BR9813548A - Micelas poliméricas misturadas biodegradáveis para distribuição de gene - Google Patents

Micelas poliméricas misturadas biodegradáveis para distribuição de gene

Info

Publication number
BR9813548A
BR9813548A BR9813548-1A BR9813548A BR9813548A BR 9813548 A BR9813548 A BR 9813548A BR 9813548 A BR9813548 A BR 9813548A BR 9813548 A BR9813548 A BR 9813548A
Authority
BR
Brazil
Prior art keywords
polyester
copolymer
nucleic acid
mixed polymeric
composition
Prior art date
Application number
BR9813548-1A
Other languages
English (en)
Inventor
Yong Kweon Chol
Jin Seok Kim
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Publication of BR9813548A publication Critical patent/BR9813548A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y10S977/916—Gene therapy

Abstract

Patente de Invenção: <B>"MICELAS POLIMéRICAS MISTURADAS BIODEGRADáVEIS PARA DISTRIBUIçãO DE GENE"<D>. Uma micela polimérica misturada biodegradável usada para distribuir um ácido nucléio selecionado em uma célula hospedeira alvo contém um copolímero de poliéster-policátion anfifílico (12) e um copolímero de poliéster-açúcar anfifílico (18). O copolímero de poliéster-policátion (12) forma uma interação eletrostática com ácidos nucléios polianiónicos e o copolímero de poliéster-açúcar (18) direciona o complexo micela-ácido nucléio às células in vivo. Copolímeros adicionais com propriedades similares também podem ser incluídos. A composição melhora a eficiência de distribuição através do fornecimento de um veículo para o gene em particular para o qual tamanho de partícula e densidade de carga são facilmente controlados através de meios multi-variados. Vários tipos de ligantes e outros compostos funcionais também podem ser introduzidos usando-se a composição. A composição pode ser usada em um método para transformação de uma célula hospedeira alvo com um ácido nucléio selecionado.
BR9813548-1A 1997-12-12 1998-12-11 Micelas poliméricas misturadas biodegradáveis para distribuição de gene BR9813548A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6955197P 1997-12-12 1997-12-12
PCT/US1998/026403 WO1999029303A1 (en) 1997-12-12 1998-12-11 Biodegradable mixed polymeric micelles for gene delivery

Publications (1)

Publication Number Publication Date
BR9813548A true BR9813548A (pt) 2000-10-10

Family

ID=22089740

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813548-1A BR9813548A (pt) 1997-12-12 1998-12-11 Micelas poliméricas misturadas biodegradáveis para distribuição de gene

Country Status (13)

Country Link
US (1) US6210717B1 (pt)
EP (1) EP1037611B1 (pt)
JP (1) JP4570776B2 (pt)
KR (1) KR20010032878A (pt)
CN (1) CN1281355A (pt)
AR (1) AR018528A1 (pt)
AT (1) ATE412403T1 (pt)
AU (1) AU740342B2 (pt)
BR (1) BR9813548A (pt)
DE (1) DE69840175D1 (pt)
IL (1) IL136681A0 (pt)
WO (1) WO1999029303A1 (pt)
ZA (1) ZA9811376B (pt)

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Also Published As

Publication number Publication date
EP1037611A1 (en) 2000-09-27
EP1037611A4 (en) 2006-09-20
AU1910899A (en) 1999-06-28
EP1037611B1 (en) 2008-10-29
ZA9811376B (en) 1999-06-28
JP4570776B2 (ja) 2010-10-27
AR018528A1 (es) 2001-11-28
ATE412403T1 (de) 2008-11-15
JP2001525357A (ja) 2001-12-11
DE69840175D1 (de) 2008-12-11
IL136681A0 (en) 2001-06-14
CN1281355A (zh) 2001-01-24
WO1999029303A1 (en) 1999-06-17
US6210717B1 (en) 2001-04-03
AU740342B2 (en) 2001-11-01
KR20010032878A (ko) 2001-04-25

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