KR100384047B1 - 포스포노세펨 유도체, 그 제법 및 용도 - Google Patents

포스포노세펨 유도체, 그 제법 및 용도 Download PDF

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Publication number
KR100384047B1
KR100384047B1 KR10-2000-7006796A KR20007006796A KR100384047B1 KR 100384047 B1 KR100384047 B1 KR 100384047B1 KR 20007006796 A KR20007006796 A KR 20007006796A KR 100384047 B1 KR100384047 B1 KR 100384047B1
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KR
South Korea
Prior art keywords
group
compound
substituted
salt
acid
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Expired - Lifetime
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KR10-2000-7006796A
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English (en)
Korean (ko)
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KR20010015885A (ko
Inventor
이시까와도모야스
하시구찌쇼헤이
이이자와유지
Original Assignee
다케다 야쿠힌 고교 가부시키가이샤
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18417716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100384047(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 다케다 야쿠힌 고교 가부시키가이샤 filed Critical 다케다 야쿠힌 고교 가부시키가이샤
Publication of KR20010015885A publication Critical patent/KR20010015885A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
KR10-2000-7006796A 1997-12-19 1998-12-17 포스포노세펨 유도체, 그 제법 및 용도 Expired - Lifetime KR100384047B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP97-351499 1997-12-19
JP35149997 1997-12-19

Publications (2)

Publication Number Publication Date
KR20010015885A KR20010015885A (ko) 2001-02-26
KR100384047B1 true KR100384047B1 (ko) 2003-05-14

Family

ID=18417716

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2000-7006796A Expired - Lifetime KR100384047B1 (ko) 1997-12-19 1998-12-17 포스포노세펨 유도체, 그 제법 및 용도

Country Status (19)

