CN1194980C - 膦酰基头孢烯衍生物,其制备和用途 - Google Patents

膦酰基头孢烯衍生物,其制备和用途 Download PDF

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Publication number
CN1194980C
CN1194980C CNB988122944A CN98812294A CN1194980C CN 1194980 C CN1194980 C CN 1194980C CN B988122944 A CNB988122944 A CN B988122944A CN 98812294 A CN98812294 A CN 98812294A CN 1194980 C CN1194980 C CN 1194980C
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CN
China
Prior art keywords
group
compound
phosphono
substituted
substituents
Prior art date
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Expired - Lifetime
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CNB988122944A
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English (en)
Chinese (zh)
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CN1282335A (zh
Inventor
石川智康
桥口昌平
饭泽佑史
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18417716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1194980(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of CN1282335A publication Critical patent/CN1282335A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
CNB988122944A 1997-12-19 1998-12-17 膦酰基头孢烯衍生物,其制备和用途 Expired - Lifetime CN1194980C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP351499/1997 1997-12-19
JP35149997 1997-12-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2005100079635A Division CN1679595B (zh) 1997-12-19 1998-12-17 膦酰基头孢烯衍生物，其制备和用途

Publications (2)

Publication Number Publication Date
CN1282335A CN1282335A (zh) 2001-01-31
CN1194980C true CN1194980C (zh) 2005-03-30

Family

ID=18417716

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB988122944A Expired - Lifetime CN1194980C (zh) 1997-12-19 1998-12-17 膦酰基头孢烯衍生物,其制备和用途
CN2005100079635A Expired - Lifetime CN1679595B (zh) 1997-12-19 1998-12-17 膦酰基头孢烯衍生物，其制备和用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2005100079635A Expired - Lifetime CN1679595B (zh) 1997-12-19 1998-12-17 膦酰基头孢烯衍生物，其制备和用途

Country Status (19)

