ATE365183T1 - Positiv geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit negativ geladenem arzneistoff - Google Patents
Positiv geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit negativ geladenem arzneistoffInfo
- Publication number
- ATE365183T1 ATE365183T1 AT02749399T AT02749399T ATE365183T1 AT E365183 T1 ATE365183 T1 AT E365183T1 AT 02749399 T AT02749399 T AT 02749399T AT 02749399 T AT02749399 T AT 02749399T AT E365183 T1 ATE365183 T1 AT E365183T1
- Authority
- AT
- Austria
- Prior art keywords
- drug
- block copolymer
- complex
- amphiphile
- positively charged
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003937 drug carrier Substances 0.000 title abstract 2
- 229920001400 block copolymer Polymers 0.000 title 1
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 title 1
- 229920000469 amphiphilic block copolymer Polymers 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
- C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20010042563 | 2001-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365183T1 true ATE365183T1 (de) | 2007-07-15 |
Family
ID=19712179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02749399T ATE365183T1 (de) | 2001-07-14 | 2002-07-13 | Positiv geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit negativ geladenem arzneistoff |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7226616B2 (de) |
| EP (1) | EP1406946B1 (de) |
| JP (1) | JP4015994B2 (de) |
| KR (1) | KR100527291B1 (de) |
| CN (1) | CN1220717C (de) |
| AT (1) | ATE365183T1 (de) |
| AU (1) | AU2002319922B2 (de) |
| CA (1) | CA2452827C (de) |
| DE (1) | DE60220796T2 (de) |
| ES (1) | ES2287297T3 (de) |
| MX (1) | MXPA04000317A (de) |
| NZ (1) | NZ530588A (de) |
| WO (1) | WO2003008480A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4763459B2 (ja) * | 2003-05-29 | 2011-08-31 | 株式会社東京大学Ｔｌｏ | 安定化高分子ミセル |
| ITMI20031872A1 (it) * | 2003-09-30 | 2005-04-01 | Mediolanum Farmaceutici Srl | Copolimeri di poliesteri e polivinilpirrolidone. |
| WO2005040247A1 (en) * | 2003-10-24 | 2005-05-06 | Samyang Corporation | Polymeric composition for drug delivery |
| US7576145B2 (en) | 2004-04-28 | 2009-08-18 | Plasbio, Inc. | Method for producing degradable polymers |
| ES2310326T3 (es) * | 2004-04-28 | 2009-01-01 | Plasbio Inc. | Metodo de produccion de polimeros degradables. |
| US8007775B2 (en) | 2004-12-30 | 2011-08-30 | Advanced Cardiovascular Systems, Inc. | Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same |
| CA2600085A1 (en) * | 2005-03-09 | 2006-09-14 | Toray Industries, Inc. | Microparticle and pharmaceutical preparation |
| KR100714458B1 (ko) * | 2005-11-24 | 2007-05-07 | 헤벨 주식회사 | 변전설비용 차단기 |
| KR100918524B1 (ko) * | 2007-02-14 | 2009-09-21 | 성균관대학교산학협력단 | 온도 및 피에치 민감성 블록공중합체 고분자 하이드로겔을이용한 주사가능한 약물전달체 및 약물전달방법 |
| US8652506B2 (en) * | 2008-06-05 | 2014-02-18 | Boston Scientific Scimed, Inc. | Bio-degradable block co-polymers for controlled release |
| US9271929B2 (en) * | 2008-11-25 | 2016-03-01 | École Polytechnique Fédérale De Lausanne (Epfl) | Block copolymers and uses thereof |
| WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
| JP2012522055A (ja) * | 2009-03-30 | 2012-09-20 | セルリアン・ファーマ・インコーポレイテッド | ポリマー‐薬剤抱合体、粒子、組成物、および関連する使用方法 |
| WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
| CN101869712B (zh) | 2009-04-21 | 2016-01-20 | 财团法人工业技术研究院 | 使用包囊抗肿瘤药物的聚合胶束用于治疗肿瘤的药物组合物 |
| KR101249389B1 (ko) * | 2010-10-28 | 2013-04-03 | 재단법인대구경북과학기술원 | 자극반응성 수화젤 |
