DE60105016D1 - Verfahren zur reinigung eines salzes der clavulansäure - Google Patents
Verfahren zur reinigung eines salzes der clavulansäureInfo
- Publication number
- DE60105016D1 DE60105016D1 DE60105016T DE60105016T DE60105016D1 DE 60105016 D1 DE60105016 D1 DE 60105016D1 DE 60105016 T DE60105016 T DE 60105016T DE 60105016 T DE60105016 T DE 60105016T DE 60105016 D1 DE60105016 D1 DE 60105016D1
- Authority
- DE
- Germany
- Prior art keywords
- salt
- acid
- clavulic
- purifying
- exposed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0011519A GB0011519D0 (en) | 2000-05-13 | 2000-05-13 | Process |
| GB0011521A GB0011521D0 (en) | 2000-05-13 | 2000-05-13 | Process |
| GB0011519 | 2000-05-13 | ||
| GB0011521 | 2000-05-13 | ||
| PCT/GB2001/002025 WO2001087891A1 (en) | 2000-05-13 | 2001-05-09 | Process for the purification of a salt of clavulanic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE60105016D1 true DE60105016D1 (de) | 2004-09-23 |
| DE60105016T2 DE60105016T2 (de) | 2005-08-18 |
| DE60105016T3 DE60105016T3 (de) | 2009-06-25 |
Family
ID=26244256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60105016T Expired - Lifetime DE60105016T3 (de) | 2000-05-13 | 2001-05-09 | Verfahren zur reinigung eines salzes der clavulansäure |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7767823B2 (de) |
| EP (1) | EP1284978B2 (de) |
| JP (1) | JP4954421B2 (de) |
| KR (1) | KR100827898B1 (de) |
| CN (1) | CN1222528C (de) |
| AT (1) | ATE273982T1 (de) |
| AU (1) | AU776184B2 (de) |
| BR (1) | BRPI0110774B8 (de) |
| CA (1) | CA2408853C (de) |
| CZ (1) | CZ304775B6 (de) |
| DE (1) | DE60105016T3 (de) |
| DK (1) | DK1284978T4 (de) |
| ES (1) | ES2225524T5 (de) |
| HK (1) | HK1055111A1 (de) |
| HU (1) | HU228593B1 (de) |
| IL (2) | IL152643A0 (de) |
| MX (1) | MXPA02011192A (de) |
| NO (1) | NO328528B1 (de) |
| NZ (1) | NZ522414A (de) |
| PL (1) | PL206316B1 (de) |
| PT (1) | PT1284978E (de) |
| SI (1) | SI1284978T2 (de) |
| WO (1) | WO2001087891A1 (de) |
| ZA (1) | ZA200209141B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100827898B1 (ko) | 2000-05-13 | 2008-05-07 | 스미스클라인비이참피이엘시이 | 클라불란산의 염의 정제 방법 |
| CN105384758B (zh) * | 2015-12-01 | 2018-05-01 | 国药集团威奇达药业有限公司 | 克拉维酸胺盐的制备方法 |
| SG11201811345TA (en) | 2016-07-14 | 2019-01-30 | Achaogen Inc | Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections |
| CN109305978A (zh) * | 2017-07-26 | 2019-02-05 | 山东睿鹰先锋制药有限公司 | 一种制备克拉维酸盐的新方法 |
| CN109535184B (zh) * | 2017-09-21 | 2020-11-20 | 联邦制药(内蒙古)有限公司 | 一种克拉维酸叔辛胺制备克拉维酸钾的方法 |
| CN108558909B (zh) * | 2018-05-17 | 2019-09-17 | 国药集团威奇达药业有限公司 | 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法 |
| MX2022000250A (es) | 2019-07-05 | 2022-02-03 | Glaxosmithkline Ip No 2 Ltd | Streptomyces clavuligerus. |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1299883A (fr) | 1961-09-06 | 1962-07-27 | Pfizer & Co C | Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses |
| GB1508977A (en) | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
| GB2003863B (en) | 1977-09-01 | 1982-03-31 | Beecham Group Ltd | Chemical process |
| EP0026044B1 (de) | 1979-08-24 | 1983-06-08 | Beecham Group Plc | Aminsalz der Clavulansäure, seine Herstellung und Verwendung |
| US4449182A (en) * | 1981-10-05 | 1984-05-15 | Digital Equipment Corporation | Interface between a pair of processors, such as host and peripheral-controlling processors in data processing systems |
| NZ213963A (en) | 1984-10-27 | 1989-01-06 | Antibioticos Sa | Production of clavulanic acid |
| NZ223316A (en) | 1987-01-29 | 1989-10-27 | Beecham Group Plc | Crystalline potassium clavulanate and pharmaceutical compositions |
| GB2204944B (en) | 1987-05-18 | 1991-10-02 | Frederick John Anderson | Rechargeable light |
| DE3729338A1 (de) | 1987-09-02 | 1989-03-23 | Biotechnolog Forschung Gmbh | Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion |
| US5318896A (en) | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