Country Link
US (1) US6417175B1 (enExample)
EP (2) EP2080765A1 (enExample)
JP (3) JP3467418B2 (enExample)
KR (1) KR100384047B1 (enExample)
CN (2) CN1679595B (enExample)
AT (1) ATE430155T1 (enExample)
AU (1) AU1683299A (enExample)
BE (1) BE2013C004I2 (enExample)
CA (1) CA2314564C (enExample)
CY (2) CY1109276T1 (enExample)
DE (1) DE69840796D1 (enExample)
DK (1) DK1043327T3 (enExample)
ES (1) ES2325139T3 (enExample)
FR (1) FR13C0008I2 (enExample)
LU (1) LU92134I2 (enExample)
NL (1) NL300568I2 (enExample)
PT (1) PT1043327E (enExample)
TW (1) TW473479B (enExample)
WO (1) WO1999032497A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1189471C (zh) * 2000-08-10 2005-02-16 武田药品工业株式会社 膦酰基头孢烯化合物
US20070238719A1 (en) * 2005-05-10 2007-10-11 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070249577A1 (en) * 2005-05-10 2007-10-25 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070238720A1 (en) * 2005-05-10 2007-10-11 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
CN101456871B (zh) * 2007-06-22 2011-01-12 山东轩竹医药科技有限公司 含有巯基噻唑的头孢菌素衍生物
CN101868240A (zh) * 2007-09-21 2010-10-20 阿斯利康(瑞典)有限公司 适合肠胃外给药的包含头孢烯衍生物的可溶剂型
US20100197650A1 (en) * 2008-08-28 2010-08-05 Forest Laboratories Holdings Ltd. Compositions and methods of treatment comprising ceftaroline
CA2753387C (en) * 2009-02-23 2017-01-24 Forest Laboratories Holdings Limited Novel cephem compounds useful for the treatment of bacterial infections
AU2010295269B2 (en) * 2009-09-21 2014-06-05 Pfizer Anti-Infectives Ab Compositions and methods for treating bacterial infections using ceftaroline
FR2951171A1 (fr) 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
WO2012172368A1 (en) 2011-06-17 2012-12-20 Astrazeneca Ab Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
US20140350240A1 (en) 2011-12-07 2014-11-27 Ranbaxy Laboratories Limited Process for preparing ceftaroline salts or hydrates thereof
USRE47787E1 (en) * 2012-10-19 2019-12-31 Sandoz Ag Process for preparing ceftaroline fosamil
CN102977124B (zh) * 2012-12-13 2014-11-26 山东诚创医药技术开发有限公司 7β-[(苯乙酰)氨基]-3-[4-(1-甲基-4-吡啶鎓)-2-噻唑硫基]-3-头孢烯-4-羧酸二苯甲基酯的制备方法
US9534004B2 (en) 2012-12-20 2017-01-03 Sandoz Ag Crystalline forms of ceftaroline fosamil
JP6671303B2 (ja) 2014-02-21 2020-03-25 ミクウルク ファーマシューティカルズ，インコーポレイテッド 治療的投与のための水溶性ｏ−カルボニルホスホルアミダートプロドラッグ
CN106565784B (zh) * 2016-10-31 2019-02-26 瑞阳制药有限公司 头孢洛林酯二钠盐的纯化方法
CN110872322B (zh) * 2018-08-29 2022-08-02 上海博志研新药物技术有限公司 乙酸头孢罗膦一水合物及其中间体的制备方法
CN113072567B (zh) * 2021-03-26 2022-10-14 海南海灵化学制药有限公司 一种拉氧头孢钠合成工艺
CN113214323A (zh) * 2021-04-30 2021-08-06 瑞阳制药股份有限公司 分段式头孢罗膦高效稳定析晶方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5941999B2 (ja) * 1975-07-24 1984-10-11 武田薬品工業株式会社 セフエムまたはベナム化合物の製造法
JPS5511600A (en) 1978-07-10 1980-01-26 Fujisawa Pharmaceut Co Ltd Cephem compound, its salt, their preparation and remedy and prophylactic for microbism containing mainly the same
US4268509A (en) 1978-07-10 1981-05-19 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
FR2511372A1 (fr) * 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur preparation
US4563449A (en) * 1982-07-19 1986-01-07 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS5931791A (ja) * 1982-07-19 1984-02-20 Fujisawa Pharmaceut Co Ltd 新規セフエム化合物およびその製造法、並びに細菌感染症予防・治療剤
JPS62238291A (ja) * 1986-04-10 1987-10-19 Fujisawa Pharmaceut Co Ltd セフエム化合物および医薬として許容されるその塩
US4978663A (en) 1989-08-16 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility
JP3514495B2 (ja) 1992-10-02 2004-03-31 エーザイ株式会社 ハロゲン化アミノチアジアゾリル酢酸誘導体の製造法
JP3927262B2 (ja) * 1995-07-19 2007-06-06 武田薬品工業株式会社 セフェム化合物、その製造法および抗菌組成物
JPH10265488A (ja) * 1997-03-27 1998-10-06 Takeda Chem Ind Ltd ホスフォノセフェム誘導体

Also Published As

Publication number Publication date
EP1043327A4 (en) 2001-12-12
LU92134I2 (fr) 2013-03-18
EP1043327B1 (en) 2009-04-29
US6417175B1 (en) 2002-07-09
CN1679595A (zh) 2005-10-12
JP2001048893A (ja) 2001-02-20
JPH11255772A (ja) 1999-09-21
CA2314564C (en) 2008-11-18
AU1683299A (en) 1999-07-12
NL300568I1 (enExample) 2016-01-18
CY1109276T1 (el) 2014-07-02
EP2080765A1 (en) 2009-07-22
EP1043327A1 (en) 2000-10-11
ATE430155T1 (de) 2009-05-15
ES2325139T3 (es) 2009-08-26
WO1999032497A1 (en) 1999-07-01
KR20010015885A (ko) 2001-02-26
BE2013C004I2 (en) 2018-01-29
DK1043327T3 (da) 2009-08-17
FR13C0008I1 (enExample) 2013-03-22
FR13C0008I2 (fr) 2013-08-16
TW473479B (en) 2002-01-21
CY2013003I2 (el) 2015-08-05
CN1194980C (zh) 2005-03-30
PT1043327E (pt) 2009-07-02
JP2009114202A (ja) 2009-05-28
CA2314564A1 (en) 1999-07-01
NL300568I2 (enExample) 2016-01-18
DE69840796D1 (de) 2009-06-10
CN1679595B (zh) 2010-05-12
CY2013003I1 (el) 2014-07-02
JP3467418B2 (ja) 2003-11-17
CN1282335A (zh) 2001-01-31

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