン酸の組み合わせ
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法
CN109535184B (zh) * 2017-09-21 2020-11-20 联邦制药(内蒙古)有限公司 一种克拉维酸叔辛胺制备克拉维酸钾的方法
KR20220031043A (ko) 2019-07-05 2022-03-11 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 스트렙토미세스 클라불리게루스

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GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB2003863B (en) 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
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GB2204944B (en) 1987-05-18 1991-10-02 Frederick John Anderson Rechargeable light
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AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
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US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
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AT400846B (de) 1994-02-25 1996-03-25 Fermic S A De C V Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
WO1997005143A1 (en) * 1995-07-25 1997-02-13 Asahi Kasei Kogyo Kabushiki Kaisha Novel group 4 transition metal compounds
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
BR9713339A (pt) * 1996-11-11 2000-05-09 Gist Brocades Bv Processo para preparação de sais e ésteres do ácido clavulânico.
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
RO120653B1 (ro) * 1997-04-22 2006-05-30 Gist-Brocades B.V. Procedeu îmbunătăţit pentru preparare de cefalosporine
CA2337072A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
PT1284978E (pt) 2000-05-13 2004-12-31 Smithkline Beecham Plc Processo para a purificacao de um sal de acido clavulanico

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108558909A (zh) * 2018-05-17 2018-09-21 国药集团威奇达药业有限公司 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法

Also Published As

Publication number Publication date
BRPI0110774B8 (pt) 2021-05-25
PL206316B1 (pl) 2010-07-30
ZA200209141B (en) 2003-12-31
NO328528B1 (no) 2010-03-08
WO2001087891A1 (en) 2001-11-22
SI1284978T2 (sl) 2008-12-31
CZ20023723A3 (cs) 2003-05-14
IL152643A (en) 2012-12-31
NZ522414A (en) 2004-05-28
BRPI0110774B1 (pt) 2015-07-07
CA2408853C (en) 2012-01-10
MXPA02011192A (es) 2003-03-10
DE60105016D1 (de) 2004-09-23
ATE273982T1 (de) 2004-09-15
KR100827898B1 (ko) 2008-05-07
JP4954421B2 (ja) 2012-06-13
ES2225524T5 (es) 2009-03-01
HUP0300869A3 (en) 2003-10-28
DE60105016T3 (de) 2009-06-25
EP1284978A1 (en) 2003-02-26
CA2408853A1 (en) 2001-11-22
DK1284978T4 (da) 2009-01-05
IL152643A0 (en) 2003-06-24
PT1284978E (pt) 2004-12-31
AU5243201A (en) 2001-11-26
HU228593B1 (en) 2013-04-29
AU776184B2 (en) 2004-09-02
NO20025422D0 (no) 2002-11-12
US20060079676A1 (en) 2006-04-13
CZ304775B6 (cs) 2014-10-15
JP2003533529A (ja) 2003-11-11
DE60105016T2 (de) 2005-08-18
NO20025422L (no) 2003-01-07
EP1284978B2 (en) 2008-09-10
US7767823B2 (en) 2010-08-03
ES2225524T3 (es) 2005-03-16
HK1055111A1 (en) 2003-12-24
PL358368A1 (en) 2004-08-09
CN1429227A (zh) 2003-07-09
DK1284978T3 (da) 2004-12-13
BR0110774A (pt) 2003-05-13
KR20030014222A (ko) 2003-02-15
SI1284978T1 (en) 2005-02-28
HUP0300869A2 (hu) 2003-08-28
EP1284978B1 (en) 2004-08-18

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