| WO2015013510A1 (en) | 2013-07-25 | 2015-01-29 | Ecole Polytechnique Federale De Lausanne Epfl | High aspect ratio nanofibril materials |
| CN105362251B (zh) * | 2015-12-14 | 2019-02-26 | 四川大学 | DOTAP-mPEG-PLA纳米粒及其纳米粒溶液、载药复合物和制备方法和应用 |
| WO2024009268A1 (en) * | 2022-07-07 | 2024-01-11 | Biorchestra Co., Ltd. | Micellar nanoparticles and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3677019D1 (de) | 1986-11-21 | 1991-02-21 | Agfa Gevaert Nv | Oberflaechenaktives polymer. |
| US5035972A (en) | 1989-10-31 | 1991-07-30 | E. I. Du Pont De Nemours And Company | AB diblock copolymers as charge directors for negative electrostatic liquid developer |
| US5783178A (en) | 1994-11-18 | 1998-07-21 | Supratek Pharma. Inc. | Polymer linked biological agents |
| JP2690276B2 (ja) | 1995-01-10 | 1997-12-10 | 科学技術振興事業団 | 静電結合型高分子ミセル薬物担体とその薬剤 |
| US5569448A (en) | 1995-01-24 | 1996-10-29 | Nano Systems L.L.C. | Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
| JPH11510837A (ja) | 1995-07-28 | 1999-09-21 | フォーカル，インコーポレイテッド | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
| AU726749B2 (en) | 1995-08-10 | 2000-11-16 | Kazunori Kataoka | Block polymer having functional groups on its both ends |
| KR0180334B1 (ko) | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
| US6201072B1 (en) | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| CA2305621C (en) * | 1997-10-03 | 2009-01-20 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US5939453A (en) | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
| AU785288B2 (en) * | 2000-01-28 | 2006-12-21 | Azopax Therapeutics Llc | Slow release protein polymers |
-
2002
- 2002-07-13 AT AT02749399T patent/ATE365183T1/de not_active IP Right Cessation
- 2002-07-13 WO PCT/KR2002/001328 patent/WO2003008480A1/en active IP Right Grant
- 2002-07-13 NZ NZ530588A patent/NZ530588A/en not_active IP Right Cessation
- 2002-07-13 ES ES02749399T patent/ES2287297T3/es not_active Expired - Lifetime
- 2002-07-13 JP JP2003514034A patent/JP4015994B2/ja not_active Expired - Fee Related
- 2002-07-13 EP EP02749399A patent/EP1406946B1/de not_active Expired - Lifetime
- 2002-07-13 MX MXPA04000317A patent/MXPA04000317A/es active IP Right Grant
- 2002-07-13 CN CNB028141652A patent/CN1220717C/zh not_active Expired - Lifetime
- 2002-07-13 AU AU2002319922A patent/AU2002319922B2/en not_active Ceased
- 2002-07-13 KR KR10-2002-0040975A patent/KR100527291B1/ko active IP Right Grant
- 2002-07-13 US US10/483,826 patent/US7226616B2/en not_active Expired - Lifetime
- 2002-07-13 CA CA002452827A patent/CA2452827C/en not_active Expired - Fee Related
- 2002-07-13 DE DE60220796T patent/DE60220796T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04000317A (es) | 2004-05-04 |
| DE60220796D1 (de) | 2007-08-02 |
| CA2452827A1 (en) | 2003-01-30 |
| KR100527291B1 (ko) | 2005-11-09 |
| DE60220796T2 (de) | 2007-10-18 |
| NZ530588A (en) | 2005-06-24 |
| WO2003008480A1 (en) | 2003-01-30 |
| CN1220717C (zh) | 2005-09-28 |
| CN1531566A (zh) | 2004-09-22 |
| US7226616B2 (en) | 2007-06-05 |
| ES2287297T3 (es) | 2007-12-16 |
| JP2004536189A (ja) | 2004-12-02 |
| CA2452827C (en) | 2009-12-08 |
| KR20030007176A (ko) | 2003-01-23 |
| EP1406946B1 (de) | 2007-06-20 |
| JP4015994B2 (ja) | 2007-11-28 |
| AU2002319922B2 (en) | 2004-12-16 |
| EP1406946A1 (de) | 2004-04-14 |
| US20040234494A1 (en) | 2004-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |