ATE412403T1 - Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung - Google Patents

Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung

Info

Publication number
ATE412403T1
ATE412403T1 AT98963871T AT98963871T ATE412403T1 AT E412403 T1 ATE412403 T1 AT E412403T1 AT 98963871 T AT98963871 T AT 98963871T AT 98963871 T AT98963871 T AT 98963871T AT E412403 T1 ATE412403 T1 AT E412403T1
Authority
AT
Austria
Prior art keywords
micellars
mixed polymeric
gene administration
biodegradable mixed
biodegradable
Prior art date
Application number
AT98963871T
Other languages
English (en)
Inventor
Young Choi
Jin Kim
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE412403T1 publication Critical patent/ATE412403T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery
    • Y10S977/907Liposome
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915Therapeutic or pharmaceutical composition
    • Y10S977/916Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98963871T 1997-12-12 1998-12-11 Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung ATE412403T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6955197P 1997-12-12 1997-12-12

Publications (1)

Publication Number Publication Date
ATE412403T1 true ATE412403T1 (de) 2008-11-15

Family

ID=22089740

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98963871T ATE412403T1 (de) 1997-12-12 1998-12-11 Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung

Country Status (13)

Country Link
US (1) US6210717B1 (de)
EP (1) EP1037611B1 (de)
JP (1) JP4570776B2 (de)
KR (1) KR20010032878A (de)
CN (1) CN1281355A (de)
AR (1) AR018528A1 (de)
AT (1) ATE412403T1 (de)
AU (1) AU740342B2 (de)
BR (1) BR9813548A (de)
DE (1) DE69840175D1 (de)
IL (1) IL136681A0 (de)
WO (1) WO1999029303A1 (de)
ZA (1) ZA9811376B (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69941447D1 (de) 1998-01-05 2009-11-05 Univ Washington Erhöhter transport unter benutzung membranzerstörender stoffe
SE9904581D0 (sv) * 1999-12-15 1999-12-15 A & Science Invest Ab A novel helicobacter pylori-binding substance and use thereof
US7737108B1 (en) * 2000-01-07 2010-06-15 University Of Washington Enhanced transport using membrane disruptive agents
US20030134420A1 (en) * 2000-02-18 2003-07-17 Lollo Charles Peter Methods and compositions for gene delivery
MXPA02012198A (es) * 2000-06-09 2004-08-19 Teni Boulikas Encapsulacion de polinucleotidos y drogas en liposomas objetivos.
US20030072794A1 (en) * 2000-06-09 2003-04-17 Teni Boulikas Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
TWI246524B (en) * 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) * 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
EP1418945A2 (de) * 2001-03-13 2004-05-19 Angiotech Pharmaceuticals, Inc. Mizellare arzneimittelabgabe vehikel und ihre anwendungen
DE60220519T2 (de) * 2001-04-20 2007-09-27 The University Of British Columbia, Vancouver Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
KR100566911B1 (ko) * 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
US7030127B2 (en) 2001-06-29 2006-04-18 Ethicon, Inc. Composition and medical devices utilizing bioabsorbable polymeric waxes
US7034037B2 (en) 2001-06-29 2006-04-25 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US6967234B2 (en) 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
WO2003078576A2 (en) * 2002-03-12 2003-09-25 Nitto Denko Corporation Vector for transfection of eukaryotic cells
US7326426B2 (en) 2002-03-29 2008-02-05 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable liquid polymers
US7005136B2 (en) 2002-03-29 2006-02-28 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
WO2003090807A1 (en) * 2002-04-24 2003-11-06 Poly-Med, Inc. Multifaceted endovascular stent coating for preventing restenosis
US7368125B2 (en) 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
AR037006A1 (es) * 2002-06-20 2004-10-20 S I G Sist S De Identificacion Marcador de objetos a identificar consistente en al menos un fragmento de adn.
US7026374B2 (en) 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7101566B2 (en) 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
GB0228525D0 (en) * 2002-12-06 2003-01-15 Univ Cambridge Tech Polymers and their use
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
US6872799B2 (en) 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
US6866860B2 (en) 2002-12-19 2005-03-15 Ethicon, Inc. Cationic alkyd polyesters for medical applications
US7135523B2 (en) * 2003-03-14 2006-11-14 Industrial Technology Research Institute Nanoscale helical microstructures and channels from chiral poly(L-lactide) block containing block copolymers
SE0300805D0 (sv) * 2003-03-25 2003-03-25 Biacore Ab Immobilization method and kit therefor
ES2298738T3 (es) * 2003-03-25 2008-05-16 Biacore Ab Metodo de inmovilizacion y kit para ello.
US7309757B2 (en) * 2003-06-20 2007-12-18 Agency For Science, Technology And Research Polymers for the delivery of bioactive agents and methods of their preparation
WO2006088647A1 (en) * 2005-02-17 2006-08-24 Medivas, Llc Polymer particle delivery compositions and methods of use
