AR018528A1 - Mezcla polimerica biodegradable de micelas para transferencia genetica - Google Patents
Mezcla polimerica biodegradable de micelas para transferencia geneticaInfo
- Publication number
- AR018528A1 AR018528A1 ARP980106330A ARP980106330A AR018528A1 AR 018528 A1 AR018528 A1 AR 018528A1 AR P980106330 A ARP980106330 A AR P980106330A AR P980106330 A ARP980106330 A AR P980106330A AR 018528 A1 AR018528 A1 AR 018528A1
- Authority
- AR
- Argentina
- Prior art keywords
- nucleic acid
- copolymer
- polyester
- sugar
- host cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/916—Gene therapy
Abstract
Una mezcla polimérica biodegradable de micelas utilizada para introducir un ácido nucleico seleccionado enuna célula huésped determinada, cuyo contenido esun copolímero anfifílico de poliéster-polication y un copolímero anfifílico depoliéster-azucar . El copolímero de poliéster-polication forma una interaccionelectrostática con ácidos nucleicos polianionicos y el copolímero de poliéster-azucar dirige el complejo de micelas-ácido nucleico a las células in vivo.También puedenincluirse otros copol ímeros con propiedades similares. La composicion optimiza la eficiencia de introduccion mediante un transportador de genesparticulado, para lo cual se controlan fácilmente mediante multivariados medios, el tamano de lapartícula y la densidad de carg a. Asimismo, puedenincorporarse diversas clases de ligandos y otros compuestos funcionales. La composicion puede utilizarse en un método para transformar una célula huéspeddeterminada con un ácido nucleicoseleccionado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6955197P | 1997-12-12 | 1997-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR018528A1 true AR018528A1 (es) | 2001-11-28 |
Family
ID=22089740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980106330A AR018528A1 (es) | 1997-12-12 | 1998-12-11 | Mezcla polimerica biodegradable de micelas para transferencia genetica |
Country Status (13)
Country | Link |
---|---|
US (1) | US6210717B1 (es) |
EP (1) | EP1037611B1 (es) |
JP (1) | JP4570776B2 (es) |
KR (1) | KR20010032878A (es) |
CN (1) | CN1281355A (es) |
AR (1) | AR018528A1 (es) |
AT (1) | ATE412403T1 (es) |
AU (1) | AU740342B2 (es) |
BR (1) | BR9813548A (es) |
DE (1) | DE69840175D1 (es) |
IL (1) | IL136681A0 (es) |
WO (1) | WO1999029303A1 (es) |
ZA (1) | ZA9811376B (es) |
Families Citing this family (84)
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WO1999034831A1 (en) * | 1998-01-05 | 1999-07-15 | University Of Washington | Enhanced transport using membrane disruptive agents |
WO2002085337A1 (en) * | 2001-04-20 | 2002-10-31 | The University Of British Columbia | Micellar drug delivery systems for hydrophobic drugs |
SE9904581D0 (sv) * | 1999-12-15 | 1999-12-15 | A & Science Invest Ab | A novel helicobacter pylori-binding substance and use thereof |
AU2764801A (en) * | 2000-01-07 | 2001-07-24 | University Of Washington | Enhanced transport of agents using membrane disruptive agents |
US20030134420A1 (en) * | 2000-02-18 | 2003-07-17 | Lollo Charles Peter | Methods and compositions for gene delivery |
WO2001093836A2 (en) * | 2000-06-09 | 2001-12-13 | Teni Boulikas | Encapsulation of polynucleotides and drugs into targeted liposomes |
US20030072794A1 (en) * | 2000-06-09 | 2003-04-17 | Teni Boulikas | Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes |
US7265186B2 (en) * | 2001-01-19 | 2007-09-04 | Nektar Therapeutics Al, Corporation | Multi-arm block copolymers as drug delivery vehicles |
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CA2440935A1 (en) * | 2001-03-13 | 2002-09-19 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
US20030157170A1 (en) * | 2001-03-13 | 2003-08-21 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
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US7326426B2 (en) | 2002-03-29 | 2008-02-05 | Ethicon, Inc. | Compositions and medical devices utilizing bioabsorbable liquid polymers |
US7005136B2 (en) | 2002-03-29 | 2006-02-28 | Ethicon, Inc. | Bone replacement materials utilizing bioabsorbable liquid polymers |
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AR037006A1 (es) * | 2002-06-20 | 2004-10-20 | S I G Sist S De Identificacion | Marcador de objetos a identificar consistente en al menos un fragmento de adn. |