Country Link
US (1) US6417175B1 (enExample)
EP (2) EP2080765A1 (enExample)
JP (3) JP3467418B2 (enExample)
KR (1) KR100384047B1 (enExample)
CN (2) CN1194980C (enExample)
AT (1) ATE430155T1 (enExample)
AU (1) AU1683299A (enExample)
BE (1) BE2013C004I2 (enExample)
CA (1) CA2314564C (enExample)
CY (2) CY1109276T1 (enExample)
DE (1) DE69840796D1 (enExample)
DK (1) DK1043327T3 (enExample)
ES (1) ES2325139T3 (enExample)
FR (1) FR13C0008I2 (enExample)
LU (1) LU92134I2 (enExample)
NL (1) NL300568I1 (enExample)
PT (1) PT1043327E (enExample)
TW (1) TW473479B (enExample)
WO (1) WO1999032497A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2020416A1 (en) * 2000-08-10 2009-02-04 Takeda Pharmaceutical Company Limited Phosphonocephem compound
US20070238719A1 (en) * 2005-05-10 2007-10-11 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070249577A1 (en) * 2005-05-10 2007-10-25 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070238720A1 (en) * 2005-05-10 2007-10-11 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
CN101357929B (zh) * 2007-06-22 2010-12-15 山东轩竹医药科技有限公司 含有巯基噻二唑的头孢菌素衍生物
KR101599560B1 (ko) * 2007-09-21 2016-03-03 아스트라제네카 아베 비경구 투여에 적합한 세펨 유도체를 함유하는 가용성 제형
CN103212076A (zh) * 2008-08-28 2013-07-24 阿斯利康(瑞典)有限公司 包含头孢洛林的组合物和治疗方法
CA2753387C (en) * 2009-02-23 2017-01-24 Forest Laboratories Holdings Limited Novel cephem compounds useful for the treatment of bacterial infections
MX2012003201A (es) 2009-09-21 2012-05-08 Astrazeneca Ab Composiciones y metodos para tratar infecciones bacterianas utilizando ceftarolina.
FR2951171A1 (fr) * 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
BR112013032415B1 (pt) 2011-06-17 2021-07-27 Pfizer Anti-Infectives Ab Processos para preparar compostos e compostos
US20140350240A1 (en) 2011-12-07 2014-11-27 Ranbaxy Laboratories Limited Process for preparing ceftaroline salts or hydrates thereof
CA2887391C (en) * 2012-10-19 2019-06-18 Sandoz Ag Novel process for preparing ceftaroline fosamil
CN102977124B (zh) * 2012-12-13 2014-11-26 山东诚创医药技术开发有限公司 7β-[(苯乙酰)氨基]-3-[4-(1-甲基-4-吡啶鎓)-2-噻唑硫基]-3-头孢烯-4-羧酸二苯甲基酯的制备方法
CN104870457B (zh) * 2012-12-20 2017-08-08 桑多斯股份公司 头孢洛林酯的新晶形
CA2939098A1 (en) 2014-02-21 2015-08-27 Micurx Pharmaceuticals, Inc. Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration
CN106565784B (zh) * 2016-10-31 2019-02-26 瑞阳制药有限公司 头孢洛林酯二钠盐的纯化方法
CN110872322B (zh) * 2018-08-29 2022-08-02 上海博志研新药物技术有限公司 乙酸头孢罗膦一水合物及其中间体的制备方法
CN113072567B (zh) * 2021-03-26 2022-10-14 海南海灵化学制药有限公司 一种拉氧头孢钠合成工艺
CN113214323A (zh) * 2021-04-30 2021-08-06 瑞阳制药股份有限公司 分段式头孢罗膦高效稳定析晶方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5941999B2 (ja) * 1975-07-24 1984-10-11 武田薬品工業株式会社 セフエムまたはベナム化合物の製造法
JPS5511600A (en) * 1978-07-10 1980-01-26 Fujisawa Pharmaceut Co Ltd Cephem compound, its salt, their preparation and remedy and prophylactic for microbism containing mainly the same
US4268509A (en) * 1978-07-10 1981-05-19 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
FR2511372A1 (fr) * 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur preparation
JPS5931791A (ja) * 1982-07-19 1984-02-20 Fujisawa Pharmaceut Co Ltd 新規セフエム化合物およびその製造法、並びに細菌感染症予防・治療剤
US4563449A (en) * 1982-07-19 1986-01-07 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS62238291A (ja) * 1986-04-10 1987-10-19 Fujisawa Pharmaceut Co Ltd セフエム化合物および医薬として許容されるその塩
US4978663A (en) * 1989-08-16 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility
JP3514495B2 (ja) 1992-10-02 2004-03-31 エーザイ株式会社 ハロゲン化アミノチアジアゾリル酢酸誘導体の製造法
JP3927262B2 (ja) * 1995-07-19 2007-06-06 武田薬品工業株式会社 セフェム化合物、その製造法および抗菌組成物
JPH10265488A (ja) * 1997-03-27 1998-10-06 Takeda Chem Ind Ltd ホスフォノセフェム誘導体

Also Published As

Publication number Publication date
FR13C0008I2 (fr) 2013-08-16
EP2080765A1 (en) 2009-07-22
AU1683299A (en) 1999-07-12
KR20010015885A (ko) 2001-02-26
NL300568I2 (enExample) 2016-01-18
ES2325139T3 (es) 2009-08-26
ATE430155T1 (de) 2009-05-15
JP3467418B2 (ja) 2003-11-17
DE69840796D1 (de) 2009-06-10
CY2013003I1 (el) 2014-07-02
CN1679595A (zh) 2005-10-12
LU92134I2 (fr) 2013-03-18
JP2001048893A (ja) 2001-02-20
EP1043327A4 (en) 2001-12-12
KR100384047B1 (ko) 2003-05-14
CA2314564C (en) 2008-11-18
CN1679595B (zh) 2010-05-12
CY1109276T1 (el) 2014-07-02
DK1043327T3 (da) 2009-08-17
FR13C0008I1 (enExample) 2013-03-22
CA2314564A1 (en) 1999-07-01
US6417175B1 (en) 2002-07-09
TW473479B (en) 2002-01-21
BE2013C004I2 (en) 2018-01-29
PT1043327E (pt) 2009-07-02
JPH11255772A (ja) 1999-09-21
CY2013003I2 (el) 2015-08-05
CN1282335A (zh) 2001-01-31
NL300568I1 (enExample) 2016-01-18
JP2009114202A (ja) 2009-05-28
EP1043327B1 (en) 2009-04-29
EP1043327A1 (en) 2000-10-11
WO1999032497A1 (en) 1999-07-01

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