| RO116648B1 (ro) | 1991-10-15 | 2001-04-30 | Merck & Co Inc | Bioprocedeu pentru prepararea acidului 7-amino-3-deacetil-cefalosporanic si a acidului 7-aminocefalosporanic |
| AT400033B (de) * | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
| SI9300296B (sl) | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
| KR100200239B1 (ko) * | 1992-10-21 | 1999-06-15 | 김충환 | 클라불란산 칼륨염의 제조방법 |
| GB9305565D0 (en) | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds and processes |
| US5821364A (en) * | 1993-03-26 | 1998-10-13 | Gist-Brocades N.V. | Diamine salts of clavulanic acid |
| CN1103814C (zh) | 1993-07-30 | 2003-03-26 | 吉斯特·布罗卡迪斯公司 | 通过2－(羧乙硫基)乙酰－7－adca和3－(羧甲硫基)丙酰－7－adca有效生产7－adca的方法 |
| AT400846B (de) | 1994-02-25 | 1996-03-25 | Fermic S A De C V | Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure |
| SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
| GB9426261D0 (en) | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
| SI9500074A (en) | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
| SI9500134B (sl) | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
| KR100200242B1 (ko) | 1995-05-16 | 1999-06-15 | 김충환 | 클라불란산염의 제조 방법 |
| WO1997005143A1 (fr) * | 1995-07-25 | 1997-02-13 | Asahi Kasei Kogyo Kabushiki Kaisha | Nouveaux composes a base de metaux de transition du groupe 4 |
| GB9515809D0 (en) * | 1995-08-02 | 1995-10-04 | Smithkline Beecham Plc | Process |
| AU5551698A (en) | 1996-11-11 | 1998-06-03 | Gist-Brocades B.V. | Process for the preparation of salts and esters of clavulanic acid |
| AT404728B (de) | 1996-11-27 | 1999-02-25 | Biochemie Gmbh | Verfahren zur herstellung von clavulansäure-aminsalzen |
| WO1998042858A1 (en) | 1997-03-24 | 1998-10-01 | Cipan-Companhia Industrial Produtora De Antibióticos, S.A. | Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid |
| DE69828940T2 (de) | 1997-04-22 | 2005-12-29 | Dsm Ip Assets B.V. | Verbessertes verfahren zur fermentativen herstellung von cephalosporin |
| WO2000004028A1 (en) * | 1998-07-16 | 2000-01-27 | Dsm N.V. | Improved process for the preparation of salts and esters of clavulanic acid |
| KR100827898B1 (ko) | 2000-05-13 | 2008-05-07 | 스미스클라인비이참피이엘시이 | 클라불란산의 염의 정제 방법 |
-
2001
- 2001-05-09 KR KR1020027015169A patent/KR100827898B1/ko active IP Right Grant
- 2001-05-09 WO PCT/GB2001/002025 patent/WO2001087891A1/en active Application Filing
- 2001-05-09 HU HU0300869A patent/HU228593B1/hu unknown
- 2001-05-09 CZ CZ2002-3723A patent/CZ304775B6/cs not_active IP Right Cessation
- 2001-05-09 PT PT01925753T patent/PT1284978E/pt unknown
- 2001-05-09 PL PL358368A patent/PL206316B1/pl unknown
- 2001-05-09 AT AT01925753T patent/ATE273982T1/de active
- 2001-05-09 DK DK01925753T patent/DK1284978T4/da active
- 2001-05-09 MX MXPA02011192A patent/MXPA02011192A/es active IP Right Grant
- 2001-05-09 US US10/275,852 patent/US7767823B2/en active Active
- 2001-05-09 SI SI200130207T patent/SI1284978T2/sl unknown
- 2001-05-09 NZ NZ522414A patent/NZ522414A/en not_active IP Right Cessation
- 2001-05-09 CN CNB018094236A patent/CN1222528C/zh not_active Expired - Lifetime
- 2001-05-09 CA CA2408853A patent/CA2408853C/en not_active Expired - Lifetime
- 2001-05-09 ES ES01925753T patent/ES2225524T5/es not_active Expired - Lifetime
- 2001-05-09 EP EP01925753A patent/EP1284978B2/de not_active Expired - Lifetime
- 2001-05-09 BR BRPI0110774A patent/BRPI0110774B8/pt not_active IP Right Cessation
- 2001-05-09 AU AU52432/01A patent/AU776184B2/en not_active Expired
- 2001-05-09 JP JP2001584285A patent/JP4954421B2/ja not_active Expired - Lifetime
- 2001-05-09 DE DE60105016T patent/DE60105016T3/de not_active Expired - Lifetime
- 2001-05-09 IL IL15264301A patent/IL152643A0/xx unknown
-
2002
- 2002-11-04 IL IL152643A patent/IL152643A/en active IP Right Grant
- 2002-11-11 ZA ZA2002/09141A patent/ZA200209141B/en unknown
- 2002-11-12 NO NO20025422A patent/NO328528B1/no not_active IP Right Cessation
-
2003
- 2003-08-21 HK HK03106008A patent/HK1055111A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent | ||
| 8366 | Restricted maintained after opposition proceedings |