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US8039587B2 (en) 2003-10-24 2011-10-18 Gencia Corporation Methods and compositions for delivering polynucleotides
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
EP1765403A4 (de) * 2004-05-10 2011-03-30 Univ Utah Res Found Kombiniertes aktives und passives targeting von biologisch aktiven wirkstoffen
US8568705B2 (en) * 2005-07-18 2013-10-29 Nektar Therapeutics Method for preparing branched functionalized polymers using branched polyol cores
BRPI0616877A2 (pt) 2005-10-05 2011-07-05 Tokyo Cro Inc copolìmero em bloco biocompatìvel, micela, particulado, compósito, composição farmacêutica, método para fabricar uma micela, particulado ou compósito, e, uso de um copolìmero em bloco biocompatìvel
US7718193B2 (en) * 2006-03-16 2010-05-18 University Of Washington Temperature- and pH-responsive polymer compositions
US7820408B2 (en) * 2006-11-29 2010-10-26 Novozymes, Inc. Methods of improving the introduction of DNA into bacterial cells
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
JP5270884B2 (ja) * 2007-09-03 2013-08-21 大阪瓦斯株式会社 分散剤およびこの分散剤を含むポリ乳酸系複合樹脂粒子
CN102083972B (zh) * 2008-01-25 2013-03-06 金拓 由内源性携带氨基的单体形成的聚阳离子基因载体
EP2281011B1 (de) 2008-05-13 2013-02-27 University Of Washington Diblockcopolymere und polynukleotidkomplexe daraus für den transport in zellen
CN102066444A (zh) 2008-05-13 2011-05-18 华盛顿大学 胶束装配体
CN102065902A (zh) 2008-05-13 2011-05-18 华盛顿大学 聚合物载体
EP2331069A4 (de) 2008-08-22 2011-10-26 Univ Washington Heterogene polymere mizellen für intrazelluläre freisetzung
WO2010053596A1 (en) 2008-11-06 2010-05-14 University Of Washington Bispecific intracellular delivery vehicles
CA2742880A1 (en) 2008-11-06 2010-05-14 University Of Washington Multiblock copolymers
JP2012511053A (ja) 2008-12-08 2012-05-17 ユニヴァーシティ オブ ワシントン オメガ機能性化ポリマー、ジャンクション機能性化ブロック共重合体、およびラジカル連鎖延長重合
EP2201935B1 (de) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymere Mizellenzusammensetzung, die ein schlecht lösliches Arzneimittel enthält, und zugehöriges Herstellungsverfahren
AU2009331027B2 (en) * 2008-12-26 2012-12-13 Samyang Holdings Corporation Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
AU2010234916A1 (en) * 2009-03-30 2011-10-13 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
WO2011062965A2 (en) 2009-11-18 2011-05-26 University Of Washington Through Its Center For Commercialization Targeting monomers and polymers having targeting blocks
US8765098B2 (en) 2010-03-30 2014-07-01 International Business Machines Corporation Star polymers, methods of preparation thereof, and uses thereof
US9163107B2 (en) * 2010-07-26 2015-10-20 Shanghai Jiao Tong University Cationic polymers formed from amino group-bearing monomers and heterocyclic linkers
US20130344053A1 (en) 2010-12-28 2013-12-26 University Of Rochester Methods of Modifying Insulin Signaling Using Biliverdin Reductase (BVR) and BVR Derived Peptides
EP3159368B1 (de) 2011-06-23 2024-07-24 DSM IP Assets B.V. Neue biologisch abbaubare polyesteramid-copolymere zur arzneimittelabgabe
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CN102516534B (zh) * 2011-11-14 2013-11-20 上海交通大学 可降解为精胺的聚阳离子及其合成方法、纳米颗粒
EP2908853B1 (de) 2012-10-21 2018-12-05 University Of Rochester Thy1 (cd90) als therapie zur steuerung von fettgewebeakkumulation
AU2014296278C1 (en) 2013-07-30 2023-02-02 Genevant Sciences Gmbh Block copolymers and their conjugates or complexes with oligonucleotides
CN105722530B (zh) 2013-08-16 2020-06-02 罗切斯特大学 用于紧密连接屏障调节的设计肽
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
WO2015099839A1 (en) * 2013-12-27 2015-07-02 Wu, David Ts Novel sugar alcohol-based compositions for delivering nucleic acid-based drugs in vivo and in vitro
CN107106509B (zh) 2014-12-18 2021-11-30 帝斯曼知识产权资产管理有限公司 用于递送酸敏感药物的药物递送系统
AU2016209295B2 (en) 2015-01-21 2021-08-12 Genevant Sciences Gmbh Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
CN104829786A (zh) * 2015-05-04 2015-08-12 中国科学院上海有机化学研究所 侧挂天然半乳糖和赖氨酸的阳离子大分子、制备方法及其用途
JP6933379B2 (ja) 2015-09-24 2021-09-08 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 転移を低減するための方法および組成物
CN108366964B (zh) * 2015-12-18 2022-04-08 三养控股公司 制备含阴离子药物的聚合物胶束的方法
WO2018126084A1 (en) 2016-12-30 2018-07-05 Phaserx, Inc. Branched peg molecules and related compositions and methods
JP7196850B2 (ja) * 2017-09-05 2022-12-27 味の素株式会社 ポリリジン誘導体
WO2019129657A1 (en) 2017-12-28 2019-07-04 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Actively targeted polymeric micelles for drug and gene delivery
WO2020247347A1 (en) 2019-06-05 2020-12-10 University Of Rochester New designed inhibitors of tight junction formation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3808531C1 (de) 1988-03-15 1989-07-13 Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De
US5501662A (en) 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
EP0712421A1 (de) * 1993-07-23 1996-05-22 Massachusetts Institute Of Technology Nanopartikel und mikropartikel aus nichtlinearen hydrophilen-hydrophoben multiblockcopolymeren
ES2171186T3 (es) * 1994-04-08 2002-09-01 Atrix Lab Inc Composiciones liquidas de difusion.
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body