US7026374B2 (en) | 2002-06-25 | 2006-04-11 | Aruna Nathan | Injectable microdispersions for medical applications |
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US6872799B2 (en) | 2002-12-18 | 2005-03-29 | Ethicon, Inc. | Functionalized polymers for medical applications |
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US7135523B2 (en) * | 2003-03-14 | 2006-11-14 | Industrial Technology Research Institute | Nanoscale helical microstructures and channels from chiral poly(L-lactide) block containing block copolymers |
SE0300805D0 (sv) * | 2003-03-25 | 2003-03-25 | Biacore Ab | Immobilization method and kit therefor |
WO2004086046A1 (en) * | 2003-03-25 | 2004-10-07 | Biacore Ab | Immobilization method and kit therefor |
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US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
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US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
CA2543257C (en) | 2003-10-24 | 2013-12-31 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
US20050238675A1 (en) * | 2004-04-26 | 2005-10-27 | Wenjie Li | Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications |
EP1765403A4 (en) * | 2004-05-10 | 2011-03-30 | Univ Utah Res Found | COMBINED ACTIVE AND PASSIVE TARGETING OF BIOLOGICALLY ACTIVE ACTIVE SUBSTANCES |
CN101115471B (zh) * | 2005-02-17 | 2011-02-09 | 梅迪沃什有限公司 | 聚合物颗粒输送组合物及使用方法 |
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KR20080064827A (ko) | 2005-10-05 | 2008-07-09 | 도쿄 씨알오 가부시키가이샤 | 생체 적합성 블록 공중합체, 그 용도 및 제조법 |
US7718193B2 (en) * | 2006-03-16 | 2010-05-18 | University Of Washington | Temperature- and pH-responsive polymer compositions |
CN101595214B (zh) * | 2006-11-29 | 2013-06-12 | 诺维信股份有限公司 | 改进向细菌细胞中导入dna的方法 |
US7981688B2 (en) | 2007-03-08 | 2011-07-19 | University Of Washington | Stimuli-responsive magnetic nanoparticles and related methods |
JP5270884B2 (ja) * | 2007-09-03 | 2013-08-21 | 大阪瓦斯株式会社 | 分散剤およびこの分散剤を含むポリ乳酸系複合樹脂粒子 |
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US9476063B2 (en) | 2008-05-13 | 2016-10-25 | University Of Washington | Diblock copolymers and polynucleotide complexes thereof for delivery into cells |
KR101764427B1 (ko) | 2008-05-13 | 2017-08-02 | 유니버시티 오브 워싱톤 | 미셀성 어셈블리 |
JP2011523641A (ja) | 2008-05-13 | 2011-08-18 | ユニヴァーシティ オブ ワシントン | 高分子キャリア |
EP2331069A4 (en) | 2008-08-22 | 2011-10-26 | Univ Washington | HETEROGENEOUS POLYMER MICELLES FOR INTRACELLULAR DELIVERY |
US9464300B2 (en) | 2008-11-06 | 2016-10-11 | University Of Washington | Multiblock copolymers |
US8822213B2 (en) | 2008-11-06 | 2014-09-02 | University Of Washington | Bispecific intracellular delivery vehicles |
WO2010077678A2 (en) | 2008-12-08 | 2010-07-08 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
AU2009331027B2 (en) * | 2008-12-26 | 2012-12-13 | Samyang Holdings Corporation | Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug |
EP2201935B1 (en) * | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Polymeric micelle composition containing a poorly soluble drug and preparation method of the same |
WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
EA201171195A8 (ru) * | 2009-03-30 | 2014-08-29 | Серулин Фарма Инк. | Конъюгаты, частицы, композиции "полимер-агент" и способы их применения |
US8426214B2 (en) * | 2009-06-12 | 2013-04-23 | University Of Washington | System and method for magnetically concentrating and detecting biomarkers |
US9080933B2 (en) | 2009-11-09 | 2015-07-14 | University Of Washington Through Its Center For Commercialization | Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates |
US20110117668A1 (en) * | 2009-11-09 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Self-powered smart diagnostic devices |
US9415113B2 (en) | 2009-11-18 | 2016-08-16 | University Of Washington | Targeting monomers and polymers having targeting blocks |
US8765098B2 (en) | 2010-03-30 | 2014-07-01 | International Business Machines Corporation | Star polymers, methods of preparation thereof, and uses thereof |
EP2658567A4 (en) | 2010-12-28 | 2014-09-24 | Univ Rochester | METHOD FOR MODIFYING INSULIN SIGNAL TRANSMISSION BY BILIVERDINREDUCTASE (BVR) AND BVR-DERIVED PEPTIDES |
EP2661454A4 (en) * | 2011-01-06 | 2014-12-10 | Univ Shanghai Jiaotong | CATIONIC POLYMERS FORMED FROM MONOMERS HAVING AMINO GROUPS AND HETEROCYCLIC COUPLERS |
CA2839526A1 (en) | 2011-06-23 | 2012-12-27 | Dsm Ip Assets B.V. | Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents |
US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
CN102516534B (zh) * | 2011-11-14 | 2013-11-20 | 上海交通大学 | 可降解为精胺的聚阳离子及其合成方法、纳米颗粒 |
EP2908853B1 (en) | 2012-10-21 | 2018-12-05 | University Of Rochester | Thy1 (cd90) as a therapy to control adipose tissue accumulation |
AU2014296278C1 (en) | 2013-07-30 | 2023-02-02 | Genevant Sciences Gmbh | Block copolymers and their conjugates or complexes with oligonucleotides |
EP3033108B1 (en) | 2013-08-16 | 2021-03-24 | University Of Rochester | Designed peptides for tight junction barrier modulation |
JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
CN106102777B (zh) * | 2013-12-27 | 2019-12-17 | 林希龙 | 用于生物体内及体外递送核酸系药物的新颖糖醇系组成物 |
CA2969171C (en) | 2014-12-18 | 2023-12-12 | Dsm Ip Assets B.V. | Drug delivery system for delivery of acid sensitive drugs |
AU2016209295B2 (en) | 2015-01-21 | 2021-08-12 | Genevant Sciences Gmbh | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
CN104829786A (zh) * | 2015-05-04 | 2015-08-12 | 中国科学院上海有机化学研究所 | 侧挂天然半乳糖和赖氨酸的阳离子大分子、制备方法及其用途 |
ES2907486T3 (es) | 2015-09-24 | 2022-04-25 | Univ North Carolina Chapel Hill | Métodos y composiciones para reducir metástasis |
CA3008788C (en) * | 2015-12-18 | 2021-05-25 | Samyang Biopharmaceuticals Corporation | Method for preparing polymeric micelles containing an anionic drug |
EP3562510A4 (en) | 2016-12-30 | 2021-01-06 | Genevant Sciences GmbH | BRANCHED PEG MOLECULES AND ASSOCIATED COMPOSITIONS AND PROCEDURES |
WO2019049862A1 (ja) * | 2017-09-05 | 2019-03-14 | 味の素株式会社 | ポリリジン誘導体 |
WO2019129657A1 (en) | 2017-12-28 | 2019-07-04 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Actively targeted polymeric micelles for drug and gene delivery |
WO2020247347A1 (en) | 2019-06-05 | 2020-12-10 | University Of Rochester | New designed inhibitors of tight junction formation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3808531C1 (es) | 1988-03-15 | 1989-07-13 | Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De | |
US5501662A (en) | 1992-05-22 | 1996-03-26 | Genetronics, Inc. | Implantable electroporation method and apparatus for drug and gene delivery |
US5273525A (en) | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
WO1995003356A1 (en) * | 1993-07-23 | 1995-02-02 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
DE69534780T2 (de) * | 1994-04-08 | 2006-10-05 | Qlt Usa Inc., Fort Collins | Flüssige Zusammensetzungen zur Arzneistoffabgabe |
US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
-
1998
- 1998-12-11 AT AT98963871T patent/ATE412403T1/de not_active IP Right Cessation
- 1998-12-11 BR BR9813548-1A patent/BR9813548A/pt not_active IP Right Cessation
- 1998-12-11 AU AU19108/99A patent/AU740342B2/en not_active Ceased
- 1998-12-11 DE DE69840175T patent/DE69840175D1/de not_active Expired - Lifetime
- 1998-12-11 US US09/209,631 patent/US6210717B1/en not_active Expired - Lifetime
- 1998-12-11 AR ARP980106330A patent/AR018528A1/es not_active Application Discontinuation
- 1998-12-11 JP JP2000523975A patent/JP4570776B2/ja not_active Expired - Lifetime
- 1998-12-11 EP EP98963871A patent/EP1037611B1/en not_active Expired - Lifetime
- 1998-12-11 KR KR1020007006208A patent/KR20010032878A/ko active IP Right Grant
- 1998-12-11 WO PCT/US1998/026403 patent/WO1999029303A1/en active IP Right Grant
- 1998-12-11 IL IL13668198A patent/IL136681A0/xx unknown
- 1998-12-11 CN CN98812132A patent/CN1281355A/zh active Pending
- 1998-12-11 ZA ZA9811376A patent/ZA9811376B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1037611A1 (en) | 2000-09-27 |
ATE412403T1 (de) | 2008-11-15 |
EP1037611B1 (en) | 2008-10-29 |
JP2001525357A (ja) | 2001-12-11 |
CN1281355A (zh) | 2001-01-24 |
KR20010032878A (ko) | 2001-04-25 |
WO1999029303A1 (en) | 1999-06-17 |
AU1910899A (en) | 1999-06-28 |
IL136681A0 (en) | 2001-06-14 |
DE69840175D1 (de) | 2008-12-11 |
EP1037611A4 (en) | 2006-09-20 |
JP4570776B2 (ja) | 2010-10-27 |
BR9813548A (pt) | 2000-10-10 |
US6210717B1 (en) | 2001-04-03 |
ZA9811376B (en) | 1999-06-28 |
AU740342B2 (en) | 2001-11-01 |
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