CN1161396C - 具有可逆热胶凝性能的可生物降解的低分子量三嵌段聚酯聚乙二醇共聚物 - Google Patents

具有可逆热胶凝性能的可生物降解的低分子量三嵌段聚酯聚乙二醇共聚物 Download PDF

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Publication number
CN1161396C
CN1161396C CNB998124958A CN99812495A CN1161396C CN 1161396 C CN1161396 C CN 1161396C CN B998124958 A CNB998124958 A CN B998124958A CN 99812495 A CN99812495 A CN 99812495A CN 1161396 C CN1161396 C CN 1161396C
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China
Prior art keywords
hormone
drug
biodegradable
composition
releasing
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Expired - Fee Related
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CNB998124958A
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English (en)
Chinese (zh)
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CN1324374A (zh
Inventor
Rc
R·C·拉思
G·M·赞特纳
B·乔恩
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Proserix Pharmaceutical Development Corp
Prosser Salt Lake City Co
BTG International Ltd
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MacroMed Inc
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Priority claimed from US09/164,865 external-priority patent/US6117949A/en
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Publication of CN1324374A publication Critical patent/CN1324374A/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CNB998124958A 1998-10-01 1999-09-30 具有可逆热胶凝性能的可生物降解的低分子量三嵌段聚酯聚乙二醇共聚物 Expired - Fee Related CN1161396C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/164,865 US6117949A (en) 1998-10-01 1998-10-01 Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US09/164,865 1998-10-01
US09/396,589 1999-09-15
US09/396,589 US6201072B1 (en) 1997-10-03 1999-09-15 Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties

Publications (2)

Publication Number Publication Date
CN1324374A CN1324374A (zh) 2001-11-28
CN1161396C true CN1161396C (zh) 2004-08-11

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Application Number Title Priority Date Filing Date
CNB998124958A Expired - Fee Related CN1161396C (zh) 1998-10-01 1999-09-30 具有可逆热胶凝性能的可生物降解的低分子量三嵌段聚酯聚乙二醇共聚物

Country Status (19)

Country Link
US (1) US6201072B1 (enExample)
EP (1) EP1141079B1 (enExample)
JP (1) JP4628545B2 (enExample)
KR (1) KR100558025B1 (enExample)
CN (1) CN1161396C (enExample)
AT (1) ATE378365T1 (enExample)
AU (1) AU758475B2 (enExample)
BR (1) BR9914258B1 (enExample)
CA (1) CA2345659C (enExample)
CY (1) CY1107888T1 (enExample)
DK (1) DK1141079T3 (enExample)
ES (1) ES2301250T3 (enExample)
IL (1) IL142313A0 (enExample)
NO (1) NO332941B1 (enExample)
NZ (1) NZ510832A (enExample)
PL (1) PL205127B1 (enExample)
RU (1) RU2232779C2 (enExample)
TR (1) TR200100900T2 (enExample)
WO (1) WO2000018821A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105062021A (zh) * 2015-08-18 2015-11-18 九江学院 一种非温敏可降解聚合物胶乳及其制备方法

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