Also Published As

Publication number Publication date
EP1037611A4 (de) 2006-09-20
JP2001525357A (ja) 2001-12-11
AR018528A1 (es) 2001-11-28
CN1281355A (zh) 2001-01-24
ZA9811376B (en) 1999-06-28
EP1037611B1 (de) 2008-10-29
BR9813548A (pt) 2000-10-10
DE69840175D1 (de) 2008-12-11
JP4570776B2 (ja) 2010-10-27
AU1910899A (en) 1999-06-28
US6210717B1 (en) 2001-04-03
IL136681A0 (en) 2001-06-14
EP1037611A1 (de) 2000-09-27
KR20010032878A (ko) 2001-04-25
WO1999029303A1 (en) 1999-06-17
AU740342B2 (en) 2001-11-01

Similar Documents

Publication Publication Date Title
ATE412403T1 (de) Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung
DE69927198D1 (de) Rundfunk-Informationsversorgungssystem
DE69811774D1 (de) Polymer zur Modifikation von Asphalt
DE69738238D1 (de) Epoxy-polysiloxan polymerzusammensetzung
DE69822337D1 (de) Mischkatalysatorsystem
DE69825475D1 (de) Injektionsmischer
DE69821381D1 (de) Bioabbaubare thermoplastische zusammensetzung
DE69711357D1 (de) Bodenbelüfter
DE69716887D1 (de) Mischer
DE69821842D1 (de) System zur Positionsbestimmung
DE69909015D1 (de) Polymere Zusammensetzungen mit kontrollierter Wirkstoffabgabe
DK1011851T3 (da) Homogeniseringsventil
PL338031A1 (en) Thermoplastic mix based on biopolymers for making biodegradable mouldings
NO20000857D0 (no) Mikseapparat
IS5331A (is) Ný lyfjablanda
DE69815835D1 (de) Schäumbare polymerzusammensetzung
DE69728130T2 (de) Bodenanordnung zur Entgasung
DE69838223D1 (de) Anordnung zur medikamentenzuführung
DE69806110D1 (de) Integriertes System zur Abgabe mehrerer Toner
ID26779A (id) Campuran-campuran kasturi makrosiklik
DE69815773D1 (de) System zur Zufuhr von Toner
DE59806033D1 (de) Milchsäurepolymerisate
DE19983309T1 (de) Mischersystem
DE69820650D1 (de) Verbesserter alginatmischer
ATE293931T1 (de) Implantsystem

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties