ATE337357T1 - Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff - Google Patents

Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff

Info

Publication number
ATE337357T1
ATE337357T1 AT02730999T AT02730999T ATE337357T1 AT E337357 T1 ATE337357 T1 AT E337357T1 AT 02730999 T AT02730999 T AT 02730999T AT 02730999 T AT02730999 T AT 02730999T AT E337357 T1 ATE337357 T1 AT E337357T1
Authority
AT
Austria
Prior art keywords
drug
block copolymer
complex
amphiphile
positively charged
Prior art date
Application number
AT02730999T
Other languages
English (en)
Inventor
Min-Hyo Seo
In-Ja Choi
Han-Uk Kong
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE337357T1 publication Critical patent/ATE337357T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02730999T 2001-06-25 2002-06-05 Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff ATE337357T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020010036203A KR100566911B1 (ko) 2001-06-25 2001-06-25 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체

Publications (1)

Publication Number Publication Date
ATE337357T1 true ATE337357T1 (de) 2006-09-15

Family

ID=36792807

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02730999T ATE337357T1 (de) 2001-06-25 2002-06-05 Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff

Country Status (16)

Country Link
US (1) US6890560B2 (de)
EP (1) EP1399501B1 (de)
JP (1) JP4154328B2 (de)
KR (1) KR100566911B1 (de)
CN (1) CN1226332C (de)
AT (1) ATE337357T1 (de)
AU (1) AU2002303027C1 (de)
BR (1) BRPI0210335B8 (de)
CA (1) CA2449244C (de)
DE (1) DE60214173T2 (de)
ES (1) ES2269694T3 (de)
IL (2) IL159166A0 (de)
MX (1) MXPA03011619A (de)
NZ (1) NZ530176A (de)
WO (1) WO2003000778A1 (de)
ZA (1) ZA200309357B (de)

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JP4733113B2 (ja) * 2004-05-05 2011-07-27 フイルメニツヒ ソシエテ アノニム 生分解性グラフトコポリマー
US20060260639A1 (en) * 2005-03-08 2006-11-23 Pejman Fani Method and system for processing substrates with sonic energy that reduces or eliminates damage to semiconductor devices
KR100773470B1 (ko) * 2005-04-25 2007-11-05 김태균 층간 소음 방지를 위한 방음판 구조
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
ATE458773T1 (de) 2006-03-09 2010-03-15 Coloplast As Abbaubare copolymere mit einem hydrophilen block mit verbesserter biokompatibilität für die weichgeweberegeneration
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WO2009078756A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
WO2009078755A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
CA2724014C (en) * 2008-05-13 2016-09-13 University Of Washington Micellic assemblies
US8652506B2 (en) * 2008-06-05 2014-02-18 Boston Scientific Scimed, Inc. Bio-degradable block co-polymers for controlled release
MX379265B (es) * 2008-06-26 2025-03-11 Anterios Inc Aplicacion dérmica de toxina botulínica en nanoemulsiones para usarse en el tratamiento de trastornos de la piel.
EP2416763A4 (de) * 2009-04-06 2015-05-06 Mayo Foundation Verfahren und materialien zur freisetzung von molekülen
KR101220162B1 (ko) * 2009-07-02 2013-01-14 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀
KR101249389B1 (ko) * 2010-10-28 2013-04-03 재단법인대구경북과학기술원 자극반응성 수화젤
KR101685646B1 (ko) * 2010-12-29 2016-12-13 한화케미칼 주식회사 홍합 접착단백질 모방을 통한 나노입자를 수계 매질에 분산시키는 생체적합성 분산 안정화제
KR101230598B1 (ko) 2011-02-28 2013-02-15 부산대학교 산학협력단 페하 응답성을 가지는 히스트딘이 공유결합된 덱스트란과 메톡시폴리에틸렌글리콜 블록공중합체
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EP3043810B1 (de) 2013-09-09 2019-10-23 CanImGuide Therapeutics AB Immunsystemmodulatoren
DK3265117T3 (da) 2015-03-06 2021-02-08 Canimguide Therapeutics Ab Immunsystemmodulatorer og præparater
CN105362251B (zh) * 2015-12-14 2019-02-26 四川大学 DOTAP-mPEG-PLA纳米粒及其纳米粒溶液、载药复合物和制备方法和应用
KR102487144B1 (ko) 2016-11-21 2023-01-12 에이리온 테라퓨틱스, 인코포레이티드 큰 물질의 경피 전달
US11684584B2 (en) 2016-12-30 2023-06-27 Genevant Sciences Gmbh Branched peg molecules and related compositions and methods
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JP7748803B2 (ja) * 2017-12-18 2025-10-03 シー・アール・バード・インコーポレーテッド 薬物充填マイクロビーズ組成物、塞栓組成物および関連の方法
CN110742903B (zh) * 2019-11-22 2021-06-01 兰州大学 含铑(ⅰ)的聚合物胶束、其制备方法与应用
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Also Published As

Publication number Publication date
CN1520437A (zh) 2004-08-11
BR0210335A (pt) 2004-07-20
ZA200309357B (en) 2005-05-25
BRPI0210335B8 (pt) 2021-05-25
US6890560B2 (en) 2005-05-10
KR20030000433A (ko) 2003-01-06
US20030017206A1 (en) 2003-01-23
IL159166A (en) 2007-12-03
CA2449244C (en) 2007-10-02
DE60214173D1 (de) 2006-10-05
AU2002303027B2 (en) 2005-06-09
IL159166A0 (en) 2004-06-01
WO2003000778A1 (en) 2003-01-03
NZ530176A (en) 2005-06-24
HK1067950A1 (en) 2005-04-22
BR0210335B1 (pt) 2014-06-24
ES2269694T3 (es) 2007-04-01
CN1226332C (zh) 2005-11-09
MXPA03011619A (es) 2004-04-05
DE60214173T2 (de) 2007-08-23
AU2002303027C1 (en) 2006-06-01
KR100566911B1 (ko) 2006-04-03
EP1399501A1 (de) 2004-03-24
EP1399501B1 (de) 2006-08-23
JP2004530768A (ja) 2004-10-07
CA2449244A1 (en) 2003-01-03
EP1399501A4 (de) 2005-02-16
JP4154328B2 (ja) 2008-09-24

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